SIF - Societą
Italiana di Farmacologia
"SIF - La Ricerca Farmacologica in Italia"
PHARMACOLOGY OF THE LIPID METABOLISM
RESEARCH GROUP MEMBERS:
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Catapano Alberico L., P.A.
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Maggi Franco M., R.U.
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Roma Paola, B.PDR.
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Zanelli Tiziano, B.PDR.
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Grignaffini Paola, D.DR.
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Zoppo Adele, D.DR.
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Pirillo Angela, B.
AFFILIATION:
Istituto di Scienze Farmacologiche
Universitą degli Studi di Milano
ADDRESS: Via Balzaretti, 9
CITY: Milano
POSTAL CODE: 20133
TELEPHONE: 02 - 20 488 302
FAX: 02 - 20 488 386
E-MAIL: catapano@isfunix.farma.unimi.it
PUBLICATIONS:
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FUNKE, A., VON ECKARDSTEIN, A., PRITCHARD, P.H., HORNBY, A.E., WIEBUSCH,
H., MOTTI, C., HAYDEN, M.R., DACHET, C., JACOTOT, B., GERDES, U., FAEGERMAN,
O., ALBERS, J.J., COLLEONI, N., CATAPANO, A.L., FROHLICH, J., AND ASSMANN,
G. Genetic and phenotypic heterogeneity in familial lecithin: cholesterol
acyltransferase (LCAT) deficiency. J. Clin. Invest. 91: 677-683, 1993.
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ZANELLI, T., CATAPANO, A.L., AVERNA, M.R., BARBAGALLO, C.M., MOTTA, A., AND
NOTARBARTOLO, A. A new case of apo C-II deficiency with a nonsense mutation
in the apo C-II gene. Clin. Chim. Acta. 224: 111-118, 1994.
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ZHU, W., ROMA, P., PELLEGATTA, F., AND CATAPANO, A.L. Oxidized-LDL induce
the expression of heat shock protein 70 in human endothelial cells. Biochem.
Biophys. Res. Commun. 200: 389-394, 1994.
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FIELDING, P.E., KAWANO, M., CATAPANO, A.L., ZOPPO, A., MARCOVINA, M., AND
FIELDING, C.J. A unique epitope of apolipoprotein A-I expressed in preß-1
high density lipoprotein and its role in the catalysed efflux of cellular
cholesterol. Biochemistry. 33: 6981-6985, 1994
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MAGGI, F.M., PIGLIONICAM, M.R., DE MICHELE, L., BARONI, S., GIONCHETTA, C.,
BIASI, G.M., AND CATAPANO, A.L. Bezafibrate lowers elevated plasma levels
of fibrinogen and Lp(a) in patients with type IIa and b dyslypoproteinaemia.
Nutr. Metab. Cardiovasc. Dis. 4: 215-220, 1994.
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CORSINI, A., MAGGI, F.M., AND CATAPANO, A.L. Pharmacology of competitive
inhibitors of HMG-CoA reductase. Pharmacol. Res. 31: 9-27, 1995.
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ZHU, W., ROMA, P., PIRILLO, A., PELLEGATTA, F., AND CATAPANO, A.L. Oxidized
LDL induce hsp70 expression in human smooth muscle cells. FEBS Lett.
372: 1-5, 1995.
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SOMA, M.R., DONETTI, E., PAROLINI, C., BARBERI, L., FUMAGALLI, R., PAOLETTI,
R., AND CATAPANO, A.L. Effect of lacidipine on fatty and proliferative lesions
induced in hypocholesterlemic rabbits. Brit. J. Pharmacol., 118 :
215-219, 1996.
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ZHU, W., ROMA, P., PIRILLO, A., PELLEGATTA, F., AND CATAPANO, A.L. Human
endothelial cells exposed to oxidized LDL express hsp70 only when
proliferating. Arterioscler. Thromb. Vasc. Biol. 16: 1104-1111, 1996.
RESEARCH GROUP MEMBERS:
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Franceschini Guido, P.A.
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Calabresi Laura, B.PDR.
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Chiesa Giulia, B.PDR.
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Parolini Cinzia, D.DR.
AFFILIATION:
Istituto di Scienze Farmacologiche
Centro E. Grossi Paoletti
Facoltą di Farmacia
Universitą degli Studi di Milano
ADDRESS: via Balzaretti 9
CITY: Milano
POSTAL CODE: 20133
TELEPHONE: 02-6471690
FAX: 02-6470594
E-MAIL: francesc@isfunix.farma.unimi.it
PUBLICATIONS:
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CHIESA G., MICHELAGNOLI S., CASSINOTTI M., GIANFRANCESCHI G., WERBA J.P.,
PAZZUCCONI F., SIRTORI C.R., AND FRANCESCHINI G. Mechanisms of HDL reduction
after probucol treatment: changes in plasma cholesterol esterification/transfer
and lipase activities. Metabolism 42: 229-235, 1993.
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CALABRESI L., CASSINOTTI M., GIANFRANCESCHI G., SAFA O., SIRTORI C.R., AND
FRANCESCHINI G. Increased postprandial lipemia in the apolipoprotein A-IMilano
carriers. Arterioscl. Thromb. 13:521-528, 1993.
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FRANCESCHINI G., WERBA J.P., AND CALABRESI L. Drug control of reverse cholesterol
transport. Pharmacol. Ther. 61:289-324, 1994.
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FRANCESCHINI G., CASSINOTTI M., VECCHIO
G., GIANFRANCESCHI G., PAZZUCCONI F., MURAKAMI T., SIRTORI M., D'ACQUARICA
A.L., AND SIRTORI C.R. Pravastatin effectively lowers LDL cholesterol in
familial combined hyperlipidemia without changing LDL subclass pattern.
Arterioscler. Thromb. 14:1569-1575, 1994.
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CALABRESI L., VECCHIO G., LONGHI R., GIANAZZA E., PALM G., WADENSTEN H.,
HAMMARSTRÖM A., OLSSON A., KARLSTRÖM A., SEJLITZ T., AGELAND H.,
SIRTORI C.R., AND FRANCESCHINI G. Molecular characterization of native and
recombinant apolipoprotein A-IMilano dimer. The introduction of an interchain
disulfide bridge remarkably alters the physicochemical properties of
apolipoprotein A-I. J. Biol. Chem. 269:32168-32174, 1994.
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FRISONI G.B., GOVONI S., GEROLDI C., BIANCHETTI A., CALABRESI L., FRANCESCHINI
G., AND TRABUCCHI M. Gene dose of the 4 allele apolipoprotein E and disease
progression in sporadic late-onset alzheimer's disease. Ann. Neurol.
37:596-604, 1995.
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MURAKAMI T., MICHELAGNOLI S., LONGHI R., GIANFRANCESCHI G., PAZZUCONI F.,
CALABRESI L., SIRTORI C.R., AND FRANCESCHINI G. Triglycerides are major
determinants of cholesterol esterification/transfer and HDL remodeling in
human plasma. Arterioscl. Thromb. Vasc. Biol. 15:1819-1828, 1995.
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BERNINI F., CALABRESI L., BONFADINI G., AND FRANCESCHINI G. The molecular
structure of apolipoprotein A-II modulates the capacity of HDL to promote
cell cholesterol efflux. Biochim. Biophys. Acta 1299:103-109, 1996.
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CALABRESI L., LUCCHINI A., VECCHIO G., SIRTORI C.R., AND FRANCESCHINI G.
Human apolipoprotein A-II inhibits the formation of pre- high density
lipoproteins. Biochim. Biophys. Acta; In press, 1996.
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FRANCESCHINI G. Apolipoprotein function in health and disease: insights from
natural mutations. Eur. J. Clin. Invest., In press, 1996.
RESEARCH GROUP MEMBERS:
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Fumagalli Remo P.O.
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Corsini Alberto R.U.
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Soma Maurizio R.U.
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Bellosta Stefano B.PDR.
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Donetti Elena D.DR.
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Baetta Roberta D.DR.
-
Quarato Pierangelo B.
-
Canavesi Monica B.
AFFILIATION:
Istituto di Scienze Farmacologiche
Facoltą di Farmacia
Universitą degli Studi di Milano
ADDRESS: Via Balzaretti, 9
CITY: Milano
POSTAL CODE: 20133
TELEPHONE: 02 - 20488321/322/346
FAX: 02 - 29404961
E-MAIL: corsiniaisfunix.farma.unimi.it
PUBLICATIONS:
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SOMA MR, DONETTI E, PAROLINI C, MAZZINI G, FERRARI C, FUMAGALLI R, PAOLETTI
R. HMGCoA reductase inhibitors: in vivo effects on carotid intimal
thickening in normocholesterolemic rabbits. Arterioscler. Thromb.
13: 571-578. 1993
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BERNINI F, DIDONI G, BELLOSTA S, FUMAGALLI R. Requirement for mevalonate
in acetylated LDL induction of cholesterol esterification in macrophages.
Atherosclerosis. 104: 19-26, 1993
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CORSINI A, MAZZOTTI M, RAITERI M, SOMA MR, GABBIANI G, FUMAGALLI R, AND PAOLETTI
R. Relationship between mevalonate pathway and arterial myocyte proliferation:
"in vitro" studies with inhibitors of HMG-CoA reductase.
Atherosclerosis. 101: 117-125, 1993
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SOMA MR, BAETTA R, BERGAMASCHI S, DE RENZIS MR, DAVEGNA C, BATTAINI F, FUMAGALLI
R, GOVONI S. PKC activity in rat C6 glioma cells: changes associated with
cell cycle and simvastatin treatment. Biochem. Biophys. Res. Commun.
200: 1143-1149, 1994
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SOMA MR, BAETTA R, DE RENZIS R, MAZZINI G, DAVEGNA C, MAGRASSI L, BUTTI G,
PEZZOTTA S, PAOLETTI R, FUMAGALLI R. In vitro and in vivo enhanced anti-tumor
activity of carmustine (BCNU) by simvastatin, a hypocholesterolemic drug.
Cancer Res. 55: 597-602, 1995
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SOMA MR, DONETTI E, PAROLINI C, SIRTORI C, FUMAGALLI R, FRANCESCHINI G.
Recombinant apolipoprotein A-IMilano dimer inhibits carotid intimal thickening
induced by perivascular manipulation in rabbits. Circ. Res. 76: 405-411,
1995
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CORSINI A, VERRI D, RAITERI M, QUARATO P, PAOLETTI R, FUMAGALLI R. Effect
of 26-aminocholesterol, 27-hydroxycholesterol, and 25-hydroxycholesterol
on proliferation and cholesterol homeostasis in arterial myocytes.
Arterioscler. Thromb. Vasc. Biol. 15:420-428, 1995
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BERNINI F, SCURATI N, BONFADINI G, FUMAGALLI R. HMG-CoA reductase inhibitors
reduce acetyl LDL endocytosis in mouse peritoneal macrophages. Arterioscl.,
Thromb. Vasc. Biol. 15: 1352-1358, 1995
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SOMA MR, DONETTI E, PAROLINI C, BARBERI L, FUMAGALLI L, PAOLETTI R, CATAPANO
AL. Effect of lacidipine on fatty and proliferative lesions induced in
hypercholesterolemic rabbits. Brit. J. Pharmacol. 118: 215-219, 1996.
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CORSINI A, BONFATTI M, QUARATO P, RAITERI M, SARTANI A, TESTA R, PAOLETTI
R, FUMAGALLI R. Effect of the new calcium antagonist lercanidipine and its
enantiomers on the migration and proliferation of arterial myocytes. J.
Cardiovasc. Pharmacol. 28 : In press, 1996.
RESEARCH GROUP MEMBERS:
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Galli Claudio, P.O.
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Petroni Anna, R.U.
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Visioli Francesco, B.PDR.
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Marangoni Franca, B.PDR.
-
Risé Patrizia, D.DR.
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Papini Nadia, Spec.
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Colombo Claudio, T.
-
Blasevich Milena, T.
AFFILIATION:
Istituto di Scienze Farmacologiche
Facoltą di Farmacia
Universitą degli Studi di Milano
ADDRESS: Via Balzaretti, 9
CITY: Milano
POSTAL CODE: 20133
TELEPHONE: 02-20488309-307
FAX: 02-29404961
E-MAIL: gallic@isfunix.farma.unimi.it.
PUBBLICATIONS:
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GALELLA, G., MARANGONI, F., RISÆ, P., COLOMBO, C., GALLI, G. AND GALLI,
C. n-6 and n-3 fatty acid accumulation in THP-1 cell phospho-lipids.
Biochim. Biophys. Acta, 1169: 280-290, 1993
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F. MARANGONI, M.T. ANGELI, S. COLLI, S. ELIGINI, E. TREMOLI, C.R. SIRTORI,
C. GALLI. Changes of n-3 and n-6 fatty acids in plasma and circulating cells
of normal subjects, after prolonged administration of 20:5 (EPA) and 22:6
(DHA) ethyl esters and prolonged washout. Biochim Biophys Acta, 1210:
55-62, 1993.
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A. PETRONI, M. SALAMI, M. BLASEVICH, N. PAPINI, G. GALELLA, C. COLOMBO, C.
GALLI. Eicosanoid and inositol phosphate response to platelet-activating
factor (PAF) and to a PAF antagonist in rat astroglial cells. Dev Brain
Res., 1-6, 1993.
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D. CARUSO, P.RISÉ, G.GALELLA, C.REGAZZONI, A.TOIA, G.GALLI AND C.GALLI.
Formation of 22 and 24 carbon 6-desaturated fatty acids from exogenous deuterated
arachidonic acid is activated in THP-1 cells at high substrate concentrations.
FEBS Letters, 343:195-199, 1994.
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F. VISIOLI AND C. GALLI. Oleuropein protects low density lipoprotein from
oxidation. Life Sciences, 55:1965-71,1994
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E.TREMOLI, P.MADERNA, F.MARANGONI, S.COLLI, S.ELIGINI, I. CATALANO, MT ANGELI,
F PAZZUCCONI, G GIANFRANCESCHI, G DAVI, E STRAGLIOTTO, CR SIRTORI, C GALLI.
Prolonged inhibition of platelet aggregation after n-3 fatty acid ethyl ester
ingestion by healthy volunteers. Am. J. Clin. Nutr. 61: 1-7, 1995.
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VISIOLI F, BELLOMO G, MONTEDORO GF AND GALLI C. Low density lipoprotein oxidation
is inhibited in vitro by olive oil constituents. Atherosclerosis 117:
25-32, 1995.
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A. PETRONI, M. BLASEVICH, N. PAPINI, P. LA SPADA AND C. GALLI. Changes in
arachidonic acid levels and formation and in lipid synthesis in the human
neuroblastoma SK-NBE during retinoic acid-induced differentiation. J
Neurochem 67:549-556, 1996
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P. PAULETTO, PUATO M, CAROLI MG, CASIGLIA E, MUNHAMBO AE, CAZZOLATO G, BITTOLO
BON G, ANGELI MT, GALLI C, AND PESSINA A. Blood pressure and atherogenic
lipoprotein profiles of fish-diet and vegetarian villagers in Tanzania :
the Lugalawa Study. Lancet, 348:784-88, 1996.
RESEARCH GROUP MEMBERS:
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Sirtori Cesare, P.O.
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Lovati Maria Rosa, R.U.
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Gianazza Elisabetta, R.U.
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Gianfranceschi Gemma, R.U.
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Bertoli Marina, R.U.
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Manzoni Cristina, T.L.
-
Pazzucconi Franco, T.L.
-
Battistin Paolo, T.L.
AFFILIATION:
Istituto di Scienze Farmacologiche
Facoltą di Farmacia
Universitą degli Studi di Milano
Centro E. Grossi Paoletti, Ospedale Niguarda Cą Granda
ADDRESS: Via Balzaretti, 9
CITY: Milano
POSTAL CODE: 20133
TELEPHONE: 02/20.488.311, 303
FAX: 02 - 29.404.961
E-MAIL: sirtori@isfunix.farma.unimi.it
PUBLICATIONS:
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BEKAERT E.D., ALAUPOVIC P., KNIGHT-GIBSON C.S., FRANCESCHINI G., AND SIRTORI
C.R. Apolipoprotein A-1Milano: sex related differences in the concentration
and composition of apo A-I and apoB-containing lipoprotein particles. J.
Lipid Res. 34: 111-123, 1993.
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ROMA P., GREGG R.E., MENG M.S., RONAN R., ZECH L.A., FRANCESCHINI G., SIRTORI
C.R., AND BREWER H. B. Jr. In vivo metabolism of a mutant form of apolipoprotein
A-I, apo A-IMilano, associated with familial hypoalphalipoproteinemia. J.
Clin. Invest. 91: 1445-1452, 1993.
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PAZZUCCONI F., FRANCESCHINI G., GIANFRANCESCHI G., BRAMBILLA E., AND SIRTORI,
C.R. Lipoprotein structure in male subjects during in vivo lipolysis: effect
of an antilipolytic treatment with acipimox. J. Lipid Res. 34: 1465-1472,
1993.
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MARANGONI F., ANGELI M.T., COLLI S., ELIGINI S., TREMOLI E., SIRTORI C.R.,
AND GALLI C. Changes of n-3 and n-6 fatty acids in plasma and circulating
cells of normal subjects, after prolonged administration of 20:5 (EPA) and
22:6 (DHA) ethyl esters and prolonged washout. Biochim. Biophys. Acta
1210: 55-62, 1993.
-
FRANCESCHINI G., CASSINOTTI M., VECCHIO G., GIANFRANCESCHI G., PAZZUCCONI,
F., MURAKAMI T., SIRTORI M., D'ACQUARICA A.L., AND SIRTORI C.R. Pravastatin
effectively lowers LDL cholesterol in familial combined hyperlipidemia without
changing LDL subclass pattern. Arterioscler. Thromb. 14: 1569-1575,
1994.
-
SOMA M.R., DONETTI E., PAROLINI C., SIRTORI C.R., FUMAGALLI R., AND FRANCESCHINI,
G. Recombinant apolipoprotein A-IMilano dimer inhibits carotid intimal thickening
induced by perivascular manipulation in rabbits. Circ. Res. 76: 405-411,
1995.
-
FRANCESCHINI G., WERBA J.P., D'ACQUARICA A.L., GIANFRANCESCHI G., MICHELAGNOLI
S., AND SIRTORI C.R. Microsomal enzyme inducers raise plasma HDL-cholesterol
levels in healthy controls but not in patients with primary
hypoalphalipoproteinemia. Clin. Pharmacol. Ther. 57: 434-440, 1995.
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SIRTORI C.R. New targets for lipid lowering and atherosclerosis prevention.
Pharmacol. Ther. 67: 433-447, 1995
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BALDASSARRE D., GIANFRANCESCHI G., PAZZUCCONI F., AND SIRTORI C.R. Non-invasive
assessment of unstimulated forearm arterial compliance in human subjects.
Impaired vasoreactivity in hypercholesterolaemia. Eur. J. Clin. Invest.
25: 859-866, 1995.
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PAZZUCCONI F., BARBI S., BALDASSARRE D., COLOMBO N., DORIGOTTI F., AND SIRTORI
C.R. Iron-ovotransferrin preparation does not interfere with ciprofloxacin
absorption. Clin. Pharmacol. Ther. 59: 418-422, 1996.
RESEARCH GROUP MEMBERS:
-
Tacconi Maria Teresa, C.L..
-
Sciarretta Birolo Roberto B.
-
Tsankova Virginia, visiting scientist
AFFILIATION:
Istituto di Ricerche Farmacologiche "Mario Negri" Milano
ADDRESS: Via Eritrea, 62
CITY: Milano
POSTAL CODE: 0157
TELEPHONE: O2-39014464
FAX: 02-3546277
E-MAIL: tacconi@irfmn.mnegri.it
PUBLICATIONS:
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PELLEGRINI G, TOTANI L, DISANTO A, PICCOLI A, TACCONI MT, DONATI MB AND LORENZET
R, Supplementation-induced changes in polyunsaturated fatty acid membrane
and plasma composition do not modify mononuclear cell procoagulant activity
, Thromb. Res., 71: 95-101, 1993.
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LLIGONA TRULLA LLUIS, MAGISTRELLI A. , M SALMONA AND TACCONI MT Effect of
cell density on cytotoxicity of Ether lipids analogues in variants of B16
murine melanoma; Lipids, 28, 403-406,1993.
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M VISENTIN, M SALMONA AND MT TACCONI. Reye's and Reye-like syndrome: drug-related
deseases? Causative agents, etiology, pathogenesis and therapeutic approach,
Drug Metab. Rev. 27: 517-539, 1995.
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A MAGISTRELLI, P VILLA, E BENFENATI, M SALMONA, E J MODEST AND MT TACCONI.The
fate of 1-O-octadecyl-2-O-methyl -rac-glycero-3-phosphocholine (ET18OMe)
in malignant cells, normal cells and isolated and perfused rat liver. Drug
Metab. Disposition, 23 : 113-118, 1995.
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M VISENTIN, M SALMONA AND MT TACCONI. Reye syndrome model in rat:protection
against liver abnormalities by L-carniytine and L-acetylcarnitine J.
Pharmacol. Exp. Ther., 275:1069-1075, 1995.
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TSANKOVA, A MAGISTRELLI, L CANTONI, AND MT TACCONI. Peripheral benzodiazepine
receptor ligands in rat liver: Effect on mitochondrial cholesterol translocation,
Eur. J. Pharmacol., 294:601-607, 1995.
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LUSUARDI M, CAPELLI A, SALMONA M, TACCONI MT, CERUTTI CG, DONNER CF. Intraluminal
inflammationin airways of patients with chronic bronchitis after treatment
with ambroxol. Monaldi Arch. Chest Dis. 50:346-351, 1995.
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TSANKOVA, M VISENTIN, M CARELLI, L CANTONI, AND MT TACCONI. Peripheral
benzodiazepine receptor ligands in rat liver: Effect on 27- hydroxylation
of cholesterol, Eur. J. Pharmacol., 299:197-203, 1996.
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