SIF - Società
Italiana di Farmacologia
"SIF - La Ricerca Farmacologica in Italia"
PHARMACOLOGY OF THE
CENTRAL NERVOUS SYSTEM IV
RESEARCH GROUP MEMBERS:
-
Pepeu Giancarlo, P.O.
-
Marconcini Pepeu Ileana, P.A.
-
Pedata Felicita, P.A.
-
Casamenti Fiorella, R.U.
-
Giovannelli Lisa, R.U.
-
Giovannini Maria Grazia, T.L.
-
Corsi Claudia, D.D.R
-
Latini Serena, D.D.R.
-
Prosperi Costanza, D.D.R.
-
Pazzagli Marta, B.
-
Scali Carla, B.
AFFILIATION :
Dipartimento di Farmacologia Preclinica e Clinica
Università di Firenze
Unità Operativa Neurofarmacologia
ADDRESS: Viale Morgagni, 65
CITY: Firenze
POSTAL CODE: 50134
TELEPHONE: 055-4237.411 (centralino),
418, 441, 442, 443, 446.
FAX : 055-4361613
E-MAIL : pepeu@stat.ds.unifi.it
unit12@stat.ds.unifi.it
PUBLICATIONS:
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CASAMENTI, F., SCALI, C., VANNUCCHI, M. G., BARTOLINI, L., AND PEPEU, G.
Long-term ethanol consumption by rats: effect on acetylcholine release in
vivo, choline acetyltransferase activity, and behavior. Neuroscience
56 : 465-471, 1993.
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PAZZAGLI, M., CORSI, C., LATINI, S. PEDATA, F. AND PEPEU, G. In vivoregulation
of extracellular adenosine levels in the cerebral cortex by NMDAand muscarinic
receptors. Eur. J. Pharmacol. 254: 277-282, 1994.
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GIOVANNINI, M.G., MUTOLO, D., BIANCHI, L., MICHELASSI, A. AND PEPEU, G.NMDA
receptor antagonists decrease GABA outflow from the septum andincrease
acetylcholine outflow from the hippocampus: a microdialysis study.
Neuroscience 4: 1358-1365, 1994.
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GIOVANNINI, M.G., CAMILLI, F., MUNDULA, A., BIANCHI, L., COLIVICCHI, M.A.
AND PEPEU, G. Differential regulation by N-methyl-d-aspartate
andnon-N-methylaspartate receptors of acetylcholine release from the ratstriatum
in vivo Neuroscience 65: 409-415, 1995.
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VANNUCCHI, M.G. AND PEPEU, G. Muscarinic receptor modulation ofacetylcholine
release from rat cerebral cortex and hippocampus. Neurosci. Lett.
190: 53-56, 1995.
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GIOVANNELLI, L., CASAMENTI, F., SCALI, C., BARTOLINI, L. AND PEPEU, G.
Differential effects of amyloid peptides ß-(1-40) and ß-(25-35)
injectionsinto the rat nucleus basalis. Neuroscience 66: 781-792,
1995.
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PAZZAGLI, M., CORSI, C., FRATTI, S., PEDATA, F. AND PEPEU, G. Regulationof
extracellular adenosine levels in the striatum of aging rats. Brain Res.
103-106, 1995.
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BARTOLINI, L., CASAMENTI, F. AND PEPEU, G. Aniracetam restores objectrecognition
impaired by age, scopolamine, and nucleus basalis lesions. Pharmacol.
Biochem. Behav. 53: 277-283, 1996.
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ORSETTI, M., CASAMENTI, F., PEPEU, G. Enhanced acetylcholine release inthe
hippocampus and cortex during acquisition of an operant behavior. Brain
Res. 724: 89-96, 1996
RESEARCH GROUP MEMBERS:
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Pietra Claudio, R.I.
-
Arban Roberto, R.I.
-
Valerio Enzo, T.
-
Tarter Giorgio, T
-
Costa Silvano, T
AFFILIATION:
Direzione Farmacologia
Chiesi Farmaceutici S.p.A.
ADDRESS: Via Palermo 26/A
CITY: Parma
POSTAL CODE: 43100
TELEPHONE: 0521-279248
FAX: 0521-774468
PUBLICATIONS:
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M. CORSI, G. DAL FORNO, B. OLIOSI, C. PIETRA, F.TH.M. VAN AMSTERDAM AND D.
TRIST Combined Dose-Ratio Analysis for the CCK-B Antagonist Virginyamicin
in Guinea pig ileum. Ann. New York Acad. Sci. 713 : 353-354,
1994.
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J.C. MARTINOU, M. DUBOIS-DAUPHIN, J.K.STAPLE, I. RODRIGUEZ,H. FRANKOWSKI,
M. MISSOTTEN, P.ALBERTINI, D. TALABOT, S. CATSICAS, C. PIETRA AND J. HUARTE.
Overexpression of BCL-2 in Transgenic mice protects neurones from naturally
occurring cell death and experimental ischemia. Neuron. 13: 1017-1030,
1994.
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S. PALEA, C. PIETRA, D.G. TRIST, W. ARTIBANI, A. CALPISTA AND M.CORSI Evidence
for the presence of both pre-and postjunctional P2-purinoceptor subtypes
in human isolated urinary bladder. Brit. J. Pharmacol.. 114. 35-40,
1995.
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R. DI FABIO, C. PIETRA, R.J. THOMAS AND L. ZIVIANI. The asymmetric synthesis
of both enantiomers of eliprodil. Bioorg. Med. Chem. . 5: 551-554,
1995.
-
Z.C. PENG, C. PIETRA, A. SBARBATI, L. ZIVIANI, X.B. YAN, F. OSCULATI AND
M. BENTIVIGLIO. Induction of NADPH-diaphorase activity in the rat forebrain
after middle cerebral artery occlusion. Exp. Neurol. 138: 105-120,
1996.
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S. PALEA, M. CORSI, W. ARTIBANI, E. OSTARDO AND C. PIETRA. Pharmacological
characterization of tachykinin NK-2 receptor on isolated human urinary bladder,
prostatic urethra and prostate. J. Pharmacol. Exp. Ther. 277: 700-705,
1996.
-
A. SBARBATI, C. PIETRA, A.M. BALDASSARRI, U. GUERRINI, L. ZIVIANI, A. REGGIANI,
A. BOICELLI, F. OSCULATI. The microvascular system in ischemic cortical lesions.
Acta Neuropathol.. 92: 56-63, 1996.
RESEARCH GROUP MEMBERS:
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Polenzani Lorenzo, C.L.
-
Durando Lucia, C.L.
-
Magnani Maurizio, C.L.
-
Picollo Rossella, C.L.
-
Basta Francesco, R.I.
-
Del Vecchio Alessandra, R.I.
-
Garrone Beatrice, R.I.
-
Luparini Maria Rita, R.I.
-
Tolu Liliana, R.I.
AFFILIATION:
Angelini Ricerche S.p.A.
ADDRESS: P.le della Stazione snc
CITY: S. Palomba - Pomezia (Rm)
POSTAL CODE: 00040
TELEPHONE: 06 - 910451
FAX: 06 - 91984597
PUBLICATIONS:
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LEONE MG., SASO L., DEL VECCHIO A., MO M.Y., SILVESTRINI B., CHENG C.Y.
Micropurification of two human cerebrospinal fluid proteins by high performance
electrophoresis chromatography. J. Neurochem. 61: 533-540, 1993
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GRASSI F., POLENZANI L., MILEO A.M., CARATSCH C.G., EUSEBI F. AND MILEDI
R. Blockage of nicotinic acetylcholine receptors by 5-hydroxytryptamine.
J. Neurosci. Res. 34: 562-570, 1993.
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WOODWARD R.M., POLENZANI L. AND MILEDI R. Characterization of
bicuculline/baclofen-insensitive (rho-like) gamma-aminobutyric acid receptors
expressed in Xenopus oocytes II. Pharmacology of gamma-aminobutyric acidA
and gamma-aminobutyric acidB receptor agonist and antagonists. Mol.
Pharmacol. 43: 609-625, 1993.
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WOODWARD, R.M., POLENZANI, L. AND MILEDI, R. Effects of fenamates and other
non-steroidal anti-inflammatory drugs on rat brain GABA A receptors expressed
in Xenopous oocytes. J. Pharmacol. Exp. Ther. 268: 806-817, 1994.
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MILEO A.M., PALMA E., POLENZANI L., LIMATOLA C., GRASSI F. AND EUSEBI F.
Protein kinases C modulates exogenous acetylcholine receptors currents in
Xenopus oocytes J. Neurosci. Res. 41 : 443-451 1995
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DELPINO A., MILEO A.M., LAPENTA V., PISELLI P., VERDINA A. AND POLENZANI
L. Characterization of a new high temperature-induced mammalian heat shock
protein (HSP 66), antigenically related to heat shock protein 72. J. Cell.
Biochem. 63 : 51-60 1996
RESEARCH GROUP MEMBERS :
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Racagni Giorgio, P.O.
-
Ambrosini Anna, B.PDR.
-
Blom Joan, B.
-
Garbini Sara, B.
-
Lovati Emanuela, B.
-
Molteni Raffaella, B.
-
Mori Silvia, D.DR.
-
Perez Jorge, R.
-
Popoli Maurizio, T.L.
-
Riva Marco, R.
-
Iuliano Emilio, T.
AFFILIATION :
Centro di Neurofarmacologia
Istituto di Scienze Farmacologiche
Università di Milano
ADDRESS: Via Balzaretti 9
CITY: Milano
POSTAL CODE: 20133
TELEPHONE: 02-20488331
FAX: 02-29403673
E-MAIL: racagni@isfunix.farma.unimi.it
PUBLICATIONS:
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VOLTERRA A., TROTTI D., TROMBA C., FLORIDI S. AND RACAGNI G. Glutamate Uptake
Inhibition by Oxygen Free Radicals in Rat Cortical Astrocytes. J.
Neurosci. 14: 2924-2932, 1994.
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AMBROSINI A., BRESCIANI L., FRACCHIA S., BRUNELLO N., RACAGNI G. Metabotropic
glutamate receptors negatively coupled to adenylate cyclase inhibit NMDA
receptor activity and prevent neurotoxicity in mesencephalic neuron in
vitro. Mol. Pharmacol. 47: 1057-1064, 1995.
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PEREZ J., ZANARDI R., MORI S., GASPERINI M., SMERALDI E., RACAGNI G.
Abnormalities of cAMP dependent endogenous phosphorylation in platelets from
bipolar patients. Amer. J. Psych. 152: 1204-1206, 1995.
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TROTTI D., VOLTERRA A., LEHRE K.P., ROSSI D., GJESDAL O., RACAGNI G., DANBOLT
N.C. Arachidonic acid inhibits a purified and reconstituted glutamate transporter
directly from the water phase and not by via the phospholipid membrane. J.
Biol. Chem. 270: 9890-9895, 1995.
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POPOLI M., VOCATURO C., PEREZ J., RACAGNI G. Presynaptic
Ca2+/Calmodulin-dependent protein kinase II: autophosphorylation
and activity increase in the hippocampus after long-term blockade of serotonin
reuptake. Mol. Pharmacol. 48:623-629, 1995.
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RIVA M.A., FUMAGALLI F., BLOM J.C.M., DONATI E., RACAGNI G. Adrenalectomy
reduces FGF-1 and FGF-2 gene expression in specific rat brain regions and
differently affects their induction by seizures. Mol. Brain Res.,
34: 190-196, 1996.
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GIACCONE G., VERGA L., PEREZ J., RACAGNI G., PEDROTTI B., DE GIOIA L., SELVAGGINI
C., SALMONA M., GHISO J., FRANGIONE B., ISLAM K., BUGIANI O., AND TAGLIAVINI
F. ßPP and Tau nteraction: a possible link between amyloid and
neurofibrillary tangles in Alzheimer's disease. Amer. J. Pathol. 148:
79-87 1996.
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RIVA M.A., MOLTENI R., LOVATI E., FUMAGALLI F., RUSNATI M. AND RACAGNI G.
Cyclic AMP-dependent regulation of Fibroblast Growth Factor-2 messenger RNA
levels in rat cortical astrocytes: comparison with Fibroblast Growth Factor-1
and Ciliary Neurotrophic Factor. Mol. Pharmacol. 49: 699-706, 1996.
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TROTTI D., ROSSI D., GJESDAL O., LEVY L.M., RACAGNI G., DANBOLT N.C. AND
VOLTERRA A. Peroxynitrite inhibits glutamate transporter subtypes. J.
Biol. Chem., 271 :pp. 5976-5979, 1996.
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VOLTERRA A., BEZZI P., LODI RIZZINI B., TROTTI D., ULLENSVANG K., DANBOLT
N.C. AND RACAGNI G. The competitive transporter inhibitor
L-trans-pyrrolidine-2,4-dicarboxycate triggers excitotoxicity in rat cortical
neuron-astrocyte cocultures via glutamate release rather than uptake inhibition.
Eur. J. Neurosci. 8: 2019-2028, 1996.
RESEARCH GROUP MEMBERS:
-
Raiteri Maurizio, P.O.
-
Marchi Mario, P.O.
-
Maura Guido, P.A.
-
Bonanno Giambattista, P.A.
-
Gemignani Anita, R.U.
-
Marcoli Manuela, R.U.
-
Pittaluga Anna, R.U.
-
Fedele Ernesto, R.U.
-
Fassio Anna, D.DR.
-
Schmid Giovanna, D.DR.
-
Paudice Paolo, T.L.
-
Fontana Giovanni, T.
AFFILIATION:
Istituto di Farmacologia e Farmacognosia
Facoltà di Farmacia
Università di Genova
ADDRESS: Viale Cembrano 4
CITY: Genova
POSTAL CODE: 16148
TELEPHONE: 010-3532651
FAX: 010-3993360
E-MAIL: M.Raiteri@pharmatox.unige.it
PUBLICATIONS:
-
BONANNO, G., AND RAITERI M. Multiple GABAB receptors. Trends Pharmacol.
Sci. 14: 259-261, 1993.
-
RUSSO, C., MARCHI, M., ANDRIOLI, G.C., CAVAZZANI, P., AND RAITERI, M. Enhancement
of glycine release from human brain cortex by acetylcholine acting at M4
muscarinic receptors. J. Pharmacol. Exp. Ther. 266: 142-146, 1993.
-
LEVI, G., AND RAITERI, M. Carrier-mediated release of neurotransmitters.
Trends Neurosci. 16: 415-419, 1993.
-
GEMIGNANI, A., PAUDICE, P., BONANNO, G., AND RAITERI, M. Pharmacological
discrimination between GABAB receptors regulating cholecystokinin and
somatostatin release from rat neocortex synaptosomes. Mol. Pharmacol.
46: 558-562, 1994.
-
MAURA, G., GUADAGNIN, A., AND RAITERI, M. Low nanomolar serotonin inhibits
the glutamate receptor/nitric oxide/cyclic GMP pathway in slices from adult
rat cerebellum. Neuroscience 68: 455-463, 1995.
-
MAURA, G., AND RAITERI, M. Serotonin 5-HT1D and 5-HT1A
receptors respectively mediate inhibition of glutamate release and inhibition
of cyclic GMP production in rat cerebellum in vitro. J. Neurochem.
66: 203-209, 1996.
-
FEDELE, E., AND RAITERI, M. Desensitization of AMPA receptors and AMPA-NMDA
receptor interaction: an in vivo cGMP microdialysis study in rat
cerebellum. Brit. J. Pharmacol. 117: 1133-1138, 1996.
-
FASSIO, A., BONANNO, G., FONTANA, G., USAI, C., MARCHI, M., AND RAITERI,
M. Role of external and internal calcium on heterocarrier-mediated transmitter
release. J. Neurochem. 66: 1468-1474, 1996.
-
PITTALUGA, A., PATTARINI, R., SEVERI, P., AND RAITERI, M. Human brain
N-methyl-D-aspartate receptors regulating noradrenaline release are positively
modulated by HIV-1 coat protein gp120. AIDS 10: 463-468, 1996.
-
BONANNO, G., GEMIGNANI, A., SCHMID, G., SEVERI, P., CAVAZZANI, P., AND RAITERI,
M. Human brain somatostatin: release from isolated cortical nerve endings
and its modulation through GABAB receptors. Brit. J.
Pharmacol. 118: 1441-1446, 1996.
RESEARCH GROUP MEMBERS :
-
Ricci Gamalero, P.A.
-
Eva Carola, R.U.
-
Brusa Rossella, B.PDR.
-
Oberto Alessandra, D.DR.
-
Musso Rita, B.
AFFILIATION :
Sezione di Farmacologia
Dipartimento di Anatomia, Farmacologia e Medicina Legale
Università di Torino
ADDRESS: Via Pietro Giuria, 13
CITY: Torino
POSTAL CODE: 10125
TELEPHONE: 011-6707717/8
FAX: 011-658606
E-MAIL: eva@medfarm.unito.it
PUBLICATIONS:
-
EVA, C. AND SPRENGEL, R. A novel putative G protein-coupled receptor
highly expressed in lung and testes. DNA Cell Biol. 12: 393-399, 1993.
-
GALLO, M.P., ALLOATTI, G., EVA, C., OBERTO, A. AND LEVI, R.C. m1 muscarinic
receptors increase calcium current and phosphoinositide turnover in guinea-pig
ventricular cardiocytes. J. Physiol. 471:41-60, 1993.
-
EVA, C. AND SPRENGEL, R.: Cloning of G-protein coupled receptors. Met.
Neurosci. 12:24-40, 1993.
-
EVA, C., FUSCO, M., BRUSA, R., SCHIAVO, N., RICCI GAMALERO, S., VANTINI,
G. AND GENAZZANI, E. Intracerebroventricular administration of nerve growth
factor affects muscarinic cholinergic receptors in the cerebral cortex of
neonatal rats. Neurochem. Int. 24:57-65, 1994.
-
OBERTO, A., LONGONE, P., AND KRUEGER, K.E. Identification of three
transcriptional regulatory elements in the rat mitochondrial benzodiazepine
receptor encoding gene. Gene, 167:255-260, 1995.
-
BRUSA, R., RICCI GAMALERO, S., GENAZZANI, E. AND EVA, C. In primary neuronal
cultures muscarinic m1 and m3 receptor mRNA levels are regulated by agonists,
partial agonists and antagonists. Eur. J. Pharmacol., Molec. Pharmacol.
Sect., 289:9-16, 1995.
-
BRUSA, R., ZIMMERMANN, F., DUK-SU, K., FELDMEYER, D., GASS, P., SEEBURG,
P.H., SPRENGEL, R. Early-onset epilepsy and postnatal lethality associated
with an editing-deficient GluR-Ballele in mice. Science
270:1677-1680, 1995.
-
OBERTO, A., MARKS N., EVANS, H.L. AND GUIDOTTI, A. Lead (Pb2+)
promotes apoptosis in newborn rat cerebellar neurons: pathological
implications. J. Pharmacol. Exp. Ther., In press, 1996.
-
MUSSO, R., GRILLI, M.G., OBERTO, A., RICCI GAMALERO, S. AND EVA, C. Regulation
of mouse NPY-Y1 receptor gene transcription: a potential role for NF-kB/Rel
proteins. Mol. Pharmacol., In press, 1996.
RESEARCH GROUP MEMBERS:
-
Rotiroti Domenicantonio, P.O.
-
Rispoli Vincenzo, R.U.
-
Palma Ernesto, R.U.
-
Pelaia Girolamo, R.U.
-
Russo Diego, R.U.
-
Clementi Emilio, R.U.
-
Corasaniti M.Tiziana, R.U.
-
Navarra Michele, R.U.
-
Trozzi Alessandra, R.U.
AFFILIATION:
Facoltà di Farmacia
Università degli Studi di Reggio Calabria
ADDRESS: Complesso "Ninì Barbieri"
CITY: Roccelletta di Borgia (CZ)
POSTAL CODE: 88021
TELEPHONE: 0961-391157
FAX: 0961-391490
E-MAIL: rotiroti@area.cs.cnr.it
PUBLICATIONS :
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ZORZATO F., SCUTARI E., TEGAZZIN V., CLEMENTI E., TREVES S. Chlorocresol :
an activator of ryanodine receptor-mediated Ca2+ release. Mol.
Pharmacol. 44 : 1192-1201, 1993.
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BAGETTA G., CORASANTI MT., MELINO G., PAOLETTI AM., FINAZZI-AGRO A., NISTICO'
G. Lithium and tacrine increase the expression of netric oxide synthase mRNA
in the hippocampus of rat. Biochem. Biophys. Res.Com.
197 :1132-1139, 1993.
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DE SARRO G.B., ROTIROTI D., AUDINO M.G., GRATTERI S., NISTICO' G.: Effects
of interleukin-2 on various models of experimental epilepsy in DBA/2 mice.
Neuroimmunomodulation 1 : 161-369, 1994.
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BAGETTA G., IANNONE M., VECCHIO I., RISPOLI., ROTIROTI D., NISTICO' G.
Neurodegeneration produced by intrahippocampal injection of paraquat is reduced
by systemic administration of the 21-aminosteroid U7489F in rats. Free
Rad. Res. 21 : 85-93, 1994.
-
MOLLACE V., COLASANTI M., RODINO' P., LAURO G.M., ROTIROTI D., NISTICO' G:
NMDA-dependent prostaglandin E2 release by human cultured astroglial cells
is driven by nitric oxide. Biochem. Biophys. Res. Comm. 215 :
793-799, 1995.
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CLEMENTI, E., VECCHIO, I., CORASANITI, M.T. AND NISTICO', G. Nitric oxide
modulates agonist-evoked Ca2+ release and influx responses in PC12 cells.
Eur. J. Pharmacol. 289: 113-123. 1995
-
CLEMENTI E., SCIORATI C., RICCIO M., MILOSO M., MELDOLESI J., NISTICO' G.,
Nitric oxide action on growth factor-elicited signals. J. Biol. Chem.
270 : 22277-22282, 1995.
-
CAROLEO, M.C., RISPOLI, V., ARBITRIO, M., STRONGOLI, C., RAINALDI, G., ROTIROTI,
D. AND NISTICO', G. Chronic administration of Praquat produces
immunosuppression of T lymphocytes and astrocytosis in rats. Toxic Subst.
Mech. 15: 183-194. 1996
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DE SARRO G., AMMENDOLA D., DE SARRO A., NACCARI F., NAVA F., GARERI P., ROTIROTI
D. Behavioural and ECoG effects of IL-4, IL-6, IL-8 and IL-10 after
intraventricular injection in rat. Fund. Clin. Pharmacol. 10 :
184-190. 1996.
-
BAGETTA G., IANNONE M., PALMA E., NISTICO G., DOLLY J.O. N-Methyl-D-Aspartate
and non N-Methyl-D-Aspartate receptors mediate seizures and CA1 hippocampal
damage induced by dendrotoxin-k in rats. Neuroscience 71 : 613-624,
1996.
RESEARCH GROUP MEMBERS :
-
Sala Mariaelvina, R.U.
-
Braida Daniela, B
-
Leone Maria Primula, B.PDR.
-
Paladini Emma B.
AFFILIATION :
Laboratorio di Farmacologia Comportamentale
Istituto di Farmacologia
Facoltà di Scienze MM FF NN
Università degli Studi di Milano
ADDRESS: Via Vanvitelli 32/A
CITY: Milano
POSTAL CODE: 20129
TELEPHONE: 02/7385568
FAX: 02/70002270
E-MAIL: gori@i.miucca.csi.unimi.it
PUBLICATIONS :
-
SALA M., BRAIDA D., CALCATERRA P, LEONE M.P. AND GORI E. Possibility of a
spontaneous drugs abuse tested in rat. Pharmacol. Res. 27: 1-14, 1993.
-
SALA M., BRAIDA D., COLOMBO M., TERZI F., LEONE M.P. AND GORI E. Behavioral
sensitization to cocaine and its antagonism with naltrexone. Behav.
Pharmacol. 4: 456, 1993.
-
SALA M., LEONE M.P., BRAIDA D., LAMPUGNANI P. AND GORI E. Quantitative EEG
and behavioral modifications during tolerance and withdrawal after prolonged
administration of chlordiazepoxide in rats. Behav. Pharmacol.
-
SALA M., BRAIDA D., COLOMBO M., TERZI F., LEONE M.P. AND GORI E. Influence
of opioid system on behavioral sensitization induced by cocaine in the rat.
Regul. Peptides. 50:S199-200,1994.
-
SALA M., BRAIDA D., LEONE M.P., CALCATERRA P., FRATTOLA D. AND E. GORI. Chronic
morphine affects working memory during treatment and withdrawal in rats:
possible residual long-term impairment. Behav. Pharmacol.
-
SALA M., LEONE M.P.,LAMPUGNANI P., BRAIDA D., AND GORI E. Different kinetics
of tolerance to behavioral and electroencephalographic effects of
chlordiazepoxide in the rat. Eur. J. Pharmacol. 273: 35-45, 1995.
-
SALA M., BRAIDA D., COLOMBO M., GROPPETTI A., SACCO S., GORI E. AND M.PARENTI,
Behavioral and biochemical evidence of opioidergic involvement in cocaine
sensitization. J. Pharmacol. Exp. Ther.. 274: 450-457, 1995.
-
SALA M., LEONE M.P., LAMPUGNANI P., BRAIDA D., FRATTOLA D. AND GORI E. EEG
power spectra and behavioural correlates in rats given chronic morphine.
Lack of residual long-term EEG and neuronal changes. Pharmacol. Res.
32: 95-103, 1995.
-
BRAIDA D., PALADINI E., GRIFFINI P., LAMPERTI M., MAGGI A. AND M.SALA. An
inverted U-shaped curve for heptylphysostigmine on radial maze performance
in rats: comparison with other cholinesterase inhibitors. Eur. J.
Pharmacol. 302: 13-20, 1996.
RESEARCH GROUP MEMBERS:
-
Sandrini Maurizio, P.A.
-
Ottani Alessandra, B.
AFFILIATION :
Sezione di Farmacologia
Dipartimento di Scienze Biomediche
Facoltà di Medicina e Chirurgia
Università degli Studi di Modena
ADDRESS: Via G. Campi, 287
CITY: Modena
POSTAL CODE: 41100
TELEPHONE: 059428440, 451
FAX: 059372653
E-MAIL: farmacol@.unimo.it
PUBLICATIONS:
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SANDRINI, M., VERGONI A.V. AND BERTOLINI A. No modifications of GABAA and
benzodiazepine receptors following experimental dysthyroidism in rats.
Pharmacol. Res. 28: 4751, 1993.
-
SANDRINI, M., VERGONI A.V. AND BERTOLINI A. Lack of influence of aromatase
and 5Óreductase inhibition on [3H]imipramine binding in the
male rat brain. J. Endocrinol. Inv. 16: 179181, 1993.
-
PINI, L., VITALE, G. AND SANDRINI, M. The role of serotonin brain receptors
in the anlagesic effect of phenazone. Drugs Exptl. Clin. Res. 19:
1317, 1993.
-
SANDRINI, M, VITALE, G., PINI L.A., STERNIERI, E. AND BERTOLINI, A. Effects
of chronic treatment with phenazone on the hotplate test and [3H]serotonin
binding sites in pons and cortex membranes of the rat. Pharmacol.
47: 8490, 1993
-
PINI, L.A., TRENTI, T., VITALE G., AND SANDRINI, M. Action of analgesic drugs
on brain 5HT receptors as a model to study chronic drugsustained
headaches. New Adv. Head. Res. 4: 159166, 1994.
-
VITALE, G., SANDRINI, M, AND PINI L.A. Lack of activity of ketorolac in
hotplate test and serotonin binding capacity of brain membranes in
rats. Agents Actions 41: 184187, 1994.
-
PINI L.A., SANDRINI, M, AND VITALE, G. Involvement of brain serotonergic
system in the antinociceptive action of acetylsalicilic acid in the rat.
Inflamm. Res. 44: 30-35, 1995.
-
SANDRINI, M, VITALE, G., DONDI, M., AND PINI L.A. Effects of acetylsalicilic
acid on serotonin brain receptor subtypes. Gen. Pharmacol. 26:
737741, 1995.
-
SANDRINI, M, VITALE, G., VERGONI, A.V., OTTANI, A., AND BERTOLINI, A. Effect
of acute and chronic treatment with triiodothyronine on serotonin levels
and serotonergic receptor subtypes in the rat brain. Life Sci. 58:
15511559, 1996.
-
PINI L.A., SANDRINI, M, AND VITALE, G. The antinociceptive action of paracetamol
is associated with changes in the serotonergic system in the rat brain.
Europ. J. Pharmacol. 308: 3140, 1996.
RESEARCH GROUP MEMBERS:
-
Schettini Gennaro, P.O.
-
Florio Tullio, PC (B.PDR.)
-
Carlo Pia, P.A.
-
Maura Annalisa, P.A.
-
Albiano Pina, R.U.
-
Meucci Olimpia, B.
-
Scorziello Antonella, D.DR.
-
Bajetto Adriana, B.
-
Thellung Stefano, D.DR.
-
Angelini Giovanna, R.
AFFILIATION:
°Istituto di Farmacologia
Facoltà di Medicina e Chirurgia, Università di Genova
*Servizio di Farmacologia Clinica e Sperimentale,
Istituto Nazionale per la Ricerca sul Cancro (IST)
Unità di Neuroscienze, Centro Biotecnologie Avanzate (CBA)
ADDRESS: °Viale Benedetto XV 2
*Largo Rosanna Benzi 10
CITY: Genova
POSTAL CODE: 16132
TELEPHONE: °010-353-8806 *010-573-7256 /54
FAX: °010-353-8849 *010-573-7257
E-MAIL: schettini@sirio.cba.unige.it
PUBLICATIONS:
-
MEUCCI O., SCORZIELLO A., AVALLONE A., VENTRA C., GRIMALDI M., BERLINGIERI
M.T., AND SCHETTINI G., Alpha 1A and alpha 1B-adrenergic receptors mediate
the effect of norepinephrine on cytosolic calcium levels in rat PC CL3 thyroid
cells. Thyrotropin modulation of alpha 1B-linked response via a cAMP/protein
kinase A-dependent pathway. Endocrinology 134:424-431, 1994.
-
GRIMALDI M., POZZOLI G., NAVARRA P., PREZIOSI P. AND SCHETTINI G. Vasoactive
Intestinal peptide and forskolin stumulate interleukin 6 production by rat
cortical astrocytes in culture via a cAMP-dependent prostaglandins-independent
mechanism. J. Neurochem. 63:344-350, 1994.
-
FLORIO T., RIM C., HERSHBERGER R.E., LODA M., STORK P.J.S. The somatostatin
receptor SSTR1 is coupled to phosphotyrosine phosphatase activity in CHO-K1
cells. Mol. Endocrinol. 8: 1289-1297, 1994.
-
MEUCCI O., SCORZIELLO A., AVALLONE A., FLORIO T., SCHETTINI G. A1A, but not
1B, adrenoreceptors activates calcium influx through the stimulation of a
tyrosine kinase/phosphotyrosine phosphatase pathway, following
noradrenaline-induced emptying of IP3 sensitive calcium stores, in PC Cl3
thyroid cell line. Biochem. Biophys. Res. Comm. 209: 630-638, 1995.
-
GALLI C., MEUCCI O., SCORZIELLO A., CALISSANO P., SCHETTINI G. Apoptosis
in cerebellar granule cells is blocked by high KCl, forskolin, IGF-I through
distinct mechanisms of action: the involvement of intracellular calcium and
RNA synthesis. J. Neurosci. 15: 1172-1179, 1995.
-
GRIMALDI M., ARCONE R., CILIBERTO G., AND SCHETTINI G. Synergistic stimulation
of IL-6 release and gene expression by phorbol esters and IL-1 beta in rat
cortical astrocytes: role of protein kinase C blockade and activation. J.
Neurochem. 64: 1945-1953, 1995.
-
VENTRA C., PORCELLINI A., FELICIELLO A., GALLO A., PAOLILLO M., MELE E.,
AVVEDIMENTO V., AND SCHETTINI G. The differential response of protein kinase
A to cyclic AMP in discrete brain areas correlates with the abundance of
regulatory subunit II. J. Neurochem. 66 :1752-1761, 1996.
-
FLORIO T., SCORZIELLO A., FATTORE M., D'ALTO V., SALZANO S., ROSSI G.,
BERLINGIERI M.T., FUSCO A., SCHETTINI G., Somatostatin inhibits PC Cl3 thyroid
clonal cell line proliferation through the modulation of phosphotyrosine
phosphatase activity: impairment of the somatostatinergic effects by stable
expression of E1A viral oncogene. J. Biol. Chem. 271: 6129-6136, 1996.
-
SCORZIELLO A., MEUCCI O., FLORIO T., FATTORE M., FORLONI G., SALMONA
M., SCHETTINI G. 25-35 alters calcium homeostasis and induces neurotoxicity
in cerebellar granule cells. J. Neurochem. 66: 1995-2003, 1996.
-
MEUCCI O., MILLER R.J. gp120-induced neurotoxicity in hippocampal pyramidal
neuron cultures: protective action of TGF-1 J. Neurosci. 16:4080-4088,
1996.
RESEARCH GROUP MEMBERS:
-
Sgaragli Giampietro, P.O.
-
Mantovani Piero, P.A.
-
Palmi Mitri, R.U.
-
Valoti Massimo, R.U.
-
Giséle Youmby Tchuisseu, D.DR.
-
Frosini Maria, B.PDR.
-
Fusi Fabio, B.
AFFILIATION:
Istituto di Scienze Farmacologiche
Facoltà di Farmacia
Università degli Studi di Siena
ADDRESS: Via Enea Silvio Piccolomini, 170
CITY: Siena
POSTAL CODE: 53100
TELEPHONE: 0577-221255, 48724
FAX: 0577-281928
E-MAIL: farmacologia@unisi.it
PUBLICATIONS:
-
SGARAGLI, G.P., VALOTI, M., FUSI, F., PALMI, M., MANTOVANI, P., DE SANTI,
M.M., LORENZINI, L., AND TOSI, P. Toxic injury to the gut musculature by
2-t-butyl-4-methoxyphenol. Eur. J. Pharmacol. 248: 121-129, 1993.
-
DELLA CORTE, L., VALOTI, M., PALMI, M., GIOVANNINI, M.G., AND SGARAGLI, G.P.
Pharmacokinetics of chlorimipramine, chlorpromazine and their N-dealkilated
metabolites in plasma of healty volunteers after a single oral dose of the
parent compounds. J. Pharm. Pharmac. 45: 825-829, 1993.
-
SGARAGLI, G.P., VALOTI, M., GORELLI, B., FUSI, F., PALMI, M., AND MANTOVANI,
P. Calcium antagonist and antiperoxidant properties of some hindered phenols.
Brit. J. Pharmacol. 110: 369-377, 1993.
-
FROSINI, M., GORELLI, B., MATTEINI, M., PALMI, M., VALOTI, M., AND SGARAGLI,
G.P. HPLC determination of inorganic cation levels in CSF and plasma of conscious
rabbits. J. Pharmacol. Toxicol. Met. 29: 99-104, 1993.
-
VALOTI, M., COSTANZO, M., SGARAGLI, G.P., PEREZ, V., FERNANDEZ-ALVAREZ, E.,
AND UNZETA M. Interactions of monoamine oxidase inhibitors, N-acetylenic
analogues of tryptamine, with rat liver microsomal cytochrome P450. J.
Pharm. Pharmacol. 46:360-365, 1994.
-
PALMI, M., FROSINI, M., BECHERUCCI, C., SGARAGLI, G.P., AND PARENTE, L. Increase
of extracellular brain calcium involved in interleukin-1ß-induced pyresis
in the rabbit: antagonism by dexamethasone. Brit. J. Pharmacol. 112:
449-452, 1994.
-
SGARAGLI, G.P., VALOTI, M., PALMI, M., FROSINI, M., GIOVANNINI, M.G., BIANCHI,
L., AND DELLA CORTE, L. Rat tissue concentrations of chlorimipramine,
chlorpromazine and their N-demethylated metabolites after a single oral dose
of the parent compounds. J. Pharm. Pharmacol. 47: 782-790, 1995.
-
MORI, F., LAI, C.C., FUSI, F., GIACOBINI, E. Cholinesterase inhibitors increase
secretion of APPs in rat brain cortex. NeuroReport. 6: 633-636, 1995
-
PALMI, M., FROSINI, M., AND SGARAGLI, G.P. Interleukin-1 of 45Ca2+ release
from rat striatal slices. Brit. J. Pharmacol. 118: 1705-1710, 1996.
RESEARCH GROUP MEMBERS :
-
Sher Emanuele, R.CNR
-
Passafaro Maria, R.CNR
-
Codignola Agnese, B.
-
Francolini Maura, B.
-
Giovannini Federica, B.
-
Gasperi Cristina, B.
-
Brioschi Angelica, B.
AFFILIATION :
Consiglio Nazionale delle Ricerche
Centro per lo studio della Farmacologia Cellulare e Molecolare
ADDRESS: Via Vanvitelli, 32
CITY: Milano
POSTAL CODE: 20129
TELEPHONE: 02-70146-320, 253
FAX: 02-7490574
E-MAIL: Sher@farma6.csfic.mi.cnr.it
PUBLICATIONS:
-
PELUCCHI, A., CICERI, E., CLEMENTI, F., MARAZZINI, L., FORESI, A. AND SHER,
E. Calcium channel autoantibodies in myasthenic syndrome and small-cell lung
cancer. Amer. Rev. Resp. Dis. 147: 1229-1232, 1993.
-
CATTANEO, M.G., CODIGNOLA, A., VICENTINI, L.M., CLEMENTI, F. AND SHER, E.
Nicotine stimulates a serotonergic autocrine loop in human small-cell lung
carcinoma. Cancer Res. 53: 5566-5568, 1993.
-
CODIGNOLA, A., TARRONI, P., CLEMENTI, F., POLLO, A., LOVALLO, M., CARBONE,
E. AND SHER, E. Calcium channel subtypes controlling serotonin release from
human small cell lung carcinoma cell lines. J. Biol. Chem. 268:
26240-26247, 1993.
-
PASSAFARO, M., CLEMENTI, F., POLLO, A., CARBONE, E., AND SHER, E. w-conotoxin
and Cd++ stimulate the recruitment to the plasmamembrane of an
intracellular pool of voltage-operated calcium channels. Neuron. 12:
317-326, 1994.
-
TARRONI, P., PASSAFARO, M., POLLO, A., CARBONE, E., POPOLI, M., CLEMENTI,
F. AND SHER, E. Anti-b2 subunit antisense oligonucleotides modulate surface
expression of the a1 subunit of N-type w-conotoxin sensitive Ca++
channel in IMR32 human neuroblastoma cells. Biochem. Biophys. Res. Comm.
201: 180-185, 1994.
-
MAGNELLI, V., POLLO, A., SHER, E. AND CARBONE, E. Block of non-L, non-N-type
Ca++ channels in rat insulinoma RINm5F cells by w-agatoxin IVA
and w-conotoxin MVIIC. Eur. J. Physiol. 429: 762-771, 1995.
-
CODIGNOLA, A., MCINTOSH, M., CATTANEO, M.G., VICENTINI, L.M., CLEMENTI, F.
AND SHER, E. a-conotoxin ImI inhibits nicotine-evoked hormone release and
cell proliferation in human neuroendocrine carcinoma cells. Neurosci.
Lett. 206: 53-56, 1996.
-
RICHMOND, J.E., CODIGNOLA, A., COOKE, I.M. AND SHER, E. Calcium- and
barium-dependent exocytosis from the rat insulinoma cell line RINm5F assayed
using membrane capacitance measurements and serotonin release. Eur. J.
Physiol. 432: 258-269, 1996.
-
SHER, E., CESARE, P., CODIGNOLA, A., CLEMENTI, F., POLLO, A., MAGNELLI, V.
AND CARBONE, E. Activation of d-opioid receptors inhibits neuronal-like
Ca++-channels and distal steps of Ca++-dependent secretion
in human small-cell lung carcinoma. J. Neuroscience. 16: 3672-3684,
1996.
-
SHER, E., CODIGNOLA, A., ROGERS, M. AND RICHMOND, J. Noradrenaline inhibition
of Ca++ channels and secretion in single patch clamped insulinoma
cells. FEBS Lett. 385: 176-180, 1996.
RESEARCH GROUP MEMBERS:
-
Spampinato Santi, P.A.
-
Canossa Marco, R.U.
-
Cacciaguerra Silvia D.DR.
-
Campana Gabriele D.DR.
AFFILIATION:
Dipartimento di Farmacologia
Università degli Studi di Bologna
ADDRESS: Via Irnerio, 48
CITY: Bologna
POSTAL CODE: 40126
TELEPHONE: 051-243597, 242025
FAX: 051-248862
E-MAIL: spampi@biocfarm.unibo.it,
gabri@biocfarm.unibo.it silvia@biocfarm.unibo.it
marco@biocfarm.unibo.it
PUBLICATIONS:
-
SPAMPINATO, S., PARADISI, R., CANOSSA, M., CAMPANA, G., FRANK, G., FLAMIGNI,
C., AND FERRI, S. Immunoreactive dynorphin A-like material in extracted human
hypothalamic-hypophysial plasma. Life Sci. 52: 223-230, 1993.
-
CANOSSA, M., VENTURA, C., VAONA, I., CARBONI, L., GUARNIERI, C., AND SPAMPINATO,
S. Prodynorphin mRNA expression in adult cultured rat ventricular cardiac
myocytes. Biochim. Biophys. Acta. 1172: 247-250, 1993.
-
SPAMPINATO, S., BACHETTI, T., CARBONI, L., RATTI, E., Van AMSTERDAM, F.T.M.,
AND FERRI, S. Ca2+ channel blocking activity of lacidipine and
amlodipine in A7r5 vascular smooth muscle cells. Eur.
J. Pharmacol. Molecular Pharmacology Section. 244: 139-144, 1993.
-
ROVELLI, G., HELLER, R.A., CANOSSA, M., AND SHOOTER, E.M. Chimeric tumor
necrosis factor-TrkA receptors reveal that ligand-dependent activation of
the TrkA tyrosine kinase is sufficient for differentation and survival of
PC12 cells. Proc. Nat. Acad. Sci. USA 90: 8717-8721, 1993.
-
MELCHIORRE, C., BOLOGNESI, M.L., CHIARINI, A., MINARINI, A., AND SPAMPINATO,
S. Synthesis and biological activity of some methoctramine-related tetraamines
bearing a 11-Acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one
moiety as antimuscarinics: a second generation of highly selective
M2 muscarinic receptor antagonists. J. Med. Chem. 36:
3734-3737, 1993.
-
VENTURA, C., GUARNIERI, C., VAONA, I., CAMPANA, G., PINTUS, G., AND SPAMPINATO,
S.Dynorphin gene expression and release in the myocardial cell. J. Biol.
Chem. 269: 5384-5386, 1994.
-
FLAMIGNI, F., CAMPANA, G., CARBONI, L., GUARNIERI, C., AND SPAMPINATO, S.
Zinc is required for the expression of ornithine decarboxylase in a
difluoromethylornithine-resistant cell line. Biochem. J. 299: 515-519,
1994.
-
SPAMPINATO, S., CANOSSA, M., CARBONI, L., CAMPANA, G., LEANZA, G., and FERRI,
S. Inhibition ofproopiomelanocortin expression by an oligodeoxynucleotide
complementary in beta-endorphin mRNA. Proc. Nat. Acad. Sci. USA. 91:
8072-8076, 1994.
-
SPAMPINATO, S., CANOSSA, S., CAMPANA, G., CARBONI, L., AND BACHETTI , T.
Estrogen regulation of prodynorphin gene expression in the rat
adenohypophisis:effect of the anti-estrogen tamoxifen. Endocrinology.
136: 1589-1594, 1995.
-
CANOSSA, M., TWISS, J., VERITY, N., AND SHOOTER, E.M. p75NGFR and TrkA receptors
cooperate to rapidly activate a p75NGFR associated protein kinase. EMBO
J. 15: 3369-3376, 1996.
RESEARCH GROUP MEMBERS :
-
Tagliamonte Alessandro, P.O.
-
De Montis M. Graziella, R.U.
-
Bianchi Enrica, R.U.
-
Gambarana Carla, B.PDR.
-
Ghiglieri Ombretta, D.DR.
-
Meloni Domenico, D.DR.
AFFILIATION :
Istituto di Farmacologia
Facoltà di Medicina e Chirurgia
Università di Siena
ADDRESS: Via Delle Scotte, 6
CITY: Siena
POSTAL CODE: 53100
TELEPHONE: 0577-263-285, 226
FAX: 0577-280896
E-MAIL: tagliamonte@unisi.it
PUBLICATIONS:
-
DE MONTIS M.G., C. GAMBARANA, D. MELONI, I. TADDEI, AND A. TAGLIAMONTE.
"Long-term imipramine effects are prevented by NMDA receptor blockade".
Brain Res., 606: 63-67, 1993.
-
MELONI D., C. GAMBARANA, M.G. DE MONTIS, P. DAL PRà, I. TADDEI, AND
A. TAGLIAMONTE. "Dizocilpine antagonizes the effect of chronic imipramine
on learned helplessness in rats". Pharmacol. Biochem. Behav., 46:
423-426, 1993.
-
DE MONTIS M.G., C. GAMBARANA, AND D. MELONI. "a-Methyl-para-tyrosine antagonizes
the effect of chronic imipramine on learned helplessness in rats". Eur.
J. Pharmacol., 249: 179-183, 1993.
-
BIANCHI E., C. ALESSANDRINI, M. GUARNA, AND A. TAGLIAMONTE. "Endogenous codeine
and morphine are stored in specific brain neurons". Brain Res. 627:
210-215, 1993.
-
BIANCHI E., M. GUARNA, AND A, TAGLIAMONTE. "Immunocytochemical localization
of endogenous codeine and morphine". Adv. Neuroimm. 4: 83-92,1994.5.
-
GAMBARANA C., O. GHIGLIERI, A. TAGLIAMONTE, N. D'ALESSANDRO, AND M.G. DE
MONTIS. "Crucial role of D1 dopamine receptors in mediating the antidepressant
effect of imipramine". Pharmacol. Biochem. Behav., 50: 147-151, 1995.
-
GAMBARANA C., O. GHIGLIERI, I. TADDEI, A. TAGLIAMONTE, AND M.G. DE MONTIS.
"Imipramine and fluoxetine prevent the stress-induced escape deficits in
rats through a distinct mechanism of action". Behav. Pharmacol., 6:
66-73, 1995.
-
GAMBARANA C., O. GHIGLIERI, AND M.G. DE MONTIS. "Desensitization of the D1
dopamine receptors in rats reproduces a model of escape deficit reverted
by imipramine". Prog. Neuro-Psych. Biol. Psych., 19: 741-755, 1995.
-
DWORKIN S.I., S. GLEESON, D. MELONI, T.R KOVES, T.J. MARTIN. "Effects of
ibogaine on responding maintained by food, cocaine and heroin reinforcement
in rats". Psychopharmacology 117: 257-261, 1995
-
DE MONTIS M.G., C. GAMBARANA, O. GHIGLIERI, AND A. TAGLIAMONTE. "Reversal
of stable behavioural modifications through NMDA receptor inhibition in rats".
Behav. Pharmacol., 6: 562-567, 1995.
RESEARCH GROUP MEMBERS:
-
Vertua Rodolfo, P.O.
-
Florio Chiara, R.U.
-
Frausin Fabiana, D.DR.
AFFILIATION:
Sezione di Farmacologia
Dipartimento di Scienze Biomediche
Università di Trieste
ADDRESS: via L.Giorgieri, 7/9
CITY: Trieste
POSTAL CODE: 34127
TELEPHONE: 040-676-3529, 3532, 3534
FAX: 040-577435
PUBLICATIONS:
-
ROSATI, A.M., TRAVERSA, U., FLORIO C., AND VERTUA, R. Circadian rhythm of
cortical and striatal adenosine receptors. Life Sci. 52: 1677-1684;
1993
-
FLORIO, C., MARTIN, J. G., STHYLER, A., AND HEISLER, S. Antiproliferative
effect of prostaglandin E2 in guinea pig tracheal smooth muscle cells.
Amer. J. Physiol. 266: L131-L137, 1994.
-
FLORIO, C., ROSATI, A.M., TRAVERSA, U., AND VERTUA, R. Strain-related differences
in adenosine receptor density and in behavioral sensitivity to adenosine
analogs in mice. Pharmacol. Biochem. Behav. 49: 271- 276, 1994.
-
TRAVERSA, U., ROSATI, A.M., FLORIO, C., AND VERTUA, R. Effects of divalent
cations on adenosine agonist binding to A1 and non A1/A2 sites in rat cerebral
cortex. Pharmacol. Toxicol. 75: 28-35, 1994.
-
TRAVERSA, U., ROSATI, A.M., FLORIO, C., AND VERTUA, R. Effects of chronic
administration of adenosine antagonists on adenosine A1 and A2 receptos in
mouse brain. In Vivo. 8: 1073-1078, 1994.
-
NAURCCKAS, E.T., HERSHENSON, M. B., ABE, M.K., KELLEHER, M.D., FLORIO, C.,
HEISLER, S., ABSHER, M., EVANS, J.N., SAMSEL, R.W., AND SOLWAY, J.
Bronchoalveolar lavage fluid from immature rats with hyperoxia-induced airway
remodelling is mitogenic for airway smooth muscle. Amer. J. Res. Cell.
Mol. Biol. 12: 268-274, 1995.
-
TUBARO, A., FLORIO, C., LUXICH, E., SOSA, S., DELLA LOGGIA, R., AND YASUMOTO,
T. A protein phosphatase 2A inhibition assay for a fast and sensitive assessment
of okadaic acid contamination in mussels. Toxicon. 34: 743-752, 1996.
-
TUBARO, A., FLORIO, C., LUXICH, E., VERTUA, R., DELLA LOGGIA, R., AND YASUMOTO,
T. Suitability of the MTT-based cytotoxicity assay to detect okadaic acid
contamination of mussels. Toxicon. 34: 965-974, 1996.
RESEARCH GROUP MEMBERS:
-
Vicentini Lucia, P.A.
-
Cattaneo M. Grazia, T.L.
AFFILIATION:
Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica
Facoltà di Medicina e Chirurgia
Università degli Studi di Milano
ADDRESS: Via Vanvitelli, 32
CITY: Milano
POSTAL CODE: 20129
TELEPHONE: 02 - 70146240
FAX: 02 - 70146371
E-MAIL: luciav@imiucca.csi.unimi.it
PUBLICATIONS:
-
SKOLNICK E.Y., LEE C.H., BATZER A., VICENTINI L.M., ZHOU M., DALY R., MYERS
M.J., BACKER J.M., ULLRICH A., WHITE M.F. E SCHLESSINGER J. The SH2/SH3
domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1
and Shc: implication for insulin control of ras signalling. EMBO J.,
12: 1929-1936, 1993.
-
CATTANEO M.G., GULLO M. E VICENTINI L.M. Ca2+ and Ca2+ channel antagonists
in the control of human small cell lung carcinoma cell proliferation. Eur.
J. Pharmacol., 247: 325-331, 1993.
-
CATTANEO M.G., CODIGNOLA A., VICENTINI L.M., CLEMENTI F. E SHER E. Nicotine
stimulates a serotoninergic autocrine loop in human small cell lung carcinoma.
Cancer Res., 53: 5566-5568, 1993.
-
CODIGNOLA A., TARRONI P., CATTANEO M.G., VICENTINI L.M., CLEMENTI F. E SHER
E. Serotonin release and cell proliferation are under the control of
-bungarotoxin-sensitive nicotinic receptors in small-cell lung carcinoma
cell lines. FEBS Lett., 342: 286-290, 1994.
-
CATTANEO M.G., PALAZZI E., BONDIOLOTTI G.P. E VICENTINI L.M. 5-HT1D receptor
type is involved in stimulation of cell proliferation in human small cell
lung carcinoma. Eur. J. Pharmacol., 268: 425-430, 1994.
-
CATTANEO M.G., FESCE R. E VICENTINI L.M. Mitogenic effect of serotonin in
human small cell lung carcinoma cells via both 5-HT1A and 5-HT1D receptors.
Eur. J. Pharmacol., 291: 209-211, 1995.
-
CODIGNOLA A., MCINTOSH J.M., CATTANEO M.G., VICENTINI L.M., CLEMENTI F. E
SHER E. -conotoxin Imperialis I inhibits nicotine-evoked hormone release
and cell proliferation in human neuroendocrine carcinoma cells. Neurosci.
Lett., 206: 53-56, 1996.
-
VICENTINI L.M., CATTANEO M.G. E FESCE R. Evidence for receptor subtype cross-talk
in the mitogenic action of serotonin on human small-cell lung carcinoma cells.
Eur. J. Pharmacol., In press, 1996.
-
CATTANEO M.G., AMOROSO D., GUSSONI G., SANGUINI A.M. E VICENTINI L.M. A
somatostatin analogue inhibits MAP kinase activation and cell proliferation
in human neuroendocrine cells, FEBS Lett., In press, 1996.
RESEARCH GROUP MEMBERS :
-
Volterra Andrea, R.U.
-
Trotti Davide, D.DR.
-
Bezzi Paola, D.DR.
-
Lodi Rizzini Barbara, B.
-
Rossi Daniela, B.
AFFILIATION:
Centro di Neurofarmacologia, Istituto di Scienze Farmacologiche
Facoltà di Farmacia
Università di Milano
ADDRESS: Via Balzaretti, 9
CITY: Milano
POSTAL CODE: 20133
TELEPHONE: 02-20488206
FAX: 02-29404961
E-MAIL: volterra@isfunix.farma.unimi.it
PUBLICATIONS:
-
VOLTERRA A., TROTTI D., TROMBA C., FLORIDI S. AND RACAGNI G. Oxygen free
radicals inhibit glutamate uptake in rat cortical astrocytes. J.
Neurosci. 14: 2924-2932, 1994.
-
TROMBA C., SALVAGGIO A., RACAGNI G. AND VOLTERRA A. Hippocampal
hypoglycemia-activated K+ channels: single-channel analysis of
glucose- and voltage-dependence. Pflügers Arch. Eur. J. Physiol.
429: 58-63, 1994.
-
VOLTERRA A., TROTTI D. AND RACAGNI G. Glutamate uptake is inhibited by
arachidonic acid and oxygen radicals via two distinct and additive
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VOLTERRA A., TROTTI D., BEZZI P., CIVENNI G. AND RACAGNI G. [Ca++]
modulates the ratio between cycloxygenase and lipoxygenase metabolism of
arachidonic acid in homogenates of hippocampal astroglial cultures.
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TROTTI D., VOLTERRA A., LEHRE K.P., ROSSI D., GJESDAL O., RACAGNI G. AND
DANBOLT NC. Arachidonic acid inhibits a purified and reconstituted glutamate
transporter directly from the water phase and not by via the phospholipid
membrane. J. Biol. Chem. 270: 9890-9895, 1995.
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TROTTI D., ROSSI D., GJESDAL O., LEVY L.M., RACAGNI G., DANBOLT N.C. AND
VOLTERRA A. Peroxynitrite inhibits glutamate transporter subtypes. J.
Biol. Chem. 271: 5976-5979, 1996.
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VOLTERRA A., BEZZI P., LODI RIZZINI B., TROTTI D., ULLENSVANG K., DANBOLT
N.C. AND RACAGNI G. The competitive transport inhibitor
L-trans-pyrrolidine-2,4-dicarboxylate triggers excitotoxicity in rat cortical
neuron-astrocyte co-cultures via glutamate release rather than uptake inhibition.
Eur. J. Neurosci. 8: 2019-2028, 1996.
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