SIF - Societą
Italiana di Farmacologia
"SIF - La Ricerca Farmacologica in Italia"
PHARMACOTOXICOLOGY
RESEARCH GROUP MEMBERS:
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Barone Domenico, Dir.R.
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Fracchia Sergio, C.L.
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Fassio Franca, C.L.
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Di Giovanni Franca, R.I.
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Golzio Lucia, R.I.
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Pasquali Emanuela, R.I.
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Peroglio Flavio, R.I.
AFFILIATION:
Dipartimento di Biotecnologie
Istituto di Ricerche Biomediche "Antoine Marxer" RBM S.p.A.
ADDRESS: Via Ribes, 1
CITY: Colleretto Giacosa (To)
POSTAL CODE: 10010
TELEPHONE: 0125 - 53746 (r.a.)
FAX: 0125 - 53585, 538079
PUBLICATIONS:
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BIANCHI G., BARONE D., LANZAROTTI E., TETTAMANTI R., PORTA R., MOLTRASIO
D. AND PRINO G. Defibrotide, a single-stranded polydeoxyribonucleotide acting
as an adenosine receptors agonist. Eur. J. Pharmacol., 238 :
327-334, 1993
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BARONE D., RAITERI F. AND FERRARA B. An Overview on a new kind of medicine:
human somatic gene therapy. Minerva Biotecnologica, 6 : 137-145,
1994
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BARONE D., RAITERI F. AND FERRARA B. Human somatic cell therapy and gene
therapy: A comparative analysis of USA/EEC regulatory requirements. Minerva
Biotecnologica, 6: 159-167, 1994
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BARONE D. Toxicokinetics of antitumor drugs. Eur. Bull. Drug Res.,
3 : 131-140, 1994
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BARONE D., SALVETTI L., DI VADI P. Piperonyl-ranitidine: a gastroprotective
agent with a novel pharmacological affinity profile. Eur. Bull. of Drug.
Res., 4 :1-16, 1995
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DAVICO BONINO L., DE MONTE L.B., SPAGNOLI G.C., VOLA R., MARIANI M., BARONE
D., MORO A.M., RIVA P., NICOTRA M.R., NATALI P.G. AND MALAVASI F. Bio-specific
monoclonal antibody anti-CD3 x anti-tenascin: an immunotherapeutic agent
for human glioma. Int. J. Cancer, 61 : 509-515, 1995
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PESCADOR R., TETTAMANTI R., SALVETTI L., CONTO A., BARONE D., PORTA R., MANTOVANI
M. AND FERRO L. Effects of Defibrotide on leukocytosis in rabbits with
diet-induced atherosclerosis. Life Sci. 57 : 579-589, 1995
RESEARCH GROUP MEMBERS:
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Brambilla Giovanni P.O.
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Cavanna Marco P.O.
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Martelli Antonietta P.A.
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Robbiano Luigi R.U.
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Mattioli Francesca T.L.
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Ghia Marco DR.
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Allavena Alessandra DR.
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Mereto Eugenio DR.
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Canonero Roberta DR.
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Brambilla Campart Giulia B.DR.
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Angiola Marianna B.
AFFILIATION:
Sezione di Farmacologia e Tossicologia
Dipartimento di Medicina Interna
Facoltą di Medicina e Chirurgia
Universitą di Genova
ADDRESS: Viale Benedetto XV, 2
CITY: Genova
POSTAL CODE: 16132
TELEPHONE: 010-353-8801
FAX: 010-353-8849
PUBLICATIONS:
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MARTELLI A., ALLAVENA A., GHIA M., ROBBIANO L., AND BRAMBILLA G. Cytotoxic
and genotoxic activity of 1,3-dichloropropene in cultured mammalian cells.
Toxicol. Appl. Pharmacol. 120: 114-119, 1993
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GHIA M., ROBBIANO L, ALLAVENA A., MARTELLI A., AND BRAMBILLA G. Genotoxic
activity of 1,3-dichloropropene in a battery of in vivo short-term tests.
Toxicol. Appl. Pharmacol. 120: 120-125, 1993.
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MARTELLI A., ALLAVENA A., SOTTOFATTORI E., AND BRAMBILLA G. Low clastogenic
activity in vivo of the N-nitrosoderivetives of five
b-adrenergic-blocking drugs proved to be potent
genotoxins in vitro. Toxicol. Lett. 73: 185-191, 1994.
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MARTELLI A., ALLAVENA A., BRAMBILLA CAMPART G., CANONERO R., GHIA M., MATTIOLI
F., MERETO E., ROBBIANO L., AND BRAMBILLA G. In vitro and in vivo testing
of hydralazine genotoxicity. J. Pharmacol. Exp. Ther. 273: 113-120,
1995.
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MARTELLI A., BRAMBILLA CAMPART G., CANONERO R., MATTIOLI F., AND BRAMBILLA
G. Testing of metoclopramide and procainamide for their ability to induce
genotoxic effects in cultured mammalian cells. Toxicol. Appl. Pharmacol.
131: 185-191, 1995.
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MERETO E., ROBBIANO L., GHIA M., ALLAVENA A., MARTELLI A., AND BRAMBILLA
G. Evaluation of DNA-damaging, clastogenic and promoting activities of
metoclopramide and procainamide in rats. Toxicol. Appl. Pharmacol.
131: 192-197, 1995.
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BRAMBILLA G., MARTELLI A., SOTTOFATTORI E. Nitrosation of propranol under
simulated gastric conditions. Carcinogenesis 16: 1239-1242, 1995.
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MARTELLI A., MATTIOLI F., FAZIO S., ANDRAE U., AND BRAMBILLA G. DNA repair
synthesis and DNA fragmentation in primary cultures of human and rat hepatocytes
exposed to cyproterone acetate. Carcinogenesis 16: 1265-1269, 1995.
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MARTELLI A., BRAMBILLA CAMPART G., GHIA M., ALLAVENA A., MERETO E., AND BRAMBILLA
G. Induction of micronuclei and inhibition of enzyme-altered foci in the
liver of female rats trated with cyproterone acetate, chlormadinone acetate
or megestrol acetate. Carcinogenesis 17: 551-554, 1996.
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MARTELLI A., MATTIOLI F., GHIA M., MERETO E., AND BRAMBILLA G. Comparative
study of DNA repair induced by cyproterone acetate, chlormadinone and megestrol
acetate in primary cultures of human and rat hepatocytes. Carcinogenesis
17: 1153-1156, 1996.
RESEARCH GROUP MEMBERS:
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Cantelli Forti Giorgio,P.O.
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Guerra Maria Clelia, P.A.
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Paolini Moreno, P.A.
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Hrelia Patrizia, R.U.
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Maffei Francesca, D.DR.
-
Pozzetti Laura, D.DR.
-
Fimognari Carmela, D.DR.
-
Vigagni Fernanda, B.
AFFILIATION:
Dipartimento di Farmacologia
Universitą degli Studi di Bologna
ADDRESS: Via Irnerio 48
CITY: Bologna
POSTAL CODE: 40126
TELEPHONE: 051-24.31.01, 24.31.51
FAX: 051-24.88.62
E-MAIL: cantelli@biocfarm.unibo.it
PUBLICATIONS:
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CANTELLI FORTI, G., PAOLINI, M. AND HRELIA, P. Multiple end point procedure
to evaluate risk from pesticides. Environm. Health Perspect. 101:
15-20, 1993.
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HRELIA, P., VIGAGNI, F., MOROTTI, M., CANTELLI FORTI, G., BARBIERI, C.L.,
SPINELLI, D. AND LAMARTINA, L. Mechanism of genotoxicity and electron density
distribution by NMR of 5-nitro-3-thiophenecarboxamides, a novel group of
direct-acting mutagens in Salmonella typhimurium. Chem.-Biol. Interact.
86:229-254, 1993.
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HRELIA, P., VIGAGNI, F., MAFFEI, F., PAOLINI, M., MESIRCA, R., POZZETTI,
L. AND CANTELLI FORTI, G. A battery of biomarkers for detecting carcinogenic
risk from fungicides. Clinical Chem. 40: 1460-1462, 1994.
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RODA, A., PELLICCIARI, R., CERR, C., POLIMENI, C., SADEGHPOUR, B.,
MARINOZZI, M, CANTELLI FORTI, G. AND SAPIGNI, E. New 6-substituted bile acids:
physico-chemical and biological properties of 6-methyl ursodeoxycholic acid
and 6-methyl-7-epicholic acid. J. Lipid Research. 35: 2268-2279, 1994.
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RODA, A., PELLICCIARI, R., POLIMENI, C., CERRE', C., CANTELLI FORTI,
G., SADEGHPOUR, B., SAPIGNI, E., GIOACCHINI, A.M. AND NATALINI, B. Metabolism,
pharmacokinetics, and activity of a new 6-fluoro analogue of ursodeoxycholic
acid in rats and hamsters. Gastroenterology. 108: 1204-1214, 1995.
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VIGAGNI, F., HRELIA, P., CANTELLI FORTI, G., SORSA, M. AND NORPPA, H. An
improved assay to detect 6-thioguanine resistant mutants in human lymphocytes.
J. Exp. Clin. Cancer Res. 14: 171-173, 1995.
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PAOLINI, M., MESIRCA, R., POZZETTI, L., SAPONE, A. AND CANTELLI FORTI, G.
Molecular non-genetic biomarkers related to Fenarimol cocarcinogenesis: organ-and
sex-specific CYP induction in rat. Cancer Lett. 101: 171-178, 1996.
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HRELIA, P., FIMOGNARI, C., MAFFEI, F., VIGAGNI, F., MESIRCA, R., POZZETTI,
L., PAOLINI, M. AND CANTELLI FORTI G. The genetic and non-genetic toxicity
of the fungicide Vinclozolin. Mutagenesis 11: 445-453, 1996.
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HRELIA, P., MAFFEI, F., FIMOGNARI, C., VIGAGNI, F. AND CANTELLI FORTI, G.
Cytogenetic effects of Metalaxyl on human and animal chromosomes. Mutation
Res. 369: 81-86, 1996.
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PAOLINI, M., MESIRCA, R., POZZETTI, L., MAFFEI, F., VIGAGNI, F., HRELIA,
P. AND CANTELLI FORTI, G. Genetic and non-genetic biomarkers related to
carcinogenesis in evaluating toxicological risk from Fenarimol. Mutation
Res. 368: 27-39, 1996.
RESEARCH GROUP MEMBERS:
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Cantoni Orazio, P.A.
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Sestili Piero, R.U.
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Brambilla Liliana, D.DR.
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Palomba Letizia, B.PDR.
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Guidarelli Andrea, T.L.
AFFILIATION:
Istituto di Farmacologia e Farmacognosia
Facoltą di Farmacia
Universitą degli Studi di Urbino
ADDRESS: Via Santa Chiara, 27
CITY: Urbino
POSTAL CODE: 61029
TELEPHONE: 0722-2671, 327670
FAX: 0722-327670
E-MAIL: cantoni@fis.uniurb.it
PUBLICATIONS:
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SESTILI, P., CATTABENI F., AND CANTONI, O. Simultaneous determination of
DNA double strand breaks and DNA fragment size in cultured mammalian cells
exposed to hydrogen peroxide/histidine or etoposide with CHEF electrophoresis.
Carcinogenesis. 16: 703-706, 1995.
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PALOMBA, L., GUIDARELLI, A., CATTABENI, F., AND CANTONI, O. The effect of
hydrogen peroxide/L-Histidine-induced DNA single- vs. DNA double strand breaks
on poly(ADP-rybose)polymerase. Eur. J. Pharmacol. 291: 167-173, 1995.
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SESTILI, P., CATTABENI F., AND CANTONI, O. The L-Histidine-mediated enhancement
of hydrogen peroxide-induced DNA double strand breakage and cytotoxicity
does not involve metabolic processes. Biochem. Pharmacol. 50: 1823-1830,
1995.
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GUIDARELLI, A., SESTILI, P., CATTABENI, F., AND CANTONI, O. Evidence for
a dissimilar mechanism of enhancement of inorganic and organic hydroperoxide
cytotoxicity by L-Histidine. J. Pharmacol. Exp. Therap. 275: 1575-1582,
1995.
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SESTILI, P., GUIDARELLI, A., CATTABENI, F., MURRAY, D., AND CANTONI, O. AG8
cells, which are highly resistant to hydrogen peroxide, display collateral
sensitivity to the combination of hydrogen peroxide and L-histidine.
Carcinogenesis. 17: 885-888, 1996.
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CANTONI, O., SESTILI, P., PALOMBA, L., GUIDARELLI, A., MURRAY, D., AND CATTABENI,
F. Isolation and characterization of a Chinese Hamster Ovary cell line with
high-degree resistance to hydrogen peroxide. Biochem. Pharmacol. 51:
1021-1029, 1996.
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SESTILI, P., BRANDI, G., BRAMBILLA, L., CATTABENI, F., AND CANTONI, O. Hydrogen
peroxide mediates the killing of U937 tumor cells elicited by pharmacologically
attainable concentrations of ascorbic acid: cell death prevention by
extracellular catalase or catalase from co-cultured erythrocytes or fibroblasts.
J. Pharmacol. Exp. Therap. 277: 1719-1725, 1996.
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GUIDARELLI, A., BRAMBILLA, L., CATTABENI, F., ROTA, C., TOMMASI, A., AND
CANTONI, O. The respiratory-chain poison antimycin A promotes the formation
of DNA single strand breaks and reduces toxicity in U937 cells exposed to
tert-butylhydroperoxide. Biochem. J. 317: 371-375, 1996.
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CANTONI, O., BOSCOBOINIK, D., FIORANI, M., STAUBLE, B. AND AZZI, A. The
phosphorylation state of MAP-kinases modulates the cytotoxic response of
smooth muscle cells to hydrogen peroxide. FEBS Lett. 389: 285-288,
1996.
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PALOMBA, L., SESTILI, P., CATTABENI, F., AZZI, A., AND CANTONI, O. Prevention
of necrosis and activation of apoptosis in oxidatively injured human myeloid
leukemia U937 cells. FEBS Lett. 390: 91-94, 1996.
RESEARCH GROUP MEMBERS :
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Chiesara Enzo, P.O.
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Marabini Laura, R.U.
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Radice Sonia, B.
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Cipelletti Barbara, B.
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Gervasoni Marco, C.L.
AFFILIATION:
Dipartimento di Farmacologia
Facoltą di Medicina e Chirurgia
Universitą di Milano
ADDRESS: Via Vanvitelli, 32
CITY: Milano
POSTAL CODE: 20129
TELEPHONE: 02-70146389
FAX: 02-28106260
E-MAIL: tossicol@imiucca.csi.unimi.it
PUBLICATIONS:
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DEL PUPPO, M., GALLI KIENLE, M., RATIGLIA, R., GALIMBERTI, D., ACERBI, G.,
BOERCI, L., MARABINI, L. AND CHIESARA, E. Intraocular and plasma kinetics
of tenoxicam in rabbits. Graefeís Arch Clin Exp Ophthalmol.
231: 115-117, 1993.
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STANKOV, B., GERVASONI, M., SCAGLIONE, F., PEREGO, R., COVA, D., MARABINI,
L. AND FRASCHINI, F. Primary pharmaco-toxicological evaluation of 2-iodomelatonin
agonist. Life Sci. 53: 1357-1365, 1993.
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CHIESARA, E., BIANCHI, L., ZANNOLI, A., PIZZALA, R.AND STIVALA, L.A. Genotoxicity
assay of five pesticides and their mixture in Saccharomyces cerevisiae
D7. Mutation Res. 321: 203-211, 1994.
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PIATTI, E., MARABINI, L. AND CHIESARA, E. Increase of micronucleus frequency
in cultured rat hepatocytes treated in vitro with benomyl and pirimiphos-methyl
separately and in mixture. Mutation Res. 324: 59-64, 1994.
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MARABINI, L., RADICE, S., CIPELLETTI, B. AND CHIESARA, E. Different amounts
of cytochrome P-450 dependent monooxygenases in tulip bulbs, pea seedlings
and maize endosperm cells. Plant Science. 99: 135-140, 1994.
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CORSINI, E., MARINOVICH, M., MARABINI, L., GALLI, C.L. AND CHIESARA, E.
Interleukin-1 production after treatment with non-ionic surfactants in a
murine keratinocytes cell line. Toxic. in Vitro. 8: 361-369, 1994.
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URANI, C., CHIESARA, E., GALVANI, P., MARABINI, L., SANTAGOSTINO, A. AND
CAMATINI, M. Benomyl affect the microtubule cytoskeleton and the glutathione
level of mammalian primary cultured hepatocytes. Toxicol. Lett. 76:
135-144, 1995
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CHIESARA, E., MARABINI, L. AND BORGHINI, R. Dietary fibre and drug
interactions. Eur. J. Clin. Nutr. 49: 123-128, 1995.
RESEARCH GROUP MEMBERS:
-
Cimino Mauro, R.U.
-
Balduini Walter, R.U.
AFFILIATION:
Istituto di Farmacologia e Farmacognosia
Facoltą di Farmacia e Scienze Biologiche
Universitą degli Studi di Urbino
ADDRESS: Via S. Chiara, 27
CITY: Urbino
POSTAL CODE: 61029
TELEPHONE: 0722-2671, 2894
FAX: 0722-327670
E-MAIL: farmacol@fis.uniurb.it
PUBLICATIONS:
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BALDUINI, W., CIMINO, M., RENO', F., MARINI, P., PRINCIVALLE, A. AND
CATTABENI, F. Effects of postnatal or adult chronic acetylcholinestarase
inhibition on muscarinic receptors, phosphoinositide turnover and m1 mRNA
expression. Eur. J. Pharmacol.- Environmental Toxicology and Pharmacology
Section 248: 281-288, 1993.
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STANKOV, B., CIMINO, M., MARINI, P., LUCINI, V., FRASCHINI, F., CLEMENTI,
F. Identification and functional significance of nicotinic cholinergic receptors
in the rat pineal gland. Neurosci. Letters 156 : 131-134, 1993.
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CIMINO, M., MARINI, P., COLOMBO, S., CATTABENI, F., MELDOLESI, J. [3H]-CGP
39653 mapping of glutamatergic N-methyl-D-aspartate receptors in the brain
of aged rats. Neurosci. Res. Commun. 12 : 31-40, 1993.
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BALDUINI, W., RENO', F., COSTA, L.G., AND CATTABENI, F. Developmental
neurotoxicity of ethanol: further evidence for an involvement of muscarinic
receptor-stimulated phosphoinositide hydrolysis. Eur. J. Pharmacol.
- Mol. Pharmacol. Section. 266: 283-289, 1994.
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CIMINO, M., MARINI, P., COLOMBO, S., CATTABENI, F., BIANCHI, M., MAGNANI,
M. Localization and age-dependent expression of hexokinase mRNA in the rat
brain. Mol. Brain Res. 25 : 1-6, 1994.
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BALDUINI, W., RENO', F., CATTABENI, F., AND CANTONI O. Oxidative transition
of intracellular protein thiols modulates muscarinic receptor-stimulated
phosphoinositide breakdown in rat cortical slices. Neurosci. Res.
Commun. 15: 125-134, 1994.
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BALDUINI, W., RENO', F., COSTA, L.G. Interaction of ethanol and anoxia
with muscarinic receptor-stimulated phosphoinositide metabolism during brain
development. Life Sci. 57: 1667-1673, 1995
-
BALDUINI, W., LOMBARDELLI, G., PERUZZI G., AND CATTABENI F. Effect of prenatal
treatment with methylazoxymethanol on carbachol-, norepinephrine- and
glutamate-stimulated phosphoinositide metabolism in the neonatal, young and
adult offspring. Neurochem. Res. 20: 1211-1216, 1995.
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CIMINO, M., MARINI, M., COLOMBO, S., ANDENA, M., CATTABENI, M., FORNASARI,
D., CLEMENTI, F. Expression of neuronal acetylcholine nicotinic receptor
a4 and b2 subunits during postnatal development of the rat brain. J. Neural
Transm. 100 : 77-92, 1995.
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CIMINO, M., CATTABENI, F., DI LUCA, M., PERUZZI , G., ANDENA, M., TIRASSA,
P., ANGELUCCI, F., COZZARI, C., ALOE, L. Levels of NGF, p75NGFR and ChAT
immunoreactivity in brain of adult and aged microencephalic rats.
Neurobiol. Aging 17 : 137-142, 1996.
RESEARCH GROUP MEMBERS:
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Cima Lorenzo, P.O.
-
Carrara Maria, T.L.
AFFILIATION:
Dipartimento di Farmacologia "E. Meneghetti"
Facoltą di Medicina e Chirurgia
Universitą di Padova
ADDRESS: Largo E. Meneghetti,2
CITY: Padova
POSTAL CODE: 35131
TELEPHONE: 049/827-5078,5103,5099,5076
FAX: 049/827-5093
E-MAIL: cima@ipdunidx.unipd.it
PUBLICATIONS:
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CARRARA M., CIMA L., CERINI R., DALLE CARBONARE M. An in vitro method for
assessing potential toxicity of cosmetic products. J. Toxicol. - Cutaneous
& Ocular Toxicology, 12 : 3-13, 1993.
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VALENTI P., DA RE P., RAMPA A., MONTANARI P., CARRARA M., CIMA L. BENZO--pyrone
analogues of geiparvarin: synthesis and biological evaluation against B16
melanoma cells. Anti-Cancer Drug Design, 8: 349-360, 1993.
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HAIDAR N.H., CARRARA M., ANDRIAMAMPANDRY C., KANFER J.N., FREYSZ L., DREYFUS
H., MASSARELLI R. Incorporation of [3H]ethanolamine into acetylcholine
by a human cholinergic neuroblastoma clone. Neurochem. Res., 19: 9-13,
1994.
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HAIDAR N.H., ANDRIAMAMPANDRY C., CARRARA M., KANFER J.N., FREYSZ L., DREYFUS
H., MASSARELLI R. The conversion of ethanolamine and its metabolites to choline
in human neuroblastoma clones: effect of differentiation induced by retinoic
acid. Neurochem. Res., 19: 457-462, 1994.
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BOVA S., TREVISI L., DEBETTO P., CIMA L., FURNARI M., LUCIANI S., PADRINI
R.,CARGNELLI G. Vasorelexant properties of norbormide, a selective
vasoconstrictor agent for the rat microvasculature. British J.
Pharmacol.. 117: 1041-1046, 1996.
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VALENTI P., FABBRI G., RAMPA A., BISI A., GOBBI S., DA RE P., CARRARA M.
SGEVANO A., CIMA L. Synthesis and antitumor activity of some analogues of
flavone acetic acid. Anti-Cancer Drug Design., 11: 243-252, 1996.
RESEARCH GROUP MEMBERS:
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Dolara Piero, P.O.
-
Caderni Giovanna, T.L.
-
Lodovici Maura, R.U.
-
Salvadori Maddalena, T.
-
Luceri Cristina, D.DR.
-
Casalini Chiara, D.DR.
-
De Filippo Carlotta, B.
-
Briani Carla, B.
-
Lancioni Lorella, B.
AFFILIATION:
Sezione di tossicologia sperimentale e ambientale
Dipartimento di Farmacologia
Facoltą di Farmacia
Universitą di Firenze
ADDRESS: Viale Morgagni 65,
CITY: Firenze
POSTAL CODE: 50134
TELEPHONE: (39.55) 4237411 o 413;
FAX: (39.55)4361613
E-MAIL: dolara@stat.ds.unifi.it
farm4@stat.ds.unifi.it
PUBLICATIONS:
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CADERNI G., DOLARA P., SPAGNESI M.T., LUCERI C., BIANCHINI F., MASTRANDREA
V. AND MOROZZI G. Rats fed high starch diets have lower colonic proliferation
and fecal bile acids than high sucrose-fed controls. J. Nutr. 123 :
704-712, 1993.
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LA VECCHIA C., FRANCESCA S., DOLARA P., BIDOLI E., BARBONE F. Refined sugar
intake and the risk of colorectal cancer in humans.Int. J. Cancer
55 : 1-4, 1993.
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CADERNI G., BIANCHINI F., RUSSO A., SPAGNESI M.T., GABBRIELLI M., GIANNESCHI
U., LAGI A., MONTIGIANI A., CIPRIANI F., PALLI D., RIZZI M., TONELLI F.,
VALANZANO R. AND DOLARA P. Mitotic activity in colorectal mucosa of healthy
subjects in two italian areas with different dietary habits. Nutr.
Cancer 19 : 263-269, 1993.
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CADERNI G., LUCERI C., SPAGNESI M.T., GIANNINI A., BIGGERI A. AND DOLARA
P. Dietary carbohydrates affect azoxymethane induced intestinal carcinogenesis
in rats. J. Nutr. 124 : 517-523, 1994.
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SPAGNESI M.T., DOLARA P., CADERNI G., BIANCHINI F., TONELLI F., VALANZANO
R. AND ANASTASI A. Rectal proliferation and polyp occurence in patients with
familial adenomatous polyposis after sulindac treatment.
Gastroenterology 106 : 362-366 1994.
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LODOVICI M., DOLARA P., TAITI S., DEL CARMINE P., BERNARDI L., AGATI L. AND
CIAPPELLANO S. Polynuclear aromatic hydrocarbons in the leaves of the Evergreen
Laurus Nobilis. Science Total Environm. 153: 61-68, 1994.
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CADERNI G., GIANNINI A., LANCIONI, L., LUCERI C., BIGGERI A. AND DOLARA
P.Characterization of aberrant crypt foci in carcinogen treated rats: association
with intestinal carcinogenesis. Brit. J. Cancer 71 : 763-769,
1995.
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TONELLI F., DOLARA P., CADERNI G., BATIGNANI G., MONACI I., SPAGNESI M.T.,
LUCERI C., AND AMOROSI A. Effects of short chain fatty acids on mucosal
proliferation and inflamation in patients with ulcerative colitis and familial
polyposis. Diseases of Colon and Rectum, 38: 974-978, 1995.
RESEARCH GROUP MEMBERS:
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Galli Corrado Lodovico, P.A.
-
Marinovich Marina, R.U.
-
Restani Patrizia, R.U.
-
Viviani Barbara, B.PDR.
-
Corsini Emanuela, B.DDR.
-
VelonąTeresa, D.DR.
AFFILIATION:
Sezione di Tossicologia
Istituto di Scienze Farmacologiche
Facoltą di Farmacia
Universitą degli Studi di Milano
ADDRESS: Via G. Balzaretti, 9
CITY: Milano
POSTAL CODE: 20132
TELEPHONE: 02 - 20488.315/225/350/356
FAX: 02 - 20404961
E-MAIL: gallil@isfunix.farma.unimi.it
PUBLICATIONS:
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FIOCCHI, P. RESTANI, E. RIVA, R. QUALIZZA, P. BRUNI, A. R. RESTELLI, C. L.
GALLI. Meat Allergy: I-Specific IgE to BSA and OSA in atopic, beef sensitive
children. J. Amer. College of Nutrition 14: 239-244, 1995.
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FIOCCHI, P. RESTANI, E. RIVA, A.R. RESTALLI, G. BIASUCCI, C. L. GALLI AND
GIOVANNINI. Meat Allergy. II- Effects of food processing and enzymatic digestion
on the allergenicity of bovine and ovine meats. J. Amer. College of
Nutrition, 14: 245-250, 1995
-
RESTANI, T. VELONą, A. PLEBANI, A.G. UGAZIO, C. POIESI, A. MURARO,
C. L. GALLI. Evaluation by SDS-PAGE and immunoblotting of residual antigenicity
in hydrolysed protein formulas. Clin. Exp. Allergy, 25: 651-658 selected
by Infant Nutrition Digest 1995.
-
MARINOVICH, M. GUIZZETTI, T. ZANELLI, E. CORSINI, C.L. GALLI. Cloning of
a new FRTL-5 derived cell line stably expressing active human thyroid peroxidase.
Bioch. Bioph. Res. Commun., 212: 602-608, 1995
-
CORSINI, A. BRUCCOLERI, M. MARINOVICH, C.L. GALLI. Endogenus interleukin-1alpha
is required for skin irritation. Toxicol. App. Pharmacol. 138: 268-274,
1996.
-
RESTANI, T. VELONą, A. CARPEN, M. DURANTI, C.L. GALLI. Gamma Casein
as a marker of ripening and/or quality of grana padano cheese. J. Agricultural
Food Chem. 44 : 2026-2029, 1996.
-
MARINOVICH, F. GHILARDI, C. L. GALLI. Effect of pesticide mixture on neural
cells in vitro: comparison with single pesticides. Toxicology, 108:
201-206, 1996.
-
VIVIANI, M. MARINOVICH, C. L. GALLI. Is actin polymerization relevant to
neurosecretion? A study on neuroblastoma cells. BBRC, 223:712-717,
1996.
-
RESTANI, A. PLEBANI, T. VELONą, G. CAVAGNI, A. G. UGAZIO, C. POIESI,
A. MURARO, C. L. GALLI. Use of immunoblotting and monoclonal antibodies to
evaluate the residual antigenic activity of milk protein hydrolised formulas.
Clin. Exp. Allergy, in press, 1996.
-
MARINOVICH, B. VIVIANI, E. CORSINI, F. GHILARDI AND C. L. GALLI. NF-kB Activation
by Triphenyltin Triggers Apoptosis in HL-60 Cells. Exp. Cell Res.
226 : 98-104, 1996.
RESEARCH GROUP MEMBERS:
-
Manzo Luigi, P.O.
-
Candura Stefano R.U.
-
Coccini Teresa C.L.
-
Locatelli Carlo C.L..
-
Randine Giovanna B.
-
Varango Concetta B.
-
Mattachini Margherita C.L.
-
Castoldi Anna D.DR
-
Rossi Anna Maria D.DR.
-
Butera Raffaella B.
-
Gandini Cristiano C.L.
-
Pergami Paola D.DR
AFFILIATION:
Sezione di Farmacologia e Tossicologia
Dipartimento di Medicina Interna e Terapia Medica
Universitą degli Studi di Pavia
ADDRESS: Piazza Botta 10
CITY: Pavia
POSTAL CODE: 27100
TELEPHONE: 0382 - 506.357, 506.365, 26261
FAX: 0382 - 22741
E-MAIL: manzo@ipv36.unipv.it
PUBLICATIONS:
-
CASTOLDI, A.F., MANZO, L., AND COSTA, L.G. Cyclic GMP formation induced by
muscarinic receptors is mediated by nitric oxide synthesis in rat cortical
primary cultures. Brain Res.. 610: 57-61, 1993.
-
ROSSI, A.D., LARSSON, O., MANZO, L., ORRENIUS, S., VAHTER, M., BERGGREN,
P.O., AND NICOTERA, P. Modifications of Ca2+ signalling by inorganic mercury
in PC12 cells. FASEB Journal. 7: 1507-1514, 1993.
-
CANDURA, S.M., MANZO L., MARRACCINI, P., COCCINI, T., AND TONINI, M.
Investigation into vanadate-induced potentiation of smooth muscle contractility
in the rabbit isolated ileum. Life Science. 54: 237-244, 1994.
-
GREGOTTI, C., KIRBY, Z., MANZO, L., COSTA, L.G., AND FAUSTMAN, E.M. Effects
of styrene oxide on differentiation and viability of rodent embryo cultures.
Toxicol. Appl. Pharmacol. 128: 25-35, 1994.
-
MANZO, L., LOCATELLI, C., CANDURA, S.M., AND COSTA, L.G. Nutrition and alcohol
neurotoxicity. Neurotoxicol. 15: 555-566, 1994.
-
BONFOCO, E., CECCATELLI, S., MANZO, L., AND NICOTERA, P. Colchicine induces
apoptosis in cerebellar granule cells. Experimental Cellular Research. 218:
189-200, 1995.
-
COSTA, L.G., AND MANZO, L. Biochemical markers of neurotoxicity. Research
strategies and epidemiological applications. Toxicol. Lett. 77: 137-144,
1995.
-
COCCINI, T., DI NUCCI, A., TONINI, M., MAESTRI, L., COSTA, L.G., LIUZZI,
AND MANZO, L. Effects of ethanol administration on cerebral non-protein
sulfhydryl content in rats exposed to styrene vapour. Toxicology.
106: 115-122, 1996.
-
MANZO, L., ARTIGAS, F., MARTINEZ, M., MUTTI, A., BERGAMASCHI, E., NICOTERA,
P., TONINI, M., CANDURA, S.M., RAY, D.E., AND COSTA, L.G. Biochemical markers
of neurotoxicity: basic issues and a review of mechanistic studies. Human
and Exp. Toxicol. 15: 20-35, 1996.
-
COCCINI, T., MAESTRI, L., ROBUSTELLI, F.S., LI BIN, COSTA, L.G., AND MANZO,
L. Urinary mercapturic acid diastereoisomers in rats subchronically exposed
to styrene and ethanol. Arch. Toxicol. 70: 736-741, 1996.
RESEARCH GROUP MEMBERS:
-
Palmery Maura R.U.
-
Leone Maria Grazia. B. PDR.
-
Giacomelli Sabrina, B. PDR.
-
Luzi Anna, D.DR.
-
Abdel-Haq Hanin, D.DR.
AFFILIATION:
Istituto di Farmacolgia e Farmacognosia
Facoltą di Farmacia
Universitą di Roma 'La Sapienzą
ADDRESS : Piazzale A. Moro, 5
CITY: Roma
POSTAL CODE: 00185
TELEPHONE: 06-49912573
FAX: 06-49912480
E-MAIL: palmery@axrma.uniroma1.it
PUBLICATIONS:
-
LEONE, M.G., SILVESTRINI, B., PALMERY, M. AND CHENG, C.Y. Identification
of multiple biological factors in rabbit serum that modulate dopamine-mediated
aortic constriction. Biochem. Int. 26: 1079-1090, 1992.
-
LEONE, M.G., SASO, L., DEL VECCHIO, A., MO, M.Y., SILVESTRINI B. AND CHENG,
C.Y. Micropurification of the two human cerebrospinal fluid proteins by high
performance electrophoresis chromatography. J. Neurochem. 61: 533-540,
1993.
-
SASO, L., SILVESTRINI, B., AND CHENG, C.Y. The use of high performance
electrophoresis cromatograhy for the micropurification of cerebrospinal fluid
proteins in the rat. Anal. Biochem. 212: 315-324, 1993.
-
SILVESTRINI, B., PALMERY, M., TOLU, L., BASTA, F., LEONE, M.G. AND CHENG,
C.Y ; Facilins , a novel class of biological factors that facilitate the
aortic response to dopamine and other biogenic amines. J. Neural Transm.
95: 77-93, 1994.
-
LI, A.H.Y., SILVESTRINI, B., LEONE, M.G., GIACOMELLI, S. AND CHENG, C.Y.
Cerebrin-50, a human cerebrospinal fluid proteins whose mRNA is present in
multiple tissues but predominantly expressed in the lymphoblastoid cells
and the brain. Biochem. Mol. Int. 35: 135-144, 1995.
-
PIMPINELLA G., PALMERY M. ; Interaction of beta-carbolines with central
dopaminergic transmission in mice: structure-activity relationships.
Neurosci. Lett. 189: 121-124, 1995.
-
GIACOMELLI, S., BRAGHIROLI, L., PONZIANELLI, A., KOPPENAAL, D.W. AND DE FEO
G. A sensitive assay for the study of
dopaminergic activity with pituitary cell culture. J. Pharm. Pharmacol.,
in press, 1996.
RESEARCH GROUP MEMBERS:
-
Preziosi Paolo, P.O.
-
Martire Maria, P.A.
-
Tempesta Enrico, P.A.
-
Minotti Giorgio, R.U.
-
Ragazzoni Enzo, R.U.
-
Mores Nadia, R.U.
AFFILIATION:
Istituto di Farmacologia
Facoltą di Medicina e Chirurgia
Universitą Cattolica del Sacro Cuore
ADDRESS: Largo Francesco Vito, 1
CITY: Roma
POSTAL CODE: 00168
TELEPHONE: 06-3015 4253
FAX: 06-3050159, 3051343
PUBLICATIONS:
-
MARTIRE, M., PISTRITTO, G., MORES, N., AGNATI, L.F. AND FUXE, K. Regional
specific inhibition of potassium-evoked 3H-noradrenaline release
by NPY13-36 from rat brain synaptosomes. Involvement of NPY receptors
of the Y2 type. Eur. J. Pharmacol. 230: 231-234, 1993.
-
CIABATTONI, G., MONTUSCHI, P., CURRO', D., TOGNA, G., PREZIOSI, P.
Effects of vasoactive intestinal polypeptide on antigen-induced
bronchocostriction and thromboxane release in guinea-pig lung. Brit. J.
Pharmacol. 109: 243-250, 1993.
-
CURRO', D., PREZIOSI, P., RAGAZZONI, E., CIABATTONI, G. Peptide hystidine
isoleucine-like immunoreactivity release from the rat gastric fundus. Brit.
J. Pharmacol. 113: 541-549, 1994.
-
GRIMALDI, M., POZZOLI, G., NAVARRA, P., PREZIOSI, P., SCHETTINI, G. Vasoactive
intestinal peptide and forskolin stimulate interleukin 6 production by rat
cortical astrocytes in culture via a cyclic AMP-dependent,
prostaglandin-independent mechanism. J. Neurochem. 63: 344-350, 1994.
-
MARTIRE, M., PISTRITTO, G., MORES, N., AGNATI, L.F. AND FUXE, K. Presynaptic
2-receptors and neuropeptide Y Y2-receptors inhibit
3H-noradrenaline release from rat hypothalamic synaptosomes via
different mechanisms. Neurosci. Lett. 188: 9-12, 1995.
-
MINOTTI, G., CAVALIERE, A.F., MORDENTE, A., ROSSI, M., SCHIAVELLO, R.,
ZAMPARELLI, R., POSSATI, G.F. Secondary alcohol metabolites mediate iron
delocalization in cytosolic fractions of myocardial biopsies exposed to
anticancer anthracyclines. J. Clin. Invest. 95: 1595-1605, 1995.
-
MINOTTI, G., MANCUSO, C., FRUSTACI, A., MORDENTE, A., SANTINI, A., CALAFIORE,
A.M., LIBERI, G., GENTILONI, N. Paradoxical inhibition of cardiac lipid
peroxidation in cancer patients treated with doxorubicin. J. Clin.
Invest. 98: 650-661, 1996.
-
MONTUSCHI, P., TRINGALI, G., MIRTELLA, A., PARENTE, L., RAGAZZONI, E., PREZIOSI,
P. AND NAVARRA, P. Interleukin-1 release from rat gastric fundus. Amer.
J. Physiol. 271 (Gastrointest. Liver Physiol. 84): G275-G281, 1996.
-
CURRO', D., VOLPE, A.R. AND PREZIOSI, P. Nitric oxide synthase activity
and non-adrenergic non-cholinergic relaxation in the rat gastric fundus.
Brit. J. Pharmacol. 117: 717-723, 1996.
-
NAVARRA, P., GROHMANN, U., NOCENTINI, G., TRINGALI, G., PUCCETTI, P., RICCARDI,
C. AND PREZIOSI, P. Hydroxyurea induces the gene expression and synthesis
of proinflammatory cytokines in vivo.. J. Pharmacol Exp. Ther. In
press, 1996.
RESEARCH GROUP MEMBERS:
-
Santagostino Angela, P.A.*
-
Colleoni Mariapia, R.U.#
-
Galvani Pietro, D.D.R.*
-
Fumagalli Pietro, T.L.#
-
Costa Barbara, B.#
-
Conte Massimo, B.*
-
Zanolli Luisa, B.*
AFFILIATION:
* Dipartimento di Scienze dell'ambiente e del Territorio ed
# Istituto di Farmacologia,
Facoltą di Scienze MM.FF.NN. Universitą degli Studi di Milano
ADDRESSES: *via Emanueli,15
# via Vanvitelli, 32/A
CITY: Milano
POSTAL CODE: * 20126 e # 20129
FAX: *02 64474500 e # 02-70002270
E-MAIL: * angela@alpha.disat.unimi.it
# gori@imiucca.csi.unimi.it
PUBLICATIONS:
-
URANI C., BRAMBILLA E., SANTAGOSTINO A., CAMATINI M.:
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes actin stress fibers
disorganization and calcium elevation in Swiss 3T3 mouse fibroblasts.
Toxicology. 91: 117-126, 1994.
-
URANI C., CHIESARA E., GALVANI P., MARABINI L., SANTAGOSTINO A., CAMATINI
M.: Benomyl affects the microtubule cytosckeleton and glutathione level of
mammalian primary cultured hepatocytes. Toxicol. Lett. 76: 135-144,
1995.
-
COLLEONI M, COSTA B., PAROLARO D., SALA M., GORI E.: Effects of repeated
administrations of CP 55,940 on liver microsomal and liver and brain
mitochondrial activities in the rat. Behav. Pharmacol. 6: 51-52, 1995.
-
GALVANI P.,FUMAGALLI P., SANTAGOSTINO A.:Vulnerability of mitochondrial complex
I in PC12 cells exposed to manganese.Eur. J. Pharmacol., Environ. Toxicol
and Pharmacol. section. 293: 377-383, 1995.
-
GALVANI P., COLLEONI M., ORIGGI M., SANTAGOSTINO A.: Mitochondria toxicity
of iron and the protective role of ferritin on dopaminergic PC12 cell line.
Toxicol. in vitro. 9 :365-368, 1995.
-
COLLEONI M, COSTA B.,GORI E, SANTAGOSTINO A.:Biochemical characterization
of the effects of the benzodiazepine, midazolam on mitochondrial electron
transfer. Pharmacol. Toxicol. 78: 69-76, 1996.
-
COSTA B., PAROLARO D. AND COLLEONI M.: Chronic cannabinoid, CP-55,940,
administration alters biotransformation in the rat Eur. J. Pharmacol.
313, 17-24,1996.
RESEARCH GROUP MEMBERS:
-
Valeri Pacifico, P.A.
-
Romanelli Luca, B.PDR.
-
Amico Maria Carmela, B.PDR.
-
Mattioli Francesca, D.DR.
AFFILIATION:
Istituto di Farmacologia e Farmacognosia
Facoltą di Farmacia
Universitą di Roma 'La Sapienzą
ADDRESS: P.le Aldo Moro, 5
CITY: Roma
POSTAL CODE: 00185
TELEPHONE: 06-49912670
FAX: 06-49912480
E-MAIL: valeri@axrma.uniroma1.it
PUBLICATIONS:
-
MORRONE, L.A., ROMANELLI, L. AND VALERI, P. Withdrawal contractures of guinea-pig
isolated ileum after acute activation of k opioid receptors. Brit. J.
Pharmacol., 109: 48-52, 1993.
-
VALERI, P., MORRONE, L.A., ROMANELLI, L. AND AMICO, M.C. Effect of non-steroidal
anti-inflammatory drugs on withdrawal responses in guinea-pig ileum after
a brief exposure to morphine. J. Pharmacol. Exp. Ther., 264: 1028-1032,
1993.
- NENCINI, P. AND VALERI, P. The role of opioid mechanisms in the anoretic
effect of stimulants: U-50,488H enhances amphetamine inhibition of free feeding
in rats. Pharmacol. Bioch. Behav., 48: 63-68, 1994.
-
VALERI, P., MORRONE, L.A., ROMANELLI, L. AND AMICO, M.C. Acute withdrawal
after bremazocine and the interaction between Mu and Kappa opioid receptors
in isolated gut tissues. Brit. J. Pharmacol., 114: 1206-1210, 1995.
-
VALERI, P., ROMANELLI, L., MORRONE, L.A., AMICO, M.C. AND MATTIOLI, F. Mu
and Kappa opioid system interactions in the expression of acute opioid dependence
in isolated guinea-pig ileum. Neuropharmacology, 35: 377-84, 1996.
-
ROMANELLI L., MORRONE L.A., AMICO M.C., MATTIOLI F., STATTI, G. AND VALERI,
P. Ineractions of Centaurea deusta and Crepis lacera methanolic
extracts with stimulatory peptides in isolated guinea-pig ileum. Phytother
Res. In press, 1996.
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