SIF - Società
Italiana di Farmacologia
"SIF - La Ricerca Farmacologica in Italia"
PHARMACOLOGY OF THE
RESPIRATORY SYSTEM
RESEARCH GROUP MEMBERS:
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Folco Giancarlo, P.O.
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Sala Angelo, R.U.
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Rossoni Giuseppe, T.L.
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Bolla Manlio, D.Dr.
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Armetti Laura, D.Dr.
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Buccellati Carola, B.
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Hernandez Alicia, B.
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Bonazzi Albino, B.
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Zarini Simona, B.
AFFILIATION:
Istituto di Scienze Farmacologiche
Centro di Studio e Ricerca di Farmacologia Cardiopolmonare Sperimentale
Facoltà di Farmacia
Università di Milano
ADDRESS: Via Balzaretti 9
CITY: Milano
POSTAL CODE: 20133
TELEPHONE: 02-20488312
FAX: 02-29404961
E-MAIL: folco@isfunix.farma.unimi.it
PUBLICATIONS:
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SALA A., ROSSONI G., BUCCELLATI C., BERTI F., FOLCO G.C., MACLOUF J. Formation
of sulphidopeptide-leukotrienes by cell cell interaction causes coronary
vasoconstriction in isolated, cell-perfused heart of rabbit. Brit. J.
Pharmacol. 110: 1206-1212, 1993.
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LETARI O., MIOZZO A., FOLCO G.C., BELLONI P.A., SALA A., ROVATI G.E., NICOSIA
S. Effects of Loratadine on cytosolic calcium levels and leukotriene release:
novel mechanisms of action independent of the anti-histamine activity.
Eur. J. Pharmacol. 266: 219-227, 1994.
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WHEELAN P., SALA A., FOLCO G.C., NICOSIA S., FALCK J.R., BHATT R.K., MURPHY
R.C. Stereochemical analysis of the 3-hydroxy-leukotriene B4 metabolite from
ethanol treated rat hepatocytes and biological activity of 3(S)-hydroxy-
and 3(R)-hydroxy-leukotriene B4. J. Pharmacol. Exp. Ther. 271: 1514-1519,
1994.
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VIGANO' T., HERNANDEZ A., CORSINI A., GRANATA A., BELLONI P., FUMAGALLI
R., PAOLETTI R., FOLCO G.C. Mevalonate pathway and isoprenoids regulate human
bronchial myocyte proliferation. Eur. J. Pharmacol.-Mol. Pharmacol.
Section 291: 201-203, 1995.
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FERIOLI R., FOLCO G.C., FERRETTI C., GASCO A.M., MEDANA C., FRUTTERO R.,
CIVELLI M., GASCO A. A new class of furoxan derivatives as NO donors: mechanism
of action and biological activity. Brit. J. Pharmacol. 114:816-820,
1995.
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ROSSONI G., SALA A., BERTI F., TESTA T., BUCCELLATI C., MOLTA C.,
MÜLLER-PEDDINGHAUS R., MACLOUF J., FOLCO G.C. Myocardial protection
by the leukotriene synthesis inhibitor BAY X1005: importance of transcellular
biosynthesis of cysteinyl-leukotrienes. J. Pharmacol. Exp. Ther. 276:
335-341, 1996.
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SESTINI P., ARMETTI L., GAMBARO G., PIERONI M.G., REFINI R.M., SALA A., VAGHI
A., FOLCO G.C., BIANCO S., ROBUSCHI M. Inhaled PGE2 prevents aspirin-induced
bronchoconstriction and urinary LTE4 excretion in aspirin-sensitive asthma.
Amer. J. Respir. Crit. Care Med. 153:572-575, 1996.
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SALA A., ALIEV G.M., ROSSONI G., BERTI F., BUCCELLATI C., BURNSTOCK G., FOLCO
G.C., MACLOUF J. Morphological and functional changes of coronary vasculature
caused by transcellular biosynthesis of sulfidopeptide leukotrienes in isolated
heart of rabbit. Blood 87 : 1824-1832, 1996.
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ROSSONI G., SALA A., BUCCELLATI C., MACLOUF J., FOLCO G.C., BERTI F.
Vasoconstriction to polymorphonuclear leukocytes in the isolated, perfused
rabbit heart: inhibition by prostacyclin mimetics. J. Cardiovasc.
Pharmacol. 27: 680-685, 1996.
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SALA A., BOLLA M., ZARINI S., MULLER-PEDDINGHAUS R., FOLCO G.C. Release of
Leukotriene A4 versus Leukotriene B4 from human polymorphonuclear
leukocytes. J. Biol. Chem. 271 : 17944-17948, 1996.
RESEARCH GROUP MEMBERS:
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Lampa Enrico, P.O.
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Vacca Ciro, P.A.
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Matera Maria Gabriella, T.L.
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Cazzola Mario, professore a contratto
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Marabese Ida, D.DR.
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D'Agostino Bruno, B.
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Mangrella Mario, B.
AFFILIATION:
Istituto di Farmacologia e Tossicologia
Facoltà di Medicina e Chirurgia
Seconda Università degli Studi di Napoli
ADDRESS: Via Costantinopoli, 16
CITY: Napoli
POSTAL CODE: 80138
TELEPHONE: 081-566-5878, 5877, 459802
FAX: 081-566-5877, 5878
PUBLICATIONS:
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CAZZOLA M., MATERA M.G., LICCARDI G., SACERDOTI G., D'AMATO G., ROSSI F.:
Effect of telenzepine, an M1-selective muscarinic receptor antagonist, in
patients with nocturnal asthma. Pulm. Pharmacol. 7: 91-97, 1994.
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MATERA M.G., D'AGOSTINO B., COSTANTINO M., MANGRELLA M., CALDERARO V., ROSSI
F.: K+ channels and guinea pig trachea: a possible functional modulation
by GABAB receptors. Pulm. Pharmacol. 7: 259-263, 1994.
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MAROTTA T., FERRARA L.A., DI MARINO L., MANCINO M., ANNUZZI G., RUSSO O.,
D'ORTA G., LUCARELLI C., ROSSI F.: Factors affecting lipoprotein lipase in
hypertensive patients. Metabolism 44: 712-718, 1995.
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MATERA M.G., DE SANTIS D., D'AGOSTINO B., PALLOTTA M., VACCA C., CAZZOLA
M., ROSSI F.:Role of 5-hydroxytryptamine in mediating adenosine-induced airway
contraction. Immunopharmacology 29: 73-78, 1995.
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MATERA M.G., CAZZOLA M., VINCIGUERRA A., DI PERNA F., CALDERARO F., CAPUTI
M., ROSSI F.: A comparison of the bronchodilating effects of salmeterol,
salbutamol and ipratropium bromide in patients with chronic obstructive pulmonary
disease. Pulm. Pharmacol. 8: 267-271, 1995.
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CAZZOLA M., MATERA M.G., D'AMATO G., ROSSI F.: Effects of serotonin on airways:
recent developments. Allergy 50: 1-10, 1995.
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CAZZOLA M., MATERA M.G., SANTANGELO G., VINCIGUERRA A., ROSSI F., D'AMATO
G.: Salmeterol and formeterol in partially reversible severe chronic obstructive
pulmunary disease: a dose-response study. Respir. Med. 89: 357-362,
1995.
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D'AGOSTINO B., MATERA M.G., CAZZOLA M., MANGRELLA M., ROSSI F.: Effects of
in vitro 5-HT1 receptor activation in guinea pig trachea. Life
Sci. 7: 153-160, 1996.
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EL-HASHIM A., D'AGOSTINO B., MATERA M.G., PAGE C.: Characterization of adenosine
receptors involved in adenosine-induced bronchoconstriction in allergic
rabbits. Brit. J. Pharmacol. 119: 1262-1268, 1996.
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MATERA M.G., CAPUTI M., CAZZOLA M.: A combination with clinical recommended
dosages of salmeterol and ipratropium is not more effective than salmeterol
alone in patients with chronic obstructive pulmunary disease. Respir.
Med. 90: 497-99, 1996.
RESEARCH GROUP MEMBERS:
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Nicosia Simonetta, P.O.
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Rovati Gian Enrico, R.U
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Capra Valèrie, D.DR.
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Accomazzo Maria Rosa, T.L.
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Ciceri Paola, B.
AFFILIATION:
Istituto di Scienze Farmacologiche
Facoltà di Farmacia
Università di Milano
ADDRESS: Via Balzaretti,9
CITY: Milano
POSTAL CODE: 20133
TELEPHONE: 02-20488312
FAX: 02-20488385
E-MAIL: nicosia@isfunix.farma.unimi.it
PUBLICATIONS:
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OLIVA D, ACCOMAZZO MR, GIOVANAZZI S, NICOSIA S. Correlation between LTD4-induced
contraction and cytosolic calcium elevation: a quantitative and simultaneous
evaluation in smooth muscle. J. Pharmacol. Exp. Ther. 268: 159-166,
1994.
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LETARI O, MIOZZO A, FOLCO GC, BELLONI PA, SALA A, ROVATI GE, NICOSIA S. Effects
of loratadine on cytosolic Ca2+ levels and leukotriene release: novel mechanisms
of action independent of the anti-histamine activity. Eur. J. Pharmacol.-Mol.
Pharmacol. Section 266: 219-227, 1994.
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ROVATI GE, NICOSIA S. Lower efficacy: interaction with an inhibitoty receptor
or partial agonism? Trends Pharmacol. Sci. 15: 140-144, 1994.
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WHEELAN P, SALA A, FOLCO GC, NICOSIA S, FALCK JR, BHATT RK, MURPHY RC.
Stereochemical analysis of the 3-hydroxy-leukotriene B4 metabolite from ethanol
treated rat hepatocytes and biological activity of 3(S)-hydroxy- and
3(R)-hydroxy-leukotriene B4. J. Pharmacol. Exp. Ther. 271: 1514-1519,
1994;.
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RIGHI M, LETARI O, SACERDOTE P, MARANGONI F, MIOZZO A, NICOSIA S.
Myc-immortalized microglial cells express a functional PAF receptor. J.
Neurochem. 64: 121-129, 1995.
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ROVATI GE, SHRAGER R, NICOSIA S, MUNSON PJ. KINFIT II: a nonlinear least-squares
program for analysis of kinetic binding data. Mol. Pharmacol. 50:
86-95, 1996.
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CORSINI A, BONFATTI M, QUARATO P, ACCOMAZZO MR, RAITERI M, SARTANI A, TESTA
R, NICOSIA S, PAOLETTI R, FUMAGALLI R. Effect of the new calcium antagonist
lercanidipine and its enantiomers on the migration and proliferation of arterial
myocytes. J. Cardiovasc. Pharmacol. In press, 1996.
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LEONARDI A, POGGESI E, TADDEI C, GUARNERI L, ANGELICO P, ACCOMAZZO MR, NICOSIA
S, TESTA R. In vitro calcium-antagonist activity of lercanidipine and its
enantiomers. J. Cardiovasc. Pharmacol. In press, 1996.
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