SIF - Societā
Italiana di Farmacologia
"SIF - La Ricerca Farmacologica in Italia"
PHARMACOLOGY OF THE
CENTRAL NERVOUS SYSTEM I
RESEARCH GROUP MEMBERS:
-
Annunziato Lucio, P.O.
-
Amoroso Salvatore, P.A.
-
Taglialatela Maurizio, R.U.(*)
-
Fatatis Alessandro, D.R.
-
Cataldi Mauro, D.R.
-
Iossa Silvana, DDR.
-
Gioielli Anna, DDR.
-
Castaldo Pasqualina, B.
AFFILIATION:
Sezione di Farmacologia,
Dipartimento di Scienza della Comunicazione Umana
Facoltā di Medicina e Chirurgia
Universitā Federico II
ADDRESS: Via Pansini, 5
CITY: Napoli
POSTAL CODE: 80131
TELEPHONE: 081-746-3323, 3318, 3330, 3315
FAX: 081-746-3323
E-MAIL: farmacol@unina.it;
(*) mtaglial@unina.it
PUBLICATIONS:
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BERNARDI H., DE WEILLE J.R., EPELBAUM J., MOURRE C., AMOROSO S., SLAMA
A., FOSSET M., AND LAZDUNSKI M.: ATP-modulated K+ channels sensitive to
antidiabetic sulfonylureas are present in adenohypophysis and are involved
in growth hormone release. Proc. Nat. Acad. Sci. USA. 90 :1340-1344,
1993.
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AMOROSO S., SENSI S., DI RENZO G.F., AND ANNUNZIATO L.: The inhibition
of the Na +-Ca2+ exchanger enhances anoxia and glucopenia-induced [3H]
aspartate release in h ippocampal slices. J. Pharmacol. Exp. Ther.
264: 515-520, 1993.
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CANZONIERO L.M.T., TAGLIALATELA M., DI RENZO G.F., AND ANNUNZIATO L.: Gadolinium
and Neomycin block voltage-sensitive Ca2+ channels without interfering
with the Na+-Ca2+ antiporter in brain nerve endings. Eur. J. Pharmacol.,
Molecular Pharmacology Section. 245: 97-103, 1993.
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TAGLIALATELA M., WIBLE B., CAPORASO R., AND BROWN A.M: Specification of
pore properties by the carboxyl-terminus of inwardly-rectifying K+ channels.
Science.
264: 844-847, 1994.
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FATATIS A., BASSI A., IANNOTTI E., CASO N., MITA G.D., DI RENZO G.F., AND
ANNUNZIATO L.: Appearance of depolarization and maitotoxin induce [Ca2+]i
elevation in LAN-1 human neuroblastoma cells upon exposure to retinoid
acid. J. Neurochem.. 63: 1900-1907, 1994.
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FATATIS A., HOLTZCLAW L.A., AVIDOR R., BRENNEMAN D.E., AND RUSSEL J.T.:
VIP increases intracellular calcium in astroglia: synergism with a-adrenergic
receptors. Proc. Nat. Acad. Sci. USA. 61- 2036-2040, 1994.
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FATATIS A., CAPORASO R., IANNOTTI E., BASSI A., DI RENZO G.F., AND ANNUNZIATO
L.: Relationship between time of activation of PhosPholipase C-linked plasma
membrane receptors and reloading of intracellular Ca2+ strores in LAN-1
human neuroblastoma cells. J. Biol. Chem. 269: 18021-18027, 1994.
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AMOROSO S., IANNOTTI E., SAGGESE M.L., DI RENZO G.F., AND ANNUNZIATO L.:
The A1 agonist CCPA reduced bisoxonol-monitored membrane potential depolarization
elicited by high K+ in cerebrocortical nerve endings. Biochim. Biophys.
Acta. 1239: 67-73, 1995.
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CATALDI, M., TAGLIALATELA, M., GUERRIERO, S., AMOROSO, S., LOMBARDI, G.,
DI RENZO, G.F. , and ANNUNZIATO, L. : Protein tyrosine kinases activate
while proetin tyrosine phosphatases inihibit L-type calcium channel activity
in pituitary GH3 cells. J. Biol. Chem.. 271: 9441-9446, 1996.
TAGLIALATELA, M., ONGINI, E., BROWN, A.M., DI RENZO, G.F., and ANNUNZIATO,
L. Felbamate inhibits voltage-dependent Na+ channels from human
and rat brain. Eur. J. Pharmacol. In press, 1996.
RESEARCH GROUP MEMBERS:
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Arrigo Reina Rosa, P.A.
-
Nicoletti Ferdinando, P.A.
-
Scoto Giovanna Maria, P.A.
-
Spadaro Concetta, P.A.
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Chiechio Santina, D.DR.
-
Parenti Carmela, D.DR.
-
Gentile Michele, D.DR.
AFFILIATION:
Istituto di Farmacologia e Farmacognosia,
Facoltā di Farmacia
Universitā Catania
ADDRESS: Cittā Universitaria, Viale A. Doria, 6
CITY: Catania
POSTAL CODE: 25125
TELEPHONE: 095 - 330533 (int. 222, 285),
095 - 338378
FAX: 095 - 338378
PUBLICATIONS:
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ARRIGO-REINA, R., CATTI, T. AND CHIECHIO, S. Increased analgesic potency
of morphine following repeated anaphylactoid reaction by C48/80 involves
cyclooxygenase products of arachidonic acid. Agents Actions. 38:
269-271, 1993.
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SCOTO, G.M. AND PARENTI, C. Prevention of stress-induced gastric ulcers
by and opioid agonists in the rat. J. Physiol. 87: 385-388, 1993.
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ARRIGO-REINA, R. AND CHIECHIO, S. Histaminergic mechanisms in clonidine
induced analgesia in rat tail-flick test. Inflammation Res. 44:
21-23, 1995.
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SCOTO, G.M. AND PARENTI, C. Central and peripheral involvement of endogenous
opioid peptides in gastric protection in stressed rats. Pharmacology.
52 : 56-60, 1996.
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CHIECHIO, S., SPADARO, C., AND ARRIGO-REINA, R. H3-histamine receptors
and clonidine analgesia in rats. Inflamm. Res. In press, 1996.
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NICOLETTI, F., BRUNO, V., COPANI, A., CASABONA, G., KNOEPFEL, T. Metabotropic
glutamate receptors: a new target for the therapy of neurodegenerative
disorders? Trends in Neurosci. 19: 267-271, 1996.
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THOMSEN C., BRUNO V., NICOLETTI F., MARINOZZI M., PELLICCIARI R. (2S, 1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)
glycine, a potent and selective antagonist of type II metabotropic glutamate
receptors. Mol. Pharmacol. 50 : 6-9, 1996.
RESEARCH GROUP MEMBERS:
-
Bartolini Alessandro, P.O.
-
Malmberg-Aiello Petra, R.U.
-
Ghelardini Carla, R.U.
-
Galeotti Nicoletta, D.DR.
-
Lamberti Claudia, B.
-
Ipponi Alessandra, B.
AFFILIATION :
Dipartimento di Farmacologia Preclinica e Clinica "M. Aiazzi Mancini"
Universitā di Firenze
ADDRESS: Viale Morgagni, 65
CITY: Firenze
POSTAL CODE: 50134
TELEPHONE: 055-4237-432, 437, 415
FAX: 055-4361613
E-MAIL: bartolin@stat.ds.unifi.it
PUBLICATIONS:
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ROMANELLI, M.N., GHELARDINI, C., DEI, S., MATUCCI, R., MORI, F., SCAPECCHI,
S., TEODORI, E., BARTOLINI, A., GALLI, A. AND GUALTIERI F. Synthesis and
biological activity of a series of aryl tropanyl esters and amides chemically
related to 1H-indole-3-carboxylic acid endo 8-methyl-8-azabicyclo[3.2.1.]oct-3-yl
ester: development of a 5-HT4 agonist endowed with potent antinociceptive
activity. Arzeneim-Forsch Drug Res., 43: 913-918, 1993.
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FRANCHINI, C., CHIAIA NOJA, F., CORBO, F., LENTINI, G., TORTORELLA, V.,
BARTOLINI, A., GHELARDINI, C., MATUCCI, R. AND GIOTTI, A. Stereoselectivity
in central analgesic action of tocainide and its analogs. Chirality.
5: 135-142, 1993.
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MALMBERG-AIELLO, P., LAMBERTI, C., GHELARDINI, C., GIOTTI, A. AND BARTOLINI,
A. Role of histamine in rodent antinociception. Brit. J. Pharmacol.
111: 1269-1279, 1994.
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GUALTIERI, F., CONTI, G., DEI, S., GIOVANNONI, M.P., NANNUCCI, F., ROMANELLI,
M. N., SCAPECCHI, S., TEODORI, E., FANFANI, L., GHELARDINI, C., GIOTTI,
A., BARTOLINI, A. Presynaptic cholinergic modulators as potent cognition
enhancers and analgesic drugs. I. Tropic and 2-phenylpropinic acid esters,
J.
Med. Chem. 37: 1704- 1711, 1994.
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GUALTIERI, F., BOTTALICO, C., CALANDRELLA, A., DEI, S., GIOVANNONI, M.P.,
MEALLI, S., ROMANELLI, M.N., SCAPECCHI, S., TEODORI, E., GALEOTTI, N.,
GHELARDINI, C., GIOTTI, A. AND BARTOLINI A. Presynaptic cholinergic modulators
as potent cognition enhancers and analgesic drugs. II. 2-phenoxy-,
2-(phenylthio)- and 2-(phenylamino) alkanoic acid esters, J. Med. Chem.
37 : 1712- 1719, 1994.
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GHELARDINI, C., BARTOLINI, A., GALEOTTI, N., TEODORI, E. AND GUALTIERI,
F. S-(-)-ET 126: a potent and selective M1 antagonist in vitro and in vivo.
Life
Sci. 58: 991-1000, 1996.
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LAMBERTI, C., BARTOLINI, A., GHELARDINI, C. AND MALMBERG-AIELLO, P. Investigation
into the role of histamine receptors in rodent antinociception. Pharmacol.
Biochem. Behav. 53:567-574, 1996
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GHELARDINI, C., GALEOTTI, N., CASAMENTI, F., MALMBERG-AIELLO, P., PEPEU,
G., GUALTIERI, F. AND BARTOLINI, A. Central cholinergic antinociception
induced by 5-HT4 agonists: BIMU 1 and BIMU 8. Life Sci. 58: 2297-2309,
1996.
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GALEOTTI, N., GHELARDINI, C. AND BARTOLINI, A. Piracetam and Aniracetam
antagonism of centrally-active drugs-induce antinociception, Pharmacol.
Biochem. Behav. 53 (4): 943-950, 1996.
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GALEOTTI, N., GHELARDINI, C., BARTOLINI, A. Effect of pertussis toxin on
morphine, diphenhydramine, baclofen, clomipramine and physostigmine antinociception..,
Eur.
J. Pharmacol 308: 125-133, 1996.
RESEARCH GROUP MEMBERS:
-
Battaini Fiorenzo, R.U. *
-
Pascale Alessia, D.DR. #
-
Lucchi Laura, T.#
AFFILIATION:
* Dipartimento di Medicina Sperimentale e Scienze Biochimiche
Facoltā di Medicina e Chirurgia
Universitā di Roma Tor Vergata
# Istituto di Scienze Farmacologiche
Facoltā di Farmacia
Universitā di Milano
ADDRESS: Via di Tor Vergata, 135
CITY: Roma
POSTAL CODE: 00133
TELEPHONE: 06/7259 6310
FAX: 06/7259 6302
PUBLICATIONS :
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LUCCHI L., PASCALE A., BATTAINI F., GOVONI S. AND TRABUCCHI M.: Cognition
stimulating drugs modulate PKC activity in cerebral cortex and hippocampus
of adult rats. Life Sci., 53: 1821-1832, 1993.
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MARTINI A., BATTAINI F., GOVONI S. AND VOLPE P.: Inositol 1,4,5 tris-phosphate
receptor and ryanodine receptor in the aging brain of Wistar rats. Neurobiol.
Aging, 15: 203-206,1994.
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BATTAINI F., GARBILLO G., BERGAMASCHI S., PARENTI M., WETSEL W.C., GOVONI
S. AND TRABUCCHI M.: Regulation of protein kinase C in NG 108-15 cell differentiation.
Biochem.
Biophys. Res. Comm. 201: 135-142, 1994.
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BATTAINI F., PASCALE A., LUCCHI L., RACCHI M., BERGAMASCHI S., PARENTI
M., WETSEL W.C., GOVONI S. AND TRABUCCHI M.: Expression and regulation
of calcium-independent protein kinase C in NG 108-15 cell differentiation.
Biochem. Biophys. Res. Comm. 203: 1423-1431, 1994.
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PASCALE A., MILANO S., CORSICO N., LUCCHI L., BATTAINI F., ARRIGONI E.,
TRABUCCHI M., GOVONI S. Protein kinase C activation and anti-amnesic effect
of acetyl-L-carnitine: "in vitro" and "in vivo" studies. Eur. J. Pharmacol.,
265: 1-7, 1994. .
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BATTAINI F., ELKABES S., BERGAMASCHI S., LADISA V., LUCCHI L., DE GRAAN
P.N.E., SCHUURMAN T., WETSEL W.C., TRABUCCHI M. AND GOVONI S.: Protein
kinase C activity, translocation and conventional isoforms in aging rat
brain. Neurobiol. Aging, 16: 137-148, 1995.
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BERGAMASCHI S., BATTAINI F., TRABUCCHI M., PARENTI M. LOPEZ C.M. AND GOVONI
S. Neuronal differentiation modifies the effect of ethanol exposure on
voltage-dependent calcium channels in NG108-15 cells. Alcohol, 12:
324-327, 1995.
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PINTOR A., FORTUNA S., LORENZINI P., PASCALE A., BATTAINI F., AVELLINO
C., MALVEZZI CAMPEGGI L., SALVATI S. Influence of hypothyroidism on lipid
composition, responsiveness of inositol lipid-linked receptors and protein
kinase C activity in the cerebral cortex of Lewis rats. Neurochem. Res.21:
539-543, 1996 .
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PASCALE A., FORTINO I., GOVONI S., TRABUCCHI M., WETSEL W.C., AND BATTAINI
F. Differential isoform-specific regulation of calcium-independent protein
kinase C in rat cerebral cortex. Neurosci. Lett. 214 : 99-102, 1996.
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PASCALE A., FORTINO I., GOVONI S., TRABUCCHI M., WETSEL W.C., AND BATTAINI
F. Functional impairment in protein kinase C by RACK1 (receptor for activated
C kinase) deficiency in aged rat brain cortex. J. Neurochem. 67
: 2471-2477, 1996.
RESEARCH GROUP MEMBERS:
-
Beani Lorenzo P.O.
-
Bianchi Clementina P.O.
-
Antonelli Tiziana P.A.
-
Siniscalchi Anna P.A.
-
Simonato Michele R.U.
-
Morari Michele R.U.
-
Ferraro Luca T.L.
-
Barbieri Mario B.PDR.
-
Badini Irene D.DR.
-
Bregola Gianni D.DR.
-
Tomasini Cristina D.DR.
-
Sbrenna Simone D.DR.
AFFILIATION:
Sezione di Farmacologia
Dipartimento di Medicina Clinica e Sperimentale
Facoltā di Medicina e Chirurgia
Universitā di Ferrara
ADDRESS: Via Fossato di Mortara 17-19
CITY: Ferrara
POSTAL CODE: 44100
TELEPHONE: 0532-291204, 291202, 291201
FAX: 0532-291205
E-MAIL: fma@ifeuniv.unife.it
PUBLICATIONS:
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FERRARO, L., CALO', G., ANTONELLI, T., FABRIZI, A., ACCIARRI, N.,
BIANCHI, C., BEANI, L., AND SIMONATO, M. Noradrenergic modulation of Gamma-aminobutyric
acid outflow from the human cerebral cortex. Brain Res. 629: 103-108,
1993.
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MORARI, M., O'CONNOR, W.T., UNGERSTEDT, U., AND FUXE, K. N-methyl-D-aspartate
acid differentially regulates extra-cellular dopamine, GABA and glutamate
levels in the dorsolateral neostriatum of the halothane-anesthetized rat:
An in vivo microdialysis study. J. Neurochem. 60: 1884-1893, 1993
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SINISCALCHI, A., BADINI, I., BIANCHI, C., AND BEANI, L. Monoamines modulates
the electrically-evoked efflux of 3H-choline from slices of guinea pig
nucleus basalis magnocellularis. Naunyn-Schmied. Arch. Pharmacol.
350: 10-14, 1994.
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TANGANELLI, S., O'CONNOR, W.T., FERRARO, L., BIANCHI, C., BEANI, L., UNGERSTEDT,
U., AND FUXE, K. Facilitation of GABA release by neurotensin is associated
with reduction of dopamine release in rat nucleus accumbens. Neurosci.
69 : 649-657, 1994.
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BIANCHI, C., FERRARO, L., TANGANELLI, S., MORARI, M., SPALLUTO, G., SIMONATO,
M., AND BEANI, L. 5-hydroxytryptamine-mediated effects of nicotine on endogenous
GABA efflux from guinea pig cortical slices. Brit. J. Pharmacol.
116: 2724 - 2728, 1995.
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HOSFORD, D.A., SIMONATO, M., CAO, Z., GARCIA CAIRASCO, J.M., SILVER, J.M.,
BUTLER, L., SHIN, C., AND MCNAMARA, J.O. Differences in the anatomic distribution
of immediate early gene expression in amigdala and angular bundle kindling
development. J. Neurosci. 15: 2513-2523, 1995.
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ROMUALDI, P., DONATINI, A., BREGOLA, G., BIANCHI C., BEANI, L., FERRI,
S., AND SIMONATO, M. Early changes in pro-dynorphin mRNA and ir-dynorphin
A levels after kindled seizures in the rat. Eur. J. Neurosci. 7:
1850-1856, 1995.
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FERRARO, L., O'CONNOR, W. T., LI, X.M., RIMONDINI, R., BEANI, L., UNGERSTED,
U., FUXE, K., AND TANGANELLI, S. Evidence for a differential CCKB and CCKA
receptor regulation of GABA release in the nucleus accumbens mediated via
opaminergic and cholinergic mechanisms. Neurosci. 73: 941-950, 1996.
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MORARI, M., O'CONNOR, W.T., UNGERSTED, U., AND BIANCHI, C. Functional neuroanatomy
of the nigrostriatal pathways as studied with dual microdialysis probe
in the awake rat I. Effects of perfusion with tetrodotoxin and low-calcium.
Neurosci.
72: 79-88, 1996.
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MORARI, M., O'CONNOR, W.T., UNGERSTED, U., AND BIANCHI, C. Functional neuroanatomy
of the nigrostriatal pathways as studied with dual microdialysis probe
in the awake rat. II. Evidence for striatal N-methyl-D-aspartate receptor
regulation of striatonigral gabaergic transmission and motor function.
Neurosci.
72: 89-97, 1996
RESEARCH GROUP MEMBERS:
-
Benzi GianMartino, P.O.
-
Moretti Antonio, B.
-
Viganotti Carla, P.A.
-
Marzatico Fulvio, R.U.
-
Bertorelli Laura, D.DR.
-
Guallini Paola, B.
-
Finotti Nicoletta, B.
-
Curti Daniela, R.U.
-
Cattaneo Achille, B.
-
Rognoni Francesca, B.
-
Cuccia Mariaclara, P.A.
-
Pastoris Ornella, R.U.
-
Dossena Maurizia, B.PDR.
-
Catapano Mariana D.DR.
-
Foppa Paola D.DR.
-
Pagani Sara, B.
-
Villa Roberto Federico, R.U.
-
Gorini Antonella, B.PDR.
-
Canosi Umberto, D.DR.
-
D'angelo Angela, B.
-
Maggi Anna, B.
AFFILIATION:
Istituto di Farmacologia
Facoltā di Scienze
Universitā di Pavia
ADDRESS: Piazza Botta, 11
CITY: Pavia
POSTAL CODE: 27100
TELEPHONE: 0382 506 381,384
FAX: 0382 506 385
E-MAIL: carla@ipv36.unipv.it;
curtid@ipv36.unipv.it;
fulviomk@ipv36.unipv.it;
orpast@ipv36.unipv.it;
rfvilla@ipv36.unipv.it
PUBLICATIONS:
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BENZI G.,GORINI A., ARNABOLDI R., GHIGINI B. AND VILLA R.F. Age-related
changes by hypoxia and TRH analogue treatment on synaptosomal non-mitochondrial
ATPase activities. J. Neurosci.Res. 34: 654-663, 1993
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BENZI G., GORINI A., ARNABOLDI R., GHIGINI B. AND VILLA R.F. Effect of
intermittent mild hypoxia and drug treatment on synaptic non-mitochondrial
ATPase activities. Neurobiol. Aging. 15:409-417, 1994
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PASTORIS O., DOSSENA M., FOPPA P., ARNABOLDI R., GORINI A., VILLA R., AND
BENZI G. Modifications by chronic intermittent hypoxia and drug treatment
on skeletal muscle metabolism. Neurochem. Res. 20: 143-150, 1995.
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CAFE' C., TORRI C., BERTORELLI L., TARTARA F., TANCIONI F., GAETANI
P., RODRIGUEZ Y BAENA R., MARZATICO F. Oxidative events in neuronal and
glial cell-enriched fractions of rat cerebral cortex. Free Rad. Biol.
Med. 19: 853-857, 1995
-
BENZI G. AND MORETTI, A. Age-and peroxidative stress-related modifications
of the cerebral enzymatic activities linked to mitochondria and the glutathione
system. Free Rad. Biol. Med. 77 :77-101, 1995
-
BENZI G. AND MORETTI A Are reactive oxygen species involved in Alzheimer's
disease? Neurobiol. Aging 16: 661-674, 1995
-
CAFÉ C., TORRI C., BERTORELLI L., ANGERETTI N., LUCCA E., FORLONI
G., MARZATICO F. Oxidative stress after acute and chronic apllication of
b-amyloid fragment 25-35 in cortical neurons. Neurosci. Lett. 203:
61-65, 1996
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OPASICH C., AQUILANI R., DOSSENA M., FOPPA P., CATAPANO M., PAGANI S.,
FERRARI R., PASINI E., TAVAZZI L. AND PASTORIS O. Skeletal metabolism of
the muscle in resting and fasting patients with severe chronic heart failure.
Eur.
Heart J. 17: 1686-1693, 1996
-
WHATLEY S.A., CURTI D. AND MARCHBANKS R.M. Mitochondrial involvement in
schizophrenia and other functional psychoses. Neurochem. Res. 21:1001-1010,
1996.
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CURTI D., MALASPINA A., FACCHETTI G., CAMANA C., MAZZINI L., TOSCA P.,
ZERBI F. AND CERONI M. Amyotrophic lateral sclerosis: oxidative energy
metabolism and calcium homeostasis in peripheral blood lymphocytes. Neurology
47:
1060-1064, 1996.
RESEARCH GROUP MEMBERS:
-
Bertolini Alfio, P.O.
-
Bernardi Mara, P.A.
-
Genedani Susanna, P.A.
-
Benelli Augusta, R.U.
-
Cavazzuti Elena, D.DR.
AFFILIATION:
Sezione di Farmacologia
Dipartimento di Scienze Biomediche
Facoltā di Medicina e Chirurgia
Universitā di Modena
ADDRESS: Via G. Campi, 287
CITY: Modena
POSTAL CODE: 41100
TELEPHONE: 059-428-440, 412, 417, 416
FAX: 059-372653
E-MAIL: farmacol@.unimo.it
PUBLICATIONS:
-
GENEDANI, S. AND BERNARDI, M. ACTH-(11-24) antagonizes ACTH-(1-24)-induced
behavioral syndrome. Neuropeptides 26: 241-244, 1994.
-
GENEDANI, S., BERNARDI, M. AND BERTOLINI, A. Influence of ifenprodil on
the ACTH-induced behavioral syndrome in rats. Eur. J. Pharmacol.
252: 77-80, 1994.
-
GENEDANI, S., BERNARDI, M., OTTAVIANI, E., FRANCESCHI, C., LEUNG, M.K.,
AND STEFANO, G.B. Differential modulation of invertebrate hemocyte motility
by CRF, ACTH, and its fragments. Peptides 15: 203-206, 1994.
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POGGIOLI, R., BENELLI, A., ARLETTI, R., VERGONI, A.V., MENOZZI, B., AND
BERTOLINI, A. Old rats are unresponsive to the behavioral effects of adrenocorticotropin.
Eur. J. Pharmacol. 271: 253-257, 1994.
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POGGIOLI, R., BENELLI, A., ARLETTI, R., CAVAZZUTI, E., AND BERTOLINI, A.
K+ channel openers delay intestinal transit and have antidiarrheal activity.
Eur.
J. Pharmacol. 287: 207-209, 1995.
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VERGONI, A.V., SANDRINI, M., FILAFERRO, M., AND BERTOLINI, A. Opening of
brain potassium-channel inhibits the ACTH- induced behavioral syndrome
in the male rat. Neurosci. Lett. 188: 29-32, 1995.
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POGGIOLI, R., BENELLI, A., ARLETTI, R., CAVAZZUTI, E., AND BERTOLINI, A.
Nitric Oxide is involved in the ACTH-induced behavioral syndrome. Peptides
16:
1263-1268, 1995.
-
BERTOLINI, A. The opioid/anti-opioid balance in shock: a new target for
therapy in resuscitation. Resuscitation 30: 29-42, 1995.
-
BENELLI, A., BERTOLINI, A., POGGIOLI, R., CAVAZZUTI, E., CALZā,
L., GIARDINO, L., AND ARLETTI, R. Nitric Oxide is involved in male sexual
behavior of rats. Eur. J. Pharmacol. 294: 505-510, 1995.
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BERNARDI, M., BERTOLINI, A., SZCZAWINSKA, K., AND GENEDANI, S. Blockade
of the polyamine site of NMDA receptors produces antinociception and enhances
the effect of morphine in mice. Eur. J. Pharmacol. 298: 51-55, 1996.
RESEARCH GROUP MEMBERS:
-
Borea Pier Andrea, P. O.
-
Guerra Laura, D.DR
-
Gessi Stefania, D.DR.
-
Varani Katia, B.
-
Dalpiaz Alessandro, B.
AFFILIATION:
Sezione di Farmacologia
Dipartimento di Medicina Clinica e Sperimentale
Facoltā di Medicina e Chirurgia
Universitā di Ferrara
ADDRESS: Via Fossato di Mortara, 17/19
CITY: Ferrara
POSTAL CODE: 44100
TELEPHONE: 0532-291214
FAX: 0532-291205
E-MAIL: bpa@ifeuniv.unife.it
PUBLICATIONS:
-
GILLI P., FERRETTI V., GILLI G. AND BOREA P.A. Enthalpy-entropy compensation
in drug-receptor binding. J. Phys. Chem. 98: 1515-1518, 1994.
-
VARANI K., GUERRA L., BOREA P.A., DIONISOTTI S., ZOCCHI C. AND ONGINI E.
Binding characteristics of the adenosine A2 receptor ligand [3H]-CGS 21680
to human platelet membranes. Biochem. Pharmacol. 48:1658-1661, 1994.
-
IJZERMAN A.P., VAN DERWENDEN A.M., VONFRIJTAG J.K., DRABBE KUNZEL, MATHOT
R.A.A., DANHOF M., BOREA P.A. AND VARANI K. Partial agonism of theophylline-7-riboside
on adenosine receptors. Naunyn-Schmied. Arch. Pharmacol. 350: 638-645,
1994.
-
BOREA P.A., VARANI K., DALPIAZ A., CAPUZZO A., FABBRI E. AND IJZERMAN A.P.
Full and partial agonistic behaviour and thermodynamic binding parameters
of adenosine A1 receptor ligands. Eur. J. Pharmacol., Molecular Pharmacology
Section. 267: 55-61, 1994.
-
BOREA P.A., DALPIAZ A., VARANI K., GUERRA L. AND GILLI G. Binding thermodynamics
of adenosine A2a receptor ligands. Biochem. Pharmacol. 49: 461-469,
1995.
-
DALPIAZ A., VARANI K., BOREA P.A., MARTINI C., CHIELLINI G. AND LUCACCHINI
A. Biochemical and pharmacological characterization of periodate-oxidized
adenosine analogs at adenosine A1 receptors. Biochim. Biophys. Acta.
1267: 145-151, 1995.
-
DALPIAZ A., GESSI S., BOREA P.A. AND GILLI G. Discrimination of rat brain
5HT1A, 5HT2A and 5HT3 receptors by serotonin binding thermodynamics.
Life Sci. 57: PL 141-146, 1995.
-
VARANI K., GESSI S., DALPIAZ A. AND BOREA P.A. Biochemical and pharmacological
characterization of purified A2a adenosine receptors in human platelet
membranes by [3H]- CGS 21680 binding. Brit. J. Pharmacol.. 117:
1693-1701, 1996.
-
BOREA P.A., DALPIAZ A., GESSI S. AND GILLI G. Thermodynamics of 5-HT3 receptor
binding discriminates agonistic from antagonistic behaviour. Eur. J.
Pharmacol.. 298: 329-334, 1996.
-
BOREA P.A., VARANI K., GESSI S., DALPIAZ A. AND GILLI G. Binding Thermodynamics
at Adenosine A1 and A2a Receptors. Life Sci. 59: 1373-1388, 1996.
RESEARCH GROUP MEMBERS:
-
Borsini Franco, Capo Dipartimento
-
Brambilla Alessandro, Capo Sezione
-
Ceci Angelo, Capo Sezione
-
Giraldo Ettore, Capo Sezione
-
Monferini Eugenia, Capo Sezione
-
Sagrada Angelo, Capo Sezione
-
Cesana Raffaele, C.L.
-
Pitsikas Nikolaus, C.L.
-
Schiavi Giovanni Battista, C.L.
-
Volonté Marina, C.L.
-
Ciprandi Clara, R.I.
-
Scandroglio Alessandro, R.I.
-
Targa Roberta, R.I.
-
Stefani Rita, R.I.
AFFILIATION:
Dipartimento di Biologia
Divisione Ricerca e Sviluppo
Boehringer Ingelheim Italia
ADDRESS: Via Lorenzini, 8
CITY: Milano
POSTAL CODE: 20139
TELEPHONE: 02-5355.252
FAX: 02-5355.205
PUBLICATIONS:
-
PITSIKAS, N., BRAMBILLA, A., AND BORSINI, F. Effect of DAU 6215, a novel
5-HT3 receptor antagonist, on scopolamine-induced amnesia in the rat in
a spatial learning task. Pharmacol. Biochem. Behav. 47: 95-99, 1994.
-
CECI, A., BASCHIROTTO A., AND BORSINI, F. The inhibitory effect of 8-OH-DPAT
on the firing activity of dorsal raphe serotonergic neurons in rats is
attenuated by lesion of the frontal cortex. Neuropharmacology 33:
709-713, 1994.
-
CECI, A., FODRITTO, F., AND BORSINI, F.. Repeated treatment with fluoxetine
decreases the number of spontaneously active cells per track in frontal
cortex. Eur. J. Pharmacol. 271: 231-234, 1994.
-
BORSINI, F., GIRALDO, E., MONFERINI, E., ANTONINI, G., PARENTI, M., BIETTI,
G., AND DONETTI, A. BIMT 17, a 5-HT2A antagonist and 5-HT1A receptor full
agonist, in rat cerebral cortex. Naunyn-Schmied. Arch. Pharmacol.
352: 276-282, 1995.
-
BORSINI, F., CECI, A., BIETTI, G., AND DONETTI, A.. BIMT 17 a 5-HT1A agonist/5-HT2A
antagonist, directly activates postsynaptic 5-HT inhibitory responses in
the cortex. Naunyn-Schmied. Arch. Pharmacol. 352: 283-290, 1995.
-
VOLONTÉ, M., CECI, A., AND BORSINI, F. Effect of the 5-hydroxytryptamine3
receptor antagonist itasetron (DAU 6215) on (+)-N-allylnormetazocine-induced
dopamine release in the nucleus accumbens and in the corpus striatum of
the rat: an in vivo microdialysis study. J. Pharmacol. Exp. Ther.
275: 358-367, 1995.
-
CESANA, R., CIPRANDI, C., AND BORSINI, F., The effect of BIMT 17, a new
potential antidepressant, in the forced swimming test in mice. Behav.
Pharmacol. 6: 688-694, 1995.
-
BRAMBILLA, A., PRUDENTINO, A., GRIPPA, N., AND BORSINI, F. Pharmacological
characterization of AMPA-induced biting behaviour in mice. Eur. J. Pharmacol.
305: 115-117, 1996.
-
PITSIKAS, N., AND BORSINI, F. The 5-HT3 antagonist itasetron (DAU 6215)
prevents discrete memory impairment in the aged rat in a multiple choice
avoidance task. Eur. J. Pharmacol. 311: 115-119, 1996.
-
CECI A., AND BORSINI, F. Effects of desipramine and maprotiline on the
coeruleus-cortical noradrenergic system in anaesthetized rats. Eur.
J. Pharmacol. 312: 189-193, 1996.
RESEARCH GROUP MEMBERS:
-
Buffoni Franca, P.O. (fuori ruolo)
-
Ignesti Giovanni, P.A.
-
Cambi Sandro, T.
AFFILIATION:
Dipartimento di Farmacologia preclinica e clinica "M. Aiazzi Mancini"
Universitā di Firenze
ADDRESS: Viale G.B. Morgagni, 65
CITY: Firenze
POSTAL CODE: 50134
TELEPHONE: 055-4237411,405,400
FAX: 055-4361613
E-MAIL: buffoni@stat.ds.unifi.it
PUBLICATIONS:
-
BUFFONI F., BANCHELLI G., CAMBI S., IGNESTI G., PIRISINO R., RAIMONDI L.,
AND VANNELLI G. Skin wound healing, some biochemical parameters in guinea
pig skin. J. Pharm. Pharmacol. 45: 784-790, 1993
-
IGNESTI G., BANCHELLI G., PIRISINO R., RAIMONDI L., AND BUFFONI F. Some
problem with the diamine oxidase (DAO) assay using putrescine as substrate
in rat liver. Agents Actions. 39: 6-17, 1993
-
BUFFONI F. Properties, distribution and physiological role of semicarbazide-sensitive
amine oxidases. Curr. Topics Pharmacol. 2: 33-50, 1993
-
BUFFONI F., CAMBI S., BANCHELLI G., IGNESTI G., PIRISINO R., AND RAIMONDI
L. Semicarbazide-sensitive amine oxidase activity of guinea-pig dorsal
skin. J.Neural.Transm. 41: 421-426, 1994
-
BUFFONI F. Isolation and identification by GC-MS of the carbonyl active
site of pig kidney diamine oxidase. Anal. Biochem. 220: 185-191,1994
-
BUFFONI F., BANCHELLI G., IGNESTI G., PIRISINO R., AND RAIMONDI L. The
role of semicarbazide-sensitive amine oxidase with high affinity for benzylamine
(Bz.SSAO) in the catabolism of histamine in the mesenteric arterial bed
of the rat. Agents Actions. 42: 1-6, 1994
-
BUFFONI F., PIERACCINI G. Isolation and identification in rat tissues by
gas chromatography-mass spectrometry of a metabolite of 3,5-diethoxy-4-aminomethylpyridine
(B24), a specific inhibitor of the semicarbazide-sensitive amine oxidases
with high affinity for benzylamine. Pharmaceut. Sci. 1: 83-85, 1995
-
BUFFONI F., MONETI G., PIERACCINI G., AND BERTINI V. Identification by
gas chromatography- mass spectrometry of an adduct between pure pig plasma
benzylamine oxidase and the inhibitor 3,5-diethoxy-4-aminomethylpyridine.
J.
Enz. Inhib. 8: 267-179,1995
-
BUFFONI F. Semicarbazide-sensitive amine oxidases. Some biochemical properties
and general considerations. Progress. Brain Res. 106: 323-331, 1995
-
BUFFONI F., PINO R., AND DAL POZZO A. Effect of tripeptide-copper complexes
on the process of skin healing and on cultured fibroblasts. Arch. Int.
Pharmacodyn. 330: 345-360, 1995
RESEARCH GROUP MEMBERS:
-
Caciagli Francesco, P.O.
-
Ciccarelli Renata, R.U.
-
Di Iorio Patrizia, R.U.
-
Ballerini Patrizia, R.U.
-
Giuliani Patricia, T.L.
-
D'Alimonte Iolanda, B.
-
Ambrosini Grazia, B.
-
Renzetti Alessandro, B.
-
Tiboni Gian Mario, B.PDR.
-
Chimisso Michele, T.L.
AFFILIATION:
Istituto di Farmacologia e Tecnologie Bio-Mediche
Facoltā di Medicina e Chirurgia
Universitā "G. D'Annunzio"
ADDRESS: Via dei Vestini, 31
CITY: Chieti
POSTAL CODE: 66013
TELEPHONE: 0871 - 355259
FAX: 0871 - 355224
E-MAIL: isphar@phobos.unich.it
PUBLICATIONS:
-
PORRECA E., CICCARELLI R., DI FEBBO C., CUCCURULLO F. Protein kinase C
pathway and proliferative responses in adult and young rat vascular smooth
muscle cells. Atherosclerosis, 104: 137-145, 1993.
-
BALLERINI P., CICCARELLI R., DI IORIO P., GIULIANI P., FRANCANO D., CACIAGLI
F. TMB-8 and thapsigargin modulate purine release from dissociated primary
cultures of rat brain astrocytes. Res. Commun. Chem. Pathol. Pharmacol.
82: 167-174, 1993.
-
CHUANG TT., SALLESE M., AMBROSINI G., PARRUTI G., DE BLASI A. Molecular
mechanisms of receptor regulation: cloning and expression of the gene for
the beta-adrenergic receptor kinase.J. Biol. Chem. 267: 563-571,
1993.
-
CASABONA G., L'EPISCOPO M.R., DI IORIO P., CICCARELLI R., DE BERNARDIS
E., SHINOZAKI H., NICOLETTI F., CACIAGLI F. Interaction between metabotropic
receptors and purinergic transmission in rat hippocampal slices. Brain
Res. 645: 13-18, 1994
-
CICCARELLI R., DI IORIO P., BALLERINI P., AMBROSINI G., GIULIANI P., TIBONI
G.M., CACIAGLI F. Effects of exogenous ATP and related analogues on the
proliferation rate of dissociated primary cultures of rat astrocytes. J.
Neurosci. Res. 39: 556-566; 1994.
-
BALLERINI P., CICCARELLI R., DI IORIO P., GIULIANI P., CACIAGLI F. Influence
of Ca2+ channel modulators on 3H-purine release from
rat cultured glial cells. Neurochem. Res. 20: 697-704; 1995
-
DI IORIO P., BATTAGLIA G., CICCARELLI R., BALLERINI P., GIULIANI P., POLI
A., NICOLETTI F., CACIAGLI F. Interaction between A1 adenosine
and class II metabotropic glutamate receptors in the regulation of purine
and glutamate release from rat hippocampal slices. J. Neurochem.,
67: 302-309, 1996.
-
AMBROSINI G., ALTIERI D.C. Molecular dissection of effector cell protease
receptor-1 recognition of factor Xa. Assignment of critical residues involved
in antibody reactivity and ligand binding. J. Biol. Chem. 271: 1243-1248,
1996.
-
BALLERINI P., RATHBONE M.P., DI IORIO P., RENZETTI A., GIULIANI P., D'ALIMONTE
I., TRUBIANI O., CACIAGLI F., CICCARELLI R. Rat astroglial P2Z
receptors regulate intracellular calcium and purine release. NeuroReport,
7 : In press, 1996.
-
HERMANN M., REED J., CICCARELLI R., DI IORIO P., RATHBONE M.P. Trophic
effects of purines in neurons and glial cells. Prog. Neurobiology,
In press, (invited review) 1996.
RESEARCH GROUP MEMBERS :
-
Cannizzaro Gaspare, P.O.
-
Beninati Francesco
-
Flugy Anna, R.U.
-
Gagliano Mauro
AFFILIATION:
Istituto di Farmacologia
Facoltā di Medicina e Chirurgia
Universitā degli Studi di Palermo
ADDRESS: Via del Vespro, 129
CITY: Palermo
POSTAL CODE: 90127
TELEPHONE: 091-655-3259, 3215, 3274, 3257
FAX : 091- 6553212
PUBLICATIONS:
-
KLIMEK, V., ZAK-KNAPIK, S., CANNIZZARO, C. Changes in the rat brain 5-HT1a
and 5-HT2 receptors after chronic administration of levoprotiline, (+)
oxaprotiline and other antidepressant drugs. Polish J. Pharmacol.
44: 549-560, 1993.
-
CANNIZZARO, G., FLUGY, A., CANNIZZARO, C., GAGLIANO, M., SABATINO, M. Effects
of desipramine and alprazolam in the forced swim test in rats after long
lasting termination of chronic exposure to picrotoxin and pentylenetetrazol.
Eur. Neuropsychopharmacol. 3: 477-484, 1993.
-
SABATINO, M., CANNIZZARO, C., FLUGY, A., GAGLIANO, M. AND CANNIZZARO, G.
NMDA-GABA interactions in an animal model of behaviour: a gating mechanism
from motivation toward psychotic-like symptoms. Eur. Neuropsychopharmacol.
4: 103-109, 1994.
-
CANNIZZARO, C., CANNIZZARO, E., GAGLIANO, M., MINEO, M., SABATINO, M. AND
CANNIZZARO, G. Effects of desipramine and alprazolam in forced swimming
behaviour of adult rats exposed to prenatal diazepam. Eur. J. Pharmacol.
273: 239-245, 1995.
-
CANNNIZZARO G., C. CANNIZZARO, E. GAGLIANO, M., MANGIAPANE, N. Behavioural
responsiveness to picrotoxin and desipramine in adult rats prenatally exposed
to different benzodiazepine receptor agonists. Eur. Neuropsychopharmacol.
5: 523-526, 1995.
-
CANNIZZARO, C., CANNIZZARO E. , GAGLIANO, M. Motor and antidepressant-like
effects of 5-HT(1A) agonist LY 228729 in prenatally benzodiazepine-exposed
rats. Eur. Neuropsychopharmacol. In press, 1996.
RESEARCH GROUP MEMBERS:
-
Carruba Michele, P.O.
-
Briscini Luca, D. DR.
-
Nisoli Enzo, B.
-
Tonello Cristina, B.
AFFILIATION:
Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica
Facoltā di Medicina e Chirurgia
Universitā degli Studi di Milano
ADDRESS: Via Vanvitelli 32
CITY: Milano
POSTAL CODE: 20129
TELEPHONE: 02-70146370, 332
FAX: 02-70146371
E-MAIL: Carruba@imiucca.csi.unimi.it
PUBLICATIONS:
-
NISOLI E., TONELLO C., IMHOF R., SCHERSCHLICHT R., DA PRADA M., AND CARRUBA
M.O. Neurochemical and behavioral evidence that Ro 41-9067 is a selective
presynaptic dopamine receptor agonist. J. Pharmacol. Exp. Ther..
266: 97-105, 1993
-
NISOLI E., TONELLO C., AND CARRUBA M.O. SR 58611A: a novel thermogenetic
-adrenoceptor agonist. Eur. J. Pharmacol., 259: 181-186, 1994
-
GAROSI V.L., NISOLI E., BLUNDELL J.E., AND CARRUBA M.O. Pharmacological
antagonism of lipoprivic feeding induced by sodium mercaptoacetate. Eur.
J. Pharmacol., 276: 285-289, 1995
-
NISOLI E. Adaptive events. Nature, 374: 671, 1995
-
NISOLI E., TONELLO C., BENARESE M., AND CARRUBA M.O. Rat frontal cortex
1-adrenoceptors
are activated by the 3- adrenoceptor agonist SR 58611A and SR
58878A but not by BRL 37344 or ICI 215,001. J. Neurochem., 65: 1580-
1587, 1995
-
NISOLI E., TONELLO C., AND CARRUBA M.O. Differential relevance of -adrenoceptor
subtypes in modulating the rat brown adipocytes function. Archives Internationales
de Pharmacodynamie et de Thérapie, 329: 436-453, 1995
-
NISOLI E., TONELLO C., LANDI M., AND CARUBA M.O. Functional Studies of
the first selective 3- adrenergic receptor antagonist SR 59230A
in rat brown adipocytes. Mol. Pharmacol. 49: 7-14, 1996
-
NISOLI E., TONELLO C., BENARESE M., LIBERINI P., AND CARRUBA M.O. Expression
of nerve growth factor in brown adipose tissue: implications for thermogenesis
and obesity. Endocrinology, 137: 495-503, 1996
-
NISOLI E., GAROSI V.L., BLUNDELL J. E., AND CARRUBA M.O. Salbutamol antagonizes
insulin - and sodium mercaptoacetate-induced but not 2-deoxy-D-glucose-induced
hyperphagia. Pharmacol. Biochem. Behav. 54: 409-413, 1996
RESEARCH GROUP MEMBERS:
-
Cattabeni Flaminio, P.O.
-
Abbracchio Maria Pia, R.U.
-
Di Luca Monica, R.U.
-
Brambilla Roberta, D.DR.
-
Caputi Antonio, D.DR.
-
Ceruti Stefania, D.DR.
-
Pastorino Lucia, D.DR.
AFFILIATION:
Laboratorio di Farmacologia della Plasticitā Sinaptica
Istituto di Scienze Farmacologiche
Facoltā di Farmacia
Universitā di Milano
ADDRESS: Via Balzaretti 9
CITY: Milano
POSTAL CODE: 20133
TELEPHONE: 02-20488.314, .374, .355, .265, .253
FAX: 02-2940.4961
E-MAIL: cattaben@isfunix.farma.unimi.it
PUBLICATIONS:
-
DI LUCA M., CAPUTI A., CINQUANTA M., CIMINO M., MARINI P., PRINCIVALLE
A. DE GRAAN P.N.E., GISPEN W.H. AND CATTABENI F. Changes in protein kinase
C and its presynaptic substrate B-50/GAP-43 after intrauterine exposure
to methylazoxy-methanol, a treatment inducing cortical and hippocampal
damage and cognitive deficit. Eur. J. Neurosci., 7: 899-906, 1995.
-
ABBRACCHIO M.P., BRAMBILLA R., CERUTI S., KIM H.O., VON LUBITZ D.K.J.E.,
JACOBSON K.A. AND CATTABENI F. G-protein-dependent activation of phospholipase
C by adenosine A3 receptors in rat brain. Mol. Pharmacol., 48: 1038-1045,
1995.
-
ABBRACCHIO M.P., CERUTI S.,
BARBIERI D., FRANCESCHI C., MALORNI W., BIONDO L., BURNSTOCK G. AND CATTABENI
F. A novel action for Adenosine: apoptosis of astroglial cells in rat brain
primary cultures. Biochem. Biophys. Res. Commun., 213: 908-915,
1995.
-
ABBRACCHIO M.P., CERUTI S., LANGFELDER R., CATTABENI F., SAFFREY M.J. AND
BURNSTOCK G. Effects of ATP analogues and basic Fibroblast Growth Factor
on astroglial cell differentiation in primary cultures of rat striatum.
Int.
J. Develop. Neurosci., 13: 685-693, 1995.
-
DI LUCA M., PASTORINO L., RAVERDINO V., DE GRAAN P.N.E., CAPUTI A., GISPEN
W.H. AND CATTABENI F. Determination of the endogenous phosphorylation state
of B-50/GAP-43 and neurogranin in different brain regions by electrospray-mass
spectrometry. FEBS Lett. 389: 303-313, 1996.
-
CAPUTI A., RURALE S., PASTORINO L., CIMINO M., CATTABENI F. AND DI LUCA
M. Differential translocation of Protein Kinase C isozymes in rats characterized
by a chronic lack of LTP induction and cognitive impairment. FEBS Lett.
393: 121-123,1996.
-
NEARY J.T., RATHBONE M.P., CATTABENI F., ABBRACCHIO M.P. AND BURNSTOCK
G. Trophic actions of extracellular nucloetides and nucleosides on glial
and neuronal cells. Trends Neurosci. 19: 13-18, 1996.
-
DI LUCA M., PASTORINO L., CATTABENI F., ZANARDI R., SCARONE S., RACAGNI
G., SMERALDI E. AND PEREZ J. Abnormal pattern of platelet APP isoforms
in Alzheimer's disease and Down's syndrome. Arch. Neurol. In press,
1996.
-
DI LUCA M., CAPUTI A., CATTABENI F., DE GRAAN P.N.E., GISPEN W.H., RAITERI
M., FASSIO A., SCHMID G AND BONANNO G.B. Increased presynaptic protein
kinase C activity and glutamate release in rats with a prenatally induced
hippocampal lesion. Eur. J. Neurosci. In press, 1996.
-
CERUTI S., BARBIERI D., VERONESE E., CATTABENI F., COSSARIZZA A., GIAMMARIOLI
A.M., MALORNI W., FRANCESCHI C. AND ABBRACCHIO M.P. Different pathways
of apoptosis revealed by 2-Chloro-adenosine and deoxy-D-ribose in mammalian
astroglial cells. J. Neurosci. Res. In press, 1996.
RESEARCH GROUP MEMBERS:
-
Cattaneo Elena, R.U.
-
De Fraja Claudio,B.
-
Conti Luciano,B.
AFFILIATION :
Istituto di Scienze Farmacologiche
Facoltā di Farmacia
Universitā Statale di Milano
ADDRESS: Via Balzaretti,9
CITY: Milano
POSTAL CODE: 20133
TELEPHONE: 02/20488349
FAX: 02/29404961
E-MAIL: Cattaneo@isfunix.farma.unimi.it
PUBLICATIONS:
-
CATTANEO E., MAGRASSI L., BUTTI G., SANTI L., GIAVAZZI A., PEZZOTTA S.
A short t term of the behaviour of conditionali immortalized neuronal progenitors
and primary neuroepithelial cells implanted into the fetal rat brain.
Develop. Brain Res. 83 :197-208, 1994.
-
CATTANEO E., REINACH B., CAPUTI A., CATTABENI F., DI LUCA M. Selective
in vitro blockade of neuroepithelial cells proliferation by methylazoxymethanol,a
molecul capable of enducing long lasting functional impairments. J.
Neurosci. Res. 41 :640-647, 1995.
-
CATTANEO E., DE FRAJA C., REINACH B., BOLIS L., GOVONI S., LIBOI E.Activation
of the JAK/STAT pathway leads to proliferation of ST14A central nervous
system progenitor cells. J. Biol. Chem..271 : 23374-23379, 1996.
-
SALVIETTI N., CATTANEO E., GOVONI S., RACCHI M. Changes in beta-amyloid
precursor protein secretion associated with the proliferative status of
CNS derived progenitors cells. Neurosci. Lett. 212 :199-203, 1996.
-
MAGRASSI L., PEZZOTTA S., BUTTI G., CONTI L., GOVONI S., CATTANEO E. Scattered
primary and conditionally immortalized neuroepithelial cells trnsplanted
into the embryonic rat brain differentiate into neurons and glial cells.Neurosci.
Res. Comm. 18 :175-183, 1996.
-
CATTANEO E., CONTI L., GRITTI A., FROLICHSTHAL P., GOVONI S., VESCOVI A.
Non viral mediated gene transfer into human central nervous system precursors
cells. Mol. Brain Res., In press, 1996.
-
CORTI O., HORELLOU P., COLIN P., CATTANEO E., MALLET J.Intracerebral tetracycline-dependent
regulation of gene expression in grafts of neural precursors. Neuroreport.
In press, 1996.
RESEARCH GROUP MEMBERS:
-
Clementi Francesco, P.O.
-
Balestra Barbara, D.D.R.
-
Battaglioli Elena, D.D.R.
-
Flora Adriano, B.
-
Fornasari Diego, R.CNR
-
Gotti Cecilia, R.CNR
-
Moretti Milena, T.L.
-
Terzano Susanna, D.DR.
AFFILIATION:
Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica
Universitā di Milano
Centro CNR per lo Studio della Farmacologia Cellulare e Molecolare
ADDRESS: Via Vanvitelli 32
CITY: Milano
POSTAL CODE: 20129
TELEPHONE: 01-70146-254, 262, 266, 256
FAX: 02-7490574
E-MAIL: segreteria@farma5.csfic.mi.cnr.it
PUBLICATIONS:
-
GOTTI, C., MORETTI, M., LONGHI, R., MANERA, E. AND CLEMENTI, F. Anti-peptide
specific antibodies for the characterization of different a-subunits of
a-Bungarotoxin receptors present in chick optic lobe. J. Receptor Res.
13: 453-465, 1993.
-
GOTTI, C., HANKE, W., MAURY, K., MORETTI, M., BALLIVET, M., CLEMENTI, F.
AND BERTRAND, D. Pharmacological and biophysical properties of a7 and a7-a8
a-Bungarotoxin receptor subtypes immunopurified from chick optic lobe.
Eur.
J. Neurosci. 6: 1281-1291, 1994.
-
GOTTI, C., BRISCINI, L., VERDERIO, C., OORTGISIEN, M., BALESTRA, B. AND
CLEMENTI, F. Native nicotinic acetylcholine receptors in human IMR32 neuroblastoma
cells: functional, immunological and pharmacological properties. Eur.
J. Neurosci.7: 2083-2092, 1995.
-
RUBBOLI, F., COURT, J.A., SALA, C., MORRIS, C., CHINI, B., PERRY, E. AND
CLEMENTI, F. Distribution of neuronal nicotinic receptors in the human
hippocampus and thalamus. Eur. J. Neurosci. 6: 1596-1604, 1994.
-
RUBBOLI, F., COURT, J.A., SALA, C., MORRIS, C., CHINI, B., PERRY, E. AND
CLEMENTI, F. Distribution of neuronal nicotinic receptor subunits in human
brain. Neurochem. Int. 25: 69-71, 1994.
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CIMINO, M., MARINI, P., COLOMBO, S., CATTABENI, F., FORNASARI, D. AND CLEMENTI,
F. Expression of neuronal acetylcholine nicotinic receptor a4 and b2 subunits
during postnatal development of the rat brain. J. Neural Trans.
100: 77-92, 1995.
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COURT J., PERRY, E.K., SPURDEN, D., GRIFFITHS, M., KERWIN, J.M., MORRIS,
C.M., JOHNSON, M., OAKLEY, A.E., BIRDSALL, N.J.M., CLEMENTI, F. AND PERRY,
R.H. The role of cholinergic system in the development of the human cerebellum.Develop.
Brain Res. 90: 159-167, 1995.
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ZAHLER, R., SUN, W., LUFBURROW, M., FORNASARI, D., ROMANA, M. AND BRINES,
M. Selective inhibition of Na, K-ATPase isoform expression using antisense
oligodeoxynucleotide: possible functional differences between human a1
and a3 isoforms. J. Cell Physiol., In press, 1996.
RESEARCH GROUP MEMBERS:
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Corona Gian Luigi, P.O.
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Santagostino Barbone Giuseppe, P.A.
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Frattini Pietro, P.A.
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Cucchi Maria Laura, P.A.
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Schinelli Sergio, R.U.
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Paolillo Mayra, B.PDR.
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Preda Stefania, D.DR.
AFFILIATION:
Istituto di Farmacologia
Facoltā di Farmacia
Universitā di Pavia
ADDRESS: Viale Taramelli, 14
CITY: Pavia
POSTAL CODE: 27100
TELEPHONE: 0382-507395
FAX: 0382-507405
E-MAIL: mcs@chifar.unipv.it
PUBLICATIONS:
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SCHINELLI, S., PAOLILLO, M., QUARTIERI, M., AND SANTAGOSTINO, G. Dopamine
synthesis, uptake and metabolism in embryonic rat mesencephalic cell cultures.
Pharmacol.
Res. 28: 265-237, 1993.
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PAOLILLO, M., PREDA, S., CORONA, G.L., AND SCHINELLI, S. Measurement of
5-hydroxytryptamine and 5-hydroxyindoleacetic acid in cultured rat mesencephalic
neurons by high performance liquid chromatography with electrochemical
detection. J. Chromatogr. 613: 231-237, 1993.
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SCHINELLI, S., PAOLILLO, M., AND CORONA, G.L. Opposing actions of D1 and
D2 dopamine receptors on arachidonic acid release and cAMP production in
rat striatal neurons. J. Neurochem. 62: 944-949, 1994.
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SCHINELLI, S., PAOLILLO, M., AND CORONA, G.L. Modulation of dopamine-induced
cAMP production in rat striatal cultures by the calcium ionophore A23187
and by phorbol-12-myristate-13-acetate. Mol. Brain. Res. 21: 162-166,
1994.
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VILLA, I., COLANGELO, A.M., VESCOVI, A., GRITTI, A., SCHINELLI, S., PAGANI,
F., AND GUIDOBONO, F. Differential effects of CGRP on adenylyl cyclase
in adult and embryonic rat brain. Neuroreport. 5: 2489-2492, 1994.
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DIMARZO, V., FONTANA, A., CADAS, H., SCHINELLI, S., CIMINO, G., SCHWARTZ,
J.C., AND PIOMELLI, D. Formation and inactivation of endogenous cannabinoin
anandamide in central neurons. Nature. 372: 686-691, 1994.
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SANTAGOSTINO, G., AMORETTI, G., FRATTINI, P., ZERBI, F., CUCCHI, M.L.,
PREDA, S., AND CORONA, G.L. Catecholaminergic, neuroendocrine and anxiety
responses to acute psycological stress in healthy subjects. Influence of
alprazolam administration. Neuropsychobiology. 43: 34-36, 1996.
VENTRA, C., PORCELLINI, A., FELICIELLO, A., GALLO, A., PAOLILLO, M., MELE,
E., AVVEDIMENTO, V.E., AND SCHETTINI, G. The differential response of protein
kinase A to cAMP in discrete brain areas correlates with the abundance
of regulatory subunit IIb. J. Neurochem. 66: 1751-1761, 1996.
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