SIF - Società
Italiana di Farmacologia
"SIF - La Ricerca Farmacologica in Italia"
PHARMACOLOGY OF THE
CENTRAL NERVOUS SYSTEM III
RESEARCH GROUP MEMBERS:
-
Fratta Walter , P.O.
-
Fadda Paola*, R.CNR
-
Martellotta M. Cristina, B.PDR
-
Porcella Anna, B.
-
Pani Luca*, R.CNR
-
Fattore Liana, B.
-
Cossu Gregorio, B.
AFFILIATION:
Dipartimento di Neuroscienze "B.B.Brodie"
*Centro di Studio per la Neurofarmacologia (C.N.R.)
Facoltà di Medicina e Chirurgia
Università di Cagliari
ADDRESS: Via Porcell, 4
CITY: Cagliari
POSTAL CODE: 09124
TELEPHONE: 070-6758421
FAX: 070-657237
E-MAIL: wfratta@unica.it
PUBLICATIONS:
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FADDA, M.C. MARTELLOTTA, G.L. GESSA AND W. FRATTA Dopamine and opioids
interactions in sleep deprivation. Prog. Neuropsychopharmacol. Biol
Psychiat. 17 :pp.269-278; 1993.
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M.KOLMER, H.ALHO, E.COSTA, L.PANI Cloning and tissue specific functional
characterization of the rat Diazepam Binding Inhibitor promoter. 90 :
8439-8443; 1993.
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M.C.MARTELLOTTA, A.KUZMIN, P.MUGLIA, G.L.GESSA AND W. FRATTA Effect of the
calcium antagonist Isradipine on cocaine intravenous self-administration
in rats. Psychopharmacology 113 : 378-380; 1994.
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M.C.MARTELLOTTA, A.KUZMIN, E.ZVARTAU, G.COSSU, G.L.GESSA AND W.FRATTA Isradipine
inhibits nicotine intravenous self-administration in drug-naive mice.
Pharmacol. Biochem. Behav. 52 :271-274; 1995
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P.FADDA, L.PANI, A.PORCELLA AND W.FRATTA Chronic imipramine, L-sulpiride
and mianserin decrease Corticotropin releasing Factor levels in the rat brain.
Neurosci. Lett. 192 :121-123; 1995
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G.L.GESSA, L.PANI, P.FADDA AND W.FRATTA Sleep deprivation in the rat: an
animal model of mania. Eur. Neuropsychopharmacol. 89-93; 1995
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U.SAMADANI, A.PORCELLA, L.PANI, P.F.JOHNSON, J.BURCH, R.PINE, R.H.COSTA Cytokine
Regulation of the Liver Transcription Factor HNF-3 is mediated by the C/EBP
Family and Interferon Regulatory Factor 1. Cell Growth Diff.
6 :879-890; 1995.
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F.MARROSU, M.GIAGHEDDU, W.FRATTA Failure of naloxone to modify EEG interictal
seizure discharges in primary generalized epilepsy after sleep deprivation.
Epilepsia, 37 :56-59; 1996
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A.KUZMIN, M.C.MARTELLOTTA, W.FRATTA, G.L.GESSA AND E.ZVARTAU. Effect of
Isradipine, a Dihydropyridine-calcium antagonist on i.v. self-administration
of morphine in rats. Life Sci. 59 :159-164; 1996
RESEARCH GROUP MEMBERS:
-
Frigo Gianmario, P.O.
-
Lecchini Sergio, P.O.
-
Cosentino Marco, R.U.
-
Marino Franca, T.
-
Giaroni Cristina, D.DR.
-
Leoni Olivia, B.
AFFILIATION:
Dipartimento di Medicina Interna e Terapia Medica
II Facoltà di Medicina e Chirurgia
Università degli Studi di Pavia
ADDRESS: Via Ottorino Rossi, 9
CITY: Varese
POSTAL CODE: 21100
TELEPHONE: 0332 811601
FAX: 0332 811601
E-MAIL: phrm2fmc@ipv36.unipv.it
PUBLICATIONS:
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DE PONTI F, GIARONI C., COSENTINO M., LECCHINI S., FRIGO G.M. Calcium channel
blockers and gastrointestinal motility: basic and clinical aspects.
Pharmacol. Ther. 60: 121-148, 1993.
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MARINO F., MARCOLI M., DE PONTI F., COSENTINO M., LECCHINI S., FRIGO G.M.
Effect of desipramine-induced blockade of neuronal uptake mechanisms on
adrenoceptor-mediated responses in the guinea-pig colon. Naunyn-Schmied.
Arch. Pharmacol. 350: 499-506, 1994.
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COSENTINO M., DE PONTI F., MARINO F., GIARONI C., LEONI O., LECCHINI S.,
FRIGO G.M. N-methyl-D-aspartate receptors modulate neurotransmitter release
and peristalsis in the guinea-pig isolated colon. Neurosci. Lett.
183: 139-142, 1995.
-
COSENTINO M., MARINO F., DE PONTI F., GIARONI C., SOMAINI L., LEONI O., LECCHINI
S., FRIGO G.M. Tonic modulation of neurotransmitter release in the guinea-pig
myenteric plexus: effect of mu and kappa opioid receptor blockade and of
chronic sympathetic denervation. Neurosci. Lett. 194: 185-8, 1995.
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DE PONTI F., GIARONI C., COSENTINO M., LECCHINI S., FRIGO G.M. Adrenergic
mechanisms in the control of gastrointestinal motility: from basic science
to clinical applications. Pharmacol. Ther. 69: 59-78, 1996.
-
COSENTINO M., LEONI O., RISPOLI L., PELLEGRINI C., FINAVERA L., LECCHINI
S. FRIGO G.M. A one-year study of drug prescriptions and adverse drug reactions
in psychiatric hospital practice. Pharmacoepidemiology and drug safety,
In press, 1996.
-
COSENTINO M., FIETTA AM., CALDIROLI E., MARINO F., RISPOLI L., COMELLI M.,
LECCHINI S., FRIGO GM. Assessment of lymphocyte subsets and neutrophil leukocyte
function in chronic psychiatric patients on long-term drug therapy. Prog.
Neuro-Psychopharmacol. Biol. Psychiat., In press, 1996.
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COSENTINO M., LEONI O., BANFI F., LECCHINI S. FRIGO G.M. Attitudes to adverse
drug reaction reporting by medical practitioners in a northern italian district.
Pharmacol. Res. In press, 1996.
RESEARCH GROUP MEMBERS :
-
Fumagalli Guido, P.O.
-
Sala Carlo, D.DR.
-
Sava Anna, D.DR.
-
Mion Silvia, B.
-
Francolini Maura, B.
-
Di Mauro Debora, B.PDR.
AFFILIATION:
Istituto di Farmacologia
Facoltà di Medicina e Chirurgia
Università di Verona
ADDRESS: Ospedale di Borgo Roma
CITY: Verona
POSTAL CODE: 37134
TELEPHONE: 045-8098605
FAX: 045-581111
E-MAIL: fumagalli@farma.univr.it
PUBLICATIONS :
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ANDREOSE J.S., XU R., LØMO T., SALPETER M.M. AND FUMAGALLI G.: Degradation
of two AChR population at rat neuromuscular junctions: regulation in vivo
by electrical stimulation. J. Neurosci 13: 3433-3438, 1993
-
ANDREOSE J.S., FUMAGALLI G. AND CLEMENTI F.: On the effect of aging on the
distribution of Vaso-Intestinal Polypeptide and Calcitonin Gene-Related
Polypeptide in the rat brain. Neurosci. Lett. 171: 167-171, 1994
-
ANDREOSE J.S., SALA C. AND FUMAGALLI G.: Immunolocalisation of chromogranin
B, secretogranin II, calcitonin gene-related peptide and substance P at
developing and adult neuromuscular synapses. Neurosci. Lett. 174:
177-180, 1994
-
VERDERIO C, COCO S, FUMAGALLI G AND MATTEOLI M: Spatial changes in calcium
signaling during the establishment of neuronal polarity and synaptogenesis.
J. Cell Biol. 126: 1527-1536, 1994
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SALA C, ANDREOSE JS, FUMAGALLI G AND LØMO T: Calcitonin gene-related
peptide: possible role in formation and maintenance of neuromuscular
junctions. J. Neurosci. 15: 520-528, 1995
-
ANDREOSE JS, FUMAGALLI G AND LØMO T: Number of junctional acetylcholine
receptors: control by neural and muscular influences in the rat. J.
Physiol. 483.2: 397-406, 1995
-
VERDERIO C, COCO S, FUMAGALLI G AND MATTEOLI M: calcium-dependent glutamate
release during neuronal development and synaptogenesis: Different involvement
of w-Aga-IVA- and -CTx-GVIA-sensitive channels. Proc. Nat. Acad. Sci.
USA 92: 6449-6453,1995
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LORENZON P, ZACCHETTI D, CODAZZI F, FUMAGALLI G, MELDOLESI J AND GROHOVAZ
F: Ca2+ waves in PC12 neurites: a bidirectionl, receptor-oriented form of
Ca2+ signaling. J. Cell Biol. 129: 797-804, 1995
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MATTEOLI M., VERDERIO C., KRAWZESKI K., MUNDIGL O., COCO S., FUMAGALLI G.
AND DE CAMILLI P.: Mechanisms of synaptogenesis in hippocampal neurons in
primary culture. J. Physiol. 89: 51-55, 1995
-
ANDREOSE J. S., FUMAGALLI G., SIGWORTH F. J. AND CAPLAN M. J.: Real-time
detection of the surface delivery of newly synthesized membrane proteins.
Proc. Nat. Acad Sci. USA, 93: 7661-7666, 1996.
RESEARCH GROUP MEMBERS:
-
Galli Alessandro, P.A.
-
Mori Francesca, D.DR.
AFFILIATION:
Dipartimento di Farmacologia Preclinica e Clinica
Facoltà di Farmacia
Università di Firenze
ADDRESS: Viale G.B. Morgagni 65
CITY: Firenze
POSTAL CODE: 50134
TELEPHONE: 055-4237416
FAX: 055-4361613
E-MAIL: gallia@stat.ds.unifi.it
PUBLICATIONS :
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GALLI, A., MORI, F., BARGELLINI, M., AND COPPINI, L. Sodium-dependent release
of exogenous glycine from preloaded rat hippocampal synaptosomes. J. Neur.
Transm., 93: 167-179, 1993.
-
COLOTTA, V., CECCHI, L., CATARZI, D., FILACCHIONI, G., GALLI A., AND MORI,
F. Synthesis and structure-activity relationships of 1-aminophthalazinium
salts as GABAA receptor antagonists. Eur. J. Med. Chem. 29: 95-105,
1994.
-
GALLI, A., MORI, F., BENINI, L., AND CACCIARELLI, N. Acetylcholinesterase
protection and the anti-diisopropylfluorophosphate efficacy of E2020. Eur.
J. Pharmacol., 270: 189-193, 1994.
-
MORONI, F., GALLI, A., MANNAIONI, G., CARLà, V., COZZI, A., MORI,
F., MARINOZZI, M., AND PELLICCIARI, R. NMDA receptor heterogeneity in mammalian
tissues: focus on two agonists, (2S,3R,4S)cyclopropylglutamate and the sulfate
ester of 4-hydroxy-(S)-pipecolic acid. Naunyn-Schmied. Arch. Pharmacol.
351: 371-376, 1995.
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PELLICCIARI, R., ARENARE, L., DE CAPRARIIS, P., NATALINI, B., MARINOZZI,
M., AND GALLI, A. Synthesis of all four diasteroisomers of
4-(carboxymethyl)proline, a conformationally constrained analogue of
2-aminoadipic acid. J. Chem. Soc. Perkin Trans., 1,1251-1257, 1995.
-
GALLI, A., AND MORI, F. Acetylcholinesterase inhibition and protection by
dizocilpine (MK-801) enantiomers. J. Pharm. Pharmacol. 48: 71-76,
1996.
-
COLOTTA, V., CATARZI, D., VARANO, F., MELANI, F., FILACCHIONI, G., CECCHI,
L., GALLI, A., AND COSTAGLI, C. Benzodiazepine binding activity of some tricyclic
heteroaromatic systems to define the hydrogen bonding strength of the proton
donors of the receptor site. Farmaco. 51: 223-229, 1996.
-
COLOTTA, V., CATARZI, D., VARANO, F., CECCHI, L., FILACCHIONI, G., COSTAGLI,
C., AND GALLI, A. Synthesis and binding activity of some
pyrazolo[1,5-c]quinazolines as tools to define an optional binding site of
a benzodiazepine receptor ligand. J. Med. Chem., In press, 1996.
RESEARCH GROUP MEMBERS:
-
Gandolfi Ottavio, P.A.
-
Dall'Olio Rossella, R.U.
-
Rimondini Roberto, B.
AFFILIATION:
Dipartimento di Farmacologia
Facoltà di Medicina e Chirurgia
Università degli Studi di Bologna
ADDRESS: Via Irnerio, 48
CITY: Bologna
POSTAL CODE: 40126
TELEPHONE: 051-242025, 243101, 249561
E-MAIL: Gandolfi@biocfarm.unibo.it
PUBLICATIONS:
-
DALL'OLIO R., AND GANDOLFI O. The NMDA positive modulator D-cycloserine
potentiates the neuroleptic activity of D1 and D2 dopamine receptor blockers
in the rats. Psychopharmacology. 110: 165-168, 1993.
-
GANDOLFI O., AND DALL'OLIO R. Chronic treatment with MK-801 decreases D2
dopamine receptor function in rat striatum. Pharmacol. Biochem.
Behav. 44: 683-687, 1993.
-
DALL'OLIO R., RIMONDINI R., AND GANDOLFI O. The NMDA sensitive modulator
D-cycloserine inhibits dopamine-mediated behaviors in the rat.
Neuropharmacology. 33: 55-59, 1994.
-
GANDOLFI O., DALL'OLIO R., RIMONDINI R., BONGRANI S., AND VALSECCHI B. Repeated
administrations of (-)-deprenyl increase [3H]-MK 801 binding in rat brain
and antagonize the impairment of passive avoidance conditioning induced by
N-methyl-D-aspartate receptor antagonists. Neurosci. Lett. 165: 113-116,
1994.
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FACCHINETTI F., DALL'OLIO R., CIANI E., SPARAPANI M., VIRGILI M., AND
CONTESTABILE A. Long lasting effects of chronic neonatal blockade of NMDA
receptor through the competitive antagonist CGP 39551 in rats.
Neuroscience. 60: 343-353, 1994.
-
GANDOLFI O., RIMONDINI R., AND DALL'OLIO R. D-cycloserine decreases both
D1 and D2 dopamine receptors number and their function in rat brain.
Pharmacol. Biochem. Behav. 48: 351-356, 1994.
-
DALL'OLIO R., FACCHINETTI R., CONTESTABILE A., AND GANDOLFI O. Chronic neonatal
blockade of N-methyl-D-aspartate receptor by CGP 39551 increases dopaminergic
function in adult rat. Neuroscience. 63: 451-455, 1994.
-
DALL'OLIO R., RIMONDINI R., AND GANDOLFI O. The competitive NMDA antagonists
CGP 43487 and APV potentiate dopaminergic function.
Psychopharmacology. 118: 310-315, 1995.
-
DALL'OLIO R., RIMONDINI R., AND GANDOLFI O. Effect of NMDA receptor antagonists
on D1, D2, D1/D2 mediated behaviors in intact rats.
Psychopharmacology. 123 : 187-190, 1996.
-
GANDOLFI O., AND DALL'OLIO R. Modulatory role of dopamine on excitatory aminoacid
receptors. Prog. Neuro-Psychopharmacol. Biol. Psychiat. 20: 659-671,
1996.
RESEARCH GROUP MEMBERS:
-
Gessa Gian Luigi, P.O.
-
Collu Maria, R.U
-
Imperato Assunta, T.L.
-
Devoto Paola, T.L.
-
Colombo Giancarlo, R.CNR
-
Obinu Maria Carmen, D.DR.
-
Fà Mauro, D.DR.
-
Lobina Carla, D.DR
-
Reali Roberta, D.DR.
-
Casu Maria Antonietta, D.DR.
-
Mascia Maria Stefania, D.DR.
-
Agabio Roberta, B.
-
Muntoni Annalisa, B.
-
Melis Miriam ,.
-
Pistis Marco, B.
-
Marchese Giorgio, B.
AFFILIATION:
Dipartimento di Neuroscienze "B.B. Brodie"
Facoltà di Medicina e Chirurgia
Università di Cagliari
ADDRESS: Via Porcell, 4
CITY: Cagliari
POSTAL CODE: 09124
TELEPHONE: 070-6758318
FAX: 070-657237
E-MAIL: LGessa@unica.it
PUBLICATIONS:
-
IMPERATO, A., OBINU, M.C., CASU M.A., MASCIA, M.S., DAZZI, L., AND GESSA,
G.L., Evidance That Neuroleptics Increase Striatal Acetylcholine Release
through Stimulation of Dopamine D1 Receptors. J. Pharmacol. Exp. Ther..
266:557-562, 1993.
-
IMPERATO, A., OBINU, M.C., AND GESSA, G.L., Stimulation of both dopamine
D1 and D2 receptors facilitates in vivo acetylcholine release in the
hippocampus. Brain Res. 618:341-345,1993.
-
IMPERATO, A., OBINU, M.C., AND GESSA, G.L., Effects of cocaine and amphetamine
on acetylcholine release in the hippocampus and caudate nucleus. Eur.
J. Pharmacol. 238:377-381, 1993.
-
IMPERATO, A., OBINU, M.C., DAZZI, L., AND GESSA, G.L., Does dopamine exert
a tonic inhibitory control on the release of striatal acetylcholine in vivo?
Eur. J. Pharmacol. 251:271-279, 1994.
-
COLOMBO, G., AGABIO, R., LOBINA, C., REALI, R., FADDA, F., AND GESSA., G.L.,
Blockade of ethanol discrimination by isradipine. Eur. J. Pharmacol.
265: 167-170, 1994.
-
COLOMBO, G., AGABIO, R., LOBINA, C., REALI, R., FADDA, F., AND GESSA., G.L.,
Symmetrical generalization between the discriminative stimulus effects of
gamma- hydroxybutyric acid and ethanol: Occurrence within narrow dose ranges.
Physiol. Behav. 57: 105-111,1995.
-
COLOMBO, G., AGABIO, R., LOBINA, C., REALI, R., FADDA, F., AND GESSA.,
G.L.,Cross-tolerance to ethanol and y-hydroxybutyric acid. Eur. J.
Pharmacol. 273: 235-238, 1995.
-
D'AQUILA, P.S., COLLU, M., PANI, L., GESSA, G.L., AND SERRA, G.,
Antidepressant-like effect of selective D1 receptor agonists in the behavioural
despair animal model of depression. Eur. J. Pharmacol. 262: 107-111,
1995.
-
DEVOTO, P., COLLU, M., MUNTONI, A.M., PISTIS, M., SERRA, G., GESSA, G.L.,
AND DIANA, M., Biochemical and electrophysiological effects of 7-OH-DPAT
on the mesolimbic dopaminergic system. Synapse 20:153-155, 1995.
-
COLLU, M., POGGIU, A.S., PANI, L., AND SERRA, G., Fluoxetine -induced conditioned
place preference: a preliminary study. Synapse, In press, 1996.
RESEARCH GROUP MEMBERS:
-
Gorio Alfredo, P.O.
-
Di Giulio Anna Maria, P.A.
-
Vergani Letizia, D.DR.
-
De Tollis Angela, Specializzanda
-
Finco Cristina, B.
-
Lesma Elena, D.DR.
-
Germani Elena, D.DR.
AFFILIATION:
Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica
Facoltà di Medicina e Chirurgia
Università degli Studi di Milano
ADDRESS: Via Vanvitelli, 32
CITY: Milano
POSTAL CODE: 20129
TELEPHONE: 02-70146-360, 364
FAX: 02-70146-368
E-MAIL: AMDG@imiucca.csi.unimi.it
ALGORIO@imiucca.csi.unimi.it
PUBLICATIONS:
-
GORIO A., DONADONI M.L., DI GIULIO A.M.,
Nitric oxide sensitive protein ADP-ribosylation is altered in diabetic
neuropathy. J. Neurosci. Res., 40 : 420-426, 1995
-
DONADONI M.L., GAVEZZOTTI R., BORELLA
F., DI GIULIO A.M., GORIO A., Experimental diabetic neuropathy. Inhibition
of protein mono-ADP-ribosylation prevents reduction of substance P axonal
transport. J. Pharm. Exp. Ther., 274 : 570-576, 1995
-
DI GIULIO A.M., LESMA E., GORIO A., Diabetic
neuropathy in the rat. I. Alcar augments the reduced levels and axoplasmatic
transport of substance P. J. Neurosci. Res., 40 : 414-419,
1995
-
DI GIULIO A.M., TENCONI B., MALOSIO M.L.,
VERGANI L., BERTELLI A., GORIO A., Perinatal morphine. I: Effects on synapsin
and neurotransmitter system in the brain. J. Neurosci. Res., 42 :
479-485, 1995
-
GERMANI E., LESMA E., DE BIASI S., DI
GIULIO A.M., BERTELLI A., GORIO A., Perinatal morphine. II: Changes in cortical
plasticity, J. Neurosci. Res., 42 : 829-834, 1995
-
CONTI A.M., SCARPINI E., MALOSIO M.L.,
DI GIULIO A.M., BARON P., SCARLATO G., MANTEGAZZA P., GORIO A., In situ
hybridization of Po and MBP myelin protein mRNA in experimental diabetic
neuropathy. Neurosci. Lett., 206 : 1-5, 1996
-
TENCONI B., LESMA E., DI GIULIO A.M.,
GORIO A., High opioid doses inhibit whereas low doses enhance neuritogenesis
in PC12 cells. Develop. Brain Res., 94 : 175-181, 1996
-
GORIO A., VERGANI L., MALOSIO M.L., LESMA
E., DI GIULIO A.M., Perinatal exposure to morphine: reactive changes in the
brain after 6-hydroxidopamine, Eur. J. Pharmacol., 303 : 21-26,
1996
-
GORIO A., MALOSIO M.L., VERGANI L., DI
GIULIO A.M., Exposure to morphine promotes developmental changes in the rat
striatum. Int. J. Develop. Neurosci., 14 : 471-479, 1996
RESEARCH GROUP MEMBERS:
-
Govoni Stefano, P.O. *
-
Racchi Marco,D.DR. # ^
-
Ianna Paola ,B. #
-
Gasparini Laura, B. ^
-
Benussi Luisa, B ^
AFFILIATION :
* Istituto di Farmacologia, Facoltà di Farmacia Università
di Pavia
# Istituto di Scienze Farmacologiche, Facoltà di Farmacia,
Università di Milano
^ Lab. di Neurobiologia Cellulare e Molecolare, Istituto Sacro Cuore FBF,
Brescia
ADDRESS: Viale Taramelli 14
CITY: Pavia
POSTAL CODE: 27100
TELEPHONE: 0382/507397
FAX: 0382/507405
E-MAIL: Govoni@isfunix.farma.unimi.it
PUBLICATIONS:
-
GOVONI S., BERGAMASCHI S., RACCHI M., BATTAINI F., BINETTI G., BIANCHETTI
A. AND TRABUCCHI M.: Cytosol protein kinase C downregulation in fibroblasts
from Alzheimer' disease patients, Neurology 43 : 2581-2586, 1993.
-
RACCHI M., BERGAMASCHI S., GOVONI S., WETSEL W.C., BIANCHETTI A., BINETTI
G., BATTAINI F. AND TRABUCCHI M.: Characterization of presence and distribution
of protein kinase C isoforms in human skin fibroblasts. Arch. Biochem.
Biophys. 314: 107-111, 1994.
-
FRISONI G.B., GOVONI S., GEROLDI C., BIANCHETTI A., CALABRESI L., FRANCESCHINI
G., TRABUCCHI M.: Gene dose of the e4 allele of apolipoprotein E and disease
progression in sporadic late-onset Alzheimer's disease. Ann. Neurol.
37 : 110-118, 1995.
-
BERGAMASCHI S., BINETTI G.,GOVONI S.,WETSEL W.C.,BATTAINI F.,TRABUCCHI
M.,BIANCHETTI A. AND RACCHI M.: Defective phorbol ester stimulated secretion
of b-amyloid precursor protein from Alzheimer's disease fibroblasts.
Neurosci. Lett.,201 : 1-4 1995.
-
PERRONE R., BERARDI F., COLABUFO N.A., LEOPOLDO M., TORTORELLA V., FIORENTINI
F., OLGIATI V., GHIGLIERI A., GOVONI S., High affinity and selectivity on
5HT1A receptor of 1-aryl-4-((1-tetralin)alkyl)piperazines. 2., J. Med.
Chem. 38 : 942-949, 1995.
-
HIRASHIMA N. ,ETCHEBERRIGARAY R. ,BERGAMASCHI S. ,RACCHI M., BATTAINI F.,
BINETTI G. ,GOVONI S., AND ALKON D.: Intracellular release and influx of
calcium: diagnostic molecular profile for Alzheimer's disease fibroblasts.
Neurobiol. Aging, 17:549-555, 1996.
-
GOVONI S., GASPARINI L., RACCHI M., AND TRABUCCHI M.: Peripheral cells as
an investigational tool for Alzheimer's disease. Life Sci. 59: 461-468,
1996
-
GOVONI S., BERGAMASCHI S., GASPARINI L., QUAGLIA C., RACCHI M., CATTANEO
E., BINETTI G., BIANCHETTI A., GIOVETTI F., BATTAINI F., AND TRABUCCHI M.
: Fibroblasts of patients affected by Down's syndrome oversecrete amyloid
precursor protein and are hyporesponsive to protein kinase C stimulation.
Neurology,47:1069-1075, 1996
-
BERARDI F., COLABUFO N.A., GIUDICE G., PERRONE R., TORTORELLA V., GOVONI
S., LUCCHI L., New sigma and 5HT1A receptor ligands
w-(tetralin-1-yl)-n-alkylamine derivatives. J.
Med.Chem. 39 : 176-182, 1996.
- RACCHI M., BAETTA R., SALVIETTI N., IANNA., FRANCESCHINI G., PAOLETTI R.,
FUMAGALLI R., GOVONI S., TRABUCCHI M., AND SOMA M. : Secretory processing
of amyloid precursor protein is inhibited by increase in cellular cholesterol
content. Biochem J., In press, 1996.
RESEARCH GROUP MEMBERS :
-
Matteoli Michela, R.CNR
-
Verderio Claudia, D.DR.
-
Coco Silvia, B.
-
Bacci Alberto, D.DR.
AFFILIATION :
Centro CNR per lo Studio della Farmacologia Cellulare e Molecolare
Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica
Università di Milano
ADDRESS: via Vanvitelli 32
CITY: Milano
POSTAL CODE: 20129
TELEPHONE: 02-70146-391, 254
FAX: 02-7490574
E-MAIL: MichelaM@Farma.csfic.cnr.mi.it
PUBLICATIONS :
-
MUNDIGL, O., MATTEOLI, M., DANIELL, L., THOMAS REETZ, A., MATCALF, A., JAHN,
R. AND DE CAMILLI, P. Synaptic vesicle proteins in cultured hippocampal neurons:
differential effects of brefeldin A in axon and dendrites. J. Cell
Biol., 122: 1207-1221, 1993.
-
CAPORASO, G.L., TAKEI, K., GANDY, S.E., MATTEOLI, M., MUNDIGL, O., GREENGARD,
P. AND DE CAMILLI, P. Microscopic and biochemical examination of the
intracellular traffic of the Alzheimer b/A4 Amyloid Precursor Protein. J.
Neurosci.,14: 3122-3138, 1994.
-
VERDERIO, C., COCO, S., FUMAGALLI, G. AND MATTEOLI, M. Activity independent
spatial changes in calcium signaling during the establishment of neuronal
polarity. J. Cell Biol., 126: 1527-1536, 1994.
-
MUNDIGL, O., VERDERIO, C., KRASZEWSKI, K., DE CAMILLI, P. AND MATTEOLI, M.
A radioimmunoassay to monitor synaptic activity in hippocampal neurons in
vitro. Eur. J. of Cell Biol., 66: 246-256, 1995.
-
KRASZEWSKI, K., MUNDIGL, O., DANIELL, L., VERDERIO, C., MATTEOLI, M. AND
DE CAMILLI, P. Synaptic vesicle dynamics in living cultured hippocampal neurons
visualized with CY3-conjugated antibodies directed against the lumenal domain
of synaptotagmin. J. Neurosci, 15: 4328-4342, 1995.
-
VERDERIO, C., COCO, S., FUMAGALLI ,G. AND MATTEOLI, M. Calcium-dependent
glutamate release during neuronal development and synaptogenesis: different
involvement of w-aga-iva and w-ctx-gvia sensitive channels. Proc. Nat.
Acad. Sci. USA 92: 6449-6453, 1995.
-
MATTEOLI, M., VERDERIO, C., KRAWZESKI, K., MUNDIGL, O., COCO, S., FUMAGALLI,
G. AND DE CAMILLI, P. Mechanisms of synaptogenesis in hippocampal neurons
in primary culture. J. Physiol., 89: 51-55, 1995.
-
MATTEOLI,M., VERDERIO, C., ROSSETTO, O., IEZZI,N., COCO, S., SCHIAVO, G.
AND MONTECUCCO, C. Synaptic vesicle endocytosis mediates the entry of tetanus
neurotoxin into hippocampal neurons. Proc Nat. Acad. Sci. USA
In press, 1996.
RESEARCH GROUP MEMBERS:
-
Melchiorri Pietro, P.O.
-
ImprotaGiovanna,P.A.
-
Negri Lucia, P.A.
-
Sopranzi Nello, P.A.
-
Broccardo Maria, R.U.
-
Noviello Vittoria, R.U.
-
Noviello Lia, R.U.
-
Lattanzi Roberta, D.DR.
-
LuchettiFabio, D.DR.
-
Narzi Lorena, D.DR.
-
Tabacco Alessandra, D.DR.
-
Tabacco Fabio, D.DR.
AFFILIATION:
Istituto di Farmacologia Medica
Facoltà di Medicina e Chirurgia
Università "La Sapienza" di Roma
ADDRESS: Piazzale A. Moro,5
CITY: Roma
POSTAL CODE: 00185
TELEPHONE: 06-49912488
FAX : 06-4450307
E-MAIL: melchiorri@uniromal.it
PUBLICATIONS:
-
RENDA,T., NEGRI, L., TOOYAMA, I., CASU, C., AND MELCHIORRI, P. Autoradiographic
study on [3H] [D-Ala2 ]deltorphin-I binding sites in
the rat brain. NeuroReport. 4: 1143- 1146, 1993.
-
BROCCARDO, M., AND IMPROTA, G. Sauvagine-induced hypothermia: evidence for
an interaction with the dopaminergic system. Eur. J. Pharmacol. 258:
179-184, 1994.
-
IMPROTA, G., AND BROCCARDO, M. Effect of selective m1,
m2 and d2 opioid receptor agonists on gastric functions
in the rat. Neuropharmacology. 33: 977-981, 1994.
-
NEGRI L., LATTANZI R., AND MELCHIORRI P. Lys7 dermorphin, a naturally occuring
peptide with high affinity for opioid receptors, produces antinociception
by peripheral administration. Brit. J. Pharmacol. 114 : 57-66,
1995.
-
NEGRI, L., IMPROTA, G., LATTANZI, R., POTENZA, R. L., LUCHETTI, F., AND
MELCHIORRI, P. Interaction between the mu agonist dermorphin and the delta
agonist [D-Ala2, Glu4]deltorphin in supraspinal
antinociception and_d opioid receptor binding. Brit. J. Pharmacol.
116: 2931-2938, 1995.
-
KITCHEN, I., LESLIE, F.M., KELLY, M., BARNES, R., CROOK, T.J., HILL, R.J.,
BORSODI, A., TOTH, G., MELCHIORRI, P., AND NEGRI, L. Development of d-opioid
receptor subtypes and the regulatory role of weaning: radioligand binding,
autoradiography and in situ hybridization studies. J. Pharmacol. Exp.
Ther. 275: 1597-1607, 1995.
-
BROCCARDO, M., IMPROTA, G., AND SEVERINI C. Parallel bioassay of PG-SPI,
an amphibian acidiclike peptide, mammalian basic substance P and neurokinins
A and B, on in vitro and in vivo test systems. Peptides, 16: 609-614,
1995.
-
BROCCARDO, M., IMPROTA, G., BRANDONI, A., AND TABACCO A. Effect of PG-SPI
and PG-KII, two novel and natural tachykinins, on salivary secretion in the
rat. Peptides, 17: 729-732, 1996.
-
NEGRI, L., NOVIELLO, L., AND NOVIELLO, V. Antinociceptive and behavioral
effects of synthetic deltorphin analogs. Eur. J. Pharmacol. 296: 9-16,
1996.
RESEARCH GROUP MEMBERS:
-
Meldolesi Jacopo, P.O.
-
Gatti Giuliana, T.L.
-
Malosio M.Luisa, B. PDR.
-
Lievremont J. Philippe, B.PDR.
-
Podini Paola, R.
-
Borgonovo Barbara, D. DR.
-
Racchetti Gabriella, T.
AFFILIATION:
Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica
Facoltà di Medicina e Chirurgia
Università di Milano e DIBIT, Istituto Scientifico San Raffaele
ADDRESS: Via Olgettina, 58
CITY: Milano
POSTAL CODE: 20090
TELEPHONE: 02-2643 2770
FAX: 02-2643 4813
E-MAIL: meldolj@dibit.hsr.it
PUBLICATIONS:
-
POZZAN, T., RIZZUTO, R., VOLPE, P. AND MELDOLESI J. Molecular and cellular
physiology of intracellular Ca2+ stores. Physiol. Rev. 74: 595-637,
1994.
-
FISCHER, G.A., CLEMENTI, E., RAICHMAN, M., SUDHOF, T., ULLRICH, A. AND MELDOLESI
J. Stable expression of truncated inositol 1,4,5-trisphosphate receptor subunits
in 3T3 fibroblasts: coordinate signalling changes and differential suppression
of cell growth and transformation. J. Biol. Chem. 269: 19216-19224,
1994.
-
RAICHMANN, M., PANZERI, M.C., CLEMENTI, E., PAPAZAFIRI, P., ECKLEY, M., CLEGG,
D.O., VILLA, A. AND MELDOLESI J. Differential localization and functional
role of calsequestrin in growing and differentiated myoblasts. J. Cell
Biol. 128: 341-354, 1995.
-
GRIERSON, J.P. AND MELDOLESI J. Shear stress-induced [Ca2+]i transients and
oscillations in mouse fibroblasts are mediated by endogenously released ATP.
J. Biol. Chem. 270: 4451-4456, 1995.
-
LORENZON, P., ZACCHETTI, D., CODAZZI, F., FUMAGALLI, G., MELDOLESI, J.
AND GROHOVAZ F. Ca2+ waves in PC12 neurites a bidirectional, receptor
oriented form of Ca2+ signalling. J. Cell Biol. 129: 797-804, 1995.
-
BASTIANUTTO, C., CLEMENTI, E., CODAZZI, F., PODINI, P., DE GIORGI, F., RIZZUTO,
R., MELDOLESI, J. AND POZZAN T. Overexpression of calreticulin increases
the Ca2+ capacity of rapidly exchanging Ca2+ stores and reveals aspects of
their lumenal microenvironment and function. J. Cell Biol. 130: 847-855,
1995.
-
LORENZON, P., ZACCHETTI, D., CODAZZI, F., FUMAGALLI, G., MELDOLESI, J.
AND GROHOVAZ F. Ca2+ waves in PC12 neurites a bidirectional, receptor
oriented form of Ca2+ signalling. J. Cell Biol. 129: 797-804, 1995.
-
BASTIANUTTO, C., CLEMENTI, E., CODAZZI, F., PODINI, P., DE GIORGI, F., RIZZUTO,
R., MELDOLESI, J. AND POZZAN T. Overexpression of calreticulin increases
the Ca2+ capacity of rapidly exchanging Ca2+ stores and reveals aspects of
their lumenal microenvironment and function. J. Cell Biol. 130: 847-855,
1995.
-
MELDOLESI, J., KRAUSE, H. AND MICHALAK M. Calreticulin: how many functions
in how many cellular compartments? Cell Calcium 20: 83-86, 1996.
-
CORRADI, N., BORGONOVO, B., CLEMENTI, E., BASSETTI, M., RACCHETTI, G., CONSALEZ,
G.G., HUTTNER, W.B., MELDOLESI, J. AND ROSA P. Overall lack of regulated
secretion in a PC12 variant cell clone. J. Biol. Chem. In press, 1996.
RESEARCH GROUP MEMBERS :
-
Miele Egidio, P.O.
-
De Natale Guglielmo, P.O.
-
Miele Maddalena, R.U.
-
Enrico Paolo, R.U.
AFFILIATION:
Istituto di Farmacologia
Facoltà di Medicina e Chirurgia
Università di Sassari
ADDRESS: Viale S.Pietro 43B
CITY: Sassari
POSTAL CODE: 07100
TELEPHONE: 079-2285-15,16,17,26,27,56,57
079-218024
FAX: 079-228525
E-MAIL : pharmaco@ssmain.uniss.it
PUBLICATIONS :
-
MIELE M., BOUTELLE M.G. AND FILLENZ M. The physiologically-induced release
of ascorbate in rat brain is dependent on impulse traffic, calcium influx
and glutamate uptake. Neuroscience 62: 87-91, 1994.
-
MIELE M., ESPOSITO G., SIRCANA S.,ZANGANI D., MIGHELI R.,FRESU L. AND DESOLE
M.S. Effects of allopurinol on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP)-induced neurochemical changes in the striatum and in the brainstem
of the rat. Neurosci. Lett. 183: 155-159, 1995.
-
MIELE M., ENRICO P., ESPOSITO G., FRESU L., MIGHELI R., DE NATALE G. AND
DESOLE M.S. Cortical ablation and drug-induced changes in striatal ascorbic
acid oxidation and behavior in the rat. Pharmacol. Biochem. Behav.
50: 1-7,1995.
-
DESOLE M.S., MIELE M., ESPOSITO G., MIGHELI R., FRESU L. G., MIGHELI R.,
ZANGANI D., SIRCANA S., GRELLA G. AND MIELE E. Neuronal antioxidant system
and MPTP-induced oxidative stress in the striatum and brainstem of the rat.
Pharmacol. Biochem. Behav. 51: 581-592,1995.
-
DESOLE M.S., ESPOSITO G., MIGHELI R., FRESU L., SIRCANA S., MIELE M., DE
NATALE G. AND MIELE E. Allopurinol protects against manganese-induced oxidative
stress in the striatum and in the brainstem of the rat. Neurosci.
Lett.192:73-76, 1995.
-
MIELE M., BERNERS M., BOUTELLE M. G., KUSAKABE H. AND FILLENZ M. The
determination of true extracellular concentrations of glutamate using
quantitative microdialysis. Brain Res. 707: 131-133, 1996.
-
DESOLE M.S., ESPOSITO G., FRESU L., MIGHELI R., ENRICO P., MURA M. A., DE
NATALE G., MIELE E. AND MIELE M. Effects of morphine treatment and withdrawal
on striatal and limbic monoaminergic activity and ascorbic acid oxidation
in the rat. Brain Res. 723:154-161,1996.
-
MIELE M. AND FILLENZ M. In vivo determination of extracellular brain ascorbate.
J. Neurosci. Meth. 69: 23-28, 1996.
RESEARCH GROUP MEMBERS :
-
Molinengo Costa Luigi, P.O.
-
Orsetti Marco, R.U.
-
Ghi Piera, R.U.
-
Di Carlo Giovanni, D.DR.
AFFILIATION:
Sezione di Farmacologia
Dipartimento di Anatomia, Farmacologia e Medicina Legale
Università di Torino
ADDRESS: Via P. Giuria, 9
CITY: Torino
POSTAL CODE: 10125
TELEPHONE: 011-6707688, 7691
FAX: 011-6707688
PUBLICATIONS:
-
MOLINENGO L., ORSETTI M., GHI P., AND PASTORELLO B. Action of chronic choline
administration on behavior and on cholinergic and noradrenergic systems.
Pharmacol. Biochem. Behav. 44: 587-594, 1993.
-
MOLINENGO L., SCORDO I., AND PASTORELLO B. Action of caffeine, L-PIA and
their combination on memory retention in the rat. Life Sci. 54: 1247-1250,
1994.
-
MOLINENGO L., ORSETTI M., PASTORELLO B., SCORDO I., AND GHI P. The action
of arecoline on retrieval and memory storage evaluated in the staircase maze.
Neurobiol. Learn. Mem. 63: 167-173, 1995.
-
MOLINENGO L., ORSETTI M., PASTORELLO B., SCORDO I., AND GHI P. Habituation
of exploratory activity in rats: action of N6-Phenylisopropyladenosine, caffeine
and their combination. Prog. Neuro-Psychopharmacol. Biol. Psychiat.
1189-1200, 1995.
-
GHI P., FERRETTI C., BLENGIO M., AND PORTALEONE P. Stress induces changes
in histaminergic system: effects of diazepam and amitriptyline. Pharmacol.
Biochem. Behav. 51: 65-68, 1995.
-
GHI P., BLENGIO M., FERRETTI C., AND PORTALEONE P. Stress and brain H3-histamine
receptors. Inflamm. Res. 44: 62-63, 1995.
-
GHI P., FERRETTI C., BLENGIO M. Effects of different types of stress on
histamine-H3 receptors in the rat cortex. Brain Res. 690: 104-107,
1995.
-
ORSETTI M., CASAMENTI F., PEPEU G. Enhanced acetylcholine release in the
hippocampus and cortex during acquisition of an operant behavior. Brain
Res. 724: 89-96, 1996.
-
MOLINENGO L., SCORDO I., PASTORELLO B., ORSETTI M., AND GHI P. Behavioral
and neurochemical effects induced by chronic L-DOPA administration.
Pharmacol. Biochem. Behav. 54: 779-785, 1996.
RESEARCH GROUP MEMBERS :
-
Morelli Micaela, P.O.
-
Fenu Sandro, T.L.
-
Pinna Annalisa, B.
-
Carta Anna, B.
AFFILIATION :
Dipartimento di Tossicologia
Facoltà di Farmacia
Università di Cagliari
ADDRESS: Viale A. Diaz 182
CITY: Cagliari
POSTAL CODE: 09100
TELEPHONE: 070-300437, 300463
FAX: 070-300740
E-MAIL: mmorelli@mbox.vol.it
PUBLICATIONS:
-
MORELLI M., FENU S., COZZOLINO A., PINNA A., CARTA A. AND DI CHIARA G. Blockade
of muscarinic receptors potentiated D-1 dependent turning behavior and c-fos
expression in 6-hydroxydopamine lesioned rats while does not influence D-2
mediated responses. Neurosci. 53: 673-678, 1993
-
MORELLI M., COZZOLINO A., PINNA A., FENU S., CARTA A. AND DI CHIARA G. L-DOPA
stimulates c-fos expression in dopamine denervated striatum by combined
activation of D-1 and D-2 receptors. Brain Res. 623: 334-336, 1993.
-
MORELLI M., FENU S., PINNA A., COZZOLINO A., CARTA A. AND DI CHIARA G. "Priming"
to dopamine agonist-induced contralateral turning as a model of non associative
sensitization to the expression of the post-synaptic dopamine message.
Behav. Pharmacol. 4: 389-397, 1993
-
MORELLI. M., PONTIERI F., LINFANTE I., ORZI F. AND DI CHIARA G. Local cerebral
glucose utilization after D1 receptor stimulation in 6-OHDA lesioned rats:
effect of sensitization (priming) with a dopaminergic agonist.
Synapse, 13: 264-269, 1993.
-
MORELLI M., FENU S., PINNA A. AND DI CHIARA G. Adenosine A-2 receptors interact
negatively with dopamine D-1 and D-2 receptors in unilaterally 6-hydroxydopamine
lesioned rats. Eur. J. Pharmacol. 251: 21-25, 1994.
-
MORELLI M., PINNA A., FENU S., CARTA A., COZZOLINO A. AND DI CHIARA G.
Differential effect of MK 801 and scopolamine on c-fos expression induced
by l-dopa in the striatum of 6-hydroxydopamine lesioned rats. Synapse,
18: 288-293, 1994.
-
FENU S., CARTA A. AND MORELLI M. Modulation of dopamine
D1-mediated turning behavior and striatal c-fos expression by
the substantia nigra. Synapse, 19: 233-240, 1995.
-
FENU S, CARTA A. AND MORELLI M. Intranigral injections of glutamate antagonists
modulate dopamine D-1-mediated turning behavior and striatal c-fos
expression. J. Neural. Transm., 45: 75-81, 1995
-
MORELLI M., PINNA A., WARDAS J. AND DI CHIARA G. Adenosine A2 receptors stimulate
c-fos expression in striatal neurons of 6-hydroxydopamine-lesioned rats.
Neurosci. 67: 49-55, 1995.
-
PINNA A., DI CHIARA G., WARDAS J. AND MORELLI M. Blockade of A2a adenosine
receptors positively modulates turning behavior and c-fos expression induced
by D1 agonists in dopamine denervated rats. Eur. Jour. Neurosci 8:
1176-1181, 1996.
RESEARCH GROUP MEMBERS:
-
Moroni Flavio, P.O.
-
Pellegrini-Giampietro Domenico E.,
R.U.
-
Carlà Vincenzo, R.U.
-
Cozzi Andrea, T.
-
Leonardi Patrizia, B.
-
Mannaioni Guido, B.
-
Chiarugi Alberto, B.
-
Carpenedo Raffaella, B.
-
Albani Torregrossa Serenella, D.DR.
-
Attucci Sabina, D.DR.
-
Peruginelli Fiamma, B.
AFFILIATION:
Dipartimento di Farmacologia Preclinica e Clinica "Mario Aiazzi Mancini"
Università degli Studi di Firenze
ADDRESS: Viale G.B. Morgagni, 65
CITY: Firenze
POSTAL CODE: 50134
TELEPHONE: 055-4237-411, 419, 433, 428, 459
FAX: 055-4361-613
E-MAIL: moronif@stat.ds.unifi.it,
dompel@stat.ds.unifi.it
PUBLICATIONS:
-
LOMBARDI, G., ALESIANI, M., LEONARDI, P., CHERICI, G., PELLICCIARI, R. AND
MORONI, F. Pharmacological characterization of the metabotropic glutamate
receptor inhibiting D-3H-aspartate output in rat striatum, Brit.
J. Pharmacol. 110 : 1407-1412, 1993.
-
CARPENEDO, R., CHIARUGI, A., RUSSI, P., LOMBARDI, G., CARLà, V.,
PELLICCIARI, R., MATTOLI, L. AND MORONI, F. Inhibitors of kynurenine hydroxylase
and kynureninase increase cerebral formation of kynurenic acid and have sedative
and anticonvulsant activities, Neuroscience, 61 :237-244, 1994.
-
FRIEDMAN, L.K., PELLEGRINI-GIAMPIETRO, D.E., SPERBER, E.F., BENNETT, M.V.L.,
MOSHÉ, S.L. AND ZUKIN, R.S. Kainate-induced status epilepticus alters
glutamate and GABAA receptor gene expression in adult rat hippocampus:
an in situ hybridization study, J. Neurosci. 14 :2697-2707, 1994.
-
LOMBARDI, G., MORONI, F.J. AND MORONI, F. Glutamate receptor antagonists
protect against ischemia-induced retinal damage, Eur. J. Pharmacol.
271 :489-495, 1994.
-
PELLEGRINI-GIAMPIETRO, D.E., PULSINELLI, W.A. AND ZUKIN, R.S. NMDA and non-NMDA
receptor gene expression following global ischemia in rats: effect of NMDA
and non-NMDA receptor antagonists, J. Neurochem. 62 :1067-1073,
1994.
-
PELLEGRINI-GIAMPIETRO, D.E., COZZI, A. AND MORONI, F. The glycine antagonist
and free radical scavenger 7-Cl-thio-kynurenate reduces CA1 ischemic damage
in the gerbil, Neuroscience, 63 :701-709, 1994.
-
CHIARUGI, A., CARPENEDO, R., MOLINA, M.T., MATTOLI, L., PELLICCIARI, R. AND
MORONI, F. Comparison of the neurochemical and behavioral effects resulting
from the inhibition of kynurenine hydroxylase and/or kynureninase. J.
Neurochem. 65 :1176-1183, 1995.
-
LOMBARDI, G., LEONARDI, P. AND MORONI, F. Metabotropic glutamate receptors,
transmitter output and fatty acids: studies in rat brain slices, Brit.
J. Pharmacol. 117 :189-195, 1996.
-
MANNAIONI, G., CARLà, V. AND MORONI, F. Pharmacological characterization
of metabotropic glutamate receptors potentiating NMDA responses in mouse
cortical wedge preparations, Brit. J. Pharmacol. 118 :1530-1536,
1996.
-
PELLEGRINI-GIAMPIETRO, D.E., ALBANI TORREGROSSA, S. AND MORONI, F.
Pharmacological characterization of metabotropic glutamate receptors coupled
to phospholipase D in the rat hippocampus, Brit. J. Pharmacol.
118 :1035-1043, 1996.
RESEARCH GROUP MEMBERS:
-
Navarra Pierluigi, P.A.
-
Pozzoli Giacomo, R.U.
-
Tringali Giuseppe, B.
-
Pistritto Giuseppa, T.L.
-
Mancuso Cesare, D.D.R.
AFFILIATION :
Istituto di Farmacologia
Facoltà di Medicina e Chirurgia
Università Cattolica del Sacro Cuore
ADDRESS: Largo Francesco Vito, 1
CITY: Roma
POSTAL CODE: 00168
TELEPHONE: 06-3015-4367, 4531
FAX: 06-3050159
PUBLICATIONS:
-
NAVARRA, P., POZZOLI, G., BECHERUCCI, C., PREZIOSI, P., GROSSMAN, A. AND
PARENTE, L. Prostaglandin E2 and bacterial lipopolysaccharide specifically
stimulate interleukin-1 release by rat hypothalamic explants.
Neuroendocrinol. 57: 257-261, 1993.
-
POZZOLI, G., COSTA, A., GRIMALDI, M., SCHETTINI, G., PREZIOSI, P., GROSSMAN
A. AND NAVARRA, P. Bacterial lipopolysaccharide modulation of eicosanoid
and corticotrophin releasing hormone release from rat hypothalamic explants
and astrocyte cultures in vitro: evidence for the involvement of prostaglandin
E2 but not F2, and lack of effect of NGF. J. Endocrinol. 140: 103-109,
1994.
-
YASIN, S., COSTA, A., POZZOLI, G., NAVARRA, P., FORSLING, M. AND GROSSMAN,
A. Endothelin-1 stimulates the in vitro release of neurohypophyseal hormones,
but not corticotrophin-releasing hormone, via ETa receptors.
Neuroendocrinol. 60: 553-558, 1994.
-
POZZOLI, G., MANCUSO, C., MIRTELLA, A., PREZIOSI, P., GROSSMAN, A.B. AND
NAVARRA, P. Carbon monoxide as a novel neuroendocrine modulator: inhibition
of stimulated CRH release from acute rat hypothalamic explants.
Endocrinology 135: 2314-2317, 1994.
-
MIRTELLA, A., TRINGALI, G., GUERRIERO, G., GHIARA, P., PARENTE, L., PREZIOSI,
P. AND NAVARRA, P. Evidence that interleukin-1-induced prostaglandin E2 release
from rat hypothalamus is mediated by both type I and type II receptors. J.
Neuroimmunol. 61: 171-177, 1995.
-
AMBROSETTI, D.-C., PALLA, E., MIRTELLA, A., GALEOTTI, C., SOLITO, E., NAVARRA,
P., PARENTE, L. AND MELLI, M. Synthetic alleles at position 121 define a
functional domain of human interleukin-1. Eur. J. Biochem. 238: 308-316,
1996.
-
COSTA, A., POMA, A., NAVARRA, P., FORSLING,
M.L., GROSSMAN, A. Gaseous transmitters as new agents in neuroendocrine
regulation. J. Endocrinol. 149: 199-207, 1996.
-
KOSTOGLOU-ATHANASSIOU, I., FORSLING,
M.L., NAVARRA, P. AND GROSSMAN, A.B. Oxytocin release is inhibited by the
generation of carbon monoxide from the rat hypothalamus - further evidence
for carbon monoxide as a neuromodulator. Mol. Brain Res. In press,
1996.
-
MANCUSO, C., PISTRITTO, G., TRINGALI, G.,
GROSSMAN, A., PREZIOSI, P. AND NAVARRA, P. Evidence that carbon monoxide
stimulates prostaglandin endoperoxide synthase activity in rat hypothalamic
explants and in primary cultures of rat hypothalamic astrocytes. Mol.
Brain Res. In press, 1996.
-
TRINGALI, G., MANCUSO, C., MIRTELLA,
A., POZZOLI, G., PARENTE, L., PREZIOSI, P. AND NAVARRA, P. Evidence for the
neuronal origin of immunoreactive interleukin-1 released by hypothalamic
explants. Neurosci. Lett. In press, 1996.
RESEARCH GROUP MEMBERS:
-
Navone Francesca, R. CNR
-
Vignali Giovanna, B.
-
Sprocati Maria Teresa, T.
AFFILIATION:
Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica
Università di Milano
Centro CNR per lo Studio della Farmacologia Cellulare e Molecolare
ADDRESS: Via Vanvitelli 32
CITY: Milano
POSTAL CODE: 20129
TELEPHONE: 01-70146-254, 258
FAX: 02-7490574
E-MAIL: segreteria@farma5.csfic.mi.cnr.it
France@farma7.csfic.mi.cnr.it
PUBLICATIONS:
-
NICLAS, J., NAVONE, F., HOM-BOOHER, N., AND VALE, R.D. Cloning and localization
of a conventional kinesin motor expressed exclusively in neurons.
Neuron 12: 1059-1072, 1994.
-
VIGNALI, J., NICLAS, J., SPROCATI, M. T., VALE, R., D., SIRTORI, C., AND
NAVONE, F. Differential expression of ubiquitous and neuronal kinesin heavy
chains during differentiation of human neuroblastoma and PC12 cells. Eur.
J. Neurosci. 8: 536-544, 1996.
RESEARCH GROUP MEMBERS:
-
Nencini Paolo, P.O.
-
Fraioli Sabina, D.DR.
-
Cioli I., B.
-
Nucerito V., B.
AFFILIATION:
Istituto di Farmacologia Medica
Facoltà di Medicina e Chirurgia
Università di Roma "La Sapienza"
ADDRESS: P.le A. Moro 5
CITY: Roma
POSTAL CODE: 00185
TELEPHONE: 06-49912497
FAX: 06-49910348
PUBLICATIONS:
-
NENCINI, P. AND FRAIOLI, S.:Environment specific reinstatement of
amphetamine-mediated hyperdipsia by morphine and (-)-norpseudoephedrine.
Pharmacol. Biochem. Behav. 47 : 339-343, 1994.
-
NENCINI, P. AND VALERI, P.: The role of opioid mechanisms in the anorectic
effects of stimulants: U-50,488H enhances amphetamine inhibition of free
feeding in rats. Pharmacol. Biochem. Behav. 48 : 63-68, 1994.
-
CAMANNI, S. AND NENCINI, P., Physiological and environmental aspects of drinking
stimulated by chronic exposure to amphetamine in rats. Gen. Pharmacol.
24 : 7-13, 1994.
-
NENCINI, P., FRAIOLI, S. AND PERRELLA, D., Tolerance does not develop to
the suppressant effects of (-)-norpseudoephedrine on ingestive behavior in
the rat. Pharmacol. Biochem. Behav. 53 : 297-301, 1996.
RESEARCH GROUP MEMBERS:
-
Nisticò Giuseppe,
P.O.
-
Mollace Vincenzo, R.U.
-
Libri Vincenzo, R.U.
-
Politi Giovanni, C.T.
-
Del Duca Claudio, C.T.
-
Berliocchi Laura, B.
-
Piccirilli Silvia, B.
-
Melchiorri Daniela, D.DR.
AFFILIATION:
Dipartimento di Biologia - Cattedra di Farmacologia
Facoltà di Scienze Matematiche, Fisiche e Naturali
Università di Roma "Tor Vergata"
ADDRESS: Via della Ricerca Scientifica
CITY: Roma
POSTAL CODE: 00133
TELEPHONE: 06-72594875
FAX: 06-2022720
PUBLICATIONS:
-
CONSTANTI A., BAGETTA G., AND LIBRI V. Electrophysiological characterization
of a slow post-stimulus afterdepolarization induced by muscarinic receptor
activation in guinea-pig olfactory cortex neurones in vitro.
Neuroscience. 56: 887-904, 1993.
-
BAGETTA G., IANNONE M., DEL DUCA C., AND NISTICO' G. Inhibition by
Nw-nitro-L-arginine methyl ester of the electrocortical arousal response
in rats. Brit. J. Pharmacol. 108: 858-860. 1993.
-
LIBRI V., CONSTANTI A., CALAMINICI M., AND NISTICO' G. A comparison
of the muscarinic response and morphological properties of identified cells
in the guinea-pig olfactory cortex in vitro. Neuroscience. 59: 331-347,
1994.
-
MOLLACE V., COLASANTI M., RODINO' P., LAURO G.M., AND NISTICO'
G. HIV coating gp120 glycoprotein-dependent prostaglandin E2 release by human
cultured astrocytoma cells is regulated by nitric oxide formation. Biochem.
Biophys. Res. Commun. 203: 87-92, 1994.
-
MOLLACE V., ROMEO F., MARTUSCELLI E., ROSANO G., FEDERICI G., NISTICO'
G., AND MARINO B. Law formation of nitric oxide in polymorphonuclear cells
in unstable angina pectoris. Amer. J. Cardiol. 74: 65-68, 1994.
-
BAGETTA G., AND NISTICO' G. Tetanus toxin as a neurobiological tool
to study the mechanisms of neuronal cell death in the mammalian brain.
Pharmacol. Ther. 62: 29-39, 1994.
-
BAGETTA G., CORASANITI M.T., FINAZZI-AGRO' A., AND NISTICO' G.
Does the HIV-1 coat protein gp120 produce brain damage? TIPS. 15:
363, 1994.
-
BAGETTA G., RODINO' P., PAOLETTI A.M., ARABIA A., MASSOUD R., AND
NISTICO' G. Systemic administration of lithium chloride and tacrine
but not kainic acid augments citrulline content of rat brain. Eur. J.
Pharmacol. 294: 341-344, 1995.
-
BAGETTA G., CORASANITI M.T., ALOE L., BERLIOCCHI L., COSTA N., FINAZZI-AGRO'
A., AND NISTICO' G. Intracerebral injection of human immunodeficiency
virus type 1 coat protein gp120 differentially affects the expression of
nerve growth factor and nitric oxide synthase in the hippocampus of rat.
Proc. Nat. Acad. Sci. USA. 93: 928-933, 1996
-
BAGETTA G., IANNONE M., PALMA E., NISTICO' G., AND DOLLY O.J.
N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors mediate seizures
and CA1 hippocampal damage induced by dendrotoxin-K in rats.
Neuroscience. 71: 613-624, 1996.
RESEARCH GROUP MEMBERS:
-
Oliverio Alberto, P.O.
-
Castellano Claudio, Dir.R.
-
Sansone Mario, Dir.R.
-
Ammassari Teule Martine, R.
-
D'Amato Francesca Romana, R.
-
Pavone Flaminia, R.
-
Cabib Simona, R.
AFFILIATION:
Consiglio Nazionale delle Ricerche
Istituto di Psicobiologia e Psicofarmacologia
ADDRESS: Via Reno n. 1
CITY: Roma
POSTAL CODE: 00198
TELEPHONE: 06-8554898, 85353772
FAX: 06-8553561
PUBLICATIONS:
-
CASTELLANO C., CESTARI V., CABIB S. AND PUGLISI ALLEGRA S. The effects of
morphine on memory consolidation in mice involve both D1 and D2 dopamine
receptors. Behav. Neural Biol. 61: 156-161, 1994.
-
D'AMATO F.R. Physiological evidence for genetically mediated sibling recognition
in mice. Behav. Genet.. 24: 493-496, 1994.
-
INTROINI-COLLISON I.B., CASTELLANO C. AND MCGAUGH J..L. Interaction of GABAergic
and Beta-noradrenergic drugs in the regulation of memory storage. J. Pharm.
Pharmacol.. 46: 205-213, 1994.
-
ROSSI-ARNAUD C. AND AMMASSARI-TEULE M. Radial maze performance in inbred
mice: evidence for distint neural nets subserving strain-dependent learning
abilities. Psychobiology. 22: 320-327, 1994.
-
SANSONE M, BATTAGLIA M AND CASTELLANO C. Effects of caffeine and nicotine
on avoidance lerning in mice: lack of interaction. J. Pharm. Pharmacol..
46: 765-767, 1994.
-
AMMASSARI-TEULE M., TOZZI A., ROSSI-ARNAUD C., SAVE E. AND THINUS-BLANC C.
Reactions to spatial and non spatial change in two inbred strains of mice:
further evidence supporting the ippocampal disfunction in the DBA strain.
Psychobiology. 23 : 284-289, 1995.
-
CABIB S., D'AMATO F.R., NEVEU P., DELEPLANQUE B., LE MOAL M. AND PUGLISI
ALLEGRA S. Paw preference and brain dopamine asymmetries.
.Neuroscience. 64: 427-432, 1995.
-
MELE A., CABIB S. AND OLIVERIO A.Effects of the NMDA-antagonist, MK-801,
on stress-induced alterations of dopamine dependent behavior.
Psychopharmacology. 117: 313-317, 1995.
-
MELE A., CASTELLANO C. AND OLIVERIO A. Chronic treatment with MK-801 affects
the behavioral response to both D1 and D2 dopamine agonist in one-trial
inhibitory avoidance. Psychopharmacology. 121: 401-405, 1995.
-
SANSONE M., PAVONE F., BATTAGLIA M. AND VETULANI J. Locomotor activity pattern
induced by diazepam in control and caffeine-treated mice. Polish J.
Pharmacol.,. 47: 387-392, 1995.
RESEARCH GROUP MEMBERS:
-
Ongini Ennio, Dir. R.
-
Bertorelli Rosalia, C.L.
-
Dionisotti Silvio, C.L.
-
Mattavelli Amanda, B.
-
Monopoli Angela, C.L.
-
Adami Marina, R.I.
-
Basudev Harsha, R.I.
-
Casati Carlo, R.I.
-
Ferri Nives, T.
-
Forlani Angelo, T.
-
Lozza Gianluca, T.L.
-
Molta Cristina, B.
-
Veronese Eliana, B.
-
Bianchi Daniele, T.
-
Rabuffetti Moonica, B.
-
Viganò Giulia, B.
-
Corradini Laura, B.
-
Barbieri Ilaria, B.
AFFILIATION:
Schering Plough Research Institute
San Raffaele Science Park
ADDRESS: Via Olgettina 58
CITY: Milano
POSTAL CODE: 20132
TELEPHONE: 02 - 21219202
FAX: 02 - 21219253
E-MAIL: schering-plough@science-park.spr.it
PUBLICATIONS:
-
ONGINI E., E. BONIZZONI, N. FERRI, S. MILANI AND M. TRAMPUS Differential
effects of dopamine D1 and D2 receptor antagonist
antipsychotics on sleepwake patterns in the rat. J. Pharmacol. Exp.
Ther. 266 : 726731, 1993.
-
CASATI C., A. MONOPOLI, S. DIONISOTTI, C. ZOCCHI, E. BONIZZONI AND E. ONGINI
Repeated administration of selective adenosine A1 and
A2 receptor agonists in the spontaneously hypertensive rat: tolerance
develops to A1 -mediated hemodynamic effects. J. Pharmacol.
Exp. Ther. 268 : 1506-1511, 1994.
-
DIONISOTTI S., A. CONTI, D. SANDOLI, C. ZOCCHI, F. GATTA AND E. ONGINI Effects
of the new A2 adenosine receptor antagonist 8FB-PTP, an 8-substituted
pyrazolo-triazolo-pyrimidine, on in vitro functional models. Brit. J.
Pharmacol. 112 : 659-665, 1994.
-
BONIZZONI E., S. MILANI, E. ONGINI, C. CASATI AND A. MONOPOLI Modeling
hemodynamic profiles by telemetry in the rat. A study using A1 and
A2A adenosine agonists. Hypertension, 25 : 564-569,
1995.
-
CASATI C., A. MONOPOLI, A. FORLANI, E. BONIZZONI AND E. ONGINI Telemetry
monitoring of hemodynamic changes induced over time by adenosine agonists
in spontaneously hypertensive rats. J. Pharmacol. Exp. Ther. 275 :
914-919, 1995.
-
ADAMI M., R. BERTORELLI, N. FERRI, M.C. FODDI AND E. ONGINI Effects of repeated
administration of selective adenosine A1 and A2A receptor
agonists on pentylenetetrazole-induced convulsions in the rat. Eur. J.
Pharmacol. 294 : 383-389, 1995.
-
ZOCCHI C., E. ONGINI, A. CONTI , A. MONOPOLI, A. NEGRETTI, P.G. BARALDI AND
S. DIONISOTTI The non-xanthine heterocyclic compound, SCH 58261, is a new
potent and selective A2Aadenosine receptor antagonist. J.
Pharmacol. Exp. Ther. 276 : 398-404, 1996.
-
ZOCCHI C., E. ONGINI, S. FERRARA, P.G. BARALDI AND S. DIONISOTTI Binding
of the radioligand [3H]SCH 58261, a non-xanthine A2A
adenosine receptor antagonist, to rat striatal membranes. Brit. J.
Pharmacol. 117 : 1381-1386, 1996.
-
DIONISOTTI S., S. FERRARA, C. MOLTA, C. ZOCCHI AND E. ONGINI Labeling of
the A2A adenosine receptors in human platelets using the non-xanthine
antagonist radioligand [3H]-SCH 58261. J. Pharmacol. Exp.
Ther. 278 : 1209-1214., 1996
-
ONGINI E. AND B.B. FREDHOLM Pharmacology of adenosine A2A receptors.
Trends Pharmacol. Sci. In press, 1996.
RESEARCH GROUP MEMBERS:
-
Panerai Alberto E. P.O.
-
Bianchi Mauro R.U.
-
Sacerdote Paola T.L.
-
Manfredi Barbara B.PDR.
AFFILIATION:
Dipartimento di Farmacologia Chemioterapia e Tossicologia Medica
Facoltà di Scienze MM.FF.NN.
Università di Milano
ADDRESS: Via Vanvitelli 32
CITY: Milano
POSTAL CODE: 20129
TELEPHONE: 02-719750; 70146-286; -288; -289
FAX: 02-730470
E-MAIL: panerai@imiucca.csi.unimi.it;
sacerdot@imiucca.csi.unimi.it
PUBLICATIONS:
-
MANFREDI, B, SACERDOTE, P., BIANCHI, M., LOCATELLI, L., VELIC-RADULOVIC,
J.,.AND.PANERAI, A.E. Evidence for an opioid inhibitory effect on T cell
proliferation. J. Neuroimmunol. 44: 43-48, 1993.
-
SACERDOTE, P., DENIS-DONINI, S., PAGLIA, P., GRANUCCI, F., PANERAI, A.E.,
AND RICCIARDI-CASTAGNOLI, P. Cloned microglial cells, but not macrophages
synthesize ß-endorphin in response to CRH activation. Glia 9:
305-310, 1993.
-
PANERAI, A.E., RADULOVIC, J., MONASTRA, G., MANFREDI, B., LOCATELLI, L.,
AND SACERDOTE, P. ß-endorphin concentrations in brain areas and peritoneal
macrophages in rats susceptible and resistant to experimental allergic
encephalomyelitis: a possible relationship between tumor necrosis factor
and opioids in the disease. J. Neuroimmunol. 51: 169-177, 1994.
-
BIANCHI, M., SACERDOTE, P., AND PANERAI, A.E. Chlomipramine differently affects
inflammatory edema and pain in the rat. Pharmacol. Biochem. Behav.
48:1037-1047, 1994
-
BIANCHI, M., SACERDOTE, P., AND PANERAI, A. E. Fluoxetine reduces inflammatory
edema in the rat: involvement of the pituitary-adrenal axis.
Eur.J.Pharmacol. 263: 81-84, 1994.
-
SACERDOTE, P., BIANCHI, M., MANFREDI, B. AND PANERAI, A.E.
Intracerebroventricular interleukin-1 increases immunocyte ß-endorphin
concentrations in the rat: involvement corticotrophin-releasing hormone,
catecholamines, and serotonin. Endocrinology, 135: 1346-1352, 1994.
-
PANERAI, A.E., MANFREDI, B., GRANUCCI, F., AND SACERDOTE, P. The
ß-endorphin inhibition of mitogen-induced splenocytes proliferation
is mediated by central and peripheral paracrine/autocrine effects of the
opioid. J. Neuroimmunol. 58: 71-76, 1995
-
MANFREDI, B., CLEMENTI, E., SACERDOTE, P., BASSETTI, M. AND PANERAI, A.E.
Age-related changes in mitogen-induced ß-endorphin release from human
peripheral blood mononuclear cells. Peptides, 16: 699-706, 1995
-
BIANCHI, M., AND PANERAI, A.E. The dose-related effect of paracetamol on
hyperalgesia and nociception in the rat. Brit. J. Pharmacol. 117:130-132,
1996
-
BIANCHI, M., SACERDOTE, P., AND PANERAI, A.E. Peripherally administered GM-CSF
interferes with scopolamine-induced amnesia in mice: involvement of
interleukin-1. Brain Res. 728: 285-289, 1996
RESEARCH GROUP MEMBERS:
-
Parenti Marco, R.U.
-
Galbiati Ferruccio, D.DR.
-
Guzzi Francesca, B.
AFFILIATION:
Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica
Facoltà di Medicina e Chirurgia
Università degli Studi di Milano
ADDRESS: Via Vanvitelli, 32
CITY: Milano
POSTAL CODE: 20129
TELEPHONE: 02 - 70146 282
FAX: 02 - 70146 371
E-MAIL: parenti@imiucca.csi.unimi.it
PUBLICATIONS:
-
PARENTI M., VIGANO' M.A., NEWMAN C.M.H., MILLIGAN G., AND MAGEE A.I.
A novel N-terminal motif for palmitoylation of G-protein a subunits.
Biochem. J. 291: 349-353, 1993.
-
PAROLARO D., RUBINO T., GORI E., MASSI P., BENDOTTI C., PATRINI G., MARCOZZI
C., AND PARENTI M. In situ hybridization reveals specific increases in Gas
and Gao mRNA in discrete brain regions of morphine-tolerant rats. Eur.
J. Pharmacol. (Mol. Pharm. Sec.) 244: 211-222, 1993.
-
GRASSIE M. A., MCCALLUM J. F., GUZZI F., MAGEE A. I., MILLIGAN G., AND PARENTI
M. The palmitoylation status of the G-protein Go1a regulates its avidity
of interaction with the plasma membrane. Biochem. J. 302: 913-920,
1994.
-
GALBIATI F., GUZZI F., MAGEE A.I., MILLIGAN G., AND PARENTI M. N-Terminal
fatty acylation of the a subunit of the G-protein Gi1: only the myristoylated
protein is a substrate for palmitoylation. Biochem. J. 303:
697-700, 1994.
-
MILLIGAN G., PARENTI M., AND MAGEE A.I. The dynamic role of palmitoylation
in signal transduction. Trends Biochem. Sci. 20: 181-186, 1995.
-
SALA M., BRAIDA D., COLOMBO M., GROPPETTI A., SACCO S., GORI E., AND PARENTI
M. Behavioral and biochemical evidence of opioidergic involvement in cocaine
sensitization. J. Pharmacol. Exp. Ther. 274: 450-457, 1995.
-
RUBINO T., PARENTI M., PATRINI G., MASSI P., AND PAROLARO D. Morphine withdrawal
syndrome and G protein expression: a study of the time course in the rat
Central Nervous System. Eur. J. Neurosci. 7: 2334-2340, 1995.
-
MCCALLUM J.F., WISE A., GRASSIE M.A., MAGEE A.I., GUZZI F., PARENTI M., AND
MILLIGAN G. The role of palmitoylation of the guanine nucleotide binding
protein G11a in defining interaction with the plasma membrane.
Biochem. J. 310: 1021-1027, 1995.
-
GALBIATI F., GUZZI F., MAGEE A.I., MILLIGAN G., AND PARENTI M. Chemical
inhibition of myristoylation of the G-protein Gi1a by 2-hydroxymyristate
does not interfere with its palmitoylation or membrane association. Biochem.
J. 313: 717-720, 1996.
RESEARCH GROUP MEMBERS :
-
Parolaro Daniela, P.A.
-
Giagnoni Gabriella, P.A.
-
Massi Paola, R.U.
-
Rubino Tiziana, B.
-
Patrini Gabriela, B.
-
Fuzio Domenica, B.
AFFILIATION:
Istituto di Farmacologia,
Facoltà di Scienze MMFFNN
Università degli Studi di Milano
ADDRESS: Via Vanvitelli, 32/A
CITY: Milano
POSTAL CODE: 20129
TELEPHONE: 02-7385568
FAX: 02-70002270
E-MAIL: gori@imiucca.csi.unimi.it
PUBLICATIONS :
-
PAROLARO, D., RUBINO, T., GORI, E., MASSI, P., BENDOTTI, C., PATRINI, G.,
MARCOZZI, C., AND PARENTI, M. In situ hybridization reveals specific increases
in G s and Go mRNA in discrete brain regions of morphine-tolerant rats. Eur.
J. Pharmacol. - Mol. Pharmacol. Section. 244: 211-222, 1993.
-
MASSI, P., RUBINO, T., PARENTI, M., GIAGNONI, G., GROPPETTI, A., AND PAROLARO,
D. Cholera toxin antagonizes morphine-induced catalepsy through a cyclic
AMP-independent mechanism. Eur. J. Pharmacol. 243: 65-71, 1993.
-
RUBINO, T., MASSI, P., PATRINI, G., VENIER, I., GIAGNONI, G., AND PAROLARO,
D. Effect of chronic exposure to naltrexone and opioid selective agonists
on G protein mRNA levels in the rat nervous system. Mol. Brain Res..
23: 333-337, 1994.
-
PACIFICI, R., PATRINI, G., VENIER, I., PAROLARO, D., ZUCCARO, P., AND GORI,
E. Effect of morphine and methadone acute treatment on immunological activity
in mice: pharmacokinetic and pharmacodynamic correlates. J. Pharmacol.
Exp. Ther. 269: 1112-1116, 1994.
-
RUBINO, T., MASSI, P., PATRINI, G., VENIER, I., GIAGNONI, G.,AND PAROLARO,
D. Chronic CP-55,940 alters cannabinoid receptor mRNA in the rat brain: an
in situ hybridization study. Neuroreport. 5: 2493-2496, 1994.
-
RUBINO, T., PARENTI, M., PATRINI, G., MASSI, P.,AND PAROLARO, D. Morphine
withdrawal syndrome and G protein expression: a study of the time course
in the rat central nervous system. Eur. J. Neurosci. 7: 2334-2340,
1995.
-
PATRINI, G., MASSI, P., RICEVUTI, G., MAZZONE, A., FOSSATI, G., MAZZUCCHELLI,
I., GORI, E., AND PAROLARO. D. Changes in opioid receptor density on murine
splenocytes induced by in vivo treatment with morphine and methadone. J.
Pharmacol. Exp. Ther. 279: 172-176, 1996.
-
COSTA, B., PAROLARO, D., AND COLLEONI, M.P. Chronic cannabinoid, CP-55940,
administration alters biotransformation in the rat. Eur. J. Pharmacol.
313: 17-24, 1996.
-
RUBINO, T., PATRINI, G., PARENTI, M., MASSI, P., AND PAROLARO, D. Chronic
treatment with a synthetic cannabinoid CP-55,940 alters G protein expression
in the rat central nervous system. Mol. Brain Res. In press, 1996.
-
MASSI, P., PATRINI, G., RUBINO, T., FUZIO, D., AND PAROLARO, D. Changes in
rat spleen cannabinoid receptors after chronic CP-55940: an autoradiographic
study. Pharmacol. Biochem. Behav. In press, 1996.
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