SIF - Società
Italiana di Farmacologia
"SIF - La Ricerca Farmacologica in Italia"
CARDIOVASCULAR PHARMACOLOGY
RESEARCH GROUP MEMBERS:
-
Anania Vittorio Domenico, P.O.
-
Madeddu Paolo, R.U.
-
Demontis Maria Piera, R.U.
-
Varoni Maria Vittoria, T.L.
-
Fresi Angela, D.DR.
AFFILIATION:
Sezione di Farmacologia
Dipartimento di Biologia Animale
Facoltà di Medicina Veterinaria
Università di Sassari
ADDRESS: Via Vienna, 2
CITY: Sassari
POSTAL CODE: 07100
TELEPHONE: 079-22-8518, 9519
FAX: 079-229432
PUBLICATIONS:
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MADEDDU P., ANANIA V., PINNA, PARPAGLIA P., DEMONTIS M.P., VARONI M.V., FATTACCIO
M.C., GLORIOSO N. Chronic kinin receptor blockade induces hypertension in
deoxycorticosterone-treated rats. Brit. J. Pharmacol. 108: 651-657,
1993.
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MADEDDU, P., DEMONTIS, M.P., VARONI, M.V., FATTACCIO, M.C., PALMIERI, A.,
ANANIA, V. Verapamil prevents the acute hypertensive response to
intracerebroventricular cadmium in conscious normotensive rats. Amer.
J. Hypertension 6: 193-197, 1993.
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MADEDDU, P., GLORIOSO, N., VARONI, M.V., DEMONTIS, M.P., FATTACCIO, M.C.,
ANANIA, V. Cardiovascular effects of brain kinin receptor blockade
in spontaneously hypertensive rats. Hypertension 23 (suppl. I): I189-I192,
1994.
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MADEDDU, P., PINNA, PARPAGLIA, P., VARONI, M.V., DEMONTIS, M.P., FATTACCIO,
M.C., ANANIA, V., GLORIOSO, N. Chronic inhibition of bradykinin receptors
alters cardiovascular function in rats with an excess of circulating
vasoconstrictors. Brazilian J. Med. Biol. Res. 27: 1985-1993, 1994.
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DE RIU, P.L., DEMONTIS, M.P., ANANIA, V., CARIA, M.A., MAMELI, O., BECCIU,
A., TOLU, E. Brain electrobiogenesis protection induced by nimodipine and
MK-801 during acute hypoxia in hypertensive rats. Pharm. Res. 31:169-173,
1995.
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MADEDDU, P., PINNA, PARPAGLIA, P., DEMONTIS, M.P., VARONI, M.V., FATTACCIO,
M.C., ANANIA, V., GLORIOSO, N. Early blockade of bradykinin B2-receptors
alters the adult cardiovascular phenotype in rats. Hypertension 25:
453-459, 1995.
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MADEDDU, P., PINNA, PARPAGLIA, P., DEMONTIS, M.P., VARONI, M.V., FATTACCIO,
M.C., ANANIA, V., GLORIOSO, N. Effects of kinin blockade on the blood pressure
of salt-loaded pregnant rats. Hypertension 25: 823-827, 1995.
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MADEDDU, P., ANANIA, V., VARONI, M.V., PINNA, PARPAGLIA, P., DEMONTIS, M.P.,
FATTACCIO, M.C., PALOMBA, D., POLLOCK ,D., GLORIOSO, N. Prevention by blockade
angiotensin subtype1-receptors of the development of genetic hypertension
but not its heritability. British J. Pharmacol. 115: 557-562, 1995.
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MADEDDU, P., VARONI, M.V., DEMONTIS, M.P., PINNA, PARPAGLIA, P., GLORIOSO,
N., ANANIA, V. Urinary kallikrein: A marker of blood pressure sensitivity
to salt. Kidney International 49: 1422-1427, 1996.
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MADEDDU, P., VARONI, M.V., DEMONTIS, M.P., PINNA, PARPAGLIA, P., GLORIOSO,
N., ANANIA, V. Blood pressure sensitivity to salt in rats with low urinary
kallikrein excretion. Immunopharmacol. 33: 301-304, 1996.
RESEARCH GROUP MEMBERS:
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Berti Ferruccio, P.O.
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Rossoni Giuseppe, T.L.
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Bernareggi Micaela, D.DR.
AFFILIATION:
Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica "Emilio
Trabucchi"
Facoltà di Medicina e Chirurgia
Università degli Studi di Milano.
ADDRESS: Via Vanvitelli, 32
CITY: Milano
POSTAL CODE: 20129
TELEPHONE: 02/74.90.243 - 70146.312.
FAX: 02/70146.371
E-MAIL: berti@imiucca.csi.unimi.it.
PUBLICATIONS:
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BERTI F., ROSSONI G., DELLA BELLA D., VILLA L.M., BUSCHI A., TRENTO F., BERTI
M., AND TONDO C. Nitric oxide and prostacyclin influence coronary vasomotor
tone in perfused rabbit heart and modulate endothelin-1 activity. J.
Cardiovasc. Pharmacol. 22: 321-326, 1993.
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SALA A., ROSSONI G., BUCCELLATI C., BERTI F., FOLCO G., AND MACLOUF J. Formation
of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary
vasoconstriction in isolated cell-perfused heart of rabbit. British J.
Pharmacol.. 110:1206-1212, 1993;
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SALA A., RONA P., POMPILIO G., PAROLARI A., ANTONA C., BIGLIOLI P., ROSSONI
G., VILLA L.M., AND BERTI F. Prostacyclin production by different human grafts
employed in coronary operations. Ann. Thorac. Surg. 57: 1147-1150,
1994.
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BERTI F., ROSSONI G., FERRO L,. TRENTO F., VILLA L.M., POMPILIO G., AND SALA
A. Defibrotide, via prostacyclin release, antagonizes endothelin-1 induced
vasospasm in rabbit and human coronary artery. Internal Medicine.
2: 49-56, 1994.
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ROSSONI G., BERTI F., BERTI M., BERNAREGGI M., TRENTO F., PORTA R., PESCADOR
R., AND FERRO L. Oligotide, a new single-stranded oligodeoxyribonucleotide,
preserves postsynaptic b-adrenergic and cholinergic receptor functions in
rabbit hearts after acute infarction. Thromb. Res. 78: 429-440, 1995.
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ROSSONI G., BERTI F., BERNAREGGI M., VILLA L.M., AGOZZINO S., CEREDA R.,
GIULIANI P., AND MIZRAHI J. Protective effects of ITF 296 in the isolated
rabbit heart subjected to global ischemia. J. Cardiovasc. Pharmacol.
26: S44-S52, 1995.
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ROSSONI G., SALA A., BERTI F., TESTA T., BUCCELLATI C., MOLTA C.,
MÜLLER-PEDDINGHAUS R., MACLOUF J., AND FOLCO G.C. Myocardial protection
by the leukotriene synthesis inhibitor BAY X 1005. Importance of
transcellular biosynthesis of cysteinylleukotrienes. J. Pharmacol.
Exp. Ther.. 276: 335-341, 1996.
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GJUMRAKCH M.A., SALA A., ROSSONI G., BERTI F., BUCCELLATI C., BURNSTOCK G.,
FOLCO GC., AND MACLOUF, J. Morphological and functional changes of coronary
vasculature caused by transcellular biosynthesis of sulfidopeptide leukotrienes
in isolated heart of rabbit. Blood. 87: 1824-1832, 1996.
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DE GENNARO COLONNA V., ROSSONI G., BONACCI D., CICERI S., CATTANEO L.,
MÜLLER E.E., AND BERTI F. Worsening of ischemic damage in hearts from
rats with selective growth hormone deficiency. Eur. J. Pharmacol.
In press, 1996.
RESEARCH GROUP MEMBERS:
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Bongrani Stefano, Dir. R.
-
Civelli Maurizio, C. L.
-
Giossi Massimo, R. I.
-
Galbiati Elisabetta , R.I.
-
Razzetti Roberta, C. L.
-
Bergamaschi Marco, R.I.
-
Fornasier Massenzio, R.I.
-
Pastore Fiorella, R.I.
-
Cadel Sandro, C.L.
-
Villetti Gino, R.I.
AFFILIATION:
Chiesi Farmaceutici S.p.A.
ADDRESS: Via Palermo 26/A
CITY: Parma
POSTAL CODE: 43100
TELEPHONE: 0521-2791
FAX: 0521-774468
E-MAIL: chiesi@mbox.vol.it
PUBLICATIONS:
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BONGRANI, S., FORNASIER, M., PAPOTTI,
M., RAZZETTI, R., AND ROBERTSON, B. Lung gas volumes and expiratory time
constant in immature newborn rabbits treated with natural or synthetic surfactant
or detergents. Biol. Neonate. 65: 406-415, 1994.
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RAZZETTI, R., FORNASIER, M., PAPOTTI,
M., AND BONGRANI, S. Antihypertensive and diuretic effects of Delapril,
Indapamide and their combination in spontaneously hypertensive rats. High
Blood Pressure. 3 : 8-16, 1994.
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CIVELLI, M., CARUSO, P., GIOSSI, M.,
BERGAMASCHI, M., RAZZETTI, R., BONGRANI, S., AND GASCO, A. CHF 2206, a new
potent vasodilating and antiaggregating drug as potential nitric oxide donor.
Eur. J. Pharmacol. 225: 17-24, 1994.
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ZENG, Y.C., BONGRANI, S., BRONZETTI,
E., CADEL, S., RICCI, A., VALSECCHI, B., AND AMENTA, F. Influence of long-term
treatment with L-deprenyl on the age-dependent changes in rat brain microanatomy.
Mech. Age. Dev.. 73: 113-126, 1994.
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RAZZETTI, R., AND ACERBI, D. Pharmacokinetic
and pharmacologic properties of Delapril, a lipophilic nonsulfhydryl
angiotensin-converting enzyme inhibitor. Amer. J. Cardiol.. 75 :
7-12, 1995.
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GIOSSI, M., CARUSO, P., CIVELLI, M.,
AND BONGRANI, S. Inhibition of parathyroid hormone-stimulated resorption
in cultured fetal rat long bones by the main metabolites of ipriflavone.
Calcified Tissue Int. 58: 419-422, 1996.
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CIVELLI, M., GIOSSI, M., CARUSO, P.,
RAZZETTI, R., BERGAMASCHI, M., BONGRANI, S. AND GASCO, A. The involvement
of the release of nitric oxide in the pharmacological activity of the new
furoxan derivative CHF 2363. Brit. J. Pharmacol. 118: 923-928,
1996.
RESEARCH GROUP MEMBERS:
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Caparrotta Laura, P.A.
-
Ragazzi Eugenio, P.A.
-
Froldi Guglielmina, R.U.
-
Chinellato Alessandro, B.PDR.
AFFILIATION:
Dipartimento di Farmacologia "E. Meneghetti"
Facoltà di Farmacia
Università degli Studi di Padova
ADDRESS: Largo E. Meneghetti, 2
CITY: Padova
POSTAL CODE: 35131
TELEPHONE: 049-827-5090 / 5092
FAX: 049-827-5093
E-MAIL: caparrot@ipdunidx.unipd.it
mina@dfem.unipd.it ragazzi@dfem.unipd.it
PUBLICATIONS:
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CHINELLATO A., RAGAZZI E., PANDOLFO L., FROLDI G., CAPARROTTA L., FASSINA
G. Unimpaired adenosine 5'-triphosphate-induced relaxation in in vitro Watanabe
heritable hyperlipidemic rabbit aorta. Nutr. Metab. Cardiovasc.
Dis. 3:5-9, 1993.
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FROLDI G., PANDOLFO L., DE BIASI M., CHINELLATO A., RAGAZZI E., CAPARROTTA
L., FASSINA G. Species-dependent effects of increasing hypoxia on functions
and energy balance in isolated atria. Comp. Biochem. Physiol. 105A:21-27,
1993
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RAGAZZI E., CHINELLATO A., PANDOLFO L., FROLDI G., CAPARROTTA L., PROSDOCIMI
M., ALIEV G., FASSINA G. Atherosclerosis-related remodeling of aortic relaxation
to purines in Watanabe heritable hyperlipidemic (WHHL) rabbit. J. Pharmacol.
Exp. Ther. 266:1091-1096, 1993.
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FROLDI G., PANDOLFO L., CHINELLATO A., RAGAZZI E., CAPARROTTA L., FASSINA
G. Dual effect of ATP and UTP on rat atria: which types of receptors are
involved? Naunyn-Schmied. Arch. Pharmacol., 349: 381-386, 1994.
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CHINELLATO A., RAGAZZI E., PANDOLFO L., FROLDI G., CAPARROTTA L., FASSINA
G. Purine- and nucleotide-mediated relaxation of thoracic aorta: common and
different sites of action. J. Pharm. Pharmacol. 46:337-341, 1994.
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CHINELLATO A., RAGAZZI E., PANDOLFO L., PALERMO ALVANO A., FROLDI G., DE
BIASI M., CAPARROTTA L., ALIEV G., FASSINA G. Functional and morphologic
characterization of thoracic aorta in heritable hyperlipidemic Yoshida rats
of different ages. J. Cardiov. Pharmacol. 24: 216-228, 1994.
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FROLDI G., GUERRA L., PANDOLFO L., CHINELLATO A., RAGAZZI E., CAPARROTTA
L., BOREA P.A., FASSINA G. Phentolamine and hypoxia: modulation of contractility
and a1-adrenoceptors in isolated rat atria. Naunyn-Schmied.
Arch. Pharmacol., 350: 563-568, 1994.
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CALABRO A., RAGAZZI EUGENIO, REALDON N., RAGAZZI ENRICO, PAGANO F. New topical
formulation of isosorbide dinitrate in the treatment of male impotence.
Pharmaceut. Sci. 1 :499-500, 1995.
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RAGAZZI E., CHINELLATO A., PANDOLFO L., FROLDI G., CAPARROTTA L., FASSINA
G. Endothelial nucleotide-mediated aorta relaxation in aged Watanabe hertable
hyperlipidemic rabbits. J. Cardiovasc. Pharmacol. 26: 119-126, 1995.
RESEARCH GROUP MEMBERS:
-
Caputi Achille, P.O.
-
Squadrito Francesco, P.A.
-
Spina Edoardo, P.C. (prof. a contratto)
-
Calapai Gioacchino, T.L.
-
Altavilla Domenica, T.L.
-
Zingarelli Basilia, D.DR.
-
Campo Giuseppe, D.DR.
-
Avenoso Angela, D.DR.
-
Ferlito Marcella, D.DR.
-
Minutoli Letteria, D.DR.
-
Cuzzocrea Salvatore, D.DR.
-
Mazzaglia Giampiero, B.
-
Marciano Concetta, B
AFFILIATION:
Istituto di Farmacologia
Facoltà di Medicina e Chirurgia
Università di Messina
ADDRESS: Piazza XX Settembre, 4
CITY: Messina
POSTAL CODE: 98122
TELEPHONE: 090-712533
FAX: 090-661029
PUBLICATIONS:
-
CALAPAI G., MAZZAGLIA G., CILIA M., ZINGARELLI B., SQUADRITO F., CAPUTI A.P.
Mediation by nitric oxide formation in the preoptic area of endotoxin and
tumour necrosis factor-induced inhibition of water intake in the rat. Brit.
J. Pharmacol. 111: 1328-1332, 1994.
-
CAMPO G.M., SQUADRITO F., IOCULANO M., ALTAVILLA D., CALAPAI G., ZINGARELLI
B., SCURI R., CAPUTI A.P. Reduction of myocardial infarct size in rat by
IRFI-048, a selective analogue of vitamin E. Free Rad. Bio. Med. 16:
427-435, 1994.
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SPINA E., ANCIONE M, DI ROSA A,E., ARTEMISIA A., NATOLI C., CAPUTI A.P. Iron
status in schizophrenic patients with acute neuroleptic-induced dystonic
reactions. Progr. Neuro-Psychopharmacol. Biol. Psychiat. 18: 891-898,
1994.
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SQUADRITO F., ALTAVILLA D., CANALE P., IOCULANO M., CAMPO G.M., AMMENDOLIA
L., SQUADRITO G., SAITTA A., CALAPAI G., CAPUTI A. P. Contribution of
intercellular adhesion molecule 1 (ICAM-1) to the pathogenesis of splanchnic
artery occlusion shock in the rat. Brit. J. Pharmacol. 113: 912-916,
1994
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SQUADRITO F., ALTAVILLA D., CANALE P., IOCULANO M., CAMPO G.M., AMMENDOLIA
L., FERLITO M., ZINGARELLI B., SQUADRITO G., SAITTA A., CAPUTI A. P.
Partecipation of tumour necrosis factor and nitric oxide in the mediation
of vascular dysfunction in splanchnic artery occlusion shock. Brit. J.
Pharmacol. 113: 1153-1158, 1994.
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SPINA E., AVENOSO A., CAMPO G.M., CAPUTI A.P., PERUCCA E. The effect of
carbamazepine on the 2-hydroxylation of desipramine. Psychopharmacol.
117: 413-416, 1995
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SQUADRITO F., ALTAVILLA D., AMMENDOLIA L., SQUADRITO G., CAMPO M.G., SPERANDEO
A., CANALE P., IOCULANO M., SAITTA A., CAPUTI A.P. Improved survival and
reversal of endothelial dysfunction by the 21- aminosteroid, U-74389G in
splanchnic ischemia-reperfusion injury in the rat. Brit. J. Pharmacol.
115: 395-400, 1995.
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ZINGARELLI B., O'CONNOR M., WONG H., SALZMAN A.L. SZABO' C.
Peroxynitrite-mediated DNA strand breakage activates poly-ADP ribosyl synthetase
and causes cellular energy depletion in macrophages stimulated with bacterial
lipopolysaccharide. J. Immunol. 156: 350-358, 1996.
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CAMPO G.M., SQUADRITO F., ALTAVILLA D., SQUADRITO G., AVENOSO A., CANALE
P., IOCULANO M., SPERANDEO A., CAPUTI A.P. Protection of ischemic and reperfused
rat myocardium by the nonglucocoticoid 21-aminosteroid U-74389G, a new inhibitor
of lipid peroxidation. J. Pharmacol. Exp. Ther. 277: 1-8, 1996.
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CALAPAI G., MAZZAGLIA G., SAUTEBIN L., COSTANTINO G., MARCIANO M.C., CUZZOCREA
S., DI ROSA M., CAPUTI A.P. Inhibition of nitric oxide formation reduces
voluntary ethanol consumption in the rat. Psychopharmacol. 125: 398-401,
1996.
RESEARCH GROUP MEMBERS:
-
Carmignani Marco, P.O.
-
Volpe Anna Rita, R.CNR
-
Poma Anna, R.U.
AFFILIATION:
Sezione di Farmacologia
Dipartimento di Biologia di Base ed Applicata
Facoltà di Scienze Matematiche, Fisiche e Naturali
Università degli Studi di L'Aquila
ADDRESS: Via Vetoio
CITY: Coppito (L'Aquila)
POSTAL CODE: 67010
TELEPHONE: 0862-43-3262, 3265
FAX: 0862-433273
E-MAIL: a.volpe@uniserv.ccr.rm.cnr.it
PUBLICATIONS:
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M. MIRANDA, F. AMICARELLI, A.R. VOLPE, A. POMA, L. MASCIOCCO, M. CARMIGNANI.
Specific increase of L-DOPA levels in plasma upon infusion of tyrosinase
containing liposomes. Gen. Pharmacol. 24: 1319-1322, 1993
-
C. DELLE MONACHE, B. BOTTA, R. ESPINAL, M. BOTTA, M. CARMIGNANI. Novel
hypotensive agents from "Verbesina Caracasana". 2. Synthesis and pharmacology
of Caracasanamide. J. Med. Chem. 36: 2956-2963, 1993
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P. BOSCOLO, M. CARMIGNANI, A.R. VOLPE, M. FELACO, G. DEL ROSSO, G. PORCELLI,
G. GIULIANO. Renal toxicity and arterial hypertension in rats chronically
exposed to metavanadate. Occup. Environ. Med. 51: 500-503, 1994
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M. MIRANDA, F. AMICARELLI, A. POMA, A.M. RAGNELLI, O. ZARIVI. Cyto-genotoxic
species leakage within human melanoma melanosomes. Molecular-morphological
correlations. Biochem. Mol. Biol. 32: 913-922, 1994
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N. MORES, M. MARTIRE, G. PISTRITTO, A.R. VOLPE, E. MENINI, G. FOLLI, C. CARDILLO.
Platelet alpha2-adrenoceptors and diurnal changes of platelet
aggregability in hypertensive patients. J. Hypertension 12: 939-945,
1994
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M. CARMIGNANI, A.R. VOLPE, O. MASCI, P. BOSCOLO, F. DI GIACOMO, A. GRILLI,
G. DEL ROSSO, M. FELACO. Vanadate as factor of cardiovascular regulation
by interactions with the catecholamine and nitric oxide systems. Biol.
Trace Elem. Res. 51: 1-12, 1996
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D. CURRO', A.R. VOLPE, P. PREZIOSI. Nitric oxide synthase activity
and non-adrenergic non-cholinergic relaxation in the rat gastric fundus.
Brit. J. Pharmacol. 117: 717-723, 1996
-
F. CORELLI, D. DEI, G. DELLE MONACHE, B. BOTTA, C. DE LUCA, M. CARMIGNANI,
A.R. VOLPE, M. BOTTA. Synthesis and preliminary pharmacological evaluation
of analogues of caracasamide, a hypotensive natural product. Bioorg. Med.
Chem. Lett. 6: 653-658, 1996
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A.R. VOLPE, B. GIARDINA, P. PREZIOSI, M. CARMIGNANI. Biosynthesis of
endothelium-derived nitric oxide by bradykinin as endogenous precursor.
Immunopharmacology 33: 287-290 1996
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M. CARMIGNANI, A.R. VOLPE. Nitric oxide and -opioid receptors in the tissue
interactions among enkephalins, angiotensins and kinins.
Immunopharmacology 32: 172-175, 1996
RESEARCH GROUP MEMBERS:
-
Ciabattoni Giovanni
-
Currò Diego
-
Montuschi Paolo
AFFILIATION:
Istituto di Farmacologia
Facoltà di Medicina e Chirurgia
Università Cattolica S. Cuore
ADDRESS: Largo Francesco Vito, 1
CITY: Roma
POSTAL CODE: 00168
TELEPHONE: 06-3015 4253
FAX: 06-3050159, 3051343
PUBLICATIONS:
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KOUDSTAAL P.J., CIABATTONI G., VAN GIJN J., NIEUWENHUIS H.K., DE GROOT P.,
SIXMA J., PATRONO C. Increased thromboxane biosynthesis in patients with
acute cerebral ischemia. Stroke 24:219-223, 1993.
-
CIABATTONI G., UJANG S., SRITARA P., ANDREOTTI F., DAVIES G., SIMONETTI B.M.,
PATRONO C., MASERI A. Aspirin, but not heparin, suppresses the transient
increase in thromboxane biosynthesis associated with cardiac catheterisation
or coronary angioplasty. J. Amer. Coll. Cardiol. 21:1377-1381, 1993.
-
RANGEMARK C., CIABATTONI G., WENNMALM A. Excretion of thromboxane metabolites
in healthy women after cessation of smoking. Arterioscler. Thromb.
13:777-782, 1993.
-
DI MINNO G., DAVI' G., MARGAGLIONE M., CIRILLO F., GRANDONE E., CIABATTONI
G., CATALANO I., STRISCIUGLIO P., ANDRIA G., PATRONO C., MANCINI M. Abnormally
high thromboxane biosynthesis in homozigous homocystinuria. Evidence for
platelet involvement and probucol-sensitive mechanism. J. Clin. Invest.
92:1400-1406, 1993.
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VAN KOOTEN F., CIABATTONI G., PATRONO C., SCHMITZ P., VAN GIJN J., KOUDSTAAL
P. Evidence for episodic platelet activation in acute ischemic stroke.
Stroke 25:1400-1406, 1994.
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LANDOLFI R., DE CANDIA E., ROCCA B., CIABATTONI G., ANTINORI A., MASETTI
R., PATRONO C. Effects of unfractionated and low molecular weight heparins
on platelet thromboxane biosynthesis "in vivo". Thromb. Haemostas.
72:942-946, 1994.
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WANG Z., CIABATTONI G., CREMINON C., LAWSON J., FITZGERALD G.A., PATRONO
C., MACLOUF J. Immunological characterization of urinary 8-epi-prostaglandin
F2a excretion in man. J. Pharmacol. Exp.
Ther. 275:94-100, 1995.
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ROCCA B., CIABATTONI G., TARTAGLIONE R., CORTELAZZO S., BARBUI T., PATRONO
C., LANDOLFI R. Increased thromboxane biosynthesis in essential thrombocythemia.
Thromb. Haemostas. 74:1225-1230, 1995.
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LAFFI G., CINOTTI S., FILIMBERTI E., CIABATTONI G., CAPORALE R., MARRA F.,
MELANI L., GROSSI A., Gentilini P. Defective aggregation in cirrhosis is
independent of in vivo platelet aggregation. J. Hepatol.
24:436-443, 1996.
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PATRIGNANI P., SANTINI G., PANARA M.R., SCIULLI M.G., GRECO A., ROTONDO M.T.
DI GIAMBERARDINO M., MACLOUF J., CIABATTONI G., PATRONO C. Induction of
prostaglandin endoperoxide synthase-2 in human monocytes associated with
cyclo-oxygenase-dependent F2-isoprostane formation. Brit. J. Pharmacol.
118:1285-1293, 1996.
RESEARCH GROUP MEMBERS:
-
Dorigo Paola, P.O.
-
Maragno Ildebrando, Dir. M
-
Gaion Rosa Maria, P.O.
-
Dalla Volta Sergio, P.O.
-
Fraccarollo Daniela, D. Dr.
-
Santostasi Giovanni, R.U.
AFFILIATION:
Dipartimento di Farmacologia "E. Meneghetti"
Facoltà di Farmacia
Università di Padova
ADDRESS: Largo E. Meneghetti, 2
CITY: Padova
POSTAL CODE: 35131
TELEPHONE: 049-8275101
FAX: 049-8275093
PUBLICATIONS:
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DORIGO, P., GAION, R.M., BELLUCO, P., FRACCAROLLO, D., MARAGNO, I., BOMBIERI,
G., BENETOLLO, F. A pharmacological, crystallographic and quantum chemical
study of new inotrpic agents. J. Med. Chem. 36: 2475-2484, 1993.
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MOSTI, L., SCHENONE, P., IESTER, M., DORIGO, P., GAION, R.M., FRACCAROLLO,
D. Synthesis and cardiotonic activity of esters of 2-substituted
5-acetyl-1,6-dihydro-6-oxo-3 pyridine-carboxylix acids. Eur. J. Med.
Chem. 28: 853-858, 1993.
-
DORIGO, P., SANTOSTASI, G., FRACCAROLLO, D., MARAGNO, I. Inotropic agents
in development . Exp. Invest. Drugs 3: 457-468, 1994.
-
DORIGO, P., BELLUCO, P., FRACCAROLLO, D., GAION, R.M., SANTOSTASI, G. AND
MARAGNO, I. Vasodilating action of etozoline in aorta from hypercholesterolemic
and spontaneously hypertensive rats. Pharmacol. (Life Sci. Adv.) 13:
101-105, 1994.
-
VEROTTA, L., ABURJAI, T., ROGERS, C.B., DORIGO, P., MARAGNO, I., FRACCAROLLO,
D., SANTOSTASI, G., GAION, R.M., FLOREANI, M., CARPENEDO, F. Chemical and
Pharmacological Characterization of Erythrophleum Lasiantum Alkaloids.
Planta Medica. 61: 271-274, 1995.
RESEARCH GROUP MEMBERS:
-
Ferrari Patrizia, Dir. R.
-
Torielli Lucia, C.L.
-
Conti Fabio, R.I.
-
Padoani Gloria, R.I.
-
Tripodi M. Grazia, C.L.
-
Florio Monica, R.I.
-
Reina Cristina, R.I.
-
Modica Rossana, R.I.
-
Salardi Sergio, C.L.
-
Molinari Isabella, R.I.
-
Pastore Sabrina, R.I.
-
Ferrandi Mara, C.L.
-
Duzzi Liliana, R.I.
-
Minotti Elena, R.I.
-
Barber Barry R., C.L.
AFFILIATION:
Sezione di Farmacologia Cellulare
Prassis - Istituto di Ricerca Sigma Tau
ADDRESS: via Forlanini 1/3
CITY: Settimo Milanese - Milano
POSTAL CODE: 20019
TELEPHONE: 02-33500401, 33501107
FAX: 02-33500408
E-MAIL: mc3405@mclink.it
PUBLICATIONS:
-
FERRANDI M, MINOTTI E, SALARDI S, FLORIO M, BIANCHI G, FERRARI P. Characteristics
of a ouabain-like factor from Milan hypertensive rats. J. Cardiovasc.
Pharmacol. 22: S75-S78, 1993.
-
SALARDI S., FALCHETTO R., TROFFA C., PARENTI P., BARBER B.R., PASTORE S.,
GLORIOSO N., BIANCHI G. Relationships among alterations in renal membrane
sodium transport, renin and aminopeptidase M activities in genetic hypertension.
Biochim. Biophys. Acta 1182: 22-29, 1993.
-
FERRARI P., FERRANDI M., MINOTTI E., DUZZI L., BIANCHI G. Effect of canrenone
and hydrochlorothiazide on the development of hypertension in rat models
of genetic hypertension. J. Hypertens. 11 : S330-S331, 1993.
-
BIANCHI G., TRIPODI G., CASARI G., SALARDI S., BARBER B.R., GARCIA R., LEONI
P., TORIELLI L., CUSI D., FERRANDI M., PINNA L.A., BARALLE F.E., FERRARI
P. Two point mutations within the adducin genes are involved in blood pressure
variation. Proc. Natl. Acad. Sci USA 91: 3999-4003, 1994.
-
SOLDATI L.P., BARBER B.R. SALARDI S., MOLINARI I., BIANCHI G. A new rat model
for studying the calpain-calpastatin system. Lab. Anim. 29 : 420-426,
1995.
-
TORIELLI L., CONTI F., CINATO E., CEPPI E., ANVERSA P., BIANCHI G., FERRARI
P. Alterations in energy metabolism of hypertrophied rat cardiomyocytes:
influence of Propionyl-L-Carnitine. J. Cardiovasc. Pharmacol. 26:
372-380, 1995.
-
FERRANDI M., MINOTTI E., FLORIO M., BIANCHI G., FERRARI P., Age-dependency
and dietary influence on the hypothalamic ouabain-like factor in Milan
hypertensive rats. J. Hypertension 13:1571-1574, 1995.
-
TRIPODI G., CASARI G., TISMINETZKY S., BIANCHI G., DEVESCOVI G., MURO A.,
TUTEJA R., BARALLR F.E. Characterization and chromosomal localization of
the rat alpha- and beta adducin encoding genes. Gene 166 : 307-311,
1995.
-
TRIPODI G., VALTORTA F., TORIELLI L., CHIEREGATTI E., SALARDI S., TRUSOLINO
L., MENEGON A. FERRARI P., MARCHISIO P.C., BIANCHIO G. Hypertension-associated
point mutations in the adducin alpha- and beta subunits affect actin cytoskeleton
and ion transport. J. Clin. Invest. 97: 2815-2822, 1996.
-
FERRANDI M., TRIPODI G., SALARDI S., FLORIO M;, MODICA R., BARASSI P., PARENTI
P., SHAINSKAYA A., KARLISH S., BIANCHI G., FERRARI P. Renal Na-K-ATPase in
genetic hypertension. Hypertension In press, 1996.
RESEARCH GROUP MEMBERS:
-
Floreani Maura, P.A.
AFFILIATION:
Dipartimento di Farmacologia "E.Meneghetti"
Facoltà di Scienze MM.FF.NN.
Università degli Studi di Padova
ADDRESS: Largo Meneghetti , 2
CITY: Padova
POSTAL CODE: 35131
TELEPHONE: 049-827-5088, 5083
FAX : 049-827-5093
E-MAIL: floreani@dfem.unipd.it
PUBLICATIONS:
-
CARPENEDO F. AND FLOREANI M. Stimulation of rat liver microsomal cGMP-inhibited
cAMP phosphodiesterase (PDE III) by phospholipase C and D. Biochem. Biophys.
Res. Commun.190: 609-615, 1993.
-
PALU' G., BIASOLO M.A., SARTOR G., MASOTTI L , PAPINI E., FLOREANI
M. AND PALATINI P. Effects of Herpes Simplex type 1 virus infection on plasma
membrane and related functions of HeLa S3 cells. J. Gen.Virol. 75:
3337-3344, 1994.
-
FLOREANI M. AND CARPENEDO F. Metabolism of simple quinones in guinea pig
and rat cardiac tissue. Gen.Pharmacol.26:1757-1764,1995.
-
FLOREANI M., FORLIN A., BELLIN S. AND CARPENEDO F. Structure- activity
relationship for the inhibition of cardiac sarcoplasmic reticulum Ca2+ ATPase
activity b naphthoquinones. Biochem. Mol. Biol.Int. 37: 757-763,1995.
-
GIUSTI, P., LIPARTITI, M., FRANCESCHINI, D., SCHIAVON, N., FLOREANI, M.,
AND MANEV H. Neuroprotection by melatonin from kainate-induced excititoxicity
in rats. FASEB J.10: 891-896, 1996.
-
FLOREANI M., FORLIN A., BELLIN S. AND CARPENEDO F. Cardiac sarcoplasmic reticulum
Ca2+ pump as a target for benzoquinones. Gen. Pharmacol. 27: 873-878,1996.
-
FLOREANI,M., FORLIN, A., PANDOLFO,L., PETRONE,M., AND BELLIN S. Mechanisms
of plumbagin action on guinea pig isolated atria. J.Pharmac.Exp.Ther.
278: 763-770, 1996.
RESEARCH GROUP MEMBERS:
-
Franconi Flavia, P.O.
-
Bennardini Federico, R.U.
-
Alberti Luisa, B.
AFFILIATION:
Dipartimento Scienze del Farmaco
Facoltà di Farmacia
Università di Sassari
ADDRESS: Via Muroni , 23 A
CITY: Sassari
POSTAL CODE: O7100
TELEPHONE: 079- 228717
PUBLICATIONS:
-
NARO F., FAZZINI A., GRAPPONE C., CITRO G., DINI G.,GIOTTI, A., MALATESTA F.,
FRANCONI F., BRUNORI M.,: Release of cytochromes from hypoxic and
reoxygenated guinea pig heart. Cardioscience 4:177-184, 1993.
-
SEGHIERI, G., MARTINOLI, L., MICELI, M., CIUTI, M.,D'ALESSANDRI, G.,GIRONI,
A., PALMIERI, L., ANICHINI, R.,BARTOLOMEI, G., FRANCONI F.: Renal excretion
of ascorbic acid in insulin dependent diabetes mellitus. Internat. J.
Vit. Nutr. Res. 64: 119-124, 1993.
-
MATTANA A., BENNARDINI F., JULIANO C., PICCI V., MARCEDDU S., SCIOLA L.,
PIPPIA P., FRANCONI F.: Cytotoxicity of lazaroid U-75412E in human epithelial
cell line (WISH). Biochem. Pharmacol. 48: 259-265, 1994.
-
BENNARDINI F., JULIANO C., BENETTI D., MIAN M., CHIESI M., MATTANA A., FRANCONI
F.: aB crystallin is constitutively expressed in cultures of bovine articular
chondrocytes. Biochem. Biophys. Res. Commun. 208: 742-747, 1995.
-
FRANCONI F., BENNARDINI F., MATTANA A., MICELI M., CIUTI M., MIAN M., GIRONI,
A. BARTOLOMEI G., ANICHINI R., SEGHIERI G.: Taurine deficiency in plasma
and platelets of diabetic insulin-dependent patients: effects of taurine
supplementation. Amer. J. Clin. Nutr. 61: 1115-1119, 1995.
-
TADOLINI B., PINTUS G., PINNA G.G., BENNARDINI F., FRANCONI F.: Effects of
taurine and hypotaurine on lipid peroxidation. Biochem. Biophys. Res.
Commun. 213: 820-826, 1995.
-
BENNARDINI F., MATTANA A., PINNA NOSSAI E., MIGNANO M., FRANCONI F., JULIANO
C., SCIOLA L., PIPPIA P., CHIESI M.: Kinetic changes of -crystallin expression
in neoplastic cells and syngeneic rat fibroblasts at various subculture stages.
Mol. Cell. Biochem. 152: 23-30, 1995.
-
DISIMPLICIO P., DEGIORGIO L.A., CARDAIOLI E., LECIS R., MICELI M., ROSSI
R., ANICHINI R., MIAN M., SEGHIERI G., FRANCONI F.: Glutathione, glutathione
utilizing enzymes, and thioltransferase in platelets of insulin-dependent
diabetic patients: relation with platelet aggregation and with microangiopatic
complications. Eur. J. Clin. Invest. 25: 665-669, 1995.
-
FRANCONI F., MICELI M., DE MONTIS M.G., LUPIS CRISAFI E., BENNARDINI F.,
TAGLIAMONTE A.: NMDA receptors play an anti-aggregating role in human platelets.
Thromb. Haemostatsis,76 : 84-87,1996
-
MATUCCI R., BIANCHI B., OTTAVIANI M.F., CAMPANA S., BENNARDINI F., FRANCONI
F.: Carbon centered radicals reduce the density of L-type calcium channels
in rat cardiac membranes. Biochem. Biophys. Res. Commun.
223 :85-90,1996.
RESEARCH GROUP MEMBERS:
-
Giorgi Giorgio, P.A.
-
Bruni Giancarlo, P.A.
-
Runci Francesco Michele, P.A.
-
Cerretani Daniela, T.L.
-
Fiaschi Anna Ida, T.L.
-
Micheli Lucia, T.L.
-
Romeo Maria Raffaella, B.
AFFILIATION:
Istituto di Farmacologia
Facoltà di Medicina e Chirurgia
Università degli Studi di Siena
ADDRESS: Strada delle Scotte, 6
CITY: Siena
POSTAL CODE: 53100
TELEPHONE: 0577/ 263280, 263279, 263251, 263228
FAX: 0577-280896
E-MAIL: giorgig@unisi.it
PUBLICATIONS:
-
CECCHETTI V., FRAVOLINI A., SCHIAFFELLA F., TABARRINI O., BRUNI G., AND SEGRE
G. o-chlorobenzenesulfonamidic derivatives of (Aryloxy) propanolamines as
beta-blocking/diuretic agents. J. Med. Chem. 36: 157-161, 1993.
-
CAMPIANI F., GAROFALO A., FIORINI I., NACCI V., BOTTA M., TAFI A., CHIARINI
A., BUDRIESI R., BRUNI G., AND ROMEO M.R.. Synthesis and in vitro
cardiovascular activity of 4-aryl-2,3, 3a,4-tetrahydro-1H-pyrrolo2,1-c
benzothiazin-1-ones and 7-acetoxy-6-phenyl-7A,8,9,10-tetrahydro-pyrrolo 2,1-D
1,5benzothiazepin-10-one. Bioorg. Med. Chem. Lett. 4: 1235-1240, 1994.
-
SETTIMI G., DEL GIUDICE M.R., FERRETTI R., COTOCHINI V., BRUNI G., AND ROMEO
M.R. -carbolines as inverseagonistic benzodiazepine receptor ligands. 2.
synthesis and in vitro and in vivo binding of some new 6-amino and
6-fluoro--carboline-3-carboxylates. Eur. J. Med. Chem. 30: 245-251,
1995.
-
CAMPIANI F., GAROFALO A., FIORINI I., BOTTA M., NACCI V., TAFI A., CHIARINI
A., BUDRIESI R., BRUNI G., AND ROMEO M.R. Pyrrolo2,1-cbenzothiazines: synthesis,
structure-activity relationships, molecular modelling studies, and cardiovascular
activity. J. Med. Chem. 38: 4393-4410, 1995.
-
CAMPIANI G., FIORINI I., DE FILIPPIS M.P., CIANI S.M., GAROFALO A., NACCI
V., GIORGI G., SEGA A., BOTTA M., CHIARINI A., BUDRIESI R., BRUNI G., ROMEO
M.R., MANZONI C., AND MENNINI T. Cardiovascular characterization of pyrrolo2,1-d
1,5-benzothiazepine derivatives binding selectively to the peripheral-type
benzodiazepine receptor (PBR): from dual PBR affinity andcalcium antagonist
activity to novel and selective calcium entry blockers. J. Med. Chem.
39: 2922-2938, 1996.
-
BATTISTON L., MORETTI M., TALUSSI P., MICHELI L., MARCHI P., MAZZORAN L.,
LUNAZZI G., AND POZZATO G. Hepatic glutathione determination after ethanol
administration in rat: evidence of the first-pass metabolism of ethanol.
Life Sci. 56: 241-258, 1995.
-
CERRETANI D., MICHELI L., FIASCHI A.I., AND GIORGI G. Rapid and sensitive
determination of piroxicam in rat plama, muscle and skin by high-performance
liquid chromatographic. J. Chromatogr. 614: 103-108, 1993.
-
MICHELI L., FIASCHI A.I., CERRETANI D., AND GIORGI G. Effect of acetaminophen
on glutathione levels in several regions of the rat brain. Curr. Ther.
Res. 53: 730-736, 1993.
-
CERRETANI D., MICHELI L., FIASCHI A.I., ROMEO M.R., TADDEI I., AND GIORGI
G.MK-801 potentiates the glutathione depletion induced by acetaminophen in
rat brain. Curr. Ther. Res. 55: 707-711, 1994.
-
CERRETANI D., MICHELI L., FIASCHI A.I., AND GIORGI G. High-performance liquid
chromatography of flufenamic acid in rat plasma. J. Chromatogr. 678:
365-368, 1996.
RESEARCH GROUP MEMBERS:
-
Giotti Alberto , P.O. Fuori Ruolo
-
Failli Paola, R.U.
-
Ruocco Carlo, D.DR
-
Cecchi Enrica, B.
-
Fazzini Alessandro, D.DR
AFFILIATION:
Dipartimento di Farmacologia Preclinica e Clinica "Mario Aiazzi Mancini"
Facoltà di Medicina e Chirurgia
Università degli Studi di Firenze
ADDRESS: Viale Morgagni, 65
CITY: Firenze
POSTAL CODE: 50134
TELEPHONE: 055-418663
FAX: 055-4361613
E-MAIL: Failli@stat.ds.unifi.it
PUBLICATIONS:
-
FAILLI P., CECCHI E., RUOCCO C., FAZZINI A. & GIOTTI A. - Effects of
L- and D-arginine and some related esters on the cytosolic mechanisms of
a-thrombin-induced human platelet activation. Brit. J. Pharmacol.
110 : 213-218, 1993.
-
TANINI A., FAILLI P., MAGGI M., FRANCESCHELLI F., FREDIANI U., BECHERINI
L., GIOTTI A., RUOCCO C. and BRANDI M.L. - Effects of endothelin-1 on bovine
parathyroid cells. Biochem. Biophy. Res. Comm. 193 : 59-66, 1993
.
-
NARO F., FAZZINI A., GRAPPONE C., CITRO G., DINI G., GIOTTI A., MALATESTA
F., FRANCONI F., BRUNORI M. Release of cytochromes from hypoxic and reoxygenated
guinea pig heart. Cardioscience 4 : 177-184, 1993.
-
LAFFI G., MARRA F., FAILLI P., RUGGIERO M., CECCHI E., CARLONI V., GIOTTI
A. and GENTILINI P. - Defective signal transduction in platelets from cirrhotics
is associated with increased cyclic nucleotides. Gastroenterology
105 : 148-156, 1993.
-
FALSETTI C., BALDI E., KRAUSZ C., CASANO R., FAILLI P., FORTI G. Decreased
Responsiveness to progesterone of spermatozoa in oligozoospermic patients.
J. Androl., 14 : 17-22, 1993.
-
MALMBERG AIELLO P., LAMBERTI C., GHELARDINI C., GIOTTI A. and BARTOLINI A.
- Role of histamine in rodent antinociception. Brit. J. Pharmacol.
111 : 1269-1279, 1994.
-
CECCHI E., CAPONE L., RUOCCO C., FAZZINI A., MUGELLI A., GIOTTI A., FAILLI
P.- Iloprost antagonises the increase in internal calcium concentration induced
by a-thrombin in human platelets: A study of desensitization.
Cardiovasc. Drugs & Ther. 9 : 773-777, 1995.
-
FAIILI P., RUOCCO C., DE FRANCO R., CALIGIURI A., GENTILINI A., GIOTTI A.,
GENTILINI P., PINZANI M. - The mitogenic effect of platelet--derived growth
factor in human hepatic stellate cells requires calcium influx. Amer.
J. Physiol. Cell Physiol., 269 : C1133-C1139, 1995.
-
PINZANI M., MILANI S., DE FRANCO R., GRAPPONE C., CALIGIURI A., TOSTI-GUERRA
C., MAGGI M., GENTILINI A., FAILLI P., RUOCCO C., GENTILINI P. - Endothelin-1
is overexpressed in cirrhotic liver and exerts multiple effects on activated
hepatic stellate cells. Gastroenterology, 110 : 534-548, 1996.
-
FAILLI P., TESCO G., RUOCCO C., GINESTRONI A., SORBI S., GIOTTI A., AMADUCCI
L. - The effect of tetraethylammonium on intracellular calcium concentration
in Alzheimer's disease fibroblasts with APP, S182 and E5-1 missense mutations.
Neurosci Lett., 208 : 1-3, 1996.
RESEARCH GROUP MEMBERS:
-
Guarini Salvatore, R.U.
-
Bazzani Carla, R.U.
-
Cainazzo Maria Michela, B.
AFFILIATION:
Sezione di Farmacologia, Dipartimento di Scienze Biomediche
Facoltà di Medicina e Chirurgia
Università di Modena
ADDRESS: Via Campi, 287
CITY: Modena
POSTAL CODE: 41100
TELEPHONE: 059-428-440, 415
FAX: 059-372653
E-MAIL: farmacol@unimo.it
PUBLICATIONS:
-
BAZZANI, C., BALUGANI, A., BERTOLINI, A., AND GUARINI S. Comparison of the
effects of ACTH-(1-24), methylprednisolone, aprotinin, and norepinephrine
in a model of hemorrhagic shock in rats. Resuscitation 25: 219-226,
1993.
-
GUARINI, S., BAZZANI, C., AND BERTOLINI, A. Role of neuronal and vascular
Ca2+- channels in the ACTH-induced reversal of haemorrhagic shock.
British J. Pharmacol. 109: 645-650, 1993.
-
BAZZANI, C., NARDI, M.G., FERRANTE, F., BERTOLINI, A., AND GUARINI, S. Dopamine
D1 receptors are involved in the ACTH-induced reversal of hemorrhagic shock.
Eur. J. Pharmacol. 253: 303-306, 1994.
-
BAZZANI, C., BERTOLINI, A., CASALGRANDI, L., BERTOLINI, E., BALUGANI, A.,
FIORE, L., AND GUARINI, S. Adrenocorticotropin release is not involved in
the nicotine-induced reversal of hemorrhagic shock in anesthetized rats.
Pharmacology 50: 34-39, 1995.
-
GUARINI, S., MARTINI, M.C., AND BERTOLINI, A. Reperfusion-induced arrhythmias
and lethality are reduced by a 2KDa heparin fragment. Life Sci. 57:
967-972, 1995.
-
BAZZANI, C., BERTOLINI, A., MATTERA RICIGLIANO, G., CAINAZZO, M.M., BALUGANI,
A., AND GUARINI, S. The reversal of experimental hemorrhagic shock induced
by nicotine and dimethylphenylpiperazinium is adrenal-dependent.
Resuscitation 31: 145-150, 1996.
-
GUARINI, S. A highly reproducible model of arterial thrombosis in rats.
J. Pharmacol. Toxicol. Met. 35: 101-105, 1996.
-
GUARINI, S., BAZZANI, C., BOTTICELLI, A., BALUGANI, A., AND BERTOLINI, A.
Antithrombotic activity of a 2-kDa heparin fragment in an experimental model
of carotid artery thrombosis in rats. J. Pharm. Pharmacol. 48: 407-410,
1996.
-
BAZZANI, C., FIORE, L., FERRANTE, F., BERTOLINI, A., AND GUARINI, S. Serotonin
is involved in the ACTH-induced reversal of hemorrhagic shock in anesthetized
rats. Pharmacology 52: 207-215, 1996.
-
GUARINI, S., BAZZANI, C., MATTERA RICIGLIANO, G., BINI, A., TOMASI, A., AND
BERTOLINI, A. Influence of ACTH-(1-24) on free radical levels in the blood
of haemorrhage-shocked rats: direct ex vivo detection by electron spin resonance
spectrometry. British J. Pharmacol. 119: 29-34, 1996.
RESEARCH GROUP MEMBERS:
-
Ledda Fabrizio, P.O.
-
Ziche Marina, R.U.
-
Amerina Sandra, B.
-
Morbidelli Lucia, B.
-
Parenti Astrid, D.DR.
-
Brogelli Laura, S.S.
-
Filippi Sandra, S.S.
-
Donnini Sandra, B.
AFFILIATION:
Dipartimento di Farmacologia Preclinica e Clinica
Laboratorio di Farmacologia Cardiovascolare e del Microcircolo
Università di Firenze
ADDRESS: Viale Morgagni, 65
CITY: Firenze
POSTAL CODE: 50134
TELEPHONE: 055-4237-405, 411(centralino)
055-4237-450, 451 (laboratori)
FAX: 055-4361613
E-MAIL: Ledda@Stat.Ds.UNIFI.IT
Ziche@Stat.Ds.UNIFI.IT.
PUBLICATIONS:
-
ZICHE M., MORBIDELLI L., MASINI E., GRANGER H.J., GEPPETTI P. AND LEDDA F.
Nitric oxide promotes DNAsynthesis and cyclic GMP formation in endothelial
cells from postcapillary venules. Biochem. Biophys. Res. Comm.
192: 1198-1203, 1993.
-
MANTELL L., AMERINI S., FILIPPI S. AND LEDDA F. Blockade of adenosine
receptors unmasks a stimulatory effect of ATP on cardiac contractility.
British J. Pharmacol. 109: 1268-1271, 1993.
-
AMERINI S., MANTELLI L., FILIPPI S. AND LEDDA F. Effects of aging and
hypertension on the vasorelaxant activity of calcitonin gene-related peptide:
a comparison with other vasodilator agents. J. Cardiovasc.
Pharmacol. 23: 432-437, 1994.
-
ZICHE M., MORBIDELLI L., MASINI E., AMERINI S., GRANGER H.J., MAGGI C.A,
GEPPETTI P. AND LEDDA. F. Nitric oxide mediates angiogenesis in vivo
and endothelial cell growth and migration in vitro promoted by substance
P. J. Clin. Invest. 94: 2036-2044, 1994.
-
MANTELLI L., AMERINI S. AND LEDDA. F. Roles of nitric oxide and
endothelium-derived hyperpolarizing factor in the vasorelaxant effect of
acetylcholine as influenced by aging and hypertension. J. Cardiovasc.
Pharmacol. 25: 595-602, 1995.
-
MANTELLI L., AMERINI S., LEDDA F., FORTI G. AND MAGGI M. The potent
relaxant effect of adenosine in rabbit corpora cavernosa is nitric oxide
independent and mediated by A2 receptors. J. Androl. 16: 312-317,
1995.
-
MORBIDELLI L., ORLANDO C., MAGGI C.A., LEDDA F. AND ZICHE M. Proliferation
and migration of endothelial cells is promoted by endothelins via activation
of ETB receptors.Amer. J. Physiol. 269: H686-H695, 1995.
-
PARENTI A., AMERINI S., LEDDA F. , MAGGI C.A. AND ZICHE M. The tachykinin
NK1 receptor mediates the migration-promoting effect of substance P on human
skin fibroblasts in culture. Naunyn-Schmied. Arch. Pharmacol. 353:
475-481, 1996.
-
MORBIDELLI L.,CHANG C-H., DOUGLAS J.G.,GRANGER H.J., LEDDA F. AND
ZICHE M. Nitric oxide mediates the mito-genic effect of VEGF on coronary
venular endothelium.Amer. J. Physiol. 270: H411-H415, 1996.
-
AMERINI S., FILIPPI S., PARENTI A., ZICHE M. AND LEDDA F. Thapsigargin
inhibits the vasorelaxant response to acetylcholine and substance P but does
not interfere with the responses to endothelium independent agents. J.
Cardiovasc. Pharmacol. 28: 82-88, 1996.
RESEARCH GROUP MEMBERS:
-
Luciani Sisto, P.O.
-
Cargnelli Gabriella, P.A.
-
Debetto Patrizia, R.U.
-
Bova Sergio, R.U.
-
Trevisi Lucia, B.PDR.
-
Varotto Roberto, T.
AFFILIATION:
Dipartimento di Farmacologia
Università degli Studi di Padova
ADDRESS: Largo E. Meneghetti, 2
CITY: Padova
POSTAL CODE: 35131
TELEPHONE: 049-827-5076, 5097, 5098, 5094
FAX: 049-827-5093
E-MAIL: luciani@ipdunivx.unipd.it
PUBLICATIONS:
-
LUCIANI, S., BOVA, S., CARGNELLI, G., AND DEBETTO, P. Effects of amiloride
on the cardiovascular system: role of Na+/Ca2+ exchange.Pharmacol. Res..
25: 303-310, 1992.
-
BOVA, S., PADRINI, R., GOLDMAN, W.G., BERMAN, D.M., AND CARGNELLI, G. On
the mechanism of vasodilating action of berberine: possible role of inositol
lipid signalling system. J. Pharmacol. Exp. Ther. 261: 318-323, 1992.
-
ANTOLINI, M., TREVISI, L., DEBETTO, P., AND LUCIANI, S. Effect of amiloride
on sodium-calcium exchange activity in rat cardiac myocytes. Pharmacol.
Res. 27: 227-231, 1993.
-
ROSSI, G.P., ZANIN, L., PAULETTO, P., TONELLO, M., BOVA, S., CARGNELLI, G.,
AND PESSINA, A.C. Age-related changes of endothelin-1 binding sites in aortic
smooth muscle cells of normotensive and hypertensive rats. High Blood
Pressure. 2: 313-318, 1993.
-
BOVA, S., ROSSI, G.P., LUCIANI, S., DEBETTO, P., PESSINA, A.C., AND CARGNELLI,
G. Effect of subthreshold ouabain on the tone of guinea-pig aortic strips
following repeated noradrenaline stimulation. British J. Pharmacol..
111: 1067-1072, 1994.
-
CARGNELLI, G., BOVA, S., CANNAS, S., DEBETTO, P, AND LUCIANI, S. Effect of
amiloride on inotropic and toxic actions of ouabain in guinea-pig left atria.
Eur. J. Pharmacol.. 292: 103-110, 1994.
-
LUCIANI, S., DEBETTO, P., TREVISI, L., BOVA, S., AND CARGNELLI, G.
Pharmacological modulation of Na/Ca exchange in cardiac and vascular smooth
muscle. Pharmacology (Life Sciences Advances). 13: 141-147, 1994.
-
YANG, C., PADRINI, R., BOVA, S., PIOVAN, D., AND MAGNOLFI, G.
Electrophysiological interactions between pinacidil, a potasium channel opener,
and class 1 antiarrhythmic agents in guinea-pig isolated perfused heart.
British J. Pharmacol.. 114: 1745-1749, 1995.
-
LUCIANI, S., ANTOLINI, M., BOVA, S., CARGNELLI,G., CUSINATO, F., DEBETTO,
P., TREVISI, L., AND VAROTTO, R. Inhibition of cardiac sarcolemmal sodium-calcium
exchanger by gycerophopshoinositol 4-phosphate and glycerophosphoinositol
4,5 bisphosphate. Biochim. Biophys. Res. Comm. 206: 674-680, 1995.
-
BOVA, S., TREVISI, L., DEBETTO, P., CIMA, L., FURNARI, M., LUCIANI, S., PADRINI,
R., AND CARGNELLI, G. Vasorelaxant properties of norbormide, a selective
vasoconstrictor agent for the rat microvasculature. British J.
Pharmacol.. 117: 1041-1046, 1996.
RESEARCH GROUP MEMBERS:
-
Mugelli Alessandro, P.O
-
Cerbai Elisabetta, R.U.
-
Matucci Rosanna, T.L.
-
Stendardi Isabella,.T.L.
-
Porciatti Francesco, B.PDR.
-
Pino Roberto, D.DR
-
Crucitti Antonio, Specializzando (B.)
AFFILIATION:
Dipartimento di Farmacologia Preclinica e Clinica "Mario Aiazzi Mancini"
Facoltà di Medicina e Chirurgia
Università degli Studi di Firenze
ADDRESS: viale Morgagni, 65
CITY: Firenze
POSTAL CODE: 50134
TELEPHONE: 055-4237405,411
FAX: 055-4361613
E-MAIL: mugelli@stat.ds.unif.it
PUBLICATIONS:
-
CERBAI E., BARBIERI M., LI Q., MUGELLI A. Ionic basis of action potential
prolongation of hypertrophied myocytes isolated from the heart of hypertensive
rats of different ages. Cardiovasc Res, 28:1180-1187, 1994.
-
GAMBASSI G., CERBAI E., PAHOR M., CAPOGROSSI MC., CARBONIN PU., MUGELLI A.
Temperature modulates Ca2+ homeostasis and ventricular arrhythmia.s in myocardial
preparations. Cardiovasc. Res. 28 :391-399, 1994.
-
BARBIERI M., VARANI K., CERBAI E., GUERRA L., LI Q., BOREA PA., MUGELLI A.
Electrophysiological basis for the enhanced cardiac arrhythmogenic effect
of isoprenaline in aged spontaneously hypertensive rats. J. Mol. Cell.
Cardiol. 26 : 849-860, 1994 .
-
CERBAI E., BARBIERI M. AND MUGELLI A. Characterization of the
hyperpolarization-activated current, If, in ventricular myocytes isolated
from hypertensive rats. J. Physiol. 481 :585-592, 1994.
-
PAHOR M., CECCHI E., FUMAGALLI S., MANTO A., PEDONE C., CAROSELLA L., COCCHI
A., BERNABEI R., MARCHIONNI N., MUGELLI A., CARBONIN P. Association of serum
creatinine and age with headache caused by nitrates. Clinical Pharmacol.
Ther. 58 : 470-481, 1995.
-
CERBAI E., GUERRA L., VARANI K., BARBIERI M., BOREA P.A., MUGELLI A.
b-adrenoceptor subtypes in young and old rat ventricular myocytes: A combined
patch-clamp and binding study. Brit. J. Pharmacol. 116 : 1835-1842,
1995.
-
GUERRA L., CERBAI E., GESSI S., BOREA P.A., MUGELLI A. The effect of oxygen
free radicals on calcium current and dihydropyridine binding sites in guinea-pig
ventricula myocytes. Brit. J. Pharmacol. 118 : 1278-1284, 1996.
-
MATUCCI R., BIANCHI B., OTTAVIANI M.F., CAMPANA S., BENNARDINI F. FRANCONI
F. Carbon centered radicals reduce the density of L-type calcium channel
in rat cardiac membranes. Biochem. Biophys. Res. Commun. 223 :
85-90, 1996.
-
CERBAI E., BARBIERI M., MUGELLI A. Occurrence and properties of the
hyperpolarization-activated current, if, in ventricular myocytes from
normotensive and hypertensive rats during aging. Circulation 94 :
1674-1681, 1996.
-
CERBAI E., BARBIERI M., MUGELLI A. Electrophysiological study on lercanidipine
and its enantiomers. J Cardiovasc Pharmacol. In press, 1996.
RESEARCH GROUP MEMBERS:
-
Rossi Francesco, P.O.
-
Berrino Liberato, R.U.
-
Calderaro Vincenzo, R.U.
-
Filippelli Amelia, R.U.
-
Filippelli Walter, T.L.
-
Maione Sabatino, B.
-
D'Amico Michele, D.DR.
-
De Novellis Vito, B.
-
Stella Luigi, B.PDR.
-
Falciani Maddalena, D.DR.
-
Pizzirusso Anna, D.DR.
AFFILIATION:
Istituto di Farmacologia e Tossicologia
Facoltà di Medicina e Chirurgia
Seconda Università degli Studi di Napoli
ADDRESS: Via Costantinopoli, 16
CITY: Napoli
POSTAL CODE: 80138
TELEPHONE: 081-566-5878, 5877, 459802
FAX: 081-566-5877, 5878
PUBLICATIONS:
-
MAIONE S., D'AMICO M., BERRINO L., FILIPPELLI A., LEYVA J., ROSSI F.: Involvement
of periaqueductal gray area NMDA receptors in endothelin-induced behavioural
effects. Eur. J. Pharm. 250: 209-212, 1993.
-
STELLA L., BERRINO L., MAIONE S., DE NOVELLIS V., ROSSI F.: Cardiovascular
effects of adenosine and its analogs in anaesthetized rats. Life Sci.
53: 755-763, 1993.
-
CALDERARO V., PARRILLO C., BALESTRIERI M.L., GIOVANE A., FILIPPELLI A., ROSSI
F.: Docosahexaenoic acid and signaling pathways in rabbit colon. Mol.
Pharmacol. 45: 737-746, 1994.
-
D'AMICO M., BERRINO L., MAIONE S., FILIPPELLI A., PIZZIRUSSO A., VITAGLIANO
S., ROSSI F.: Endothelin-1 in rat periaqueductal gray area induces hypertension
via glutammergic receptors. Hypertension 25: 507-510, 1995.
-
MAIONE S., LEYVA J., PALLOTTA M., BERRINO L., DE NOVELLIS V., ROSSI F.:
Involvement of opioid receptors in N-methyl-D-aspartate induced arterial
hypertension in periaqueductal gray matter. Naunyn-Schmied. Arch.
Pharmacol. 351: 87-92, 1995.
-
D'AMICO M., WARNER T.D.: Involvement of endothelin in the pressor response
following injection of NMDA to the periaqueductal gray area of rats. Brit.
J. Pharmacol. 116: 2787-2789, 1995.
-
MAIONE S., BIGGS C.S., ROSSI F., FOWLER L.J., WHITTON P.S.:
-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors modulate dopamine
release in rat hippocampus and striatum. Neurosci. Lett. 193: 1-4,
1995.
-
D'AMICO M., DASHWOOD M.R., WARNER T.D.:Endothelin-1 and the periaqueductal
gray area of the rat: an autoradiographic and functional pharmacological
study. Brit. J. Pharmacol. 118: 21-26, 1996.
-
D'AMICO M., BERRINO L., MAIONE S., FILIPPELLI A., DE NOVELLIS V., ROSSI F.:
Endothelin-1 in periaqueductal gray area of mice induces analgesia via
glutamatergic receptors. Elsevier Scientific Publishers Ireland LTD.
Pain 65: 205-209, 1996.
-
NOREL X., WALCH L., COSTANTINO M., LABAT C., GORENNE I., DULMET E., ROSSI
F. AND BRINK C.: M1 and M3 muscarinic receptors in human pulmonary arteries.
Brit. J. Pharmacol. 119: 149-157, 1996.
RESEARCH GROUP MEMBERS:
-
Rossini Luigi, P.O.
-
Bernardi Marina, B.PDR.
-
Lamura Elena, D.DR.
-
Concettoni Carolina, T.L.
-
Tonnini Cecilia, T.L., DR.
-
Moretti Vincenzo, P.C., A.O. (°)
-
Pigini Paola, P.C., A.O. (°)
AFFILIATION:
Istituto di Medicina Sperimentale e Clinica
Università degli Studi di Ancona
Servizio di Farmacologia clinica e Tossicologia
Azienda Sanitaria n. 7, Regione Marche
ADDRESS: Via Tronto
CITY: Ancona
POSTAL CODE: 60100
TELEPHONE: 071/2206037
FAX: 071/2206037
E-MAIL: animo@anvax2.cineca.it
PUBLICATIONS:
-
OLSEN, J.I., ROSSINI, P., SCHWEIZER, M.P., BERNARDI, M., MORETTI, V., RE,
L., ROSSINI, L. A 31-P NMR spectroscopy study of Xenopus laevis heart perfused
in vitro by phosphocreatine, adenosine-triphosphate, fructose-diphosphate
and ouabain. Pharmacol. Res. 28: 1-17, 1993.
-
RE, L., COLA, V., FULGENZI, G., MARINELLI, F., CONCETTONI, C., ROSSINI, L.
Post-synaptic effects of methoctramine at the mouse neuromuscular junction.
Neuroscience 57: 451-457, 1993.
-
RE, L., COLA, V., FULGENZI, G., MARINELLI, F., CONCETTONI, C., ROSSINI, L.
Muscarinic receptors in mouse neuromuscular junction: on the effects of some
agonists and antagonists. Gen. Pharmacol. 24: 1447-1453, 1993.
-
ROSSINI, L., BERNARDI, M., CONCETTONI, C., DE FLORIO, L., DESLAURIERS, R.,
MORETTI, V., PIANTELLI, F., PIGINI, P., RE, L., ROSSINI, P., TONNINI, C.
Some approaches to the pharmacology of multisubstrate enzyme systems.
Pharmacol. Res. 29: 313-335, 1994.
-
BERNARDI, M., DESLAURIERS, R., DOCHERTY, J., ROSSI, C., ROSSINI, L., ROSSINI,
P., TONNINI, C. Spectral analysis of intercycle heart fluctuations in
Xenopus laevis, conscious or spinalized, treated with calcium channel
blockers. Part I. Gen. Pharmacol. In press, 1996.
RESEARCH GROUP MEMBERS :
-
Semeraro Claudio, Dir. R.
-
Marchini Francesco, Dir. R.
-
Pocchiari Felice, Dir. R.
-
Santangelo Francesco, Dir. R.
-
Ferlenga Pier Paolo, C.L.
-
Pradella Lorenzo, C.L.
-
Morazzoni Gabriele, C.L.
-
Masotto Claudio, C.L.
-
Brambilla Nadia, R.I.
-
Zanzottera Daniele, R.I.
-
Buschi Alberto, R.I.
-
Palazzolo Laura, R.I.
-
Allievi Leopoldo R.I.
-
Bisiani Chiara, R.I.
-
Da Ros Bruna, R.I.
-
Fantoni Maurizio, R.I.
-
Moriggi Ermanno, R.I.
-
Scatturin Melania, R.I.
AFFILIATION :
Direzione Ricerca Cardiovascolare
Direzione Ricerche e Sviluppo Internazionali
Zambon Group S.p.A.
ADDRESS: Via Lillo del Duca, 10
CITY: Bresso (Milano)
POSTAL CODE: 20091
TELEPHONE: 02-665241
FAX : 02-66524524
PUBLICATIONS :
-
NORCINI, L. ALLIEVI, G. BERTOLINI, C. CASAGRANDE, G. MIRAGOLI, F. SANTANGELO,C.
SEMERARO Synthesis and pharmacological evaluation of tyramine congeners
containing fused heterocyclic rings. Eur. J. Med. Chem. 28 :
505-511, 1993.
-
BERTOLINI, C. CASAGRANDE, G. NORCINI, F. SANTANGELO Synthesis and reactivity
of mevinolin-like lactone precursors. Synthetic Comm. 24 :
1833-1845, 1994.
-
SANTANGELO, C. CASAGRANDE, G. MIRAGOLI, V. VECCHIETTI Synthesis and positive
inotropic effect of 1-alkyl-and
1-acyl-6,7-dimethoxy-3-dimethylamino-1,2,3,4-tetrahydroquinolines. Eur.
J. Med. Chem. 29 : 877-882, 1994.
-
NAPOLETANO, D. DELLA BELLA, C. FRAIRE, G. GRANCINI, C. MASOTTO, S. RICCIARDI,
C. ZAMBON Stereoselective synthesis and evaluation of all stereoisomers of
Z4349, a novel and selective -opioid analgesic. Bioorg. Med. Chem. Lett.
5 : 589-592, 1995.
-
F. SANTANGELO, C. CASAGRANDE, G. NORCINI, F. GERLI A convenient synthesis
of 9-hydroxy-3,4,5,6-tetrahydro-1H-azepino [5,4,3-cd] indole from
7-methoxyindole. Synthetic Comm. 23 : 2717-2725, 1995.
-
K.H. BANNER, F. MARCHINI, A. BUSCHI, E. MORIGGI, C. SEMERARO, C.P. PAGE The
effect of selective phosphodiesterase inhibitors in comparison with other
anti-asthma drugs on allergen-induced eosinophilia in guinea-pig airways.
Pulm. Pharmacol. 8 :37-42, 1995.
-
S. IANELLI, M. NARDELLI, F. DOGGI, G. NORCINI, F. SANTANGELO Structure and
conformation of three stereoisomers of a novel and selective opioid analgesic.
Acta Crystallographica C51 : 1338-1341, 1995.
-
M. FANTONI, E. MORIGGI, C. BISIANI, C. MASOTTO, F. POCCHIARI, C. SEMERARO
Z1046 : Biochemical characterization of its dopaminergic activity. Acta
Physiol. Hungarica, In press, 1996.
-
P. FERLANGA, D. ZANZOTTERA, I. BIASINI, F. MARCHINI, C. SEMERARO Z1046, a
new specific peripheral dopaminergic compound. Acta Physiol. Hungarica,
In press, 1996.
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