SIF - Società
Italiana di Farmacologia
"SIF - La Ricerca Farmacologica in Italia"
CLINICAL PHARMACOLOGY
AND PHARMACOKINETICS
RESEARCH GROUP MEMBERS:
-
Biagi Gian Luigi, P.O.
-
Barbaro Anna Maria, P.A.
-
Sapone Andrea, D.DR.
AFFILIATION:
Dipartimento di Farmacologia
Università di Bologna
ADDRESS: Via Irnerio, 48
CITY: Bologna
POSTAL CODE: 40126
TELEPHONE: 051-24-9561, 3101, 3151
FAX: 051-248862
PUBLICATIONS:
-
PAOLINI M., MESIRCA R., POZZETTI L., SAPONE A., SAPIGNI E., BIAGI G.L., TRIEFF
N.M., CANTELLI FORTI G. Correlation between cytochrome P450 2B1 induction
by barbiturates and toxicity in the chick embryo in ovo, Toxicol. Environ.
Chem. 44: 43-53, 1994
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PAOLINI M., BIAGI G.L. BAUER C., CANTELLI FORTI G. Cocktail Strategy :
complications and limitations. J. Clin. Pharmacol. 33 : 1011-1012,
1993.
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PAOLINI M., MESIRCA R., POZZETTI L., SAPONE A., BIAGI G.L., TRIEFF N.M.,
CANTELLI FORTI G. Correlation between murine liver cytochrome P450 2B1 induction
by halogenated hydrocarbons and toxicity, Toxicol. Environ. Chem.
44: 55-64, 1994
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PAOLINI M., BIAGI G.L., BAUER C., CANTELLI FORTI G. On the procedures for
isolation of S9 fractions from induced rodents in in vitro genotoxicity
assays. Teratogen. Carcin. Mut., 14: 101-103, 1994
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BIAGI G.L., BARBARO A.M., SAPONE A., RECANATINI M. Determination of lipophilicity
by means of reversed-phase thin-layer chromatography I. Basic aspects and
relationship between slope and intercept of TLC equations, J.
Chromatogr. A, 662: 341-361, 1994
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BIAGI G.L., BARBARO A.M., SAPONE A., RECANATINI M. Determination of lipophilicity
by means of reversed-phase thin-layer chromatography II. Influence of the
organic modifier on the slope of the thin-layer chromatographic equation,
J. Chromatogr. A, 669: 246-253, 1994
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BIAGI G.L., BARBARO A.M., RECANATINI M. Determination of lipophilicity by
means of reversed-phase thin-layer chromatography III. Study of the TLC equations
for a series of ionizable quinolone derivatives, J. Chromatogr. A,
678: 127-137, 1994
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PAOLINI M., MESIRCA R., GIALLUCA N., BAUER C., BIAGI G.L., CANTELLI FORTI
G. On cancer chemoprevention. Complications and limitations of some proposed
strategies. Cancerogenesis 14: 971-973, 1995.
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BIAGI G.L., BARBARO A.M., SAPONE A., BOREA P.A., VARANI K., RECANATINI M.
Study of lipophilic character of serotonergic ligands, J. Chromatogr.,
723: 135-143,. 1996.
RESEARCH GROUP MEMBERS:
-
Borgese Nica, P.O.
-
Barbera Massimo, B.
-
Bulbarelli Alessandra, B.
-
Pedrazzini Emanuela, D.DR.
-
Perego Carla, B.P.DR.
-
Pietrini Grazia T.L.
AFFILIATION:
Facoltà di Farmacia
Università di Reggio Calabria
Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica
Università di Milano
Centro CNR per lo Studio della Farmacologia Cellulare e Molecolare
ADDRESS: Via Vanvitelli 32
CITY: Milano
POSTAL CODE: 20129
TELEPHONE: 01-70146-254, 262, 266, 256
FAX: 02-7490574
E-MAIL: segreteria@farma5.csfic.mi.cnr.it
Nica@Farma1.csfic.mi.cnr.it
PUBLICATIONS:
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BORGESE N., D'ARRIGO A., DE SILVESTRIS M., AND PIETRINI G. NADH-cytochrome
b5 reductase and cytochrome b5: the problem of post-translational targeting
to the endoplasmic reticulum. FEBS Lett. 325: 70-75, 1993.
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GOTTARDI C. J., PIETRINI G., ROUSH D.L., AND CAPLAN M. J. Sorting of ion
transport proteins in polarized cells. J. Cell Sci. 17: 13-30, 1993.
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D'ARRIGO A., MANERA E., LONGHI R., AND BORGESE N. The specific subcellular
localization of two isoforms of cytochrome b5 suggests novel targeting
pathways. J. Biol. Chem. 268: 2802-2808, 1993.
-
PIETRINI G., SUH Y. J., EDELMANN L., RUDNICK G., AND CAPLAN M. J. The axonal
GABA transporter is sorted to the apical membranes of polarized epithelial
cells. J. Biol. Chem. 269: 4668-4674, 1994.
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SHIRABE K., LANDI M.T., TAKESHITA M., UZIEL G. FEDRIZZI E., AND BORGESE N.
A novel point mutation in a 3' splice site of the NADH-cytochrome b5 reductase
gene results in immunologically undetectable enzyme and impared NADH-dependent
ascorbate regeneration in cultured fibroblasts of a patient with type II
hereditary methemoglobinemia. Amer. J. Human Genetics 57: 302-310,
1995
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DE SILVESTRIS M., D'ARRIGO A., AND BORGESE N. The targeting information of
the outer mitochondrial membrane isoform of cytochrome b5 is contained within
the carboxyl-terminal region. FEBS Lett. 370: 69-74, 1995
-
PEDRAZZINI E., VILLA A., AND BORGESE N. A mutant cytochrome b5 with a lengthened
membrane anchor escapes from the endoplasmic reticulum and reaches the plasma
membrane. Proc. Nat. Acad. Sci. USA 93: 4207-4212, 1996.
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BORGESE N., AGGUJARO D., CARRERA P., PIETRINI G., AND BASSETTI M. A role
for N-myristoylation in protein targeting: NADH-cytochrome b5 reductase requires
myristic acid for association with outer mitochondrial but not endoplasmic
reticulum membranes. J. Cell Biol., in press, 1996.
RESEARCH GROUP MEMBERS:
-
Castelli Mariagrazia, C.L.
-
Ghiglieri Alberto, R. I.
-
Salgarollo Giuliana, R.I.
-
Castello Renato,T.
-
Cucchi Fabrizio, T.
AFFILIATION:
Sezione Drug Disposition
Dipartimento di Farmacocinetica e Metabolismo
Pharmacia & Upjohn, Nerviano (Mi)
ADDRESS: Via per Pogliano
CITY: Nerviano
POSTAL CODE: 20014
TELEPHONE: 02-4838-3169
FAX: 02-4838-3174
E-MAIL: MariaGrazia.Castelli@eu.pnu.com
PUBLICATIONS:
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STROLIN BENEDETTI M, FRAIER D., PIANEZZOLA E., CASTELLI M.G., DOSTERT P.
AND GIANNI L. Stereoselectivity of iododoxorubicin reduction in various animal
species and humans. Xenobiotica. 23: 115-121,1993.
-
BATTAGLIA R. , STROLIN BENEDETTI M., MANTEGANI S., CASTELLI M.G., COCCHIARA
G. AND DOSTERT P. Disposition and urinary metabolic pattern of cabergoline,
a potent dopaminergic agonist, in rat, monkey and man. Xenobiotica.
23: 1377-89,1993.
-
STROLIN BENEDETTI M., MARRARI P., COLOMBO M., CASTELLI M.G., ARAND M., OESCH
F., DOSTERT P. The new anticonvulsivant FCE 26743 is a selective and short-acting
MAO-B inhibitor devoid of inducing properties towords cytochrome P-450-dependent
testosterone hydroxylation. J. Pharmacol. 46: 814-819,1994.
-
DOSTERT P., CASTELLI M.G., CICIONI P. AND STROLIN BENEDETTI M. Reboxetine
prevents the tranilcypromine-induced increase in tyramine levels in rat
heart. J. Neural. Trasm. Suppl. 41: 149-153, 1994.
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STROLIN BENEDETTI M., PIANEZZOLA E., BRUGHERA M., FRAIER D., CASTELLI M.
G. Concentration of refabutin in plasma and cerobrospinal fluid in Cynomolgus
monkeys. J. Antimicrob. Chemother. 34: 600-603, 1994.
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STROLIN BENEDETTI M., FRIGERIO E., TOCCHETTI P.,BRIANCESCHI G., CASTELLI
M. G., PELLIZONI C. AND DOSTERT P. Stereoselective and species-dependent
kinetics of reboxetine in mouse and rat. Chirality. 7: 285-289,1995.
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EDWARDS D.M. F. , PELLIZONI C., BREUEL H.P., BERARDI A., CASTELLI M.G., FRIGERIO
E. ET AL. Pharmacokinetics of reboxetine in healty volunteers. Single oral
doses, linearity and plasma protein binding. Biopharmaceutics drug
disposition. 16: 443-460, 1995.
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OESCH F., ARAND M., STROLIN BENEDETTI M. CASTELLI M.G. AND DOSTERT P. Inducing
properties of rifampicin and rifabutin for selected enzyme activities of
the cytochrome P-450 and UDP-glucuronosyltransferase superfamilies in female
rat liver. J. Antimicrobial Chemotherapy . 37: 1111-1119, 1996.
RESEARCH GROUP MEMBERS:
-
Ferrari Mariano, P.O.
-
Padrini Roberto, P.A. *
-
Piovan Donatella, A.M.
-
Magnolfi Gianna, A.M.
-
Spolaore Paolo, F.T.
-
Zordan Rossella, T.
AFFILIATION:
Cattedra di Farmacologia Clinica e Servizio di Farmacologia Medica
Dipartimento di Medicina Clinica e Sperimentale
Facoltà di Medicina e Chirurgia
* Dipartimento di Farmacologia "E. Meneghetti"
Facoltà di Medicina e Chirurgia
ADDRESS: Via Giustiniani 2
CITY: Padova
POSTAL CODE: 35128
TELEPHONE: 049-821-2340,2341, 2343, 2349
FAX: 049-8754179
*ADDRESS: Via Largo Meneghetti 2
CITY: Padova
POSTAL CODE: 35100
TELEPHONE: 049-8275085,5098,5096
FAX: 049-8275093
E-MAIL: padrini@dfem.unipd.it
PUBLICATIONS:
-
PADRINI R., PIOVAN D., BUSA M., AL-BUNNI M., MAIOLINO P., AND FERRARI M.
Pharmacodynamic variability of flecainide assessed by QRS changes.Clin.
Pharmacol. Ther. 53: 59-64, 1993.
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ZEPPELLINI R., BOLOGNESI R., JAVERNARO A., DE DOMENICO R., LIBARDONI M.,
TSIALTAS D., PIOVAN D., PADRINI R., AND CUCCHINI F. Effect of dobutamine
on left ventricular relaxation and filling phase in patients with ischemic
heart disease and preserved systolic function. Cardiovasc. Drug Ther.
7: 325-331, 1993.
-
PADRINI R., PIOVAN D., JAVERNARO A., CUCCHINI F., AND FERRARI M. Pharmacokinetics
and electrophysiological effects of i.v. ajmaline. Clin. Pharmacokin.
25: 1-8, 1993.
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ZORDAN R., PADRINI R., BERNINI V., PIOVAN D., AND FERRARI M. Influence of
age and gender on the "in vitro" serum protein binding of flecainide.
Pharmacol. Res. 28: 259-264, 1993.
-
NICOLETTO M.O., PADRINI R., FERRAZZI E., NASCIMBEN O., VISONà E.,
TUMOLO S., PALUMBO M., COSTA L., VINANTE O., MONFARDINI S., AND FIORENTINO
M.V. Phase I-II intraperitoneal Mitoxantrone in advanced pretreated ovarian
cancer. Eur. J. Cancer 29A: 1242-1248, 1993.
-
PIOVAN D., PADRINI,R., SVALUTO MOREOLO G., MAGNOLFI G., ZORDAN R., PELLEGRINO
P.A., AND FERRARI M. Verapamil and norverapamil plasma levels in infants
and children during chronic oral treatment. Therap. Drug. Monitor.
17: 60-67, 1995.
-
YANG Q., PADRINI R., BOVA S., PIOVAN D., AND MAGNOLFI G. Electrophysiological
interactions between pinacidil, a potassium channel opener, and class 1
antiarrhythmic agents in guinea-pig perfused heart. Brit. J. Pharmacol.
114: 1745-1749, 1995.
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PADRINI R., BUTROUS G., CAMM A.J., AND MALIK M. Algebraic decomposition of
the TU-wave morphology patterns. PACE 18: 2209-2215, 1995.
-
LATINI R., MAGNOLFI G., ZORDAN R., FERRARI M., PADRINI R., PIOVAN D., PECORARI
T., AND BOTTAZZI L. Antiarrhythmic drug plasma concentrations in ambulatory
patients. Ann. Pharmac. 30: 298-300, 1996.
-
BOVA S., TREVISI L., DEBETTO P., CIMA L., FURNARI M., LUCIANI S., PADRINI
R., AND CARGNELLI G. Vasorelaxant properties of norbormide, a selective
vasoconstrictor agent for the rat microvasculature. Brit. J. Pharmacol.
117: 1040-1046, 1996.
RESEARCH GROUP MEMBERS:
-
Furlanut Mario, P.O.
-
Baraldo Massimo, R.U.
-
Pea Federico, A.O.
AFFILIATION:
Cattedra di Farmacologia Speciale
Dipartimento di Patologia e Medicina Sperimentale e Clinica
Istituto di Farmacologia Clinica e Tossicologia
Facoltà di Medicina e Chirurgia
Università di Udine
ADDRESS: P.le S.M. della Misericordia 3
CITY: Udine
POSTAL CODE: 33100
TELEPHONE: 0432-559833
FAX: 0432-559833
E-MAIL: furlanut@hydrus.cc.uniud.it
PUBLICATIONS:
-
BENETELLO P., FURLANUT M., ZARA G., BARALDO M., AND HASSAN E. Plasma levels
of levodopa and its main metabolites in parkinsonian patients after conventional
and controlled-release levodopa-carbidopa associations. Eur. Neurol.
33: 69-73, 1993.
-
FURLANUT M., BENETELLO P., AND SPINA E. Pharmacokinetic optimisation of tricyclic
antidepressant therapy. Clin. Pharmacokinet. 24: 301-318, 1993.
-
FERRACCIOLI G.,GUERRA P., RIZZI V., BARALDO M., SALAFFI F., FURLANUT M.,
AND BARTOLI E. Somatomedin C (Insulin-Like Growth Factor 1) levels decrease
during acute changes of stress related hormones. Relevance for fibromyalgia.
J. Rheumatol. 21: 1332-1334, 1994.
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GALLA F., MARZOCCHI V., CROATTINO L., POZ D., BARALDO M., AND FURLANUT M.
Oral and intravenous disposition of cyclosporine in psoriatic patients.
Ther. Drug Monit. 17: 302-304, 1995.
-
DAMIANI D., MICHIELI M., MICHELUTTI A., PEA F., BARALDO M., FANIN R., RUSSO
D., FURLANUT M., AND BACCARANI M. P170 - related multidrug resistance.
Enhancement of idarubicin content in leukemic cells with cyclosporine in
vivo: a report of two cases. Leukemia 9: 1792-1795, 1995
-
WU G., BARALDO M., AND FURLANUT M. Calculating percentage prediction error:
a user's note. Pharmacol. Res. 32: 241-248, 1995.
-
WU G., BARALDO M., PEA F., COSSETTINI P., AND FURLANUT M. Effects of different
sampling strategies on predictions of blood cyclosporine concentrations in
haematological patients with multidrug resistance by bayesian and nonlinear
least squares method. Pharmacol. Res. 32: 355-362, 1995.
-
FURLANUT M., BARALDO M., GALLA F., MARZOCCHI V., AND PEA F. Cyclosporin
nephrotoxicity in relation to its metabolism in psoriasis. Pharmacol.
Res. In press, 1996.
RESEARCH GROUP MEMBERS:
-
Leone Luciana, P.A.
-
Ferrante Luigi, R.U.
-
Bompadre Stefano, T.L.
AFFILIATION:
Istituto di Scienze Biomediche
Facoltà di Medicina e Chirurgia
Università di Ancona
ADDRESS: Monte d'Ago
CITY: Ancona
POSTAL CODE: 60131
TELEPHONE: 071-220-4637
FAX: 071-220-4622
E-MAIL: biomat@popcsi.unian.it
PUBLICATIONS:
-
RIPA S., FERRANTE L., PRENNA M. Pharmacokinetics of fluconazole in normal
volunteers. Chemotherapy, 39: 6-12, 1993
-
BRUNI C., FERRANTE L., KOCH G., SCOGLIO C., STARACE G. A stochastic model
for cell debris in flow cytometry. J. Theor. Biol. 161: 157-74, 1993.
-
DUBINI B., FERRANTE L., LEONARDI M., MESSINA G., MONTECCHIA F. The freezing
and thawing of water in poultry meat and vegetables irradiated by electrons
at doses of 0.1-0.4 KGy. Int. J. Rad. Biol. 63: 687 - 92, 1993.
-
FERRANTE L., BOMPADRE S., CINGOLANI ML., LEONE L. A bayesan approach to drug
disposition evaluation: application to teicoplanin. Int. J. Clin. Pharmacol.
Ther. 33: 410-14, 1995
-
BOMPADRE S., FERRANTE L., ALO' FP., LEONE L. On-line solid-phase extraction
of ceftazidime in serum and determination by high-performance liquid
chromatography. J. Chromatogr. B.:, 669: 265-69, 1995.
-
BOMPADRE S., LEONE L., FERRANTE L. Determination of cefodizime in human plasma
by high-performance liquid chromatography with column-switching. J. Liq.
Chromatogr. 18: 2895-909, 1995
-
FERRANTE L., BOMPADRE S., CINGOLANI ML., LEONE L. RIPA S. Bioavailability
study of two different formulations of azithromycin. Curr. Ther. Res.
57: 288-98, 1996
-
BOMPADRE S., FERRANTE L., LEONE L., ALO' FP., IOANNIDIS G. Extractionless
high-performance liquid chromatographic method for determination of cefazolin
in human serum. J. Liq. Chromatogr.,1996 (in press)
-
BOMPADRE S., FERRANTE L., LEONE L., MONTESI M., POSSATI L. Column-switching
high-performance liquid chromatographic assay for minocycline in nude mouse
serum.. J. Liq. Chromatogr. 1996 (in press).
RESEARCH GROUP MEMBERS:
-
Lucisano Antonia, P.O.
-
Amorena Michele, R.U.
-
Severino Lorella, R.U.
-
Pelagalli Alessandra, D.DR
-
Ferrante Maria Carmela, D.DR
-
Cavaliere Maria, D.DR
AFFILIATION:
Sezione di Tossicologia Veterinaria
Dipartimento di Patologia Profilassi ed Ispezione degli alimenti
Facoltà di Medicina Veterinaria
Università di Napoli Federico II
ADDRESS: Via F. Delpino n°1
CITY: Napoli
POSTAL CODE: 80137
TELEPHONE: 081/297122
FAX: 081/297122
E-MAIL: Lucisano@ds.unina.it
PUBLICATIONS:
-
MONTESISSA C., HUUVENEERS M.B.M., HOOGENBOMM L.A.P., AMORENA M., DE LIGUORO
M., LUCISANO A. The oxidative metabolism of aldicarb in pigs: in vivo - in
vitro comparison. Drug Metab. Drug Interact. 11 :127-38,1994.
-
MONTESISSA C., DE LIGUORO M., AMORENA M., LUCISANO A., CARLI S. In vitro
oxidation of Aldicarb by various food producing animal species. Vet. Hum.
Toxicol. 37 : 333-336,1995
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RE G., BADINO P., NOVELLI A., DI RENZO G.F., SEVERINO L., DE LIGUORO M.,
FERONE M.R. Distribution of cytosolic oestrogen (ER) and progesterone (PgR)
receptors in the genital tract of the mare. Res. Vet. Sci.
59 :214-218, 1995
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DE LIGUORO M., LUONGO F., BRAMBILLA G., CINQUINA A., BOCCA A., LUCISANO A.
Distribution of the anthelmintic drug albendazole and its major metabolites
in ovine milk and milk products after a single oral dose. J. Dairy Res.
63 : 533-542, 1996
RESEARCH GROUP MEMBERS:
-
Montesissa Clara, P.A.
-
De Liguoro Marco, R.U.
AFFILIATION:
Istituto di Patologia e Igiene Veterinaria
Facoltà di Medicina Veterinaria
Università di Padova
ADDRESS: Agripolis
CITY: Legnaro, Padova
POSTAL CODE: 35020
TELEPHONE: 049-8272604
FAX: 049-8272602
E-MAIL: monty@agripolis.unipd.it
PUBLICATIONS:
-
CARLI S., SONZOGNI O., VILLA R., MONTESISSA C. Pharmacokinetic profile of
sulphamonomethoxine and trimethoprim in horses after intravenous, intramuscolar
and oral administration. Res. Vet. Sci., 54 :184-188, 1993.
-
ANFOSSI P., RONCADA P., STRACCIARI G.L., MONTANA M., PASQUALUCCI C., AND
MONTESISSA C. Toxicokinetics and metabolism of linuron in the rabbit: in
vivo-in vitro studies. Xenobiotica, 23 :1113-1123, 1993.
-
MONTESISSA C., HUUVENEERS M.B.M., HOOGENBOOM L.A.P., AMORENA M., DE LIGUORO
M., LUCISANO A. The oxidative metabolism of aldicarb in pigs: in vivo - in
vitro comparison. Drug Metab. Drug Interact. 11 :127-138,1994.
-
MONTESISSA C., VILLA R., SONZOGNI O., BELLOLI C., CARLI S. Comparative
Pharmacokinetics of ampicillin - sulbactam combination in calves and sheep
Vet. Pharmacol. and Therap. 17 : 359-364, 1994.
-
BELLOLI C., CECI L., CARLI S., TASSI P., MONTESISSA C., DE NATALE G.,
MARCOTRIGIANO G., ORMAS P. Disposition of Antimony and Aminosidine administered
separately and in combination to the dog: implication for antileishmania
therapy. Res. Vet. Sci., 58 : 123-127, 1995.
-
RONCADA P., TOMASI L., MONTESISSA C., GROSSI G., STRACCIARI G.L., ANFOSSI
P. Absorption and dosage of theophylline in the horse after single and repeated
administration of a microincapsulated preparation. Equine Vet.J.,
27 :13-18, 1995.
-
MONTESISSA C., DE LIGUORO M., AMORENA M. , LUCISANO A., CARLI S. In vitro
oxidation of Aldicarb by various food producing animal species. Vet.Hum.
Toxicol., 37 : 333-336, 1995.
-
RE G., BADINO P., NOVELLI A., DI RENZO G.F., SEVERINO L., DE LIGUORO M.,
FERONE M.R. Distribution of cytosolic oestrogen (ER) and progesterone (PgR)
receptors in the genital tract of the mare. Res. Vet. Sci., 59 :
214-218, 1995.
-
ANFOSSI P., MONTESISSA C., PEZZI P., FORMIGONI A. Bioavalability of
microgranulated sulphamethazine in veal calves. Vet. Pharmacol. and Therap.
19 : 300-305, 1996.
-
DE LIGUORO M., LUONGO F., BRAMBILLA G., CINQUINA A., BOCCA A., LUCISANO A.
Distribution of the anthelmintic drug albendazole and its major metabolites
in ovine milk and milk products after a single oral dose. J. Dairy Res.
63 : 533-542 1996.
RESEARCH GROUP MEMBERS:
-
Pacifici Gian Maria, P.A.
AFFILIATION:
Dipartimento di Biomedicina Sperimentale, Infettiva e Pubblica
Facoltà di Medicina e Chirurgia
Università di Pisa
ADDRESS: Via Roma, 55
CITY: Pisa
POSTAL CODE: 56126
TELEPHONE: 050-554851, 554866
FAX: 050-554929
E-MAIL: pacifici@biomed.unipi.it
PUBLICATIONS:
-
PACIFICI G.M., BIGOTTI R., MARCHI G., AND GIULIANI L. Minoxidil sulphation
in human liver and platelets: a study on the interindividual variability.
Eur. J. Clin. Pharmacol. 45: 337-341, 1993.
-
PACIFICI G.M., AND MARCHI G. Phenol and catechol sulphotransferases in platelets
from adult subjects and newborns: a study on the interindividual variability.
Brit. J. Clin. Pharmacol. 36 : 593-597, 1993.
-
PACIFICI G.M., BIGOTTI R., AND GIULIANI L. The intestine is the primary site
of the in vitro sulphation of (+) and (-) terbutaline. Eur. J. Clin.
Pharmacol. 45 : 483-487, 1993.
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PACIFICI G.M., FERRONI MA., TEMELLINI A., GUCCI A., MORELLI M.C., GIULIANI
L. Human liver budesonide sulphotransferase is inhibited by testosterone
and correlates with testosterone sulphotransferase, Eur. J. Clin.
Pharmacol. 46 : 49-54, 1994.
-
DONATELLI P., MARCHI G., GIULIANI L., GUSTAFSSON L. AND PACIFICI G.M.
Stereochemical inhibition of histamine N-methyltransferase by chloroquine.
Eur. J. Clin. Pharmacol. 47 : 345-349, 1994.
-
PACIFICI G.M., AND NOTTOLI R. Transplacental transfer of drugs administered
to the mother. Clin. Pharmacokin. 28 : 235-269, 1995.
-
PACIFICI G.M., DE'SANTI C., MUSSI A., ANGELETTI C.A. Interindividual variability
in the rate of salbutamol sulphation in the human lung. Eur. J. Clin.
Pharmacol. 49 : 299-303, 1996.
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PACIFICI G.M., EVANGELISTI L., AND GIULIANI L. Zidovudine glucuronosyl
transferase is not normally distributed in human liver. Int. J. Clin.
Pharmacol. Ther. 34 : 329-334, 1996.
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FERRONI M.A., GIULIANOTTI P.C., PIETRABISSA A., MOSCA F., GOMENI R., AND
PACIFICI G.M. Captopril methylation in human liver and kidney: interindividual
variability. Xenobiotica 26 : 877-882, 1996.
-
FERRONI M.A., MARCHI G., SANSONE E., ROMEO P., GIULIANOTTI P.C., PIETRABISSA
A., MOSCA F. AND PACIFICI G.M. Variability in the rate of 6-mercaptopurine
methylation in the erythrocytes, liver and kidney of an an Italian population.
Eur. J. Clin. Pharmacol. 51 : 23-26, 1996.
RESEARCH GROUP MEMBERS:
-
Perucca Emilio, P.A.
-
Gatti Giuliana, R.U.
-
Bartoli Anna, B.
-
Fattore Cinzia, B.
AFFILIATION:
Sezione di Farmacologia e Tossicologia
Dipartmento di Medicina Interna e Terapia Medica
I Facoltà di Medicina e Chirurgia
Università di Pavia
ADDRESS: Piazza Botta 10
CITY: Pavia
POSTAL CODE: 27100
TELEPHONE: 0382-506 360 / 370
FAX: 0382-22741
PUBLICATIONS:
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TARTARA A., GALIMBERTI C.A., MANNI R., MORINI R., LIMIDO G., GATTI G., BARTOLI
A., STRADA G. AND PERUCCA E. The pharmacokinetics of oxcarbazepine and its
active metabolite 10-hydroxy-carbazepine in healthy subjects and in epileptic
patients treated with phenobarbitone or valproic acid. Brit. J. Clin.
Pharmacol. 36: 366-368, 1993.
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PISANI F., HAJ-YEHIA A., FAZIO A., ARTESI C., OTERI G., PERUCCA E., KROETZ
D.L., LEVY R.H., AND BIALER M. Pharmacokinetics of valnoctamide in epileptic
patients and its interaction with carbamazepine: In vitro/in vivo correlation.
Epilepsia 34: 954-959, 1993.
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PATRINI C., PERUCCA E., REGGIANI C., AND RINDI G. Effects of phenytoin on
the in vivo kinetics of thiamine and its hosphoesters in rat nervous tissue.
Brain Res. 628: 179-186, 1993.
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GATTI G., BARTOLI A., MARCHISELLI R., MICHELUCCI R., TASSINARI C.A., PISANI
F., ZACCARA G., TIMMINGS, P., RICHENS, A., AND PERUCCA, E. Vigabatrin-induced
decrease in serum phenytoin concentration does not involve a change in phenytoin
bioavailability. Brit. J. Clin. Pharmacol. 36: 603-606, 1993.
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PERUCCA E., GATTI G., CIPOLLA G., SPINA E., BAREL S., SOBACK S., GIPS M.,
AND BIALER M. Inhibition of diazepam metabolism by fluvoxamine: A pharmacokinetic
study in normal volunteers. Clin. Pharmacol. Ther. 56: 471-476, 1994.
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GATTI G., BARTOLI A., BERTIN D., STROLIN-BENEDETTI M., AND PERUCCA E.
Pharmacokinetic and pharmacodynamic studies following single and multiple
doses of rolafragel, a novel inhibitor of thromboxane synthase, in normal
volunteers. Eur. J. Clin. Pharmacol. 47: 275-280, 1994.
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PERUCCA E., GATTI G. AND SPINA E. Clinical pharmacokinetics of fluvoxamine.
Clinical Pharmacokinetics 27: 175-190, 1994.
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SPINA E., AVENOSO A., CAMPO G.M., CAPUTI A.P., AND PERUCCA E. Phenobarbital
induces the CYP2D6-mediated 2-hydroxylation of desipramine. Ther. Drug
Monit. 18: 60-64, 1996.
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GIACCONE M., BARTOLI A, GATTI G., MARCHISELLI R. PISANI F., AND PERUCCA E.
Effect of enzyme inducing anticonvulsants on ethosuximide pharmacokinetics
in epileptic patients. Brit. J. Clin. Pharmacol. 41: 575-579, 1996.
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PERUCCA E. AND BIALER M. The clinical pharmacokinetics of the newer antiepileptic
drugs. Focus on Topiramate, zonisamide and tiagabine. Clinical
Pharmacokinetics 31: 29-46, 1996.
RESEARCH GROUP MEMBERS:
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Pisanti Nicola, P.A.
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De Marino Vincenzo, P.A.
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Basile Vincenzo, P.A.
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Gentile Antonio, R.U.
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Capone Domenico, CPE
AFFILIATION:
Sezione di Farmacologia, Dipartimento di Neuroscienze
Facoltà di Medicina e Chirurgia
Università di Napoli Federico II
ADDRESS: Via Pansini,5
CITY: Napoli
POSTAL CODE: 80131
TELEPHONE: 081-746-3312, 3317, 3330
FAX: 081- 7463323
E-MAIL : farmacol@unina.it
PUBLICATIONS :
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CAPONE, D., DE MARINO, V., PISANTI, N., AND DE MARINO, V. New dry chemistry
immunoassay: Comparison with a fluorescence polarization system. Eur.
Rev. Med. Pharmacol. Sci. 91- 94, 1994.
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CAPONE, D., DE MARINO, V., FONTANA, R., DE MARINO, V., AND PISANTI, N. Effects
of different routes of cyclosporin A administration on blood levels in patients
undergoing bone marrow transplantion. Bone Marrow Transplantation,
In press, 1996.
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CAPONE, D., AIELLO, C., SANTORO, G.A., GENTILE, A, STANZIALE, P., D'ALESSANDRO,
R., IMPERATORE, P., AND BASILE, V. Drug interaction between cyclosporine
and two antimicrobial agents, josamycin and rifampicin, in organ transplanted
patients. Int. J. Clin. Pharmacol. Res., In press, 1996.
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PISANTI, N., STANZIALE, P., IMPERATORE, P., D'ALESSANDRO, R., DE MARINO,
V., CAPONE, D.,AND DE MARINO, V. Lack of effect of gemfibrozil on cyclosporine
blood concentrations in kidney transplanted patients. Amer. J. Nephrol.,
in press, 1996.
RESEARCH GROUP MEMBERS:
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Sternieri Emilio, P.O.
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Pini Luigi Alberto, R.U.
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Vitale Giovanni, D.DR.
-
Stefani Marina, B.
AFFILIATION:
Servizio di Tossicologia e Farmacologia Clinica
Dipartimento di Medicina Interna
Facoltà di Medicina e Chirurgia
Università di Modena
ADDRESS: via del Pozzo, 71
CITY: Modena
POSTAL CODE: 41100
TELEPHONE: 059 372001, 424064, 422098
FAX: 059 424069
PUBLICATIONS:
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PINI L.A., VITALE G., SANDRINI M. The role of serotonin brain receptors in
the analgesic effect of phenazone. Drugs Exptl. Clin. Res. 19: 13-17,
1993
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SANDRINI M., VITALE G., PINI L.A., STERNIERI E., BERTOLINI A. Effects of
chronic treatment with phenazone on the hot-plate test and [3H]-Serotonin
binding sites in pons and Cortex membranes of the rat. Pharmacology
47: 84-90, 1993.
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VITALE G., SANDRINI M., PINI L.A. Lack of activity of ketorolac in hot-plate
test and serotonin binding capacity of brain membranes in rats. Agents
Actions 41: 184-187, 1994.
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SANDRINI M, VITALE G, DONDI M, PINI L.A. Effects of Acetylsalicylic Acid
on Serotonin Brain Receptor Subtypes. Gen. Pharmacol. 26: 737-741,
1995.
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PINI LA, SANDRINI M, VITALE G. Lack of activity of Azapropazone in the hot-plate
test and in 5-HT1A and 5-HT2 receptor subtype in rat brain memebranes. Drugs
Exptl. Clin. Res. 181-186, 1995.
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PINI L.A., SANDRINI M, VITALE G. Involvement of brain serotonergic system
in the antinociceptive action of acetylsalicylic acid in the rat. Inflamm.
Res. 44: 30-35, 1995.
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PINI L.A., BIGARELLI, M, VITALE, G, STERNIERI, E. Headaches associated with
chronic use of analgesics: a therapeutic approach.. Headache 36: 433-439,
1996
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PINI L.A., VITALE G, SANDRINI M. The antinociceptive action of paracetamol
is associated with changes in the serotonergic system in the rat brain. Eur.
J. Pharmacol. 308: 31-40, 1996
RESEARCH GROUP MEMBERS:
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Velo Giampaolo, P.O.
-
Milanino Roberto, R.U.
-
Marrella Mauro, T.L.
-
Gasperini Roberta, B.
-
Pasqualicchio Mara, B.
-
Valdo Paola, B.
AFFILIATION:
Istituto di Farmacologia,
Facoltà di Medicina e Chirurgia
Università di Verona
ADDRESS: c/o Policlinico Borgo Roma
CITY: Verona
POSTAL CODE: 37134
TELEPHONE: 045-8098611, 8074244
FAX: 045-581111
E-MAIL: GPVelo@farma.univr.it
PUBLICATIONS:
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MILANINO R., FRIGO A., BAMBARA L.M., MARRELLA M., MORETTI U., PASQUALICCHIO
M., BIASI D., GASPERINI R., MAINENTI L., VELO G.P. Copper and zinc status
in rheumatoid arthritis: studies on plasma, erythrocytes and urine, and
relationship with disease activity markers and pharmacological treatment.
Clinical and Experimental Rheumatology, 11 : 271-281, 1993.
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MILANINO R., MARRELLA M., GASPERINI R., PASQUALICCHIO M., VELO G.P. Copper
and zinc body levels in inflammation: an overview of the data obtained from
animal and human studies. Agents Actions, 39 : 195-209, 1993.
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MARRELLA M., GUERRINI F., SOLERO P.L., TREGNAGHI P.L., SCHENA F., VELO G.P.
Blood copper and zinc changes in runners after a marathon. J. Trace Elem.
Electrolytes Health Dis. 7 : 248-250, 1993.
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MILANINO R., MARRELLA M., VELO G.P. Copper in the treatment of arthritic
conditions : myth or reality ? La Clinica e l'Industria,
76 : 138-143, 1994.
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PASQUALICCHIO M., DAVIES M.E., VELO G.P. Effects of copper and zinc on
chondrocyte - PBMC adhesion via ICAM-1/CD18 interactions.
Inflammopharmacology, 3 : 35-48, 1995.
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PASQUALICCHIO M., GASPERINI R., VELO G.P., DAVIES M.E. Effects of copper
and zinc on proteoglycan metabolism in articular cartilage. Mediators
of Inflammation, 5 : 95-99, 1996.
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