SIF - Società
Italiana di Farmacologia
"SIF - La Ricerca Farmacologica in Italia"
ANTINEOPLASTIC CHEMOTHERAPY
RESEARCH GROUP MEMBERS :
-
Baggio Giosuè Gabriele,
P.O.
-
Castelli Mario, P.A.
-
Rossi Tiziana, R.U.
-
Malagoli Monica, D.DR.
AFFILIATION :
Sezione di Farmacologia, Dipartimento di Scienze Biomediche
Facoltà di Medicina e Chirurgia
Università degli Studi di Modena
ADDRESS: Via Campi, 287
CITY: Modena
POSTAL CODE: 41100
TELEPHONE: 059/428411/50
FAX: 059/372653
E-MAIL: farmacol@unimo.it
PUBLICATIONS :
-
ROSSI ,T., VAMPA , G., BENVENUTI , S., PINI , L.A., GALATULAS , I., BOSSA
, R., CASTELLI , M., RUBERTO, A.I., AND BAGGIO, G. Glycyrrhizin and
18-glycyrrhetinic acid : a comparative study of the pharmacological effects
induced in the rat after prolonged oral treatment. IN VIVO 8: 317-320,
1994.
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CASTELLI , M., BAGGIO , G., RUBERTO , A.I., ROSSI , T., PROVVISIONATO , A.,
MALAGOLI , M., BOSSA , R., AND GALATULAS , I. In vitro activity of trimethoprim
in association with sulphimidazole against aerobic Gram-negative and
Gram-positive microorganisms and Clostridia. Chemotherapy 41: 337-344,
1995.
-
ROSSI , T., GALATULAS , I., BOSSA , R., TAMPIERI , A., TARTONI , P.L., BAGGIO
, G., RUBERTO , A.I., AND CASTELLI , M. Influence of glycyrrhizin on the
evolution and respiration of Ehrlich ascites tumour cells. IN VIVO
9: 183-186, 1995.
-
BOSSA , R., CHIERICOZZI , M., GALATULAS , I., SALVATORE , G., TELI , M.,
BAGGIO , G., AND CASTELLI , M. The effects of roxatidine on neuromuscolar
transmission. IN VIVO 9: 113-116, 1995.
-
CASTELLI , M., BAGGIO , G., RUBERTO , A.I., TAMPIERI ,P., TARTONI , P.L.,
ROSSI , T., BOSSA , M.R., AND GALATULAS , I. Influence of antimalarials
chloroquine, quinine, primaquine and mepacrine on the evolution of Ehrlich
ascites tumour . Anticancer Res. 16 : 1-3, 1996.
RESEARCH GROUP MEMBERS:
-
Baldini Luciano, P.O.
-
Bartoli Klugmann Fiora, P.A.
-
Decorti Giuliana, R.U.
-
Candussio Luigi, R.U.
-
Strohmayer Antonella, B.
AFFILIATION:
Sezione di Farmacologia Medica, Dipartimento di Scienze Biomediche
Facoltà di Medicina e Chirurgia
Università di Trieste
ADDRESS: Via Giorgieri, 7
CITY: Trieste
POSTAL CODE: 34127
TELEPHONE: 040 6763537
FAX: 040 55477
E-MAIL: farmed@univ.trieste.it
PUBLICATIONS:
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DECORTI G., CANDUSSIO L., BARTOLI KLUGMANN F., BALDINI L. Effect of neomycin
and other aminoglycosides on adriamycin uptake in rat peritoneal mast cells.
Pharmacol. Toxicol. 73: 341-343, 1993.
-
BARTOLI KLUGMANN F., DECORTI G., CANDUSSIO L, SOTTOCASA G.L., BALDINI L.
Adriamycin induced histamine release in rat peritoneal mast cells: evidence
for the involvement of G protein. Cell. Pharmacol. 4: 1-5; 1994.
-
CANDUSSIO L., BARTOLI KLUGMANN F., DECORTI G., BALDINI L. Effect of sodium
nedocromil on histamine release and toxicity induced by adriamycin. Curr.
Ther. Res. 55: 1238-1246, 1994.
-
DECORTI G., BARTOLI KLUGMANN F., CANDUSSIO L., BALDINI L. Effect of paclitaxel
and cremophor EL on mast cell histamine secretion and their interaction with
adriamycin. Anticancer Res.16: 317-320, 1996.
-
DECORTI G., CANDUSSIO L., BARTOLI KLUGMANN F., BALDINI L. Binding of
aminoglycoside antibiotics by degranulating mast cells. Chemotherapy,
In press, 1996.
-
CRIVELLATO E., CANDUSSIO L., DECORTI G., BARTOLI KLUGMANN F. Adriamycin binds
to the matrix of secretory granules during mast cell exocytosis.
Biotechnic-Histochem, In press, 1996.
RESEARCH GROUP MEMBERS:
-
Bonmassar Enzo, P.O.
-
De Vecchis Liana, P.A.
-
Aquino Angelo, R.U.
-
Graziani Grazia, R.U.
-
Macchi Beatrice, R.U.
-
Franchi Annibale, R.U.
-
Tentori Lucio, T.L.
-
Prete Salvatore P., T.L.
-
Giuliani Anna, Dir. R.
-
Turriziani Mario, T.L.
-
Gilberti Sara, Sp.
-
Cantagallo Daniela, Sp.
-
Minchella Ida, Sp.
-
Orlando Laura, Sp.
-
Comandini Alessandro, Sp.
-
Masci Giovanna, Sp.
-
Benincasa Elena, Sp.
-
Franzese Ornella, B.PDR.
-
Faraoni Isabella, B.PDR.
-
Lacal Pedro M., B.PDR.
-
D'Atri Stefania, B.PDR.
-
Tricarico Maria, Dir. R.
-
Fuggetta Maria Pia, T.L.
-
Alvino Ester, T.L.
AFFILIATION:
Cattedra di Farmacologia
Dipartimento di Medicina Sperimentale e Scienze Biochimiche
Facoltà di Medicina e Chirurgia
Università degli Studi di Roma "Tor Vergata"
ADDRESS: Via Tor Vergata, 135
CITY: Roma
POSTAL CODE: 00133
TELEPHONE: 06-7259-6322, 6315, 6340
FAX: 06-7259-6323
E-MAIL: disperim@utovrm.it
PUBLICATIONS:
-
FUGGETTA M.P., ALVINO E.,
PEPPONI R., DE FILIPPI R., MARINI S., BONMASSAR E.: In vitro tumor cell growth
inhibition: a comparative study between allosensitized cytotoxicity T lymphocytes
and lymphokine activated killer cells. Cell Proliferation 26:305-316,
1993.
-
GRAZIANI G., FARAONI I.,
ZHANG J., CARONTI B., LAURO G., BONMASSAR E., MACCHI B.: Transient HTLV-I
infection of a human glioma cell line following cell-free exposure. Virology
197:767-769, 1993.
-
LACAL P.M., PUGLIANIELLO
A., BONMASSAR E., D'ONOFRIO C.: Effects of cyclopentenone prostaglandins
on myeloid cells during early infection with HTLV-I. Cell differentiation
determines sensitivity to prostaglandins and virus infection. J. Pharmacol.
Exper. Ther. 271:1086-1095, 1994.
-
LACAL P.M., AMICI C., BONMASSAR
E. AND D'ONOFRIO C.: Effects of cyclopentenone prostaglandins on myeloid
cells during early infection with HTLV-I. II. Regulation of synthesis of
inducible p72 heat shock protein. J. Pharmacol. Exper. Ther.
271:1096-1102, 1994.
-
D'ATRI S., PICCIONI D.,
CASTELLANO A., TUORTO V., FRANCHI A., LU K., CHRISTIANSEN N., FRANKEL S.,
RUSTUM Y.M., PAPA G., MANDELLI F., BONMASSAR E.: Chemosensitivity to triazene
compounds and O6-alkylguanine-DNA-alkyltransferase levels: studies with blasts
of leukaemic patients. Ann. Oncol. 6:389-393, 1995.
-
D'ONOFRIO C., PUGLIANIELLO
A., AMICI C., FARAONI I., LANZILLI G. AND BONMASSAR E.: HSP70 production
and inhibition of cell proliferation in MOLT-4-T-cells after cell-to-cell
transmission of HTLV-I: effect of PGA1. Leukemia Res. 19:345-356,
1995.
-
TENTORI L., GRAZIANI G.,
GILBERTI S., LACAL P.M., BONMASSAR E., D'ATRI S.: Triazene compounds induce
apoptosis in O6-alkylguanine-DNA alkyltransferase deficient leukemia cell
lines. Leukemia 9:1888-1895, 1995.
-
GRAZIANI G., FARAONI I.,
GROHMANN U., BIANCHI R., BINAGLIA L., MARGISON G.P., WATSON A.J., ORLANDO
L., BONMASSAR E., D'ATRI S.: O6-alkylguanine-DNA alkyltransferase attenuates
triazene-induced cytotoxicity and tumor cell immunogenicity in murine L1210
leukemia. Cancer Res. 55:6231-6236, 1995.
-
TENTORI L., LEONETTI C.,
LOZUPONE F., BONMASSAR E.: Antitumor and antimetastatic effects of Dacarbazine
combined with cyclophosphamide and IL-2 in Lewis Lung Carcinoma (3LL).
Cancer Immunol. Immunother. 41(6):375-383, 1995.
-
LACAL P.M., D'ATRI S.,
ORLANDO L., BONMASSAR E. AND GRAZIANI G.: In vitro inactivation of human
O6-alkylguanine DNA alkyltransferase by antitumor triazene compounds. J.
Pharmacol. Exper. Ther., In press, 1996.
RESEARCH GROUP MEMBERS:
-
Chieco Pasquale, Dir. R.
-
Stecca Barbara A., D.DR.
-
Suozzi Anna, B.
-
Pagano Katia, B.
-
Capri Isabella, B.
AFFILIATION :
Istituto di Oncologia "F. Addarii"
Policlinico S. Orsola- Malpighi - Bologna
ADDRESS : Viale Ercolani 4/2
CITY: Bologna
POSTAL CODE: 40138
TELEPHONE: 051/6363312
FAX : 051/397244
E-MAIL : set3264@iperbole.bologna.it
PUBLICATIONS :
-
CHIECO P., JONKER A., MELCHIORRI C., VANNI G., VAN NOORDEN C.J.F. A user's
guide for avoiding errors in absorbance image cytometry : a review with
original experimental observations. Histochem. J. 26 : 1-19,
1994.
-
TRERE' D., MELCHIORRI C., CHIECO P., MARABINI A., DERENZINI M. Interphase
AgNOR quantity and DNA content in endometrial adenocarcinoma. Gynecol.
Oncol. 52 : 202-207, 1994.
-
DERENZINI M., TRERE' D., CHIECO P., MELCHIORRI C. Interphase AgNOR
quantity is not related to DNA content in 11 established human cancer cell
lines. Exp. Cell Res. 211 : 282-285, 1994.
-
MELCHIORRI C., BOLONDI L., CHIECO P., PAGNONI M., GRAMANTIERI L., BARBARA
L. Diagnostic and prognostic value of DNA ploidy and cell nuclearity in
ultrasound-guided liver biopsy specimens. Cancer 74 : 1713-1719,
1994.
-
CHIECO P., STECCA B., BOLONDI L., MELCHIORRI C., GAIANI S., BARBARA L.
Cytochemical detection of a class 3 aldehyde dehydrogenase in human
hepatocellular carcinoma. Liver 15 : 87-92, 1995.
-
CECCARELLI C., SANTINI D., CHIECO P., TUFFARELLI M., MARRANO D., MANCINI
A.M. Multiple expression patterns of biopathological markers in primary invasive
breast carcinoma : A useful tool for elucidating its biological behaviour.
Ann. Oncol. 6 : 275-282, 1995.
-
FACCIOLI S., CHIECO P., GRAMANTIERI L., STECCA B.A., BOLONDI L. Cytometric
measurement of cell proliferation in echo-guided biopsies from focal lesions
of the liver. Mod. Pathol. 9 : 120-125, 1996.
-
BOLONDI L., GRAMANTIERI L., CHIECO P., MELCHIORRI C., TRERE' D., STECCA
B., DERENZINI M., BARBARA L. Enzymatic cytochemistry, DNA ploidy and AgNOR
quantitation in hepatocellular nodules of uncertain malignant potential in
liver cirrhosis. Digest. Dis. Sci. 41 : 800-808, 1996.
RESEARCH GROUP MEMBERS:
-
D'Alessandro Natale, P.O.
-
Flugy Papè Anna Maria, R.U.
-
Crescimanno Marilena, T.L.
-
Flandina Carla, T.L.
-
Borsellino Nicolò, B.
-
Leonardi Vita, B.
AFFILIATION :
Cattedra di Farmacologia CLOPD
Istituto di Farmacologia
Facoltà di Medicina e Chirurgia
Università di Palermo
ADDRESS: Policlinico P. Giaccone, Via del Vespro 129
CITY: Palermo
POSTAL CODE: 90127
TELEPHONE: 091-6553258
FAX: 091-6553249
E-MAIL: nadales@mbox.vol.it
PUBLICATIONS:
-
N. BORSELLINO, M. CRESCIMANNO, C. FLANDINA, V. LEONARDI, L. RAUSA, N.
D'ALESSANDRO. Antiproliferative and chemomodulatory effects of interferon-gamma
on doxorubicin-sensitive and -resistant tumour cell lines. Anti-Cancer
Drugs 4: 265-272, 1993.
-
V. LEONARDI, N. BORSELLINO, M. CRESCIMANNO, C. FLANDINA, A. FLUGY, N.
D'ALESSANDRO. Combinative growth inhibitory effects of interferon-alpha on
multidrug resistant tumor cell lines. Oncology Reports 1: 161-164,
1994.
-
N. BORSELLINO, M. CRESCIMANNO, V. LEONARDI, N. D'ALESSANDRO. Effects of
8-chloro-cyclic adenosine monophosphate on the growth and sensitivity to
doxorubicin of multidrug resistant tumour cell lines. Pharmacol. Res.
30: 81-90, 1994.
-
M. CRESCIMANNO, N. BORSELLINO, V. LEONARDI, C. FLANDINA, A. FLUGY, L. RAUSA,
N. D'ALESSANDRO. Effect of buthionine sulfoximine on the sensitivity to
doxorubicin of parent and MDR tumor cell lines. J. Chemother. 6: 343-348,
1994.
-
N. BORSELLINO, M. CRESCIMANNO, C. FLANDINA, A. FLUGY, N. D'ALESSANDRO. Combined
activity of Interleukin-1alpha or TNF- alpha and doxorubicin on multidrug
resistant cell lines: evidence that TNF and DXR have synergistic antitumor
and differentiation-inducing effects. Anticancer Res. 14: 2643-2648,
1994.
-
A. FLUGY, N. BORSELLINO, N. D'ALESSANDRO. TNF-induced apoptosis in multidrug
resistant Friend erythroleukemia is not influenced by the P-glycoprotein
and glutathione status of the cell line. Oncol. Res. 7: 559-564, 1995.
-
N. BORSELLINO, A. BELLDEGRUN, B. BONAVIDA. Endogenous Interleukin 6 is a
resistance factor for cisiamminedichloroplatinum and etoposide-mediated
cytotoxicity of human prostate carcinoma cell lines. Cancer Res. 55:
4633-4639, 1995.
-
N. D'ALESSANDRO, N. BORSELLINO. In vivo effects of tumor necrosis factor-alpha
or flavone acetic acid in combination with doxorubicin on multidrug-resistant
B16 melanoma. Anti-Cancer Drugs 7: 281-287, 1996.
-
C. FLANDINA, A. FLUGY, N. BORSELLINO, N. D'ALESSANDRO. Development and partial
characterization of a human T-lymphoblastic leukaemic (CCRF-CEM) cell line
resistant to etoposide. Analysis of possible circumventing approaches. J.
Chemother. In press, 1996.
RESEARCH GROUP MEMBERS:
-
Esposito Mauro, Dir.R.
-
Viale Maurizio, A.L.
-
Vannozzi Maria Ornella, A.L.
-
Pellecchia Caterina, T.
-
Tolino Giuseppina, Contrattista
AFFILIATION:
Sezione di Farmacologia Tossicologica
Dipartimento di Oncologia Preclinica
Istituto Nazionale per la Ricerca sul Cancro (IST)
ADDRESS: Largo Rosanna Benzi, 10
CITY: Genova
POSTAL CODE: 16132
TELEPHONE: 010-5600-660, 923, 936, 523
FAX: 010-5600-659, 501
E-MAIL: esposito@hp380.ist.unige.it
PUBLICATIONS:
-
ESPOSITO, M., VANNOZZI, M.O., VIALE, M., FULCO, R.A., COLLECCHI, P., MERLO,
F., DECIAN, F., ZICCA, A., CADONI, A., AND POIRIER, M.C. Para-aminobenzoic
acid suppression of cis-diamminedichloroplatinum(II) nephrotoxicity.
Carcinogenesis. 12: 2595-2599, 1993.
-
RATTO, G.B., ESPOSITO, M., LEPRINI, A., CIVALLERI, D., DECIAN, F., VANNOZZI,
M.O., ROMANO, P., CANEPA, M., AND ZACCHEO, D. "In situ" lung perfusion with
cisplatin: an experimental study. Cancer. 71: 2962-2970, 1993.
-
LERZA, R., ESPOSITO, M., VANNOZZI, M., BOTTINO, G.B., BOGLIOLO, G, AND
PANNACCIULLI, I. High doses of intrapleural cisplatin in a case of malignant
pleural mesothelioma: clinical observations and pharmacokinetic analyses.
Cancer. 73: 79-84, 1994.
-
VIALE, M., MELIOLI, G., PASQUETTI, W., META, M., CAFAGGI, S., AND ESPOSITO,
M. Modifications of cell cycle induced by DPR, a new platinum-triamine complex
containing procaine. Int. J. Oncol. 4: 1047-1051, 1994.
-
VIALE, M., CAFAGGI, S., PARODI, B., AND ESPOSITO, M. Cytotoxicity and cellular
accumulation of a new cis-diammineplatinum(II) complex containing procaine
in murine L1210 cells sensitive and resistant to
cis-diamminedichloroplatinum(II). Cancer Chemother. Pharmacol. 35:
371-376, 1995.
-
PARODI, B., ESPOSITO, M., VIALE, M., CAFAGGI, S., AND VANNOZZI, M. Chemical
and biological properties of a new cis-diammineplatinum(II) complex containing
para-aminobenzoic acid as amino ligand. Anticancer Res. 15: 895-899,
1995.
-
ESPOSITO, M., VANNOZZI, M., VIALE, M., PELLECCHIA, C., CIVALLERI, D., AND
GOGIOSO L. Effect of para-aminobenzoic acid on the pharmacokinetics and urinary
excretion of cis-diamminedichloroplatinum(II) in rats. Anticancer Res.
15: 2541-2548, 1995.
-
ZHANG, J.G., ESPOSITO, M., CAFAGGI, S., AND LINDUP, W.E. Comparison of the
toxicities of cisplatin and a new cisplatin-procaine complex to rat renal
cortical slices. Hum. Exp. Toxicol. 15: 59-63, 1996.
-
ESPOSITO, M., VIALE, M., VANNOZZI, M.O., ZICCA, A., AND GOGIOSO, L. Effect
of antiarrhytmic drug procainamide on the toxicity and antitumor activity
of cisplatin. Toxicol. Appl. Pharmacol. 140, In press, 1996.
-
VANNOZZI, M.O., NOBILE, M.T., SANGUINETI, O., BARZACCHI, C., VIALE, M., NUMICO,
G., AND ESPOSITO, M. Pharmacokinetics of (6S)-Leucovorin and
5-Methyltetrahydrofolate after 4-hour continuous intravenous infusion followed
by repeated oral doses of (6S)-Leucovorin in patients with colorectal cancer
treated with 5-fluorouracil. Clin. Drug Invest.. 12: 39-45, 1996.
RESEARCH GROUP MEMBERS :
-
Favoni Roberto E., Dir. R.
-
de Cupis Alessandra, B.
-
Pirani Paolo, T.
-
Caci Emanuela, S.I.
-
Ferrera Alessandra, Biotecnologo
AFFILIATION :
Dipartimento di Oncologia Preclinica
Laboratorio di Farmacologia Sperimentale
Istituto Nazionale per la Ricerca sul Cancro
ADDRESS : Largo Rosanna Benzi, 10
CITY : Genova
POSTAL CODE: 16132
TELEPHONE: 010-5600-931,932
FAX : 010-355503
PUBLICATIONS :
-
RAVERA F., MIGLIETTA L., PIRANI P., FAVONI R.E. Suramin- induced growth
inhibition and IGF-I binding blockade on human breast carcinoma cell
lines : potentially realted events. Eur. J. Cancer, 29A : 225-230,
1993.
-
FAVONI R.E., DE CUPIS A., RAVERA F., CANTONI C., PIRANI P., ARDIZZONI A.,
NOONAN D., AND BIASSONI R. Expression and function of the insulin-like growth
factor-I system in human non-small-cell lung cancer and normal lung cell
lines. Int. J. Cancer, 56 : 858-866, 1994.
-
FAVONI R.E., RAVERA F., PIRANI P., ARDIZZONI A., NOONAN D., DE CUPIS A. Suramin
interferes with auto/paracrine insulin-like growth factor-I-controlled
proliferative loop on human lung cancer cell lines. Eur. J. Pharmacol.
264 : 199-206, 1994.
-
FAVONI R.E., SFORZINI S., AMOROSO D., DE CUPIS A., PENSA F., PERROTTA A.,
MIGLIETTA L. IGF-I and IGF-binding proteins blood serum levels in women with
early- and late stage- breast cancer : mutual relationship and possible
correlation with patients hormonal status. J. Cancer Res. Clin. Oncol.
121 : 674-682, 1995.
-
DE CUPIS A., NOONAN D., PIRANI P., FERRERA A., CLERICO L., FAVONI R.E. Comparison
between novel steroidal-like and conventional nonsteroidal antiestrogens
in inhibiting oestradiol- and IGF-I-induced proliferation of human breast
cancer-derived cells. Brit. J. Pharmacol. 116 : 2391-2400, 1995.
RESEARCH GROUP MEMBERS:
-
Mazzanti Gabriela, P.A.
-
Piccinelli Dario, P.O.
-
Braghiroli Laura, B.PDR.
-
Cometa Francesca, D.DR.
AFFILIATION :
Istituto di Farmacologia e Farmacognosia
Facoltà di Farmacia
Università di Roma 'La Sapienza'
ADDRESS: P.le Aldo Moro, 5
CITY: Roma
POSTAL CODE: 00185
TELEPHONE: 06-49912903
FAX: 06-49912480
E-MAIL: mazzanti@axrma.uniroma1.it
PUBLICATIONS :
-
SEVERINI, C., TITA, B. AND BOLLE, P.
Pumiliotoxin B-like alkaloid in extracts of the skin of the
australian myobatrachid frog Pseudophryne coriacea: effects on blood pressure
and heart of the rabbit. Arch. Int. Pharmacodyn. Ther., 317: 56-66,
1992
-
MAZZANTI, G., AND BRAGHIROLI, L. Anti-inflammatory action of Pfaffia
paniculata (Martius) Kuntze. Phytother. Res. 8: 413-6, 1994.
-
BONSI, P., PALMERY, M., AND AUGUSTI-TOCCO, G. Aflatoxin B1 cytotoxicity on
neurons in culture. Atla., 24: 533-40, 1996.
-
BRAGHIROLI , L., MANGANARO, M., MASCELLINO, M.T., MAZZANTI, G. AND VESPERTILLI,
T. Antimicrobial activity of Calluna Vulgaris. Phytother. Res.
10 : In press, 1996.
-
COMETA, M.F., GALEFFI, C. AND PALMERY, M. Acute effect of alkaloids from
Hydrastis canadensis L. on guinea-pig ileum: structure activity
relationships. Phytother. Res. 10 : In press, 1996.
-
MAZZANTI, G., BRAGHIROLI, L., BOLLE, P., SAIJA, A. AND SASO, L. Effects of
Panax ginseng and Ginkgo biloba on in vitro prolactin sectretion.
Phytother. Res. 10 : In press, 1996.
RESEARCH GROUP MEMBERS:
-
Pagnini Giuseppe, P.O.
-
Florio Salvatore, R.U.
-
Filosa Stefania, B. PDR.
-
Crispino Antonio, C.L.
AFFILIATION :
Sezione di Farmacologia, Dipartimento di Strutture, Funzioni e Tecnologie
Biologiche
Facoltà di Medicina Veterinaria
Università Federico II
ADDRESS: Via Veterinaria, 1
CITY: Napoli
POSTAL CODE: 80137
TELEPHONE: 081-290665
FAX: 081-440120
PUBLICATIONS:
-
PAGNINI D., PAINO G., FLORIO S., PACILIO G., IODICE G., SCALA G., PAGNINI
U. Influence of thymic factors on the transplacental cis-platinum toxicity
in rats. Acta Med. Vet. 39: 137-144, 1993.
-
AVALLONE L, LOMBARDI P., FLORIO S., CRISPINO A., POTENA M.I.,TORTORA G.,
VOLPE P., ROMANELLI G., PAPPARELLA S. Steroid receptors distribution in canine
mammary tumour. Acta Med. Vet. 40: 105-112, 1994.
-
SEVERINO L., FLORIO S., DONATO A. Influence of Fenclor 64 on the product
of conception and on some parameters correlated to the reproductive function
of the rat. Acta Toxicol. Ther. 15 : 181-193, 1994.
-
PAGNINI G., FLORIO S., PAGNINI U., CRISPINO A. Effect of
cis-diamminedichloroplatinum (II) on thymocyte membrane potential of the
rat. J. Chemother. 8: 147-153, 1996.
-
FLORIO S., PAGNINI D., CRISPINO A., AVALLONE L., LOMBARDI P., ZUCCARO S.,
LANNI P., PELAGALLI A. Preliminary observations on the interference of
antiblastic agents on membrane fluidity and potential in leukocytes. J.
Chemother. 8: 55-58, 1996.
-
DI CARLO R., MELI R. , FLORIO S. , MATTACE RASO G. , GUALILLO O. , PAGNINI
G. The effect of age and sex on the expression of prolactin binding activity
in the chicken Bursa of Fabricius. Life Sci. In press, 1996
-
AVALLONE L., LOMBARDI P., FLORIO S., D'ANGELO D., BOGIN E. Age-dependent
variations of lactic dehydrogenase and creatine kinase activities in water
buffalo calves serum. Eur. J. Clin. Chem. Clin Biochem., In press,
1996.
RESEARCH GROUP MEMBERS :
-
Pezza Barzi Anna Maria, P.A.
-
Rufini Stefano, P.A.
-
Nocentini Giuseppe, B.
-
Flaviani Miriam, B.
AFFILIATION :
Sezione di Farmacologia, Tossicologia e Chemioterapia
Dipartimento di Medicina Clinica, Patologia e Farmacologia
Facoltà di Medicina e Chirurgia
Università di Perugia
ADDRESS : Via del Giochetto
CITY : Perugia
POSTAL CODE : 06100
TELEPHONE: 075-585-3470, 3474, 3593, 3467
FAX: 075-585-3405
E-MAIL : farmaco@teseo.unipg.it
PUBLICATIONS :
-
NOCENTINI G., FEDERICI F., FRANCHETTI P., BARZI A.
2,2'-Bipyridyl-6-carbothioamide and its ferrous complex : their in vitro
antitumoral activity related to the inhibition of ribonucleotide reductase
R2 subunit. Cancer Res. 53 : 19-26, 1993.
-
SPOSITO M., SABALICH I., RUFINI S., Importance for evaluating growth hormone
defects. Med Surg. Ped. 15 : 67-71, 1993.
-
SAVINI L., MASSARELLI P., SEGA A., PELLERANO C., BARZI A., NOCENTINI G. Chelating
agents as potential antitumorals. 2-Quinoylhydrazones and
bis-2-Quinolylhydrazones. Eur. J. Med. Chem. 30 : 547-552, 1995.
-
NOCENTINI G., AND BARZI A. A predictive screening model for in vitro selection
of agents with potential antitumor activity. Arzneim-Forsch Drug Res.
45 : 1306-1311, 1995.
-
FRANCHETTI P., CAPPELLACCI L., GRIFANTINI M., BARZI A., NOCENTINI G., YANG
H., O'CONNOR A., JAYARAM H.N., CARRELL C., GOLDSTEIN B.M. Furanfurin and
thiofenfurin : two novel tiazofurin analogues. Synthesis, Structure,
Antitumor activity and interactions with inosine monophosphate deydrogenase.
J. Med. Chem. 38 : 3829-3837, 1995.
-
NOCENTINI G., AND BARZI A. . 2,2'-Bipyridyl-6-carbothioamide copper (II)
complex differs from the iron leading to cytotoxicity. Biochem.
Pharmacol. 52 : 65-71, 1996.
-
NOCENTINI G. Ribonucleotide reductase inhibitors : new strategies for
cancer chemotherapy. Critical Rev. in Oncol/Hematol. 22 : 89-126,
1996.
-
SPOSITO M., RUFINI G. Serum IGPB3 levels in GHD children after rGH therapy.
Ped. Med. Chir. 17 : 41-44, 1995.
RESEARCH GROUP MEMBERS:
-
Piccinini Francesco, P.O.
-
Monti Elena, R.U.
-
Maria Bonfà, T.L.
-
Luisa Paracchini, T.L.
-
Gianpaolo Perletti, T.L.
-
Marzia Gariboldi, T.L.
AFFILIATION:
Sezione di Farmacologia Applicata, Istituto di Farmacologia
Facoltà di Scienze Matematiche, Fisiche e Naturali
Università degli Studi di Milano
ADDRESS: Via Vanvitelli, 32
CITY: Milano
POSTAL CODE: 20129
TELEPHONE: 02-7010-0131, 0391
FAX: 02-7000-2270
E-MAIL: pharmapp@imiucca.csi.unimi.it
PUBLICATIONS:
-
MONTI, E., MIMNAUGH, E.G., AND SINHA,
B.K. Synergistic antiproliferative action of etoposide and interleukin-1
is not due to DNA damage in human melanoma cells. Biochim. Biophys. Acta
1180: 231-235, 1993.
-
LA PORTA, C., PERLETTI, G., PICCININI,
F., AND COMOLLI, R. Analysis of calcium dependent protein kinase C isoforms
in the early stages of diethylnitrosamine-induced rat hepatocarcinogenesis.
Mol. Carcinogenesis 8: 255-263, 1993.
-
BRADAMANTE, S., JOTTI, A., PARACCHINI,
L., AND MONTI, E. The hydrophilic spin trap 5,5-dimethyl-1 pyrroline-1-oxide
(DMPO) does not protect the rat heart from reperfusion injury. Eur. J.
Pharmacol. 234: 113-116, 1993.
-
MONTI, E., MIMNAUGH, E.G., AND SINHA,
B.K. Synergistic antiproliferative effects of interleukin-1 and doxorubicin
on a human ovarian carcinoma cell line (NIH:OVCAR-3) do not involve
interleukin-1a receptor modulation. Biochem. Pharmacol. 45: 2099-2107,
1993.
-
JOTTI, A., MAIORINO, M., PARACCHINI,
L., PICCININI, F., AND URSINI, F. Protective effect of dietary selenium
supplementation on delayed cardiotoxicity of adriamycin in rat: is PHGPX
but not GPX involved? Free Radical Biology & Medicine 16: 283-288,
1994.
-
TESSITORE, L., PERLETTI, G., SESCA, E.,
PANI, P., DIANZANI, M.U. AND PICCININI, F. Protein Kinase C isoenzyme pattern
in liver hyperplasia. Biochem. Biophys. Res. Comm. 205: 208-214,
1994.
-
BRADAMANTE, S., PICCININI, F., DELU', C., HUITZER, T., AND DE JONG
JW. Changes in phosphorylation potential and purine release durihng recurrent
ischemia. Biochim. Biophys. Acta 1243: 1-8, 1995.
-
PERLETTI, G., FOLINI, M., LIN, H., MISCHAK,
H., PICCININI, F., AND TASHJIAN, A.H. Jr. Overexpression of Protein Kinase
C epsilon is oncogenic in rat colonic epithelial cells. Oncogene 12:
847-854, 1996.
-
PERLETTI, G., TESSITORE, L., SESCA, E., PANI, P., DIANZANI, M.U., PICCININI,
F. PKC acts like a marker of progressive malignancy in rat liver, but fails
to enhance tumorigenesis in rat hepatoma cells in culture. Biochem. Biophys.
Res. Comm. 221: 688-691, 1995.
-
MONTI, E., COVA, D., GUIDO, E., MORELLI, R., AND OLIVA, C. Protective effect
of the nitroxide TEMPOL against the cardiotoxicity of adriamycin. Free
Radical Biology & Medicine, 21: 463-470, 1996.
RESEARCH GROUP MEMBERS:
-
Sanguedolce Rosario, P.A.
-
Vultaggio Giuseppe, B.
-
Randazzo Giuseppe, B.
-
Gancitano Rosalba, D.DR.
-
Porretto Ferdinando, D.DR.
AFFILIATION :
Istituto di Farmacologia
Policlinico Palermo
ADDRESS: via del Vespro 120
CITY: Palermo
POSTAL CODE: 90127
TELEPHONE: 091, 6553273
FAX: 091, 6553249
E-MAIL: farmapa@mbox.vol.it
PUBLICATIONS:
-
R. SANGUEDOLCE, C. FLANDINA, T. CUCCHIARA,F. VARVARA E L. RAUSA. Morphological
changes in the hearths of CD1 mice following chronic treatment with Doxorubicin
and Lonidamine.. Res Comm in Chem Path and Pharm. 82 :81-89,
1993.
-
R. SANGUEDOLCE, I. BRUMARESCU, G. DARDANONI, A. GRASSADONIA, G. VULTAGGIO
AND L. RAUSA. Thymidylate synthase level and DNA-ploidy pattern as possible
prognostic factors in human colorectal cancer: a preliminary study. Anticancer
Res. 15 : 1800-1801, 1995.
-
R. SANGUEDOLCE, G. VULTAGGIO, G. DARDANONI, A. GRASSADONIA, F. SANGUEDOLCE,
G. DI GIOVANNI E L. RAUSA. Valore prognostico dei livelli di timidilato sintetasi
in pazienti con carcinoma colo-rettale. Giornale italiano di
Chemioterapia, 42 : 23-30, 1995.
RESEARCH GROUP MEMBERS :
-
Sava Gianni, P.A.
-
Pacor Sabrina, B.PDR.
-
Gagliardi Renato, C.L.
-
Cocchietto Moreno, R.I.
-
Bergamo Alberta, B.
-
Capozzi Ilaria, B.
-
Clerici Katiuscia, B.
-
Giovanni Salerno, B.
AFFILIATION:
Sezione di Farmacologia
Dipartimento di Scienze Biomediche
Università degli Studi di Trieste
ADDRESS:
Via L. Giorgieri, 7
CITY:
Trieste
POSTAL
CODE: 34127
TELEPHONE:
040-676-3541
FAX:
040-577435
E-MAIL:
gsava@fc.univ.trieste.it
PUBLICATIONS:
-
SAVA, G., PACOR, S., VRANESIC, B., AND TOMASIC,
J., COCCHIETTO M. Modification of the growth of MCa mammary carcinoma of
CBA mouse by new adamantylpeptides. Int. J. Oncol.. 2: 607-612,
1993.
-
COLUCCIA, M., SAVA, G., LOSETO, F., NASSI, A.,
BOCCARELLI, A., GIORDANO, D., ALESSIO, E., AND MESTRONI G. Anti-leukaemic
action of RuCl2(DMSO)4 isomers and prevention of brain
involvement on P388 leukaemia and on P388/DDP subline. Eur. J. Cancer.
29A: 1873-1879, 1993.
-
PACOR, S., FRANZ, C., GAGLIARDI, R., AND SAVA
G. Lysozyme induced recovery of the response to ConA on mononuclear cells
harvested from mice bearing MCa mammary carcinoma. Int. J. Oncology.
4: 877-883, 1994.
-
GAGLIARDI, R., SAVA, G., PACOR, S., MESTRONI,
G., AND ALESSIO E. Antimetastatic action and toxicity on healthy tissues
of Na[trans-RuCl4(DMSO)Im] in the mouse. Clin. Exp.
Metastasis. 12: 93-100, 1994.
-
DASIC, G., PACOR, S., BERGAMO, A., SALERNO,
G., VRANESIC, B., JUKIC., R, TOMASIC., J, AND SAVA G. Effects of
L-(adamant-2-yl)glycyl-L-alanyl-D-isoglutamine on the antitumor action of
cyclophosphamide, 5-FU, cisplatin and dacarbazine on advanced carcinomas
of the mouse. Int. J. Oncology. 5: 275-284, 1994.
-
SAVA, G., PACOR, S., COLUCCIA, M., MARIGGIO',
M., COCCHIETTO, M., ALESSIO, E., AND MESTRONI G. Response of MCa mammary
carcinoma to cisplatin and to Na[trans-RuCl4(DMSO)Im].
Selective inhibition of spontaneous lung metastases by the ruthenium
complex. Drug Invest. 8: 150-161, 1994.
-
SAVA, G., PACOR, S., BERGAMO, A., COCCHIETTO,
M., MESTRONI, G., AND ALESSIO E. Effects of ruthenium complexes on experimental
tumors: irrelevance of cytotoxicity for metastasis inhibition. Chem.-Biol.
Interact. 95: 109-126, 1995.
-
SAVA, G., PACOR, S., DASIC, G., AND BERGAMO
A. Lysozyme stimulates lymphocyte response to ConA and IL-2 and potentiates
5-fluorouracil action on advanced carcinomas. Anticancer Res. 15:
1883-1888, 1995.
-
PACOR, S., GIACOMELLO, E., BERGAMO, A., GAGLIARDI,
R., COCCHIETTO, M., AND SAVA G. Cytofluorimetric analysis of gut-intraepitelial
and mesenteric lymph node lymphocytes of tumour bearing mice fed with egg-white
lysozyme. Anticancer Res. 16: 145-150, 1996.
-
SAVA, G., SALERNO, G., BERGAMO, A., COCCHIETTO,
M., GAGLIARDI, R., ALESSIO, E., AND MESTRONI G. Reduction of lung metastases
by Na[trans-RuCl4(DMSO)Im] is not coupled with the induction
of chemical xenogenization. Metal Based Drugs. 3: 67-73, 1996.
RESEARCH GROUP MEMBERS:
-
Viano Ilario, P.O.
-
Brunelleschi Sandra, R.U.
-
Guidotto Stefania, D.DR.
-
Colangelo Donato, B.PDR.
-
Tommasino Enrica, B.
AFFILIATION :
Dipartimento di Scienze Mediche
II Facoltà di Medicina
Università di Torino
ADDRESS: Via Solaroli, 17
CITY: Novara
POSTAL CODE: 28100
TELEPHONE: 0321- 660- 648, 600, 601.
FAX: 0321- 620421
E-MAIL: viano@no.unipmn.it
PUBLICATIONS:
-
DA COL, R., SILVESTRO, L., BAIOCCHI, C., GIACOSA, D. AND VIANO I.
High-performance liquid chromatography-mass spectrometric analysis of
cis-dichlorodiamine platinum-DNA complexes using a ion spray interface.
J. Chromatogr. 633: 119-128, 1993.
-
DA COL, R., SILVESTRO, L., NAGGI, A., TORRI, G., BAIOCCHI, C., MOLTRASIO,
D., CEDRO, A. AND VIANO I. Characterization of the chemical structure of
sulphated glycosaminoglycans after enzymatic digestion. Application of liquid
chromatography-mass spectrometry with an atmospheric pressure interface.
J. Chromatogr. 647:289-300, 1993.
-
DIANZANI, C., BRUNELLESCHI, S., VIANO, I. AND FANTOZZI, R.. Adenosine modulation
of primed human neutrophils. Eur. J. Pharmacol. 263:223-226, 1994.
-
SILVESTRO, L., SANFILIPPO, O., ZAFFARONI, N., DA COL, R., LA SALA, L., MERLACH,
P., VIANO, I. AND SILVESTRINI, R. In vitro modulation of cisplatin activity
by interferon-beta on the K562 leukemia cell line. Cell. Pharmacology
1:73-76, 1994.
-
DIANZANI, C., COLANGELO, D., TONSO, E., GUIDOTTO, S. AND VIANO, I. In vivo
antiviral effect of Pidotimod. Arzneim-Forsch Drug Res. 44:1431-1433,
1994.
-
BRUNELLESCHI, S., GUIDOTTO, S., TONSO, E., VIANO, I. AND FANTOZZI, R. Modulation
by protein Kinase C (PKC) of the enhanced responsiveness to tachychinins
in ovalbumin sensitized guinea pig macrophages. Neuropeptides
30:249-260, 1996.
-
BRUNELLESCHI, S., GUIDOTTO, S., VIANO, I., FANTOZZI, R., POZZI, E., GHIO,
P., AND ALBERA C.Tachykinin activation of human alveolar macrophages in tobacco
smoke and sarcoidosis: a phenotypical and functional study.
Neuropeptides 30: In press, 1996.
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