NICOX RESEARCH INSTITUTE
WEB ADDRESS / INDIRIZZO INTERNET

http://www.nicox.com
TEAM LEADER / RESPONSABILE

Ennio Ongini ongini@nicox.it 
RESEARCH GROUP MEMBERS / COMPONENTI DEL GRUPPO DI RICERCA

1 Massimiliano Guzzetta guzzetta@nicox.it 
2 Francesco Impagnatiello impagnatiello@nicox.it 
3 Angela Monopoli monopoli@nicox.it 
4 Cristina Presotto presotto@nicox.it 
AFFILIATION / AFFILIAZIONE

Nicox Research Institute info@nicox.itWEB
ADDRESS / INDIRIZZO

Via L. Ariosto, 21 20091 Bresso (Milano)
TELEPHONE / TELEFONO

+39 02 61036.1
FAX

+39 02 61036.430
RESEARCH TOPICS / LINEE DI RICERCA

3 Synthesis and pharmacological characterization of innovative nitric-oxide (NO) releasing drugs
3 Study of the role of nitric oxide on endothelial dysfunction by in vivo/ex vivo pharmacological techniques
3 Study of the antinflammatory and antiproliferative properties of nitric oxide using in vitro/in vivo pharmacological models
16 Biochemical effects of nitric oxide in various tissues following release by NO donors.
COLLABORATIONS / COLLABORAZIONI

Dept. of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, USA  
Dept. of Pharmaceutical Chemistry, School of Pharmacy, Univ. Milan, Italy  
Institute of Internal and Vascular Medicine, School of Medicine, Univ. Perugia, Italy  
Dept. of Biochemical Pharmacology, The William Harvey Research Institute, London, UK  
Dept. of Experimental Pharmacology, School of Pharmacy, Univ. Naples, Italy  
The Robert Gordon University, School of Pharmacy, Aberdeen, UK  
GRANTS / FINANZIAMENTI

 
PUBLICATIONS 2001-2004 / PUBBLICAZIONI 2001-2004

1 Emanueli C, Van Linthout S, Salis MB, Monopoli A, Del Soldato P, Ongini E, Madeddu P. (2004) The nitric oxide-releasing aspirin derivative, NCX 4016, promotes separative angiogenesis and prevents apoptosis in a model of peripheral vascular disease. Artherioscler Tromb Vasc Biol; 24:2082-7.
2 Furlan R, Kurne A, Bergami A, Brambilla E, Maucci R, Gasparini L, Butti E, Comi G, Ongini E, Martino G. A nitric oxide releasing derivative of flurbiprofen inhibits experimental autoimmune encephalomyelitis (2004) J Neuroimmunol. 150 : 10-9.
3 Gasparini L, Ongini E, Wenk G. Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer’s Disease: old and new mechanism of action. (2004) J Neurochem 91: 524-536.
4 Iwanaga Y, Gu Y, Mieterle T, Presotto C, Del Soldato P, Peterson KL, Ongini E, Condorelli G, Ross Jr J. A nitric oxide-releasing derivative of enalapril, NCX 899, prevents progressive cardiac dysfunction and remodeling in hamsters with heart failure. FASEB.J. : 587-588.
5 Ongini E, Impagnatiello I, Bonazzi A, Guzzetta M, Govoni M, Monopoli A, Del Soldato P, Ignarro LJ. Nitric oxide (NO)-releasing derivatives, a new class of drugs showing enhanced antiproliferative and anti-inflammatory properties. (2004) Proc Nat Acad Sci USA. 101:8497-8502.
6 Chiroli V, Benedini F, Ongini E, Del Soldato P. Nitric oxide-donating non-steroidal anti-inflammatory drugs: the case of nitroderivatives of aspirin.(2003) Eur J Med Chem. 38: 441-446.
LAST UPDATE / ULTIMO AGGIORNAMENTO DATI

January, 03rd 2005