SIF - Societā
Italiana di Farmacologia
"SIF - La Ricerca Farmacologica in Italia"
ENDOCRINE AND NEUROENDOCRINE PHARMACOLOGY
RESEARCH GROUP MEMBERS:
-
Arletti Rossana, P.A.
-
Poggioli Rosanna, P.A.
-
Vergoni Anna Valeria, R.U.
-
Calzā Laura, P.A.
-
Luppi Patrizia, B.
AFFILIATION:
Sezione di Farmacologia
Dipartimento di Scienze Biomediche
Facoltā di Medicina e Chirurgia
Universitā degli Studi di Modena
ADDRESS: Via G. Campi 287
CITY: Modena
POSTAL CODE: 41100
TELEPHONE: 059-428440
FAX: 059-372653
E-MAIL: farmacol@unimo.it
PUBLICATIONS:
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LUPPI P., LEVI-MONTALCINI R., BRACCI-LAUDIERO L., BERTOLINI A., ARLETTI R.,
TAVERNARI D., VIGNETI E. AND ALOE L. NGF is released into plasma during human
pregnancy:an oxytocin-mediated response? NeuroReport 4: 10631065,
1993.
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ARLETTI R., BENELLI A. AND BERTOLINI A. Influence of oxytocin on nociception
and morphine antinocipetion. Neuropeptides 24: 125-129, 1993.
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ARLETTI A., BENELLI A., MAZZAFERRO M., CALZā L., GIARDINO L. AND BERTOLINI
A. The effect of oxytocin on feeding, drinking and male copulatory behavior
is not diminished by neonatal monosodium glutamate. Horm. Behav. 27:
499510, 1993.
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BENELLI A., ARLETTI R., BERTOLINI A., MENOZZI B., BASAGLIA R. AND POGGIOLI
R. Galantide stimulates sexual behavior in male rats. Eur. J. Pharmacol.
260: 279-282, 1994.
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BENELLI A., POGGIOLI R., LUPPI P., RUINI L., BERTOLINI A. AND ARLETTI R.
Oxytocin enhances and oxytocin antagonism decreases, sexual receptivity in
intact female rats. Neuropeptides 27: 245-250, 1994.
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POGGIOLI R., BENELLI A., ARLETTI R., MENOZZI B. AND BERTOLINI A. Benextramine,
an NPY antagonist, improves sexual behavior in male rats.
Neuropeptides 26: 355-358, 1994.
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BENELLI A., BERTOLINI A., POGGIOLI R., MENOZZI B., BASAGLIA R. AND ARLETTI
R. Polymodal dose-response curve for Oxytocin in the social recognition test.
Neuropeptides 28: 251-255, 1995.
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ARLETTI R., BENELLI A., POGGIOLI R., LUPPI P., MENOZZI B. AND BERTOLINI A.
Aged rats are still responsive to the antidepressant and memory-improving
effects of oxytocin. Neuropeptides 29: 177-182, 1995.
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LUPPI P., ROSSIELLO M.R., FAAS S. AND TRUCCO M. Genetic background and
environment contribute synergistically to the onset of autoimmune diseases.
J. Mol. Med. 73: 381-393, 1995.
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VERGONI A.V., FORGIONE A. AND BERTOLINI A. Chronic administration of l-sulpiride
at non-neuroleptic doses reduces the duration of immobility in experimental
models of "depression-like" behavior. Psycopharmacology 121:
279281, 1995.
RESEARCH GROUP MEMBERS:
-
Canonico Pier Luigi, P.O.
-
Sortino Maria Angela, R.U. Universitā di
Catania
-
Cavallaro Sebastiano, B.
-
Favit Antonella, B.
-
Aleppo Grazia, B.
-
Condorelli Fabrizio, B.
-
Musco Simone, B.
AFFILIATION:
Sezione di Farmacologia
Dipartimento di Medicina Interna e Terapia Medica
Universitā di Pavia
ADDRESS: Piazza Botta, 10
CITY: Pavia
POSTAL CODE: 27100
TELEPHONE: 0382-506398; 095-580545
FAX: 0382-28246; 095-580545
E-MAIL: msortino@ictuniv.unict.it
PUBLICATIONS:
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FAVIT A., WETZEL W.C., AND NEGRO-VILAR A. Differential expression of
g-aminobutyric acid receptors in immortalized luteinizing hormone-releasing
hormone neurons. Endocrinology 133: 1983-1989, 1993.
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SORTINO M.A., ALEPPO G., SCAPAGNINI. U., AND CANONICO P.L. Involvement of
nitric oxide in the regulation of GnRH release from the GT1-1 neuronal cell
line. Endocrinology 134: 1782-1787, 1994.
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FAVIT A., SCAPAGNINI U., AND CANONICO P.L. Pituitary adenylate cyclase-activating
polypeptide activates different signal transducing mechanisms in cultured
cerebellar granule cells. Neuroendocrinology 61: 377-382, 1995.
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CAVALLARO S., D'AGATA V., GUARDABASSO V. TRAVALI S., STIVALA F., AND CANONICO
P.L. Differentiation induces pituitary adenylate cyclase activating polypeptide
receptor expression in PC-12 cells. Mol. Pharmacol. 48: 56-62, 1995.
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D'AGATA V., CAVALLARO S., STIVALA F., TRAVALI. S., AND CANONICO P.L. Tissue
and developmental expression of pituitary adenylate cyclase activating
polypeptide (PACAP) receptors in rat brain. Eur. J. Neurosci. 8: 310-318,
1996.
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SORTINO M.A., AND CANONICO P.L. Neuroprotective effects of insulin-like growth
factor I (IGF-I) in immortalized hypothalamic cells: Endocrinology 137:
1418-1422, 1996.
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SORTINO M.A., ALEPPO G., SCAPAGNINI U., AND CANONICO P.L. Different responses
of gonadotropin-releasing hormone (GnRH) release to glutamate receptor agonists
during aging. Brain Res. Bull. 41: In press, 1996.
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CAVALLARO S., COPANI A., D'AGATA V., MUSCO S., PETRALIA S., VENTRA C., STIVALA
F., TRAVALI S., AND CANONICO P.L. Pituitary adenylate cyclase activating
polypeptide prevents apoptosis in cultured cerebellar granule neurons. Mol.
Pharmacol.50: 60-66, 1996.
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SORTINO M.A., ALEPPO G., COPANI A., CASABONA G., NICOLETTI F., KUHN R., KNOEPFEL
T., MALITSCHEK B., AND CANONICO P.L. Immortalized hypothalamic neurons express
metabotropic glutamate receptors positively coupled to cyclic AMP formation.
Eur. J. Neurosci. 8: 2407-2415, 1996
RESEARCH GROUP MEMBERS:
-
Cocchi Daniela, P.O.
-
De Gennaro Vito, R.U.
-
Cattaneo Lorena, D.DR.
AFFILIATION:
Dipartimento Scienze Biomediche e Biotecnologie
Facoltā di Medicina e Chirurgia
Universitā di Brescia
ADDRESS: Via Valsabbina, 19
CITY: Brescia
POSTAL CODE: 25124
TELEPHONE: 030-3715290
FAX: 030 - 3701157
PUBLICATIONS:
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PARENTI M., COCCHI D., CERESOLI G., MARCOZZI C., MÜLLER E.E.: Age-related
changes of growth hormone secretory mechanisms in the rat pituitary gland.
J. Endocrinol. 131: 251-257, 1991.
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COCILOVO L., DE GENNARO COLONNA V., ZOLI M., BIAGINI G., SETTEMBRINI B.,
MÜLLER E.E., COCCHI D: Central mechanisms subserving the impaired growth
hormone secretion induced by persistent blockade of NMDA receptors in immature
rats. Neuroendocrinology 55: 416-421, 1992.
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LAMPERTI E., COCCHI D., PARATI E.A., CARACENI T., MÜLLER E.E.: Growth
hormone responses to cholinergically active drugs in patients with dementia
of the Alzheimer type. Alzheimer Disease and Associated Disorders
6: 44-50, 1992.
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MÜLLER E.E., COCCHI D., GHIGO E., ARVAT E., LOCATELLI V., CAMANNI F.:
Growth hormone response to GHRH during lifespan. J. Ped. Endocrinol.
6: 5-13, 1993.
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QUING Y., PARENTI M., GUZZI F., CERESOLI G., MÜLLER E.E., COCCHI D.:
Alterations of adenylyl cyclase-coupled growth hormone-releasing hormone
(GHRH) pituitary receptors in different conditions of GHRH deprivation.
Brain Res. 13-18, 1994.
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DE LUCA A., PIERNO S., COCCHI D., CONTE CAMERINO D. Growth hormone administration
to aged rats improves membrane electrical properties of skeletal muscle fibers.
J. Pharmacol. Exp. Ther. 269: 948-953, 1994.
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VALENTI G., COCCHI D., MÜLLER E.E., CAMANNI F.: Low doses of either
intravenously or orally administered arginine are able to enhance growth
hormone response to growth hormone releasing hormone in elderly subjects.
J. Endocrinol. Invest. 17: 113-117, 1994.
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COCCHI D., CATTANEO L., LANE M.A., INGRAM D.K., CUTLER R.G., ROTH G.S.: Effect
of a long-term dietary restriction on the somatotrophic axis in adult and
aged monkeys. Neuroendocrinol. Lett. 17: 181-186, 1995.
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CATTANEO L., MÜLLER E.E., COCCHI D.: "In vivo" microdialysis of the
hypothalamus: a suitable method to study the function of hypophysiotropic
neurons in the rat. J. Neuroendocrinol. 8: 31-33, 1996.
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CATTANEO L., DE GENNARO COLONNA V., ZOLI M., MÜLLER E.E., COCCHI D.
Characterization of the hypothalamo-pituitary-IGF-1 axis in rats made obese
by overfeeding. J. Endocrinol. 148: 347-353, 1996.
RESEARCH GROUP MEMBERS:
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Di Carlo Raffaele, P.O.
-
Meli Rosaria, R.U.
-
Gualillo Oreste, D.DR.
-
Mattace Raso Giuseppina, D.DR.
-
Pacilio Maria, D.DR.
AFFILIATION:
Dipartimento di Farmacologia Sperimentale
Universitā degli Studi di Napoli "Federico II"
ADDRESS: Via D. Montesano, 49
CITY: Napoli
POSTAL CODE: 80131
TELEPHONE: 081-7466401
FAX: 081-7486403
PUBLICATIONS:
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MELI R., GUALILLO O., MATTACE RASO G., DI CARLO R. Further evidence
for the involvement of prolactin in the inflammatory response. Life Sci.
53: pp PL 105-110, 1993
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CAPPELLO B., GRECO G., NOVELLINO E., PERISSUTTI E., SANTAGADA V., SILIPO
C., VITTORIA A., MELI R, DI CARLO R., MUCCIOLI G. Synthesis and muscarinic
receptor binding profiles of antagonist benzotriazole derivatives.
Farmaco. 48: 907-918, 1993.
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CALIENDO G., DI CARLO R., MELI R., PERISSUTTI E., SANTAGADA V., SILIPO C.,
VITTORIA A.Synthesis and trazodone-like pharmacological profiles of 1- and
2-[3-[4-(x)-1-piperazinyl]-propyl]- benzotriazoles.Eur. J. Med. Chem.
28: 969-974, 1993.
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DI CARLO R., FAGGIUOLO R., MUCCIOLI G., ORTEGA C., DI CARLO F., COSTANTINI
M., DOGLIOTTI L. Prognostic significance of prolactin receptor on
overall survival of patients with early breast cancer: a long term retrospective
analysis.The Breast. 3: 147-150, 1994.
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MUCCIOLI G., DI CARLO R. Modulation of prolactin receptors in the
rat hypothalamus in response to changes in serum concentration of endogenous
prolactin or to ovine prolactin administration.. Brain Res., 663:
244-250, 1994.
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DI CARLO R., BOLE FEYSOT C., GUALILLO O., MELI R., NAGANO M AND KELLY P.A.
Regulation of prolactin receptor mRNA expression in peripheral lymphocytes
in rats in response to changes in serum concentration of prolactin.
Endocrinology. 136: N°10, 4713-4716,1995.
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CALIENDO G., DI CARLO R., GRECO C., MELI R., NOVELLINO E., PERISSUTTI E.,
SANTAGADA V. Synthesis and biological activity of benzotriazole
derivatives structurally related to trazodone. Eur. J. Med. Chem.,
30: 77-84, 1995
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BENEDETTO N., FOLGORE A., GALDIERO M., MELI R., DI CARLO R. Effect
of prolactin, rIFN-g or rTNF-a in murine toxoplasmosis. Pathologie
Biologie. 43 :, 395-400, 1995.
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CALIENDO G., DI CARLO R., GRECO G., GRIECO P., MELI R., NOVELLINO E., PERISSUTTI
E., SANTAGADA V. Synthesis, local anesthetic activity and QSAR studies
for a set of N-[2-(alkylamino)ethyl]benzotriazol-x-yl acetamides.Eur.
J. Med. Chem. 30: 603-608, 1995.
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BERLANGA J.J., GUALILLO O., BUTEAU H., APPLANAT M., KELLY P.A., EDERY M.
Prolactin activates tyrosyl phosphorylation of insulin receptor substrate1
and phosphatidylinositol -3-OH kinase. J. Biol. Chem., In press, 1996.
RESEARCH GROUP MEMBERS :
-
Girardi Carlo, P.O.Girardi
Carlo
-
Re Giovanni, R.U.
-
Badino Paola, T.L.
-
Novelli Antonella, D.DR.
-
Odore Rosangela,
B.
AFFILIATION :
Settore di Farmacologia, Dipartimento
di Patologia Animale,
Facoltā di Medicina
Veterinaria
Universitā degli Studi di Torino
ADDRESS:
Via Nizza, 52
-
CITY:
Torino
-
POSTAL CODE:
10126
-
TELEPHONE:
011-6502155
FAX: 011-6502687
PUBLICATIONS:
-
RE, G., BADINO, P., DACASTO, M., NEBBIA,
C., BIOLATTI, B., DI CARLO, F., AND GIRARDI, C. Effects of long-term
administration of clenbuterol in mature female rats. Amer. J. Vet. Res.
54:438-442, 1993.
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RE, G., BADINO, P., DACASTO, M., DI CARLO,
F., AND GIRARDI C. Regulation of uterine estrogen receptors (ER) by
beta-adrenergic stimulation in immature rats. J. Vet. Pharmacol. Ther.
16:328-334, 1993.
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RE, G., BADINO, P., NOVELLI, A., VALLISNERI,
A., AND GIRARDI C. Specific binding of dl-cloprostenol and d-cloprostenol
to PGF2_ receptors in bovine corpus luteum and myometrial cell membranes.
J. Vet. Pharmacol. Ther. 17:455-458, 1994.
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RE, G., BADINO, P., NOVELLI, A., CANESE,
M.G., AND GIRARDI, C. Identification of ß-adrenoceptor subtypes in
bovine ovarian and myometrial cell membranes. Brit. Vet. J. 151:567-578,
1995.
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RE, G., BADINO, P., NOVELLI, A., DI RENZO,
G.F., SEVERINO, L., DE LIGUORO, M., AND FERONE M.R. Distribution of cytosolic
oestrogen and progesterone receptors in the genital tract of the mare. Res.
Vet. Sci. 59:214-218, 1995.
-
RE, G., BADINO, P., NOVELLI, A., AND
GIRARDI, C. Down-regulation of ß-adrenergic receptors and up-regulation
of estrogen and progesterone receptors induced in thereproductive system
of female veal calves by dietary clenbuterol. Amer. J. Vet. Res.
56:1493-1498, 1995.
-
CERRUTI SOLA, S., BERGERO, D., BADINO,
P., CORNAGLIA, E., NOVELLI, A., AND RE, G. Effects of dietary clenbuterol
in female broiler chickens: pathological lesions and endocrine
modifications. Eur. J. Vet. Pathol. 2:87-92,1996.
RE, G., BADINO, P., NOVELLI, A., GIRARDI,
C. AND DI CARLO, F. Evidence for functional ß-adrenoceptor subtypes
in CG-5 breast cancer cells. Pharmacol. Res. In press, 1996.
RE, G., BADINO, P., NOVELLI, A., AND
GIRARDI, C. Effects of clenbuterol as a repartitioning agent on
ß-adrenoceptor concentrations in heart, bronchi and brain of veal calves.
Brit. Vet. J. In press, 1996.
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RE, G., BELLOLI, C., BADINO, P., ARIOLI, F., NOVELLI, A., GIRARDI, C., AND
BERETTA, C. Identification of ß-adrenoceptor subtypes mediating relaxation
in horse ileum. Amer. J. Vet. Res. In press, 1996.
RESEARCH GROUP MEMBERS:
-
Maggi Adriana, P.A.
-
Agrati Paola, D.DR.
-
Bennici Simona, B.
-
Garnier Martine, B.
-
Patrone Cesare, D.DR.
-
Pollio Giuseppe, B.
-
Rebecchi Monica B.
-
Santagati Sabrina B.
-
Vegeto Elisabetta, B.PDR.
AFFILIATION :
Centro MPL, Istituto di Scienze Farmacologiche
Facoltā di Farmacia
Universitā degli Studi di Milano
ADDRESS: Via Balzaretti, 9
CITY: Milano
POSTAL CODE: 20133
TELEPHONE: 02-20488375
FAX: 02-29404961
E-MAIL: maggia@isfunix.farma.unimi.it
PUBLICATIONS :
-
MA Z. Q., SPREAFICO E., POLLIO G., SANTAGATI S., CATTANEO E. AND MAGGI A.
Activated estrogen receptor mediates growth arrest and differentiation of
a neuroblastoma cell line. Proc. Nat. Acad. Sci. USA 90: 3740-3744,
1993
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POLLIO G., XUE P., ZANISI M., NICOLIN A. AND MAGGI A. Antisense oligonucleotide
blocks progesterone-induced lordosis behavior in ovariectomized rats. Mol.
Brain Res., 19: 135-139, 1993
-
MA Z.Q., BONDIOLOTTI G.P., OLASMAA M., VIOLANI E., PATRONE,C., PICOTTI G.B.
AND MAGGI A. Estrogen modulation of catecholamine synthesis and monoamine
oxidase A activity in the human neuroblastoma cell line SK-ER3. J. Steroid
Biochem. Mol. Biol., 47: 207-211, 1993
-
MA Z.Q., SANTAGATI S., PATRONE C., POLLIO G., VEGETO E. AND MAGGI A. Insulin-like
growth factors activate estrogen receptor to control the growth and
differentiation of the human neuroblastoma cell line SK-ER3. Mol.
Endocrinology, 8: 910-918, 1994
-
SANTAGATI S., MELCANGI R.C., CELOTTI F., MARTINI L. AND MAGGI A Estrogen
receptor is expressed in different types of glial cells in cultures. J.
Neurochemistry, 63: 2058-2064, 1994
-
MAGALINI A., FERRARI F., SAVOLDI G., INGRASSIA R., ALBERTINI A., POLLIO G.,
MAGGI A. AND DI LORENZO D. Specificity of action of a herpes virus
VP16/tetracycline-dependent trans-activator in mammalian cell culture.
DNA and Cell Biology, 14: 665-671, 1995
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MA Z.Q., VIOLANI E., VILLA F., PICOTTI G.B. AND MAGGI A. Estrogenic control
of monoamine oxidase A activity in human neuroblastoma cells expressing
physiological concentrations of estrogen receptor. Eur. J. Pharmacol.
284: 171-176, 1995
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SANTAGATI S., MA Z.Q., FERRARINI C., POLLIO G. AND MAGGI A. Expression of
early genes in estrogen induced phenotypic conversion of neuroblastoma cells.
J. Neuroendocrinol. 7:875-879, 1995
-
PATRONE C., MA Z.Q., POLLIO G., ANTONUCCI A., AGRATI P., PARKER M.G. AND
MAGGI A. Cross-coupling between insulin and estrogen receptor in human
neuroblastoma cells. Mol. Endocrinol. 10:499-507, 1996
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CARLO P., VIOLANI E., DEL RIO M., OLASMAA M., SANTAGATI S., MAGGI A. AND
PICOTTI G. Monoamine oxidase B expression is selectively regulated by
dexamethasone in cultured rat astrocytes. Brain Res., 711: 175-183,
1996
RESEARCH GROUP MEMBERS
-
Marchetti Bianca, R.U.
-
Morale Maria C. B.
-
Gallo Francesco, B.
-
Pellitteri Rosalia, B.PDR.
-
Nunzio Batticane, B.
-
Brouwer Jantien, B.PDR.
AFFILIATION :
Istituto di Farmacologia
Facoltā di Medicina e Chirurgia
Universitā di Catania
ADDRESS: Viale Andrea Doria 6
CITY: Catania
POSTAL CODE: 95125
TELEPHONE: (095)330-533, int. 255
FAX: (095)333-219
E-MAIL : marc@ictuniv.unict.it
PUBLICATIONS :
-
GALLO, F., MORALE, M.C., SAMBATARO, D., FARINELLA, Z., SCAPAGNINI, U. AND
MARCHETTI, B The immune system response during development and progression
of carcinogen-induced rat mammary tumors. Breast Cancer Res. Treat.,
27:221-237, 1993.
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PEIFFER, A., MORALE, M.C., BARDEN, N. AND MARCHETTI, B Modulation of
glucocorticoid receptor gene expression in the thymus by the sex steroid
hormone milieu and correlation with sexual dimorphism of immune response.
Endocrine J. 2:181-192, 1994
-
MARCHETTI, B., MORALE, M.C., PARADIS, P. AND BOUVIER, M Characterization,
expression and hormonal control of a thymic ß2-adrenergic
receptor. Amer. J. Physiol. 267 (Endocrinol. Metab. 30): E718-E731,
1994.
-
B. MARCHETTI, MORALE, M.C., GALLO, F., BATTICANE, N., FARINELLA, Z., CIONI,
M. Invited Review: "Neuroendocrinimmunology at the turn of the century: towards
a molecular understanding of basic mechanisms and clinical implications for
reproductive physiology". Endocrine, 3: 845-871, 1995
-
MORALE MC, BATTICANE, N., GALLO F., BARDEN, N., AND MARCHETTI, B Disruption
of hypothalamic-pituitary adrenocortical system in transgenic animals expressing
type II glucocorticoid receptor antisense ribonucleic acid permanently impairs
T cell function: effects on T-cell trafficking and T cell responsiveness
during postnatal development. Endocrinology 136: 3949-3960, 1995
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TROIANO, L., MONTI, D., COSSARIZZA, A. LOVATO, E:, TROPEA, F., BARBIERI D.,
MORALE, M.C., GALLO, F., MARCHETTI, B., and Franceschi, C Involvement of
CD45 in dexamethasone and heat-shok induced apoptosis of rat thymocytes.
Biochem. Biophys. Res. Comm. 214: 941-948, 1995
-
GALLO, F., MORALE M.C., AVOLA, R., AND MARCHETTI, B Cross-talk between
luteinizing hormone-releasing hormone (LHRH) neurons and astroglial cells:
developing glia release factors that accelerate neuronal differentiation
and stimulate LHRH release from GT1 neuronal cell lines and LHRH neurons
stimulate astroglia proliferation. Endocrine, 3: 863-874, 1995
-
MARCHETTI, B. (1996). Invited Review: The LHRH-Astroglia Network of signals
as a Model to study Neuroimmune Interactions: Assessment of Messenger Systems,
Transduction Mechanisms at Cellular and Molecular Levels,
Neuroimmunomodulation 3: 1-27, 1996
-
MARCHETTI B. (1996) Invited Review: Cross-talk signals between pathways in
the CNS: Role of neurotrophic and hormonal factors, adhesion molecules and
intercellular signaling agents in luteinizing hormone-releasing hormone (LHRH)
neuron-astroglial interactions. Trends in Biosci. In press, 1996.
RESEARCH GROUP MEMBERS:
-
Motta Marcella, P.O.
-
Limonta Patrizia, R.U.
-
Negri-Cesi Paola, R.U.
-
Poletti Angelo, R.U.
-
Magni Paolo, R.U.
-
Montagnani Marelli Marina, D. D.R.
-
Brevini Tiziana , T.L.
-
Dondi Donatella, T.L.
AFFILIATION:
Istituto di Endocrinologia
Facoltā di Farmacia
Universitā degli Studi di Milano
ADDRESS: Via Balzaretti, 9
CITY: Milano
POSTAL CODE: 20133
TELEPHONE: 02-29406576
FAX: 02-29404927
E-MAIL: motta@isfunix.farma.unimi.it
PUBLICATIONS:
-
LIMONTA P., DONDI D., MORETTI R.M., MAGGI R., MOTTA M. Antiproliferative
effects of luteinizing hormone-releasing hormone agonists on the human prostatic
cancer cell line LNCaP. J. Clin. Endocrinol. Met. 75: 207-212, 1992.
-
LIMONTA P., DONDI D., MORETTI R.M., FERMO D., GARATTINI E., MOTTA M. Expression
of luteinizing hormone-releasing hormone mRNA in the human prostatic cancer
cell line LNCaP. J. Clin. Endocr. Met. 76: 797-800, 1993.
-
BREVINI T.A.L., BIANCHI R., MOTTA M. Direct inhibitory effect of somatostatin
on the growth of the human prostatic cancer cell line LNPOSTAL CODE: possible
mechanisms of action. J. Clin. Endocrinol. Met. 77: 626-631, 1993.
-
LIMONTA P., MORETTI R.M., DONDI D., MONTAGNANI MARELLI M., MOTTA M.
Androgen-dependent prostatic tumors: biosynthesis and possible actions of
LHRH. J. Steroid Biochem. Mol. Biol. 49: 347-350,1994.
-
DONDI D., LIMONTA P., MORETTI R.M., MONTAGNANI MARELLI M., GARATTINI E.,
MOTTA M. Antiproliferative effects of luteinizing hormone-releasing hormone
(LHRH) agonists on human androgen-independent prostate cancer cell line DU
145: evidence for an autocrine-inhibitory LHRH loop. Cancer Res. 54:
4091- 4095, 1994.
-
LIMONTA P., MORETTI R.M., DONDI D., MONTAGNANI MARELLI M., MOTTA M. The EGF/TGFa
system as an autocrine growth stimulatory loop in LNCaP cells. Endocr.
Rel. Cancer 1: 5-13,1994.
-
NEGRI-CESI P., MOTTA M. Androgen metabolism in the human prostatic cancer
cell line LNCaP. J. Steroid Biochem. Mol. Biol. 51: 89-96, 1994.
-
MELCANGI R.C., GALBIATI R., MESSI E., PIVA F., MARTINI L., MOTTA M. Type
1 astrocytes influence luteinizing hormone-releasing hormone release from
the hypothalamic cell line GT-1: is transforming growth factor-b the principle
involved? Endocrinology 136: 679-686,1995.
-
LIMONTA P., DONDI D., MONTAGNANI MARELLI M., MORETTI M.R., NEGRI-CESI P.,
MOTTA M. Growth of the androgen - dependent tumor of the prostate: role of
androgens and of locally expressed growth modulatory factors. J. Steroid
Biochem. Molec. Biol. 53: 401-405,1995.
-
POLETTI A., CELOTTI F., MOTTA M., MARTINI L. Characterization of rat
5a-reductases type 1 and type 2 expressed in Saccharomyces cerevisiae.
Biochem. J. 314: 1047-1052, 1996.
RESEARCH GROUP MEMBERS :
-
Muccioli Giampiero, P.A.
-
Ghigo Mariacristina, B.PDR.
-
Scordamaglia Antonella, B.
-
Ghč Corrado, T.L.
AFFILIATION :
Sezione di Farmacologia, Dipartimento di Anatomia, Farmacologia e Medicina
Legale,
Facoltā di Medicina e Chirurgia
Universitā di Torino
ADDRESS: Via P. Giuria 13
CITY: Torino
POSTAL CODE: 10125
TELEPHONE: 011-670-7789-7715
FAX: 011-658606
E-MAIL: muccioli@medfarm.unito.it
PUBLICATIONS :
-
CAPPELLO B., GRECO G., NOVELLINO E., PERISSUTTI E., SANTAGADA V., SILIPO
C., VITTORIA A., DI CARLO R., MELI R., AND MUCCIOLI G. Synthesis and muscarinic
receptor binding profiles of antagonist benzotriazole derivatives.
Farmaco. 48: 907-918, 1993.
-
GUARDABASSI A., MUCCIOLI G., ANDREOLETTI G.E., PATTONO P., AND USAI P. Prolactin
and interrenal hormone balance in adult specimens of Xenopus Laevis exposed
to hyperhosmotic stress for up to one week. J. Exp. Zool. 265: 515-521,
1993.
-
DI CARLO R., FAGGIUOLO R., MUCCIOLI G., DI CARLO F., COSTANTINI M., AND DOGLIOTTI
L. Prognostic significance of prolactin receptor on overall survival of patients
with early breast cancer: a long-term retrospective analysis. The
Breast. 3:144-150, 1994.
-
MUCCIOLI G., AND DI CARLO R. Modulation of prolactin receptors in the rat
hypothalamus in response to changes in serum concentration of endogenous
prolactin or to ovine prolactin administration. Brain Res. 663: 244-250,
1994.
-
CICCARELLI E., FACCANI G., LONGO A., DALLE ORE G., PAPOTTI M., GROTTOLI S.,
RAZZORE P., GHE' C., AND MUCCIOLI G. Prolactin receptors in human pituitary
adenomas. Clin. Endocrinol. 42: 487-491, 1995.
-
MUCCIOLI G., MATTACE RASO G., GHE' C., AND DI CARLO R. Age-dependent
changes of muscarinic receptor subtypes and membrane microviscosity in the
rat brain: effect of L-alpha-glycerylphosphorylcholine. Progr.
Neuro-Psychopharmacol Biol. Psychiat. 20: 323-339, 1996.
-
GHIGO E., ARVAT E., MUCCIOLI G., AND CAMANNI F. Growth hormone (GH)-releasing
peptides. Eur. J. Endocrinol. In press, 1996.
RESEARCH GROUP MEMBERS:
-
Müller Eugenio E., P.O.
-
Locatelli Vittorio, P.A.
-
De Gennaro Colonna Vito, R.U.
-
Cella Silvano G., T.L.
-
Torsello Antonio, T.L.
-
Grilli Roberta, D.DR.
-
Guidi Margherita, D.DR.
-
Luoni Marina, B.
-
Rigamonti Antonello, B.
AFFILIATION:
Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica
Facoltā di Medicina e Chirurgia
Universitā di Milano
ADDRESS: Via Vanvitelli, 32
CITY: Milano
POSTAL CODE: 20129
TELEPHONE: 02-70146-212, 214, 215, 208,
209, 210, 217, 237
FAX: 02-70106838
E-MAIL: muller@imiucca.csi.unimi.it
PUBLICATIONS:
-
LOCATELLI, V., GRILLI, R., TORSELLO, A., CELLA, S.G., WEHRENBERG, W.B., AND
MÜLLER, E.E. Growth hormone releasing hexapeptides is a potent stimulator
of growth hormone gene expression and release in the growth hormone-releasing
hormone-deprived infant rat. Pediat. Res. 36: 169-174, 1994.
-
CELLA, S.G., LOCATELLI, V., BROCCIA, M.L., MENEGOLA, E., GIAVINI, E., DE
GENNARO COLONNA, V., TORSELLO, A., WEHRENBERG, W.B., AND MÜLLER, E.E.
Long-term changes of somatotrophic function induced by deprivation of growth
hormone-releasing hormone during the fetal life of the rat. J.
Endocrinol. 140: 111-117, 1994.
-
CELLA, S.G., DE GENNARO COLONNA, V., LOCATELLI, V., BESTETTI, G., ROSSI,
G.L., TORSELLO, A., WEHRENBERG, W.B., AND MÜLLER, E.E. Somatotropic
dysfunction in growth hormone-releasing hormone-deprived neonatal rats: effect
of growth hormone replacement therapy. Pediat. Res. 36: 315-322, 1994.
-
DEGHENGHI, R., CANANZI, M., TORSELLO, A., BATTISTI, C., MÜLLER, E.E.,
AND LOCATELLI, V. GH-releasing activity of Hexarelin, a new growth hormone
releasing peptide, in infant and adult rats. Life Sci. 54: 1321-1328,
1994.
-
CONLEY, L.K., TEIK, J.A., DEGHENGHI, R., IMBIMBO, B.P., GIUSTINA, A., LOCATELLI,
V., AND WEHRENBERG, W.B. Mechanism of action of Hexarelin and GHRP-6: analysisof
the involvement of GHRH and somatostatin in the rat.
Neuroendocrinology 6: 44-50, 1995.
-
BOUJON, C.E., BESTETTI, G.E., ABRAMO, F., LOCATELLI, V., AND ROSSI, G.L.
The reduction of circulating growth hormone and prolactin in streptozocin-induced
diabetic male rats is possibly caused by hypothalamic rather than pituitary
changes. J. Endocrinol. 145: 19-26, 1995.
-
MÜLLER, E.E., ROLLA, M., GHIGO, E., BELLITI, D., ARVAT, E., ANDREONI,
A., TORSELLO, A., LOCATELLI, V., AND CAMANNI, F. Involvement of brain
catecholamines and acetylcholine in growth hormone hypersecretory states.
Pathophysiological, diagnostic and therapeutic implications. Drugs
50: 805-837, 1995.
-
CELLA, S.G., LUCERI, M., CATTANEO, L., TORSELLO, A., AND MÜLLER, E.E.
Somatostatin withdrawal as generator of pulsatile GH release in the dog:
a possible tool to evaluate the endogenous GHRH tone?
Neuroendocrinology 63: 481-488, 1996.
-
VRONTAKIS, M., TORSELLO, A., LEITE, V., VUILLE, J.C., AND ZHANG, H. Regulation
of galanin by dexamethasone in the rat anterior pituitary and the uterus.
Neuroendocrinology 64: 20-24, 1996.
-
HORIKAWA, R., HELLMANN, P., CELLA, S.G., TORSELLO, A., DAY, R.N., MÜLLER,
E.E., AND THORNER, M.O. Growth hormone-releasing factor (GRF) regulates
expression of its own receptor. Endocrinology 137: 2642-2645, 1996.
RESEARCH GROUP MEMBERS :
-
Pecile Antonio, P.O.
-
Guidobono-Cavalchini Francesca, P.A.
-
Netti Carmela, P.A.
-
Pagani Francesca, T.L.
-
Sibilia Valeria, T.L.
-
Ticozzi Chiara, B.
AFFILIATION:
Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica
Facoltā di Medicina e Chirurgia
Universitā degli Studi di Milano
ADDRESS: Via Vanvitelli, 32
CITY: Milano
POSTAL CODE: 20129
TELEPHONE: 02-70146-243, 247, 277, 246, 245
FAX: 02-70146-369
E-MAIL: pecile@imiucca.csi.unimi.it
PUBLICATIONS:
-
SIBILIA, V., GUIDOBONO, F., PECILE, A., PAGANI, F., VILLA, I., AND NETTI,
C. Involvement of the catecholaminergic system in the inhibitory effect of
brain histamine on growth hormone secretion. Agents Actions. 38: 272-274,
1993.
-
MICHALSKY, M., NORRIS-SUAREZ, K., BETTICA, P., PECILE, A., AND MORO, L. Rat
cortical and trabecular bone collagen glycosylation are differently influenced
by ovariectomy. Biochem. Biophys. Res. Comm. 192: 1281-1288, 1993.
-
NETTI, C., SIBILIA, V., GUIDOBONO, F., AND PECILE, A. Influence of brain
histamine on growth hormone secretion induced by 2-receptor activation.
Neuroendocrinology. 57: 1066-1070, 1993.
-
NETTI, C., SIBILIA, V., GUIDOBONO, F., VILLANI, P., PECILE, A., AND BRAGA,
P.C. Evidence for an ihnibitory role of central histamine on carrageenin-induced
hyperalgesia. Neuropharmacology. 33: 205-210, 1994.
-
GUIDOBONO, F., COLUZZI, M., PAGANI, F., PECILE, A., AND NETTI, C. Amylin
given by central and peripheral routes inhibits acid gastric secretion.
Peptides. 15: 699-702, 1994.
-
VILLA, I., COLANGELO, A.M., VESCOVI, A.L., GRITTI, A., SCHINELLI, S., PAGANI,
F., AND GUIDOBONO, F. Differential effects of CGRP on adenylyl-cyclase in
adult and embryonic rat brain. Neuroreport. 5: 2489-2492, 1994.
-
NETTI, C., SIBILIA, V., PAGANI, F., LATTUADA, N., COLUZZI, M., PECILE, A.,
AND GUIDOBONO, F. Inhibitory effect of amylin on growth hormone responsiveness
to growth hormone-releasing hormone in the rat. Neuroendocrinology.
62: 313-318, 1995.
-
REINA, G., RUBINACCI, A., MORO, L., MORO, G.L., AND PECILE, A. Time relationship
between bone growth and the increment of bone mineral content in growing
rats. Minerva Endocrinol. 20: 211-216, 1995.
-
BRAGA, P.C., SOLDAVINI, E., PECILE, A., SIBILIA, V., AND NETTI, C. Involvement
of H1 receptors in the central antinociceptive effect of histamine:
pharmacological dissection by electrophysiological analysis.
Experientia. 52: 60-65, 1996.
-
PECILE, A., NETTI, C., SIBILIA, V., VILLA, I., TENNI, R., COLUZZI, M., MORO
G.L., AND RUBINACCI A. Comparison between urinary pyridinium cross-links
and hydroxylysine glycosides in monitoring the effects of ovariectomy and
17-estradiol replacement in aged rats. J. Endocrinol. 150: 383-390,
1996.
RESEARCH GROUP MEMBERS:
-
Piva Flavio, P.A.
-
Maggi Roberto, R.U.
-
Melcangi Roberto, R.U.
-
Pimpinelli Federica, D.DR.
-
Magnaghi Valerio, D.DR.
-
Cavarretta Ilaria, B.
AFFILIATION :
Istituto di Endocrinologia
Facoltā di Farmacia
Universitā degli Studi di Milano
ADDRESS: Via Balzaretti, 9
CITY: Milano
POSTAL CODE: 20133
TELEPHONE: 02/29406576
FAX: 02/29404927
E-MAIL: endo@isfunix.farma.unimi.it
PUBLICATIONS :
-
PIVA F., CELOTTI F., DONDI D., LIMONTA P., MAGGI R., MESSI E., NEGRI-CESI
P., ZANISI M., MOTTA M., MARTINI L. Ageing of the neuroendocrine system in
the brain of male rats: receptor mechanisms and steroid metabolism. J.
Reprod. Fert. Suppl. 46: 47-59, 1993
-
MAGGI R., DONDI D., ROVATI G.E., MARTINI L., PIVA F., LIMONTA P. Binding
characteristics of hypothalamic mu opioid receptors throughout the estrous
cycle in the rat. Neuroendocrinology 58: 366-372, 1993
-
PIVA F., LIMONTA P., MAGGI R., DONDI D., MESSI E., ZANISI M., MARTINI L.
Effect of aging on opioid and LHRH receptors in the brain, pituitary, and
testis of the male rat. Neurobiol. Aging 15: 553-557,1994
-
MAGGI R., MARTINI L., PIVA F. Effect of ovariectomy on the binding
characteristics of hypotalamic mu opioid receptors in the rat. Endocr.
Regul. 28: 171-178, 1994
-
MAGGI R., PIMPINELLI F., MARTINI L. , PIVA F. Characterization of funtional
opioid delta receptors in a luteinizing hormone-releasing hormone producing
neuronal cell line. Endocrinology 136: 289-295, 1995
-
MELCANGI R.C., GALBIATI R., MESSI E., PIVA F., MARTINI L., MOTTA M. Type
1 astocytes influence luteinizing hormone-releasing hormone release from
the hypothalamic cell line GT-1: is trasforming growth factor-beta the principle
involved? Endocrinology 136 : 679-686, 1995.
-
PIVA F., LIMONTA P., DONDI D., PIMPINELLI F., MARTINI L., MAGGI R. Effects
of steroids on the brain opiod system. J. Steroid Biochem. Molec. Biol.
53: 343-348,1995
-
MAGGI R.,PIMPINELLI F.,MARTINI L., PIVA F.Inhibition of luteinizing
hormone-releasing hormone secretion by d-opioid agonists in GT1-neuronal
cells. Endocrinology 136:5177-5181,1995
-
MELCANGI R.C., FROELICHSTHAL P., MARTINI L., VESCOVI A.L. Steroid metabolizing
enzymes in pluripotential progenitor central nervous system cells: effect
of differentiation and maturation. Neuroscience 72: 467-475, 1996
-
MAGGI R., PIMPINELLI F.,CASULARI L.A., PIVA F. , MARTINI L. Antiprogestins
inhibit the binding of opioids to m-opioid receptors in nervous membrane
preparations. Eur. J. Pharmacol. 301: 169-177,1996
RESEARCH GROUP MEMBERS:
-
Rosa Patrizia, C.L.
-
Corradi Nicoletta, B.
-
Bassetti Monique, T.
AFFILIATION:
Centro CNR per lo Studio della Farmacologia Cellulare e Molecolare
Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica
Universitā di Milano
ADDRESS: Via Vanvitelli 32
CITY: Milano
POSTAL CODE: 20129
TELEPHONE: 02-70146-254, 262, 266, 256
FAX: 02-7490574
E-MAIL: RosaP@farma2.csfic.mi.cnr.it
PUBLICATIONS:
-
ROSA P. AND GERDES H.H. The granin protein family: markers for neuroendocrine
cells and tools for the diagnosis of neuroendocrine tumors. J. Endocrinol.
Invest. 17: 207-225, 1994
-
SHER E., ROSA P., BASSETTI M., ZANINI A. Immunolocalization of secreogranin
II and insulin in a nerve growth factor-differentiaties insulinoma cell line.
Eur. J. Cell Biol. 67: 15-22, 1995
-
BASSETTI M., LODI PASINI D. AND ROSA P. Degradation of gonadotropin
ß-subunits retained in the endoplasmic reticulum of the gonadotropes
of castrated rats. Endocrinology 136: 1168-1176, 1995
-
CORRADI N., BORGONOVO B., CLEMENTI E., BASSETTI M., RACCHETTI G., CONSALEZ
G.G., HUTTNER W.B., MELDOLESI J. AND ROSA P. Overall lack of regulated section
in a PC12 variant cell clone. J. Biol. Chem. 271: 27116-27124, 1996
-
PASSAFARO M., ROSA P., SALA C., CLEMENTI E. AND SHER E. N-type Ca2+ channels
are present in secretory granules and are transiently translocated to the
plasma membrane during regulated exocytosis. J. Biol. Chem., In press,
1996.
RESEARCH GROUP MEMBERS:
-
Scaccianoce Sergio, R.U.
-
Angelucci Luciano, P.O.
-
Affricano Daniela, B.
-
Lombardo Katia, B.
-
Antonelli Maria Antonietta, B.
AFFILIATION:
Istituto di Farmacologia Medica
Facoltā di Medicina e Chirurgia
Universitā "La Sapienza"
ADDRESS: Piazzale Aldo Moro, 5
CITY: Roma
POSTAL CODE: 00185
TELEPHONE: 06-4992-2511, 665
FAX: 06-4940588
E-MAIL: scaccianoce@uniroma1.it
PUBLICATIONS:
-
CATALANI A., MARINELLI M., SCACCIANOCE S. AND ANGELUCCI L. Long term behavioural
and andocrine effects of maternal hypercorticosteronemia during lactation.
Behav. Pharmacol. 4: 457-458, 1993.
-
CATALANI A., MARINELLI M., SCACCIANOCE S., NICOLAI R., MUSCOLO L.A.A., PORCU
A., KORāNYI L., PIAZZA P.V. AND ANGELUCCI L. Progeny of mothers drinking
corticosterone during lactation has lower stress-induced corticosterone secretion
and better cognitive performance. Brain Res. 624: 209-215, 1993.
-
SCACCIANOCE S., CIGLIANA G., NICOLAI R., MUSCOLO L.A.A., PORCU A., NAVARRA
D., PEREZ-POLO J.R. AND ANGELUCCI L. Hypothalamic involvement in the activation
of the pituitary-adrenocortical axis by nerve growth factor.
Neuroendocrinology 58: 202-209, 1993.
-
SCACCIANOCE S. Regolazione della risposta di stress nell' invecchiamento.
Gior. Geront. 42 :667-671, 1994.
-
MARDENTE S., SCACCIANOCE S., MISASI R., CATALANI A., LENTI L., MARINELLI
M., ANGELUCCI L. AND PONTIERI G.M. Phenotypic modifications in mouse thymocytes
during tumor growth: role of corticosterone. Medecine Biologie
Environnement 22: 485-497, 1994.
-
SCACCIANOCE S., NICOLAI R., CIGLIANA G. AND ANGELUCCI L. Reduced glucocorticoid
response to corticotropin secretagogues in the aged Sprague-Dawley rat.
Neuroendocrinology 62: 32-38, 1995.
-
BRUNO G., SCACCIANOCE S., BONAMINI M., PATACCHIOLI F.R., CESARINO F., GRASSINI
P., SORRENTINO E., ANGELUCCI L, AND LENZI G.L. Acetyl-l-carnitine in Alzheimer's
disease: a short-term study on CSF neurotransmitter and neuropeptides.
Alzheimer's disease and associated disorders 9: 128-131, 1995.
-
CALOGERO, S. SCACCIANOCE, N. BURRELLO, R. NICOLAI, L.A.A. MUSCOLO, M. A.
KLING, L. ANGELUCCI AND R. D'AGATA. The kappa-opioid agonist MR-2034 stimulates
the rat hypothalamic-pituitary-adrenal axis: studies in vivo and in
vitro. J. Neuroendocrinol. 8: 579-585, 1996.
RESEARCH GROUP MEMBERS:
-
Vacca Michele, P.O.
-
Brunetti Luigi, R.U.
-
Cannizzaro Carla, R.U.
-
Amitrano Maria, T.L.
-
Del Cecato Paolo, T.
AFFILIATION:
Cattedra di Farmacologia e Farmacognosia
Istituto di Scienza del Farmaco
Facoltā di Farmacia
Universitā G. D'Annunzio
ADDRESS: via dei Vestini
CITY: Chieti
POSTAL CODE: 66013
TELEPHONE: 0871-355384, -89, -90
FAX: 0871-355391
PUBLICATIONS:
-
BRUNETTI, L., PREZIOSI, P., RAGAZZONI, E., AND VACCA, M. Involvement of nitric
oxide in basal and interleukin-1ß-induced CRH and ACTH release in
vitro. Life Sci. 53: PL219-222, 1993.
-
CANNIZZARO, G., FLUGY, A., CANNIZZARO, C., GAGLIANO, M., AND SABATINO, M.
Effects of desipramine and alprazolam in the forced swim test in rats after
long-lasting termination of chronic exposure to picrotoxin and
pentylenetetrazol. Eur. Neuropsychopharmacol. 3: 477-484, 1993.
-
BRUNETTI, L., PREZIOSI, P., RAGAZZONI, E., AND VACCA, M. Effects of
lipopolysaccharide on hypothalamic-pituitary-adrenal axis in vitro.
Life Sci. 54: PL165-171, 1994.
-
SABATINO, M., CANNIZZARO, C., FLUGY, A., GAGLIANO, G., AND CANNIZZARO, G.
NMDA-GABA interactions in an animal model of behaviour: a gating mechanism
from motivation toward psychotic-like symptoms. Eur.
Neuropsychopharmacol. 4: 103-109, 1994
-
BRUNETTI, L., PREZIOSI, P., RAGAZZONI, E., AND VACCA M. Effects of vindesine
on hypothalamic-pituitary-adrenal axis. Toxicol. Lett. 75: 69-73,
1995.
-
BRUNETTI, L., RAGAZZONI, E., PREZIOSI, P., AND VACCA M. A possible role for
nitric oxide but not for prostaglandin E2 in basal and
interleukin-1-ß-induced PRL release in vitro. Life Sci.
56: PL277- 283, 1995.
-
CANNIZZARO, C., CANNIZZARO, E., GAGLIANO, M., MINEO, A., SABATINO, M., AND
CANNIZZARO, G. Effects of desipramine and alprazolam in forced swimming behaviour
of adult rats exposed to prenatal diazepam. Eur. J. Pharmacol.. 273:
239-245, 1995
-
BRUNETTI, L., VOLPE, A.R., RAGAZZONI, E., PREZIOSI, P., AND VACCA M.
Interleukin-1ß specifically stimulates nitric oxide production in the
hypothalamus. Life Sci. 58: PL373-377, 1996.
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