SIF - Società
Italiana di Farmacologia
"SIF - La Ricerca Farmacologica in Italia"
AUTONOMIC PHARMACOLOGY
RESEARCH GROUP MEMBERS:
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Breschi Maria Cristina, P.A.
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Nieri Paola, R.U.
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Lazzeri Nicola, B.
AFFILIATION:
Sezione di Farmacologia
Istituto Policattedra di Discipline Biologiche
Facoltà di Farmacia
Università di Pisa
ADDRESS: Via Bonanno, 6
CITY: Pisa
POSTAL CODE: 56126
TELEPHONE: 050-24092
FAX: 050-40517
E-MAIL: breschi@farm.unipi.it
PUBLICATIONS:
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MACCHIA B., BALSAMO A., BRESCHI M.C., CHIELLINI G., LAPUCCI A., MACCHIA M.,
MANERA C., MARTINELLI A., MARTINI C., SCATIZZI R. AND UCCELLO BARRETTA G.
Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis,
conformational analysis and adrenergic activity of isochroman derivatives.
J. Med. Chem. 36: 3077-3086, 1993.
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BRESCHI M.C., PELLEGRINI A., SOLDANI P., MARTINOTTI E., SCATIZZI R. AND PAPARELLI
A. Morphofunctional changes in the noradrenergic innervation of rat
cardiovascular system after various duration of noise stress. Int. J.
Neurosci. 75: 73-81, 1994.
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PELLEGRINI A., SOLDANI P., BRESCHI M.C., SCATIZZI R., NIERI P., CAMPAGNI
A., DEL BIANCHI S. AND PAPARELLI A. Noradrenergic innervation and receptor
responses of cardiovascular tissues from young and aged rats after acute
microwave exposure. Int. J. Neurosci. 76: 165-175, 1994.
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BRESCHI M.C., NIERI P., LAZZERI N. AND MARTINOTTI E. Adenosine enhances the
bronchocontractile response to histamine in anaesthetized and curarized
guinea-pigs through a mechanism partly blocked by hexamethonium.
Pharmacology 49: 42-51, 1994.
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BRESCHI M.C., SCATIZZI R., CAMPAGNI A., SOLDANI P., PELLEGRINI A., GESI M.,
PAPARELLI A. AND DEL BIANCHI S. Age-related changes in the noradrenergic
pattern and receptor responses of the rat cardiovascular system after repeated
microwave exposure. Int. J. of Neurosci. 82: 61-69, 1995.
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BRESCHI M.C., MARTINI C., SCATIZZI R., CRISTOFANI R., GIANNACCINI G., MARTINOTTI
E. AND LUCACCHINI A. Benzodiazepine agonists reverse the effects of noise
exposure on central benzodiazepine receptors and cardiac responsiveness.
Life Sci. 57: 1131-1140, 1995.
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BALSAMO A., BRESCHI M.C., CHIELLINI G., FAVERO L., MACCHIA M., MARTINELLI
A., MARTINI C., ROSSELLO A. AND SCATIZZI R. Synthesis and ß-adrenergic
properties of (E)-N-[3-(alkylamino)-2-hydroxypropilidene](methyloxy)amines
substituted with an aromatic group on their [(methyloxy)imino]methyl moiety
(MOIMM): an investigation into the biopharmacological effects of an aryl
substitution in the class of MOIM ß-blocking drugs. Eur. J. Med.
Chem. 30: 743-755, 1995.
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NIERI P., LAZZERI N., MARTINOTTI E., SCATIZZI R. AND BRESCHI M.C.
Acetylcholine-induced -bronchoconstriction modified by noise exposure in
normal but not in sensitized guinea-pigs. J. Auton. Pharmacol. 16:
55-62, 1996.
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NIERI P., MARTINOTTI E., LAZZERI N. AND BRESCHI M.C. Effects of adenosine
on NANC bronchoconstriction in anaesthetised guinea- pigs. J. Pharm.
Pharmacol. 48: 422-428, 1996.
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BRESCHI M.C., MACCHIA M., MANERA C., MICALI E., NARDINI C., NENCETTI S.,
ROSSELLO A. AND SCATIZZI R. Conformationally restrained b-blocking oxime
ethers. 3. Synthesis and b-adrenergic antagonistic activity diastereomeric
anti and syn 2-(5'-(3'-methyl)isoxazolidinyl)-N-alkylethanolamines.
Eur. J. Med. Chem. 31: 159-163, 1996.
RESEARCH GROUP MEMBERS:
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Crema Antonio, P.O.
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De Ponti Fabrizio, R.U.
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Crema Francesca, R.U.
AFFILIATION:
Dipartimento di Medicina Interna e Terapia Medica
Facoltà di Medicina e Chirurgia
Università degli Studi di Pavia
ADDRESS: Piazza Botta, 10
CITY: Pavia
POSTAL CODE: 27100
TELEPHONE: 0382-506357
FAX: 0382-22741
E-MAIL: deponti@ipv36.unipv.it
PUBLICATIONS:
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DE PONTI F., EINAUDI A., COSENTINO M., D'ANGELO L., LECCHINI S., FRIGO G.M.
AND CREMA A. Differential effects of antimuscarinic agents on intestinal
motility in the conscious dog. J. Pharmacol. Exp. Ther.. 264: 789-794,
1993.
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DE PONTI F., GIARONI C., COSENTINO M., LECCHINI S. AND FRIGO G.M. Calcium
channel blockers and gastrointestinal motility: basic and clinical aspects.
Pharmacol. Therapeut. 60: 121-148, 1993.
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SPADA M., DE PONTI F., ALESSIANI M., COSTA A., GIRANI M., DIONIGI P., VISCHI
S., PELONI G., REYES J., TODO S. AND CREMA A. Monitoring of intestinal
myoelectrical activity after isolated small bowel transplantation in
FK506-immunosuppressed pigs. Transplantation Proceedings. 26: 1537-1539,
1994.
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DE PONTI F., COSENTINO M., COSTA A., GIRANI M., GIBELLI G., D'ANGELO L.,
FRIGO G.M. AND CREMA A. Inhibitory effects of SR 58611A on canine colonic
motility: evidence for a role of 3-adrenoceptors. British J. Pharmacol..
114: 1447-1453, 1995.
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DE PONTI F., CREMA F., D'ANGELO L., CARAVAGGI M., BROCCALI G., BIANCO L.
AND LECCHINI S. Repeated administration of SL 84.0418, a new oral
antihyperglycaemic agent. A phase I study. Clinical Drug Investigation.
9: 191-196, 1995.
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DE PONTI F., GIBELLI G., CREMA F. AND LECCHINI S. Functional evidence for
the presence of 3-adrenoceptors in the guinea-pig common bile duct and colon.
Pharmacology. 51: 288-297, 1995.
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DE PONTI F., GIBELLI G., CROCI T., ARCIDIACO M., CREMA F. AND MANARA L.
Functional evidence of atypical 3-adrenoceptors in the human colon using
the 3-selective adrenoceptor antagonist SR 59230A. British J.
Pharmacol.. 117: 1374-1376, 1996.
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DE PONTI F., GIARONI C., COSENTINO M., LECCHINI S. AND FRIGO G.M. Adrenergic
mechanisms in the control of gastrointestinal motility: from basic science
to clinical applications. Pharmacol. Therapeut.. 69: 59-78, 1996.
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COSTA A., DE PONTI F., SPADA M., ALESSIANI M., BARBERA D., FERRARI P., ZANOLA
S., MORBINI P., ARBUSTINI E. AND CREMA A. Reduced intestinal myoelectrical
activity during rejection of small bowel allografts in pigs. Transplantation
Proceedings. In press, 1996.
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COSTA A., ALESSIANI M., DE PONTI F., SPADA M., MERLI M., ZANOLA S., BARBERA
D., RADEMACHER J., DRIVAS E. AND CREMA A. Stimulatory effect of FK506 and
erythromycin on pig intestinal motility. Transplantation Proceedings.
In press, 1996.
RESEARCH GROUP MEMBERS:
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Martinotti Enrica, P.A.
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Scatizzi Roberta, D.DR.
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Calderone Vincenzo, B.
AFFILIATION:
Sezione di Farmacologia
Istituto Policattedra di Discipline Biologiche
Facoltà di Farmacia
Università di Pisa
ADDRESS: Via Bonanno, 6
CITY: Pisa
POSTAL CODE: 56126
TELEPHONE: 050-24092
FAX: 050-40517
E-MAIL: emartin@farm.inupi.it
PUBLICATIONS:
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BRESCHI, M.C., MARTINOTTI, E., CATALANO, S., FLAMINI, G., MORELLI, I. AND
PAGNI, A.M. Vasoconstrictor activity of 8-o-acetylharpagide from Ajuga
Reptans. Journal of Natural Products, 8: 1145-1148, 1993
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MACCHIA, B., BRESCHI, M.C., GENTILI, D., LAPUCCI, A., MACCHIA, M., MANERA,
C., MARTINELLI, A., MARTINOTTI, E., NENCETTI, S. AND NIERI, P. Conformationally
restrained analogs of sympathomimetic catecholamines. Synthesis and adrenergic
activity of tetrahydrobenzocycloheptene derivatives. Eur. J. Med. Chem.
29: 753-760, 1994.
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MACCHIA, B., MACCHIA, M., MANERA, C., MARTINOTTI, E., NENCETTI, S., ORLANDINI,
E., ROSSELLO, A. AND SCATIZZI, R. Role of the benzylic hydroxyl group of
adrenergic catecholamines in eliciting -adrenergic activity. Synthesis and
1- and 2-adrenergic activity of 3-phenyl-3-piperidinols
and their desoxy analogs Eur. J. Med. Chem. 30: 869-880, 1995.
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DELLA PIETà, F., BRESCHI, M.C., SCATIZZI, R. AND CINELLI, F. Relaxing
activity of two linear diterpenes from Cystoseira Brachycarpa var. balearica
on intestinal preparations. Planta Medica 61 (6): 493-496, 1995.
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CALDERONE, V., MARTINOTTI, E., SCATIZZI, R., PELLEGRINI, A. AND BRESCHI,
M.C. A modified aortic multiple-ring preparation for functional studies J.
Pharmacologic and Toxicologic Methods, 35: 131-138, 1996.
RESEARCH GROUP MEMBERS:
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Mitolo-Chieppa Delia, P.O.
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Serio Miralma, B.PDR.
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Potenza Maria Assunta, D.DR.
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Macchiarulo Carmela, B.
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Montagnani Monica, B.
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Mansi Gianfranco, B.
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Rinaldi Rosanna, D.DR:
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Genualdo Marisa, D.DR:
AFFILIATION:
Istituto di Farmacologia
Facoltà di Medicina e Chirurgia
Università di Bari
ADDRESS: Piazza Giulio Cesare
CITY: Bari
POSTAL CODE: 70124
TELEPHONE: 080/5478449
FAX: 080/5478444
E-MAIL: cuomo@cimedoc.uniba.it
PUBLICATIONS:
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SERIO, M., MITOLO-CHIEPPA, D., POTENZA, M.A. Presynaptic cholinergic receptors
modulating neurotransmitters release in the guinea-pig urinary bladder.
Functional Neurology. 9 (3): 101-105, 1994.
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SERIO, M., POTENZA, M.A., VULPIS, V., PIRRELLI, A., MITOLO-CHIEPPA, D., JIRILLO,
E. Decrease of phagocytic functions in hypertensive rats. Immunopharmacol.
Immunotoxicol. 16 (2): 261-280, 1994.
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POTENZA, M.A., DE SALVATORE, G., MONTAGNANI, M., SERIO, M., MITOLO-CHIEPPA,
D. Vasodilatation induced by capsaicin in rat mesenteric vessels is probably
independend of nitric oxide synthesis. Pharmacol. Res. 30 (3): 253-261,
1994.
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POTENZA, M.A., DE SALVATORE, G., MONTAGNANI, M., SERIO, M., MITOLO-CHIEPPA,
D. Vasodilatation induced by capsaicin in rat mesenteric resistance vessels:
role of nitric oxide. Polish J. Pharmacol. 46 (4): 326-327, 1994.
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SERIO, M., MONTAGNANI, M., POTENZA, M.A., MANSI, G., DE SALVATORE, G.,
MITOLO-CHIEPPA, D. Posnatal developmental changes of receptor responsiveness
in rat mesenteric vascular bed. J. Auton. Pharmacol. 16: 63-68, 1996.
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MITOLO-CHIEPPA, D., SERIO, M., POTENZA, M.A., MONTAGNANI, M., MANSI, G.,
PECE, S., JIRILLO, E., STOCLET, J.C. Hyporeactivity of mesenteric vascular
bed in endotoxin-treated rats. Eur. J. Pharmacol. 309 (2): 175-182,
1996.
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SERIO, M., POTENZA, M.A., MONTAGNANI, M., MANSI, G., MITOLO-CHIEPPA, D.,
JIRILLO, E. Beta adrenoceptor responsiveness of splenic macrophages in
normotensive and hypertensive rats. Immunopharmacol. Immunotoxicol.
18 (2): 249-265, 1996.
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MANSI, G., SERIO, M., POTENZA, M.A., MONTAGNANI, M., MITOLO-CHIEPPA, D.
Involvement of nitric oxide in hyporeactivity of rat mesenteric vascular
bed during endotoxin shock: effect of dexamethasone and endothelin-I. J.
Biol. Res. 72: 155-162, 1996.
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SERIO, M., POTENZA, M.A., MONTAGNANI, M., MANSI, G., RINALDI, R., PECE, S.,
FUMAROLA, D., JIRILLO, E., MITOLO-CHIEPPA, D. Bacterial
lipopolysaccharide-induced hyporeactivity in rat perfused resistance vessels.
Modulating effect of dexamethasone. J. Endotoxin Res. 1996, in press.
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MONTAGNANI, M., SERIO, M., POTENZA, M.A., MANSI, G., DE SALVIA, M.A., CAGIANO,
R., CUOMO, V., AND MITOLO-CHIEPPA, D. Prenatal exposure to carbon monoxide
and vascular responsiveness of rat resistance vessels. Life Sci. 59
(18): 1553-1561, 1996.
RESEARCH GROUP MEMBERS:
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Testa Rodolfo, C.L.
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Poggesi Elena, C.L.
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Taddei Carlo, R.I.
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Guarnieri Luciano, C.L.
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Angelico Patrizia, R.I.
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Ibba Marina, R.I.
-
Sironi Giorgio, C.L.
-
Colombo Davide, R.I.
-
Leonardi Amedeo, Dir. R.
AFFILIATION:
RECORDATI Industria Chimica e Farmaceutica S.P.A.
ADDRESS: Via M. Civitali 1
CITY: Milano
POSTAL CODE: 20148
TELEPHONE: (02) 48787.1
FAX: (02) 40073747
PUBLICATIONS:
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TADDEI C., POGGESI E., LEONARDI A., AND TESTA R. Affinity if different
alpha1-antagonists for the alpha1-adrenoceptors of rabbit and rat liver
membranes. Life Sci. 53: 177-181, 1993.
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TESTA R., GUARNIERI L., IBBA M., STRADA G., POGGESI E., TADDEI C., SIMONAZZI
I., AND LEONARDI A. Characterization of alpha1-adrenoceptor subtypes in prostate
and prostatic urethra of rat, rabbit, dog, and man. Eur. J. Pharmacol.
249: 307-315, 1993.
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TESTA R., GUARNIERI L., POGGESI E., SIMONAZZI I., TADDEI C., AND LEONARDI
A. Mediation of noradrenaline-induced contractions of rat aorta by the
alpha1b-adrenoceptor subtype. Brit. J. Pharmacol. 114: 745-750, 1995.
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TESTA R., TADDEI C. POGGESI E., DESTEFANI C., COTECCHIA S., HIEBLE J.P.,
SULPIZIO A.C. NASELSKY D., BERGSMA D., ELLIS C., SWIFT A., GANGULY S., RUFFOLO
R.R. JR., AND LEONARDI A. Rec 15/2739 (SB 216469): a novel prostate selective
alpha 1-adrenoceptor antagonist. Pharmacol. Comm. 6: 1-3, 79-86, 1995.
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TESTA R., DESTEFANI C., GUARNIERI L., POGGESI E., SIMONAZZI I., TADDEI C.,
AND LEONARDI A. The alpha1d-adrenoceptor subtype is involved in the
noradrenaline-induced contractions of the rat aorta. Life Sci. 57:
PL159-PL163, 1995.
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GUARNIERI L., ANGELICO P., IBBA M., POGGESI E., TADDEI C., LEONARDI A., AND
TESTA R. Pharmacological in vitro studies of the new 1,4-dihydropyridine
calcium antagonist lercanidipine. Arzneim.-Forsch. Drug Res. 46: 15-24,
1996.
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SIRONI G., MONTAGNA E., GRETO L., BIANCHI G., LEONARDI A., AND TESTA R.
Antihypertensive effects of lercanidipine in experimental hypertensive rats
and dogs. Arzneim.-Forsch. Drug Res. 46 : 145-152, 1996.
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SIRONI G., MONTAGNA E., GRETO L., LEONARDI A., AND TESTA R. Haemodynamic
effects of lercanidipine in anaesthetized open-chest dogs. Arzneim.-Forsch.
Drug Res. 46: 256-261, 1996.
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TESTA R., GUARNIERI L., TADDEI C., POGGSI E., ANGELICO P., SARTANI A., LEONARDI
A., GOFRIT O.N., MERETYK S., AND CAINE M. Functional antagonistic activity
of Rec 15/2739, a novel alpha-1 antagonist selective for the lower urinary
tract, on noradrenalilne-induced contraction of human prostate and mesenteric
artery. J. Pharmacol. Exp. Ther. 277: 1237-1246, 1996.
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