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33°
Congresso Nazionale
della Società Italiana di Farmacologia
Cagliari, 6-9 Giugno 2007
Fiera della Sardegna |
Sessione Posters
7 Giugno
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Cliccare sul titolo di ciascun poster per aprire il relativo abstract
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POSTERS - 7 Giugno ore 12.30-15.00 |
1 |
RECETTORI E MECCANISMI DI TRASDUZIONE DEL
SEGNALE |
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1. COUPLING
OF CANNABINOID RECEPTORS TO INTRACELLULAR CALCIUM MOBILIZATION IN
RAT INSULINOMA B-CELLS
Pietro Marini1, L. De Petrocellis2, I. Matias2, A. Schiano Moriello
2,3, K. Starowicz3, L. Cristino2 and V. Di Marzo3
1 Department of Human Physiology and Pharmacology, University
of Rome “La Sapienza”, Rome, Italy 2,3Endocannabinoid
Research Group, 2Institute of Cybernetics and 3Institute of Biomolecular
Chemistry, National Research Council, Via Campi Flegrei 34, Comprensorio
Olivetti, 80078, Pozzuoli, Naples, Italy
2. DIFFERENT
STRIATAL C-FOS EXPRESSION FOLLOWING CO-ADMINISTRATION OF DELTA-9-TETRAHYDROCANNABINOL
WITH HALOPERIDOL OR CLOZAPINE
Paola Casti,a Giorgio Marchese,a Angela Sanna,a Gianluca Casu,a
Gabriele Pinna Spada,a Luca Pania,b
aNeuroscienze PharmaNess S.c.a r.l., c/o POLARIS, Edificio 5,
Loc.Piscinamanna, 09010 Pula (CA), Italy. bC.N.R. Istituto di Tecnologie
Biomediche, Sezione di Cagliari, c/o Neuroscienze PharmaNess S.c.a
r.l.
3. ALTERED
ENDOCANNABINOID-MEDIATED SYNAPTIC PLASTICITY IN HIPPOCAMPAL NEURONS
IN OBESITY
1Massa Federico, 1,2Mancini Giacomo, 2Pagotto Uberto, 1Lutz Beat
1Department of Physiological Chemistry, Johannes Gutenberg University,
Mainz, Germany. 2Endocrinology Unit, Department of Internal Medicine
and Gastroenterology, S. Orsola-Malpighi General Hospital, Alma
Mater University of Bologna, Bologna, Italy
4. CAVEOLAE/LIPID
RAFTS CONTROL SIGNALING OF CB1 CANNABINOID RECEPTOR IN HUMAN BREAST
CANCER CELLS
Claudia Grimaldi, Daniela Sarnataro, Paolo Cavallo, Anna Capasso,
Maurizio Bifulco
Department of Pharmaceutical Sciences, University of Salerno,
Fisciano, Italy
5. PHARMACOLOGICAL
CHARACTERIZATION OF SINGLE NUCLEOTIDE POLYMORPHISMS FOR HUMAN CB2
RECEPTOR
Petrò Roberta, Beltramo Massimiliano, Brusa Rossella, Downey
Patrick, Jason Simon, Foglia Chiara, Scandroglio Paola and Reggiani
Angelo
Schering Plough Research Institute, Via Olgettina 58, 20132
Milano, Italy
6. RITIRATO
7 . LITHIUM
REGULATES NEURONAL EXCITABILITY IN RAT HIPPOCAMPUS
Luca Murru, M. Carta, S. Pitzianti. G. Corda, E. Sanna and G. Biggio
Dept. Experimental Biology, Sect of Neuroscience, and Center
of Excellence for the Neurobiology of Dependence. Cittadella Universitaria,
SS 554 Km 4,500, 09042, Monserrato, Cagliari, Italy
8. THIOCOLCHICOSIDE INHIBITS THE ACTIVITY OF VARIOUS
SUBTYPES OF RECOMBINANT GABAA RECEPTORS EXPRESSED IN XENOUPS LAEVIS
OOCYTES
Mascia Maria Paola a, Bachis Elisabetta b, Obili Nicola b, Maciocco
Elisabetta a, Cocco Giovanni A c, Sechi Gian Pietro c and Biggio
Giovanni a,b
a National Research Council, Institute of Neuroscience, Cagliari,
Italy; bDepartment of Experimental Biology “B. Loddo”,
University of Cagliari, Cagliari, Italy; c Neurological Clinic ,
University of Sassari, Sassari, Italy
(abstract non disponibile su richiesta dell'autore)
9 . DIRECT
MODULATION OF GABAERGIC TRANSMISSION BY THYROID HORMONES (THs) IN
HIPPOCAMPUS
Gabriele Losi and Giulia Puia
Dept. Biomedical Science, University of Modena and Reggio Emilia,
via Campi 287, Modena, ITALY
10 . PREGNANCY
AND DELIVERY CHANGE THE GENE EXPRESSION OF SYNAPTIC AND EXTRASYNAPTIC
GABAA RECEPTORS IN THE RAT HIPPOCAMPUS
Maria Luisa Mura1, M.C. Mostallino2, E. Maciocco2, G.Biggio1,2,3
1Departement of Experimental Biology, Section of Neuroscience,
University of Cagliari, Monserrato (Cagliari), Italy; 2 CNR, Institute
of Neuroscienze, Monserrato (Cagliari), Italy; 3Center of Excellence
for the “Neurobiology of Drug Dependence”, University
of Cagliari, Monserrato (Cagliari) Italy
11. PLASTICITY
OF THE GABAERGIC TRANSMISSION IN THE RAT HIPPOCAMPUS DURING PREGNANCY
Luca Murru, G. Talani, V. Serra, M. Carta, F. Sitzia, R. Uras, E.
Sanna and
G. Biggio
Dept. Experimental Biology, Sect of Neuroscience, and Center
of Excellence for the Neurobiology of Dependence. Cittadella Universitaria,
SS 554 Km 4,500, 09042, Monserrato, Cagliari, Italy
12. ACTIVATION
OF GROUP II METABOTROPIC GLUTAMATE RECEPTORS PREVENTS THE DIFFERENTIATION
OF CULTURED NEURAL PROGENITOR CELLS ISOLATED FROM THE MOUSE SUBVENTRICULAR
ZONE INTO MATURE ASTROCYTES
Ciceroni Cinzia1, Mosillo Paola1, Mastrantoni Elisa1, Magnotti Maria
Cristina1, Cappuccio Irene1,3, Lupieri Tommaso1, Nicoletti Ferdinando1,2,
Melchiorri Daniela1
1Department of Human Physiology and Pharmacology, University
of Rome “La Sapienza”, Rome; 2I.N.M. Neuromed, Pozzilli,
Italy; 3I.R.C.C.S. San Raffaele, Rome
13. INDIVIDUAL
SUBTYPES OF METABOTROPIC GLUTAMATE RECEPTORS REGULATES NEURAL DIFFERENTIATION
OF CULTURED MOUSE EMBRYONIC STEM CELLS
Cappuccio Irene1,2*, Sarichelou Iran1*, Costantino Santa1, Ferranti
Francesca1, Niccolini Cristiano1, Nicoletti Ferdinando1,3, Melchiorri
Daniela1
1Department of Human Physiology and Pharmacology, University
of Rome “La Sapienza”, Rome; 2I.R.C.C.S. San Raffaele,
Roma, 3I.N.M. Neuromed, Pozzilli, Italy
14. THE
HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEIN (TAT) MODULATES NMDA RECEPTOR
FUNCTION BY ACTING AT COLOCALIZED METABOTROPIC GLUTAMATE RECEPTOR
1
Veronica Musante1, Elisa Neri1, Paolo Severi2, Maurizio Raiteri1,3,
and Anna Pittaluga1,3
1DI.ME.S, Pharmacology and Toxicology Section, Department of
Experimental Medicine, University of Genova, Italy, 2Dision of Neurosurgery,
Galliera Hospital, Genova, Italy, 3Center of Excellence for Biomedical
Research, University of Genova, Italy
15. COLOCALIZATION
AND FUNCTIONAL INTERACTIONS BETWEEN PRESINAPTIC AMPA; NMDA AND GROUP
I METABOTROPIC GLUTAMATE RECEPTORS
Elisa Neri, Veronica Musante, Paolo Severi, Anna Pittaluga and Maurizio
Raiteri.
1DI.ME.S, Pharmacology and Toxicology Section, Department of
Experimental Medicine, University of Genova, Genova Italy; 2Division
of Neurosurgery, Galliera Hospital, Genova, Italy; 3Center of Excellence
for Biomedical Research, University of Genova, Genova Italy
16. CO-EXPRESSION OF METABOTROPIC GLUTAMATE 1A (mGlu1A)
RECEPTOR AND CANNABINOID 1 (CB1) RECEPTOR IMMUNOREACTIVITY IN THE
RAT HIPPOCAMPUS
Boscia Francesca, *Moroni Flavio, Annunziato Lucio & *Pellegrini-Giampietro
Domenico
Dipartimento di Neuroscienze, Università di Napoli “Federico
II”
*Dipartimento di Farmacologia Preclinica e Clinica, Università
di Firenze
(abstract non disponibile su richiesta dell'autore)
17. BIOCHEMICAL
AND PHARMACOLOGICAL EVIDENCES FOR (-)-EPIGALLO CATECHIN-3-GALLATE
(EGCG) TO LINK NMDA RECEPTORS IN RAT CORTEX
Lograno M.D. and Romano M.R.
Department of Pharmacobiology, University of Bari, Via E. Orabona,
4, 70125 Bari, Italy
18. PHARMACOLOGICAL
CHARACTERIZATION OF THE NOCICEPTIN/ORPHANIN FQ RECEPTOR ANTAGONIST
SB-612111:IN VITRO STUDIES
1Fischetti Carmela, 1Spagnolo Barbara, 1Carra’ Giacomo, 1Fantin
Martina, 2Hebbes Christopher, 2McDonald John, 2Barnes Antony, 1Rizzi
Anna, 1Marzola Giuliano, 3Trapella Claudio, 3Fanton Giulia, 1Morari
Michele, 2Lambert Dave, 1Regoli Domenico and 1Calo’ Girolamo
1Dept. of Pharmacology and 3Dept of Pharmaceutical Science, University
of Ferrara, Italy.
2Dept. of Cardiovascular Sciences, University of Leicester, UK
19. ACTIVATION
OF NOCICEPTIN/ORPHANIN FQ AND CLASSICAL OPIOID RECEPTORS IN CHO
CELLS EXPRESSING THE CHIMERIC GALPHAqi5 PROTEIN PROMOTES CALCIUM
MOBILIZATION
Camarda Valeria1, Molinari Paola 2, Ambrosio Caterina 2, Kostenis
Evi3, Regoli Domenico1, Guerrini Remo4, Severo Salvadori4, and Calo’
Girolamo 1
1Dept Exp and Clin Medicine, Section of Pharmacology, University
of Ferrara, Italy;
2Dept of Pharmacology, ISS, Rome, Italy; 3: Inst for Pharmaceutical
Biology, Bonn, Germany; 4: Dept of Pharmaceutical Sciences, University
of Ferrara, Italy
20. OPPOSITE
EFFECTS ON CELL PROLIFERATION BY WNT1 AND WNT7
A
PROTEINS IN CULTURED PC12 CELLS
Spinsanti Paola1, De Vita Teresa1, Caruso Alessandra1, Lisi Ilaria1,
Melchiorri Daniela1, Caricasole Andrea2, and Nicoletti Ferdinando1,3
1Department of Human Physiology and Pharmacology, University
of Rome “La Sapienza”; 2Sienabiotech S.p.A., Siena;
and 3I.N.M. Neuromed, Pozzilli, Italy
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CONTROLLO FARMACOLOGICO DEI PROCESSI DI MORTE
E PROLIFERAZIONE CELLULARE |
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21. ROLE
OF NO/Ca2+/CaM/MAPK SIGNALLING PATHWAY IN THE MITOGENIC EFFECT OF
IL-1B IN C6 GLIOMA CELLS
Sticozzi Claudia, Meini Antonella and Palmi Mitri
Dipartimento di Scienze Biomediche, Università degli
Studi di Siena, via Aldo Moro, 2 Siena
22. NEUROGENIC
RESPONSE INDUCED BY FLUOXETINE CHRONIC TREATMENT IN NEURAL PROGENITOR
CELLS ISOLATED FROM RAT POSTNATAL CEREBELLUM
Morena Zusso, Patrizia Debetto, Massimo Barbierato, Diego Guidolin*,
and Pietro Giusti
Department of Pharmacology and Anestesiology, University of
Padova, Italy
*Department of Anatomy and Physiology, University of Padova, Italy
23. INVOLVEMENT
OF CANNABINOID SYSTEM IN PROLIFERATION OF CEREBELLAR NEURAL PROGENITOR
CELLS
Silvia Soffia, Marco Corso, Massimo Barbierato, Pietro Giusti, Patrizia
Debetto, and Morena Zusso
Department of Pharmacology and Anesthesiology “E. Meneghetti”,
University of Padova, Italy
24. EFFECT
OF OXYSTEROLS ON CELL SURVIVAL AND PROLIFERATION PATHWAYS IN HUMAN
ENDOTHELIAL CELLS
Laura Agnoletto, Chiara Poggiani, Federico Cusinato, Lucia Trevisi
and Sisto Luciani
Department of Pharmacology and Anaesthesiology, University of
Padova
25. EXPRESSION
OF CXCR4 AND SDF1/CXCL12 IN HUMAN NORMAL PITUITARY AND PITUITARY
ADENOMA TISSUES: ROLE IN CELL PROLIFERATION
Federica Barbieri, Adriana Bajetto, Carola Porcile, Alessandra Pattarozzi,
Monica Gatti, Alessandro Corsaro, Stefano Thellung, Valentina Villa,
Gennaro Schettini and Tullio Florio
Section of Pharmacology, Department of Oncology, Biology and
Genetics, University of Genova, Italy
26. DOPAMINE
AND L-DOPA INCREASE IN VITRO PROLIFERATION OF STEM CELLS FROM THE
MOUSE SUBVENTRICULAR ZONE
Pier Andrea Serra a, Rossana Migheli, Gaia Rocchitt a, Giammario
Calia, Sonia Dedola, Antonio Manca a, Francesca L‘Episcopo
c, Stefano Pluchino b, Bianca Marchetti a,c, Maria S. Desole a
aDepartment of Pharmacology, University of Sassari, 07100 Sassari,
Italy
bDepartment of Neuroscience, S. Raffaele Scientific Institute, Milano,
Italy
cOASI Institute for Research and Care on Mental Retardation and
Brain Aging (IRCCS), Neuropharmacology Section, Troina, Italy
27. ANTIPROLIFERATIVE
EFFECTS OF PYRAZOLO-PYRIMIDINE -TYPE INHIBITORS OF SRC FAMILY TYROSINE
KINASES DERIVATES ON HUMAN NEUROBLASTOMA CELLS
Navarra Michele1, Celano Marilena2, Schenone Silvia3, Botta Maurizio4,
Bramanti Placido5, Russo Diego2
1 Pharmaco-Biological Department, University of Messina, 2Department
of Pharmacobiological Sciences, University "Magna Græcia"
of Catanzaro, 2Department of Pharmaceutical Sciences, University
of Genova, 4Department of Pure and Applied Medicinal Chemistry,
University of Siena, 5IRCCS centro neurolesi “Bonino-Pulejo”
28. NEURON-LIKE
CELLS DERIVED FROM BONE MARROW STROMAL CELLS: EXPRESSION AND FUNCTIONING
OF GABAB RECEPTORS
Cervetto Chiara1, Paluzzi Paola1, Guarnieri Stefania1, Marcoli Manuela1,
Castagnola Patrizio2, Tonachini Laura2, Mastrogiacomo Maddalena2,
Monticone Massimiliano2, Pestarino Mario3, Candiani Simona3, Maura
Guido1*
1Dep. Experimental Medicine, 3Dep. Biology, *Centre of Excellence
for Biomedical Research, University of Genova and 2Ist Naz Ricerca
sul Cancro, Genova, Italy
29. INFLUENCE
OF LEPTIN ON THE EARLY PHASES OF BONE FORMATION DURING MOUSE SKELETON
ORGANOGENESIS
1Rivasi Marianna, 1Benelli Augusta, 2Ferretti Marzia, 2Benincasa
Marta, 2Bertoni Laura, 2Cavani Francesco, 2Palumbo Carla.
1Dept. of Biomedical Sciences, Section of Pharmacology; 2Dept.
of Anatomy and Istology, Section of Human Anatomy; University of
Modena and Reggio Emilia, Modena, Italy
30. PROLIFERATION
AND INVASIVENESS OF HUMAN SMOOTH MUSCLE TSC2-/- CELLS. EFFECT OF
ANTI-EGFR AND RAPAMYCIN
Di Giulio Anna Maria, Isaia Eleonora, Grande Vera, Lesma Elena,
Gorio Alfredo
Pharmacological Laboratories, Dept. of Medicine, Surgery and
Dentistry, Università degli Studi di Milano
31. REVERSION
OF THE PHENOTYPE OF HUMAN TSC2-/- SMOOTH MUSCLE CELLS. NOVEL INSIGHTS
FOR TSC AND LAM THERAPY
Lesma Elena, Grande Vera, Isaia Eleonora, Di Giulio
Anna Maria, Gorio Alfredo
Pharmacological Laboratories, Dept. of Medicine, Surgery and
Dentistry, Università degli Studi di Milano
32. EXPRESSION
OF ANNEXIN A1 IN MOUSE MYOBLAST DIFFERENTIATION CELL LINE
Valentina Bizzarro, Michela Festa, Simona F. Ercolino, Silvia Franceschelli,
Egle Solito*, Luca Parente and Antonello Putrella
Department of Pharmaceutical Sciences, University of Salerno,
Salerno, Italy
*Department of Cellular and Molecular Neuroscience, Faculty of Medicine,
Imperial College, London, UK
33. THE
GLUCOCORTICOID-INDUCED LEUCINE ZIPPER (GILZ) INHIBITS SKELETAL MYOGENESIS
BY COUNTERACTING MYOD ACTIVITY
Donato Valerio1, Velardi Enrico1, Bruscoli Stefano1, Bastianelli
Alessandra1, Donato Rosario2 and Riccardi Carlo1
1Dept. Clinical and Experimental Medicine, Sect. Pharmacology,
and 2Dept. Experimental Medicine and Biochemical Sciences, Sect.
Anatomy, Perugia University Medical School, 06122, Perugia, Italy
34. CALIXARENE
GLYCOCONJUGATES INHIBIT C6 GLIOMA CELL PROLIFERATION AND MIGRATION:
INTERACTION WITH GROWTH FACTORS
Viola Santa1, Consoli Grazia M.L.2, Merlo Sara1, Geraci Corrada2,
Sortino Maria Angela1
1Department of Experimental and Clinical Pharmacology, University
of Catania and 2Institute of Biomolecular Chemistry, CNR, Valverde,
Catania
35. CANNABINOIDS
INHIBIT HUMAN COLON CANCER CELL PROLIFERATION THROUGH CB2-RECEPTOR
AND CERAMIDE PATHWAY ACTIVATION
Mastroianni Rosanna a, Cianchi Fabio b, Magnelli Lucia c, Nicola
Schiavone c, Perna Ferderico b, Capaccioli Sergio c, Manera Clementina
d, Mannaioni Pier Francesco a and Masini Emanuela a
aDepartment of Preclinical and Clinical Pharmacology, bDepartment
of Critical Care Medicine and cDepartment Pathology and Experimental
Oncology, University of Florence, Florence, Italy; dDepartment of
Pharmaceutical Sciences, University of Pisa, Pisa, Italy
36. ROLE
OF LOX PATHWAY AND ENDOCANNABINOID SYSTEM IN ANTITUMOR ACTIVITY
OF CANNABIDIOL, A NON-PSYCHOACTIVE CANNABINOID
Massi Paola1, Valenti M. 2, Gasperi M.3, Meli S. 2, Maccarrone M.3
and Parolaro D.2
1 Department of Pharmacology, Chemotherapy and Toxicology, University
of Milan, Via Vanvitelli 32, Milan, Italy
2 Department of Structural and Functional Biology, Pharmacology
Section, Center of Neuroscience, University of Insubria, Via A.
da Giussano 10, Busto Arsizio (VA), Italy
3 Department of Biomedical Sciences, University of Teramo, 64100
Teramo, Italy
37. EFFECTS
OF THE IL-6 RECEPTOR SUPERANTAGONIST SANT7 ON TGF-B-INDUCED CELL
PROLIFERATION AND MAP KINASE PHOSPHORYLATION IN PRIMARY CULTURES
OF FIBROTIC HUMAN LUNG FIBROBLASTS
Gallelli Luca, Falcone Daniela, Renda Teresa, Pelaia Girolamo, Maselli
Rosario, Savino Rocco, De Sarro Giovambattista
Department of Experimental and Clinical Medicine, Faculty of
Medicine, University Magna Graecia of Catanzaro, Italy
38. EFFECTS
OF SIMVASTATIN AND BETAMETHASONE ON HYDROGEN PEROXIDE INDUCED MAPK
ACTIVATION, IL-8 PRODUCTION AND CELL PROLIFERATION IN PRIMARY CULTURES
OF HUMAN SQUAMOUS LUNG CANCER CELLS
Fratto Donatella1, Gallelli Luca1, Renda Teresa1, Pelaia Girolamo2,
Maselli Rosario2, De Sarro Giovambattista1
1Chair of Pharmacology, and 2Chair of Respiratory Diseases,
Department of Experimental and Clinical Medicine, Faculty of Medicine,
University Magna Graecia of Catanzaro, Italy
39. PKCd
ISOENZYME IS INVOLVED IN GROWTH AND ANGIOGENESIS OF PROSTATE CANCER
Betti Niccolò1, Morbidelli Lucia1, Corti Federico2, Mochly-Rosen
Daria3 and Ziche Marina1
1 Pharmacology section, Dept Molecular Biology, University of
Siena. 2 Proteomic section, Dept Molecular Biology, University of
Siena. 3 Molecular pharmacology, School of Medicine, Stanford University
40. TUMOR
NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND INHIBITS ANGIOGENESIS
STIMULATED BY HUMAN GLIOBLASTOMA CELLS
Scuderi Mariagrazia Rita, Albini Adriana 1, Lempereur Laurence,
Pennisi Giuseppa 2, Bernardini Renato, Giuseppina Cantarella
Department of Experimental and Clinical Pharmacology; and Department
of Chemical Sciences; University of Catania, 95100 Catania, Italy;
Laboratory of Molecular Oncology, Istituto Tumori, 16100 Genova,
Italy
41. ANTIANGIOGENIC
AND ANTITUMOUR EFFECTS OF METRONOMIC IRINOTECAN (CPT-11)
Fioravanti Anna1, Orlandi Paola1, Falcone Alfredo2, Danesi Romano1,
Del Tacca Mario1, Bocci Guido1
1Division of Pharmacology and Chemotherapy, Department of Internal
Medicine, University of Pisa, 2Oncology Unit; General Hospital,
Livorno
42. NATURAL
AND SEMISYNTHETIC ANTRAQUINONES, FLAVONOIDS AND NAPHTOQUINONES EFFECTS
ON CELL CYCLE IN HUMAN OVARIAN CANCER
M. Montopoli, S. Moro*, G. Cozza*, G. Zagotto*, G. Froldi, E. Ragazzi
and L. Caparrotta
Department of Pharmacology and Anaestesiology, University of
Padova Largo E. Meneghetti 2, 35131 Padova, Italy. * Department
of Pharmaceutical Sciences, University of Padova, Via Marzolo 5,
35131 Padova, Italy
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FARMACOLOGIA DELLA TRASMISSIONE SINAPTICA |
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43. SNAP-25
PHOSPHORYLATION ON SERIN 187 MEDIATES NEGATIVE MODULATION OF NEURONAL
CALCIUM DYNAMICS
Pozzi Davide1, Steven Condliffe1, Carlotta Grumelli1, Juri Bozzi2,
Matteo Caleo2, Véronique Proux-Gillardeaux3, Masami Takahashi4,
Claudia Verderio1 and Michela Matteoli1
1Department of Medical Pharmacology and CNR Institute of Neuroscience,
Center of Excellence for Neurodegenerative Diseases, University
of Milano, Via Vanvitelli 32, 20129 Milano, Italy. 2CNR- Institute
of Neuroscience via G. Moruzzi 1, 56100 Pisa, Italy. 3Institut Jacques
Monod UMR7592 Tour 43 2ème étage 2, place Jussieu,
F-75251 Paris Cedex 05, France. 4Department of Biochemistry, Kitasato
University School of Medicine, Kitasato 1-15-1, Sagamihara-shi,
Kanagawa 228-8555, Japan
44. SELECTIVE
REGULATION OF [3H]D-ASPARTATE RELEASE FROM HIPPOCAMPAL NERVE ENDINGS
BY LARGE-CONDUCTANCE CA2+- AND VOLTAGE-ACTIVATED K+ (BK) CHANNELS
Martire Maria1, D’Amico M.1, Calciano S.1, Panza E.2, Iannotti
F.2,3, Barrese V.2, Preziosi P.1, Annunziato L.2 and Tagliatatela
M.2,3
1Inst. of Pharmacology, Catholic University of S. Heart, Rome;
2Division of Pharmacology, Dept. of Neuroscience, University of
Naples Federico II, Naples; 3Dept. of Health Science, University
of Molise, Campobasso; Italy
45. KCNQ
CHANNELS REGULATE DEPOLARIZATION-INDUCED CHANGES IN INTRACELLULAR
Ca2+ CONCENTRATIONS IN RAT CEREBROCORTICAL NERVE ENDINGS
1Rosa Luisi, 1Elisabetta Panza, 1Agnese Secondo, 2Maria Martire,
1Lucio Annunziato, and 1,3Maurizio Tagliatatela
1Div. of Pharmacology, Dept. of Neuroscience, School of Medicine,
Univ. “Federico II”, Naples; 2Insitute of Pharmacology,
School of Medicine, Catholic Univ. of Sacred Heart, Rome; 3Dept.
of Health Sciences, Univ. of Molise, Campobasso, Italy
46. ADULT
ASTROGLIA IS COMPETENT FOR NA+/CA2+ EXCHANGER-OPERATED EXOCYTOTIC
GLUTAMATE RELEASE TRIGGERED BY MILD DEPOLARIZATION
1Zappettini Simona, 2Alloisio Susanna 1Raiteri Luca, 1Paluzzi Silvio,
2Nobile Mario, 1Bonanno Giambattista
1Department of Experimental Medicine - Pharmacology and Toxicology
Section and Center of Excellence for Biomedical Research, University
of Genoa, Italy. 2Institute of Biophysics, National Research Council,
Genoa, Italy
47. MECHANISMS
OF [3H]GLYCINE RELEASE FROM MOUSE SPINAL CORD SYNAPTOSOMES SELECTIVELY
LABELLED THROUGH GLYT2 TRANSPORTERS
Luccini Elisa and Raiteri L.
Department of Experimental Medicine, Pharmacology and Toxicology
Section, University of Genoa
48. IMPORTANCE
OF PROTEIN KINASE C EPSILON FOR THE ALLOSTERIC MODULATION OF GABA
EVOKED CURRENTS IN CORTICAL CULTURE AT DIFFERENT DIV
Garzon Giorgio, Baraldi Mario, Puja Giulia
Dept. of BioMedical Sciences, University of Modena and Reggio
Emilia, Via G. Campi 287, 41100 Modena, Italy
49. a7
NICOTINIC RECEPTOR PRESENT ON MOUSE CORTICAL ASTROCYTES MODULATES
ENDOGENEOUS GLUTAMATE RELEASE
Patti Laura 1, Raiteri Luca 1, Grilli Massimo 1, Robino Federica.1,
Zappettini Simona 1, Bonanno Gian Battista 1,2, Marchi Mario 1,2
1 Section of Pharmacology and Toxicology, Department of Experimental
Medicine, University of Genoa, Italy. 2 Center of Excellence for
Biomedical Research, University of Genoa, Italy
50. THE
AGONIST OF METABOTROPIC GLUTAMATE 5 RECEPTORS CHPG INVERTS THE EFFECTS
OF DHK (A BLOCKER OF GLIAL GLUTAMATE UPTAKE): AN IN VIVO MICRODIALYSIS
STUDY
Pintor Anita, Armida Monica, Pèzzola Antonella, Popoli Patrizia
Department of Therapeutic Research and Medicines Evaluation,
Istituto Superiore di Sanità, Roma (Italy)
51. THE
METABOTROPIC GLUTAMATE 5 (mGlu5Rs) AND THE ADENOSINE A2A RECEPTORS
(A2ARs) OPPOSITELY MODULATE CB1-INDUCED REDUCTION OF SYNAPTIC TRANSMISSION
IN THE RAT STRIATUM
Martire Alberto, Tebano Maria Teresa, Domenici Maria Rosaria, Popoli
Patrizia
Department of Therapeutic Research and Medicines Evaluation,
Istituto Superiore di Sanità, Roma (Italy)
52. GLUTAMATE
RELEASE INDUCED BY ACTIVATION OF GAT-1 TRANSPORTERS SITED ON GLUTAMATE
RELEASING SPINAL CORD GLIOSOMES AND ITS AUGMENTATION IN A MOUSE
MODEL OF AMYOTROPHIC LATERAL SCLEROSIS
1Milanese Marco, Raiteri Luca, 1Zappettini Simona, 2UsaiCesare,
1Bonanno Giambattista
1Department of Experimental Medicine - Pharmacology and Toxicology
Section and Center of Excellence for Biomedical Research, University
of Genoa, Italy. 2Institute of Biophysics, National Research Council,
Genoa, Italy
53. THYROID
HORMONES MODULATE GLUTAMATERGIC NEUROTRANSMISSION IN HIPPOCAMPUS
Puja Giulia, Losi Gabriele, Garzon Giorgio, Baraldi Mario
Dept. of BioMedical Sciences, University of Modena and Reggio
Emilia, Via G. Campi 287, 41100 Modena, Italy
54. ROLE
OF IONOTROPIC GLUTAMATERGIC RECEPTORS IN THE REGULATION OF HIPPOCAMPAL
NOREPINEPHRINE OUPUT IN VIVO
Alessandra Matzeu, Laura Dazzi, Giovanni Biggio
Department of Experimental Biology, Neuroscience section, University
of Cagliari, Cagliari, Italy
55. ALTERATIONS
OF GLUTAMATERGIC TRANSMISSION IN A MURINE MODEL OF MULTIPLE SCLEROSIS:
PRELIMINARY RESULTS
PEPICELLI Olimpia a, MARTE Antonella a, UCCELLI Antonio c, MANCARDI
Luigi c, RAITERI Maurizio a,b, FEDELE Ernesto a,b
aDept. of Experimental Medicine, Pharmacology and Toxicology
Section, University of Genoa; bCentre of Excellence for Biomedical
Research, University of Genoa; cDept. of Neurosciences, Ophthalmology
and Genetics, University of Genoa, Italy |
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56. MODIFICATION
OF PRESSURE AND PLACENTAL PROTEIN EXPRESSION IN PREGNANT SPONTANEOUSLY
HYPERTENSIVE RATS (SHR)
1Bianco Giuseppe, Iacono A., Esposito E., Mattace Raso G., 1Autore
G. and Meli R.
Department of Experimental Pharmacology, University of Naples
“Federico II”, Naples, 1Department of Pharmaceutical
Sciences, University of Salerno, Salerno, Italy
57. INCREASED
P22PHOX EXPRESSION AND REDUCED SOD ACTIVITY ARE INVOLVED IN EARLY
IMPAIRMENT OF INSULIN-INDUCED VASODILATION ON RESISTANCE VESSELS
OF SPONTANEOUSLY HYPERTENSIVE RATS (SHR)
GAGLIARDI Sara, POTENZA Maria A., MARASCIULO Flora L., MONTAGNANI
Monica
Department of Pharmacology and Human Physiology - Medical School
- University of Bari,
70124 Bari, Italy
58. VASODILATOR
ACTIVITY OF HYDROGEN SULFIDE (H2S) IN HUMAN ISOLATED MESENTERIC
ARTERIES
Materazzi Serena1, Patacchini R.2, Nassini R.1, Zagli G.1, Giannelli
M.1, Bechi P.1, Nicoletti P.1, Geppetti P.1 and Harrison S.1
1Department of Critical Care Medicine & Surgery, University
of Florence, Florence, Italy; and 2Department of Pharmacology, Chiesi
Pharmaceuticals, Parma, Italy; Florence, Italy
59. THE
VASORELAXANT AND ANTI-INFLAMMATORY ACTION OF RALOXIFENE IN RAT AORTA
IS PARTIALLY MEDIATED BY ESTROGEN RECEPTOR ALPHA
Valeria Pelosi1,2, Paola Sanvito1,2, Chiara Bolego1, Christian Pinna1,
Alberto Corsini1, Rosa Maria Gaion2, Andrea Cignarella1,2
1 Department of Pharmacological Sciences, University of Milan,
via Balzaretti 9, 20133 Milan; 2 Department of Pharmacology and
Anaesthesiology, University of Padova, Largo Meneghetti 2, 35131
Padova, Italy
60. INHIBITORS
OF CYSTATHIONINE-GAMMA-LYASE (CSE), PROPARGYLGLYCINE AND ß-CYANOALANINE,
MODULATE ARTERIAL VASORELAXATION IN RAT AORTA
Vellecco Valentina, Di Lorenzo Annarita, De Gruttola Luana, Brancaleone
Vincenzo, Roviezzo Fiorentina, Bucci Mariarosaria and Cirino Giuseppe
Department of Experimental Pharmacology, Faculty of Pharmacy,
University of Naples “Federico II”
61. DIRECT
EFFECTS OF TICLOPIDINE AND CLOPIDOGREL ON RESISTANCE VESSEL IN VITRO
Froldi Guglielmina, Montopoli Monica, Dorigo Paola, Caparrotta Laura
Department of Pharmacology and Anesthesiology
-Pharmacology Division- Largo E. Meneghetti 2, University of Padova
(Italy)
62. ASYMMETRIC
DIMETHYLARGININE (ADMA) INDUCES VASCULAR ENDOTHELIUM IMPAIRMENT
AND AGGRAVATES MYOCARDIAL ISCHEMIA-REPERFUSION INJURY IN RATS
Bonomo Sara M. a , De Gennaro Colonna Vito a, Manfredi Barbara a
, Ferrario Paolo a, Bianchi Mauro a, Berti Marco b,Guazzi Marco
c, Berti Ferruccio a, Rossoni Giuseppe a
a Department of Pharmacology, Chemoterapy and Medical Toxicology,
University of Milano, Via Vanvitelli 32, Italy; b Institute of Cardiology,
Monzino Cardiology Center, IRCCS, Milan, Italy; c Cardiopulmonary
Laboratory, Cardiology Division, University of Milano, San Paolo
Hospital, Milano, Italy
63. ANTI-INFLAMMATORY AND CARDIOPROTECTIVE
ACTIVITIES OF SYNTHETIC HDL CONTAINING THE 37PA PEPTIDE
Monica Gomaraschi*, Alan Remaley#, Giuseppe Rossoni§, Guido
Franceschini* and Laura Calabresi*
*Center Enrica Grossi Paoletti, Department of Pharmacological
Sciences, University of Milano, Italy, #Molecular Disease Section,
National Heart, Lung, and Blood Institute, National Institutes of
Health, Bethesda, MD, USA and §Department of Pharmacological
Sciences, University of Milano, Italy
(abstract non disponibile su richiesta dell'autore)
64. HUMAN
PHARMACOLOGY OF NAPROXEN SODIUM
Marta L Capone, PhD,§† S.Tacconelli, PhD,§†
M.G.Sciulli, PhD,§† P.Anzellotti, PharmD, §†
L.Di Francesco, PharmD, §† G.Merciaro,‡ P.Di Gregorio,
MD,‡ and P.Patrignani, PhD§†
§Department of Medicine and Aging, School of Medicine,
“G.d’Annunzio” University; †“G. d’Annunzio”
University Foundation, Ce.S.I.; and ‡SS Annunziata Hospital,
Chieti, Italy
65. DOXORUBICIN
CARDIOTOXICITY AND APOPTOSIS: VARIATION OF EXPOSURE TIMES TO THE
SAME CUMULATIVE DOSE
Vitelli Maria Redenta, Piegari Elena, Rodolico Gabriella, Leone
Lidia, Marino Laura, Oliva Patrizia, Rossi Francesco, Berrino Liberato
Department of Experimental Medicine, Section of Pharmacology,
Faculty of Medicine and Surgery, Second University of Naples –
Via Costantinopoli, 16 – 80138 Napoli
66. APOPTOTIC
CELL DEATH IN DOXORUBICIN-INDUCED CARDIOMYOPATHY: ROLE OF PEROXYNITRITE
AND LOX-1 RECEPTOR MODULATION
Francesca Sculco1, Carolina Muscoli1,2, Ernesto Palma1, Iolanda
Sacco1, Valeria Visalli1, Nicola Costa1, Domenicantonio Rotiroti1,
Francesco Romeo3 and Vincenzo Mollace1,2
1Faculty of Pharmacy, University “Magna Graecia”
of Catanzaro, Italy; 2San Raffaele Pisana IRCCS, Rome, Italy; 3Chair
of Cardiology, University of Rome “Tor Vergata”, Rome,
Italy; 4Faculty of Pharmacy, University of Messina, Italy
67. UBIQUITIN-PROTEASOME
SYSTEM CONTRIBUTES TO THE INFLAMMATORY INJURY OF EXPERIMENTAL ACUTE
DIABETIC MYOCARDIAL INFARCT
Di Filippo Clara1,2, Martella Raffaele3 , Rossi Francesco1,2, D’Amico
Michele 1,2
1Department of Experimental Medicine, Section of Pharmacology
L. Donatelli,2”Excellence Centre for Cardiovascular Disease”,
and 3Department of Geriatrics and Metabolic Diseases, 2nd University
of Naples, Italy
68. EFFECTS
OF ORAL ESSENTIAL AMINO ACID SUPPLEMENTATION IN CACHECTIC INSULINE
RESISTANCE PATIENTS WITH CHRONIC HEART FAILURE
Boschi Federica*, Verri M.*, Dossena M.*, Opasich C.°, Aquilani
R.^, Gualco A.°, Pastoris O*.
*Department of Physiological & Pharmacological Sciences,
University of Pavia, Pavia, Italy; ^IRCCS “S. Maugeri”
Foundation, Montescano, Italy; °IRCCS “S. Maugeri”
Foundation, Pavia, Italy
69. GENDER-DIFFERENCES
IN NO AND EDHF MODULATION OF VASCULAR REACTIVITY IN RABBIT MESENTERIC
ARTERY
Fabi Fulvia, Coletta T., Lorenzini P., Del Basso Orsini P.
Department of Drug Research and Evaluation, Istituto Superiore
di Sanità, Roma, Italy
70 . GENDER
DIFFERENCES IN NITRIC OXIDE PRODUCTION BY INDUCIBLE NITRIC OXIDE
SYNTHASE IN CYTOKINE-STIMULATED RABBIT CAROTID ARTERIES
Del Basso Orsini Paola, Calciano Simona, Fabi Fulvia
Department of Drug Research and Evaluation, Istituto Superiore
di Sanità, Roma, Italy
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71. TIME-DEPENDENT
AND SEQUENTIAL MODULATION OF SIGNALING CASCADES, CREB ACTIVATION
AND BDNF EXPRESSION INDUCED BY ANTIDEPRESSANTS
Tardito Daniela1, Tiraboschi Ettore1, Barbiero Valentina S1, Moraschi
Stefania2, Cattaneo Anna2, Gennarelli Massimo2, Racagni Giorgio1,
Popoli Maurizio1
1 Center of Neuropharmacology, Dept of Pharmacological Sciences
and Center of Excelence on Neurodegenerative Diseases, University
of Milan, Italy. 2 Genetics Unit, I.R.C.C.S. “S. Giovanni
di Dio”, Fatebenefratelli, Brescia, and Division of Biology
and Genetics, Department of Biomedical Sciences and Biotechnologies,
University of Brescia, Brescia, Italy
72. CHRONIC
ANTIDEPRESSANT TREATMENTS INDUCES SPECIFIC CHANGES IN BDNF EXPRESSION
AND SUBCELLULAR LOCALIZATION
Maj Paola F.1, Calabrese Francesca1, Molteni Raffaella1, Cattaneo
Annamaria3, Gennarelli Massimo2,3, Racagni Giorgio1, Riva Marco
A.1
1Center of Neuropharmacology, Pharmacol. Sciences Dept., University
of Milan, Via Balzaretti 9, 20133 Milan, Italy. 2I.R.C.C.S. San
Giovanni di Dio-Fatebenefratelli, Brescia, Italy. 3Biol. and Gen.
Div., Dept. Biomedicals and Biotechnology Sciences, University of
Brescia
73. HUMAN
ASTROCYTES CAN BE INDUCED BY IMIPRAMINE TO DIFFERENTIATE INTO CELLS
WITH NEURONAL PHENOTYPE
1Cabras Stefano, 1Reali Camilla, 1Scorciapino Laura, 1Saba Francesca,
1Sirigu Rita, 2Biggio Giovanni, 1Sogos Valeria
1Department of Cytomorphology, University of Cagliari
2Department of Experimental Biology “Bernardo Loddo”,
University of Cagliari
74. VAGUS
NERVE STIMULATION LIKE ANTIDEPRESSANT DRUGS ENHANCES NOREPINEPHRINE
RELEASE AND BDNF GENE EXPRESSION IN THE RAT BRAIN
Gorini Giorgio1,4, Biggio F.1, Caria S.1, Follesa P.1,2, Marrosu
F.3, Dazzi L.1,2, and Biggio G.1,2
University of Cagliari, Dept. of Experimental Biology, Section
of Neuroscience1, Cntr. of Excellence for the Neurobiology of Dependence2,
Dept. of Neurological and Cardiovascular Sciences3, 09123 Cagliari,
Italy; University of Sassari, Dept. of Pharmacology, Gynecology
and Obstetrics, Section of Pharmacology4, 07100 Sassari, Italy
75. ESCITALOPRAM
ALTERS BDNF, CREB AND CaRF GENE EXPRESSION IN DISCRETE RAT BRAIN
AREAS
Benatti Cristina1, Alboni Silvia1, Capone Giacomo1, Corsini Daniela1,
Caggia Federica1, Tascedda Fabio1, Blom Joan M.C.2, Brunello Nicoletta1.
1 Department of Biomedical Sciences, University of Modena and
Reggio Emilia, Modena, Italy; 2 Department of Pediatrics, University
of Modena and Reggio Emilia, Modena, Italy
76. ACETYL
SALICYLIC ACID INCREASES THE RESPONSE OF ESCITALOPRAM IN A RAT MODEL
OF DEPRESSION
Alboni Silvia1, Benatti Cristina1, Capone Giacomo1, Caggia Federica1,
Corsini Daniela1, Tascedda Fabio1, Mendlewicz Julien2, Brunello
Nicoletta1
1 Department of Biomedical Sciences, University of Modena and
Reggio Emilia, Modena, Italy; 2Department of Psychiatry, Erasme
Hospital, Free University of Brussels, Belgium
77. SYNAPTOPROTEOMICS
OF AN ANIMAL MODEL OF DEPRESSION COMBINING GENETIC VULNERABILITY
AND EARLY-LIFE STRESS
Mallei Alessandraa, Tiraboschi E.a, Giambelli R.a, El Khoury A.b,
Mathè A.A.b, Racagni G.a, Popoli M.a
aCenter of Neuropharmacology-Department of Pharmacological Sciences,
University of Milano (Italy). bNEUROTEC Department, Division of
Psychiatry, Karolinska Institutet, Stockholm, (Sweden)
78. GROUP-II
METABOTROPIC GLUTAMATE RECEPTOR LIGANDS AS ADJUNCTIVE DRUGS IN THE
TREATMENT OF DEPRESSION: A NEW STRATEGY TO SHORTEN THE LATENCY OF
ANTIDEPRESSANT MEDICATION?
F. Matrisciano a,b, I. Panaccionea, M. Zussod , P. Giustid , R.
Tatarelli b, A. Carusoa, L. Iacovellia, S. Scaccianocea, A.A. Mathéc,
S.H. Gruberc, D. Melchiorria, P. Girardib and F. Nicolettia,e
aDepartment of Human Physiology and Pharmacology, University
of Rome “La Sapienza”, Piazzale Aldo Moro, 5, 00185
Rome, Italy. b Department of Psychiatry and Psychological Medicine,
Sant’Andrea Hospital, University of Rome “La Sapienza”;
c Karolinska Institute, Department of Clinical Neuroscience - Psychiatry,
Karolinska University Hospital Huddinge, Stockholm, Sweden; d Department
of Pharmacology and Anesthesiology, University of Padova, Italy;
eI.N.M. Neuromed, Pozzilli, Italy
79. MODULATION
OF PRE-SYNAPTIC AND POST-SYNAPTIC PROTEINS AFTER PROLONGED TREATMENT
WITH ANTIPSYCHOTIC DRUGS
Angelisa Frasca1, Fabio Fumagalli1, Giorgio Racagni1, Marco Andrea
Riva1
1Center of Neuropharmacology, Department of Pharmacological
Sciences University of Milan, Via Balzaretti 9, 20133 Milan (Italy)
80. EFFECT
OF TYPICAL AND ATYPICAL ANTIPSYCHOTICS ON IN VIVO DOPAMINE TRANSMISSION
IN DIFFERENT BRAIN AREAS
Ullu L.M., Valentini V., Tanda G., De Luca M.A. and Di Chiara G
Department of Toxicology, Centre of Excellence “Neurobiology
of Addiction", University of Cagliari, Italy
81. AGONIST
ACTIVITY OF N-DESMETHYLCLOZAPINE, A MAJOR CLOZAPINE METABOLITE,
AT DELTA OPIOID RECEPTORS
MARIA C. OLIANAS, SIMONA DEDONI, LUCIANA GARAU and PIERLUIGI ONALI
Section of Biochemical Pharmacology, Department of Neuroscience,
University of Cagliari, Cagliari, Italy
82. HALOPERIDOL
BOTH PREVENTS AND REVERSES QUINPIROLE-INDUCED NON REGULATORY WATER
INTAKE, A PUTATIVE ANIMAL MODEL OF PSYCHOGENIC POLYDIPSIA
Amato Davide1, Stasi Maria Antonietta2, Borsini Franco2, Nencini
Paolo1
1Department of Human Phisiology and Pharmachology, University
of Rome Sapienza, 2Research and Development Division, sigma-tau
Industrie Farmaceutiche Riunite SpA, Pomezia
83. DIFFERENT
ROLE OF NMDA RECEPTORS IN THE ROSTRAL AND CAUDAL PART OF THALAMIC
RETICULAR NUCLEUS IN A RAT MODEL OF ABSENCE EPILEPSY, THE WAG/RIJ
RAT
Citraro Rita1, Marra R2., Scicchitano F1., Russo E1., Ferreri Ibbadu
G1., De Sarro G1.
1Section of Pharmacology, Department of Experimental and Clinical
Medicine, Faculty of Medicine and Surgery, University of Catanzaro,
Italy, 2ISBAF CNR, Department of Pharmacology, Faculty of Pharmacy,
University of Catanzaro, Catanzaro, Italy
84. EFFECTS
OF ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS ADMINISTRATION ON
SPIKE-WAVE DISCHARGE IN A GENETIC MODEL OF GENERALIZED ABSENCE EPILEPSY
R. Citraro1, G. Ferreri1, E. Russo1, M. D’Auro2, R. Ciccarelli2,
G. De Sarro1
1Chair of Pharmacology, Department of Experimental and Clinical
Medicine, Faculty of Medicine and Surgery, University of Catanzaro,
2Chair of Pharmacology, Faculty of Medicine and Surgery, University
of Chieti, Italy
85. EFFECTS
OF THE FOCAL ADMINISTRATION OF MGLU2/3 RECEPTOR LIGANDS IN SELECTED
BRAIN AREAS OF WAG/RIJ RAT, A GENETIC ANIMAL MODEL OF ABSENCE EPILEPSY
1De Sarro Giovambattista, 1Citrato R., 2Ngomba R., 1Russo E., 2Battaglia
G., 2,3Nicoletti F.
1Department of Experimental and Clinical Medicine, Faculty of
Medicine and Surgery, University of Catanzaro, Catanzaro, Italy,
2I.N.M. Neuromed, 86077 Pozzilli, Italy, 3Department of Human Physiology
and Pharmacology, University of Rome “La Sapienza”,
Italy
86. HOMOCYSTEINE
INDUCED AN INCREASE OF ABSENCE SEIZURES IN THE ELECTROCOGRAPHIC
PATTERN OF WAG/RIJ RAT
Ferreri Ibbadu Guido1, Citraro R1., Marra R2., Siniscalchi A1,3.,
Russo E1., De Sarro G.1
1Section of Pharmacology, Department of Experimental and Clinical
Medicine, Faculty of Medicine and Surgery, University of Catanzaro,
Italy, 2ISBAF CNR, Department of Pharmacology, Faculty of Pharmacy,
University of Catanzaro, Catanzaro, 3Depatment of Neuroscience,
Annunziata Hospital, Cosenza, Italy
87.
EFFECTS OF NON-COMPETITIVE AMPA RECEPTOR ANTAGONISTS INJECTED
INTO SOME BRAIN AREAS OF WAG/RIJ RATS, AN ANIMAL MODEL OF GENERALIZED
ABSENCE EPILEPSY
1Ferreri I. Guido, 2Palma E., 2Marra R., 1Citraro R., 1Russo E.,
1Curinga C., 3Gitto R., 3Chimirri A, 1De Sarro G
1Section of Pharmacology, Department of Experimental and Clinical
Medicine, Faculty of Medicine and Surgery, University of Catanzaro.
2National council of research institute of neurological science,
Catanzaro. 3Department of Medicinal Chemistry, Faculty of Pharmacy,
University of Messina, Italy
88. SELECTIVE
ACTIVATION OF METABOTROPIC GLUTAMATE RECEPTORS SUBTYPE 4 ENHANCES
SPONTANEOUS AND EVOKED ABSENCE SEIZURES
Ines Santolini1,4, Richard Ngomba1, Francesca Biagioni1, Rita Citraro2,
Alexandra Badura3, Giuseppe Battaglia 1, Valeria Bruno1,4, Francesco
Ferraguti5, Gilles van Luijtelaar3, Giovanbattista De Sarro2, Ferdinando
Nicoletti1,4
1I.N.M. Neuromed, Pozzilli, Italy; 2Dept. of Exp. & Clin.
Med., Univ. of Catanzaro, Italy; 3Dept. of Biol. Psychol., Univ.
of Nijmegen, The Netherlands; 4Dept. of Hum. Physiol. & Pharm.,
Univ. “La Sapienza”, Rome, Italy; 5Dept. of Pharm.,
Univ. of Innsbruck, Austria
89. PRENATAL
ETHANOL EXPOSURE EFFECTS ON MAP-KINASES PATHWAY IN A GENETIC MODEL
OF ABSENCE EPILEPSY: THE WAG/RIJ RAT
1Arbitrio Mariamena, 3Costa N., 1Vecchio I., 1Marra R., 1Iannone
M.,1Strongoli M.C., 2Cuda G., 2Casadonte R., 2De Sarro G., 1,3Rotiroti
D
1National Council of Research Institute of Neurological Science-Catanzaro.
2Department of Experimental and Clinical Medicine, Faculty of Medicine
and Surgery-Catanzaro. 3Chair of Pharmacology, Faculty of Pharmacy-Catanzaro
90. TOPIRAMATE
DOSE-DEPENDENTLY MODIFIES SLOW INHIBITORY POST SYNAPTIC POTENTIALS
EVOKED IN RAT OLFACTORY CORTICAL NEURONES IN VITRO
1Russo Emilio, 1De Sarro G., 2Constanti A.
1Chair of Pharmacology, Department of Experimental and Clinical
Medicine, Faculty of Medicine and Surgery, University of Catanzaro,
Catanzaro, Italy; 2Pharmacology Department, School of Pharmacy,
University of London, London, UK
91. ZONISAMIDE
INDUCES A SLOW DOSE-DEPENDENT HYPERPOLARIZATION IN RAT OLFACTORY
CORTICAL NEURONES IN VITRO
1Russo Emilio, 1Scarfone S., 1De Sarro G.
1Department of Experimental and Clinical Medicine, Faculty of
Medicine and Surgery, University of Catanzaro, Catanzaro, Italy
92. EFFECTS
OF NITRIC OXIDE INFLUENCE ON EXPERIMENTALLY-INDUCED HYPEREXCITABILITY
OF THE HIPPOCAMPUS: IN VIVO AND IN VITRO COMPARATIVE ELECTROPHYSIOLOGICAL
STUDY IN THE RAT
Rizzo Valerio1, Ferraro G1, Sardo P1, Carletti F1, D’Agostino
S1, La Grutta V1 and Cannizzaro G2
1 Dip. Medicina Sperimentale, Sez. Fisiologia umana, Università
di Palermo, Italy. 2 Dip. Scienze Farmacologiche, Università
di Palermo, Italy
93. CHANGES
IN NEUROACTIVE STEROIDS LEVELS, GABAA RECEPTOR PLASTICITY AND SENSITIVITY
TO ANXIOLYTIC DRUGS INDUCED BY NEONATAL EXPOSURE TO ESTROGEN
Calza A, Sogliano C, Marra C, Paganelli P, Santoru F, Angioni MM,
Biggio G, Concas A
Department of Experimental Biology and Centre of Excellence
for the “Neurobiology of Drug Dependence”, University
of Cagliari, Italy
94. SUBCHRONIC
ADMINISTRATION OF STATINS REDUCES PLASMA AND BRAIN CONTENT OF NEUROACTIVE
STEROIDS
1Dore R. – 4Pisu M.G. – 2Muntoni S. – 134Serra
M. – 134Biggio G.
1Department of Experimental Biology; 2Department of Toxicology,
Unit of Oncology and Molecular Pathology; 3Center of Excellence
for the Neurobiology of Dependence; 4CNR Institute of Neuroscience,
Section of Cagliari, University of Cagliari
95. FLUMAZENIL-SENSITIVE
DOSE-RELATED PHYSICAL DEPENDENCE IN PLANARIANS PRODUCED BY TWO BENZODIAZEPINE
AND ONE NON-BENZODIAZEPINE BENZODIAZEPINE RECEPTOR AGONISTS
Robert B. Raffa a, Federica Cavallo b, Anna Capasso b
a Department of Pharmaceutical Sciences, Temple University School
of Pharmacy, Philadelphia, PA, USA, b Department of Pharmaceutical
Sciences, University of Salerno, Salerno, Italy
96. GABAERGIC
DRUGS BECOME NEUROTOXIC IN CORTICAL NEURONS PRE-EXPOSED TO BRAIN-DERIVED
NEUROTROPHIC FACTOR
Gemma Molinaro1, Giuseppe Battaglia1, Barbara Riozzi1, Marianna
Storto1, Sergio Fucile1,2, Fabrizio Eusebi1,2, Ferdinando Nicoletti1,2
and Valeria Bruno1,2
1Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy;
2Department of Human Physiology and Pharmacology, University of
Rome “La Sapienza”, Rome, Italy
97. EXPRESSION
PATTERNS OF PROMOTERS FOR NPY Y1 AND Y5 RECEPTORS IN Y5RITTA AND
Y1RVENUS BAC TRANSGENIC MICE
Angela Longo, Alessandra Oberto, Elena Acquadro, Thorsten Busb,
Rolf Sprengel and Carola Eva
Dipartimento di Anatomia, Farmacologia e Medicina Legale; Sezione
di Farmacologia, Università degli studi di Torino. Department
of Molecular Neurobiology Max Planck Institute for Medical Research,
69120, Heidelberg, Germany
98. MODULATION
OF NEUROPEPTIDE Y AND Y1 RECEPTOR EXPRESSION IN THE AMYGDALA BY
FLUCTUATIONS IN THE BRAIN CONTENT OF NEUROACTIVE STEROIDS DURING
ETHANOL WITHDRAWAL IN MICE
Ilaria Bertocchi, Carola Eva, Paolo Mele, Devis Collura, Maria Giuseppina
Pisu, Mariangela Serra and Giovanni Biggio
Dip.Anatomia, Farmacologia e Med Leg, Sez. Farmacologia, Università
di Torino, Italy; Dip Biol Sperimentale, Sez Neuroscienze, Università
di Cagliari, Italy; Centro Ecc. Neurobiol. Dipendenza, Università
di Cagliari, Italy; C.N.R. Ist. Neurosci, Neuropsicofarmac., Cagliari
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99. SULFORAPHANE
INHIBITS 6-HYDROXYDOPAMINE-INDUCED APOPTOSIS BY UPREGULATION OF
MEK/ERK AND PI3K/AKT IN HUMAN NEURONAL CELLS
Tarozzi Andrea1, Morroni Fabiana1, Merlicco Adriana1, Angeloni Cristina2,
Hrelia Silvana2, Cantelli-Forti Giorgio1, Hrelia Patrizia1
1Department of Pharmacology, 2Department of Biochemistry "G.
Moruzzi", Alma Mater Studiorum - University of Bologna, via
Irnerio 48, 40126 Bologna
100. CHARACTERIZATION
OF THE ANTIPARKINSONIAN EFFECTS OF THE NEW ADENOSINE A2A RECEPTOR
ANTAGONIST ST1535: ACUTE AND SUBCHRONIC STUDIES IN RATS
Tronci Elisabetta(1), Simola N.(1), Borsini F.(4), Schintu N.(1),
Frau L.(1), Carminati P.(4), Morelli M.(1,2,3)
(1)Department of Toxicology, (2)Centre of Excellence for Neurobiology
of Dependence, (3)CNR Institute of Neuroscience, University of Cagliari,
Italy, (4)Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Pomezia
(Rome), Italy
101. EVALUATION
OF THE NEUROPROTECTIVE EFFECT OF THE A2A RECEPTOR ANTAGONIST SCH58261
ON THE MPTP MOUSE MODEL OF PARKINSON’S DISEASE
Schintu Nicoletta, Carta Anna R. and Morelli Micaela
Department of Toxicology, University of Cagliari, Italy
102. MITOCHONDRIAL
FACTORS INVOLVED IN PARKINSON’S DISEASE BY MPTP TOXYCITY IN
MACACA FASCICULARIS AND DRUG EFFECT
Brera Francesca, Gorini Antonella and Villa Roberto F.
Dipartimento di Scienze Fisiologiche-Farmacologiche Cellulari-Molecolari
Sezione di Farmacologia e Biotecnologie Farmacologiche Piazza Botta,
11 - 27100 Pavia, Università degli Studi di Pavia
103. CYP 2E1 MUTANT MICE ARE RESISTANT TO
DDC-INDUCED ENHANCEMENT OF MPTP TOXICITY
P. Sgadò, C. Viaggi, F. Vaglini, C. Pardini, A. Caramelli,
G. U. Corsini
Department of Neuroscience, Section of Pharmacology, University
of Pisa and Center of Excellence ‘AMBISEN’ for the study
of Environmental Toxins and CNS Diseases, Pisa, Italy
(Abstract non disponibile su richiesta dell'autore)
104. BEHAVIOURAL
CHARACTERIZATION OF ENGRAILED MUTANT MICE AS MODEL OF PARKINSON’S
DISEASE
Pontis Silvia1, Pinna Annalisa2, Paola Sgadò3, Giovanni U.
Corsini3 and Micaela Morelli1,2
1 Department of Toxicology, University of Cagliari, Italy. 2
CNR Institute for Neuroscience, Cagliari, Italy. 3 Department of
Neuroscience, Pisa, Italy
105. LOW
AND HIGH DYSKINETIC TREATMENTS INDUCE DIFFERENT MOTOR RESPONSES
AND mRNA CHANGES IN CAUDATE-PUTAMEN IN THE 6-OHDA RAT MODEL OF PARKINSON’
S DISEASE
Frau Lucia 1, Carta Anna R. 1, Pinna Annalisa 2, Pontis Silvia 1
and Morelli Micaela 1,2.
1 Department of Toxicology, University of Cagliari. 2 CNR, Institute
of Neuroscience, Cagliari
106. BLOCKADE
OF PALLIDAL ADENOSINE A2A RECEPTORS POTENTIATES CONTRALATERAL ROTATIONAL
BEHAVIOR INDUCED BY L-DOPA AND DOPAMINERGIC AGONISTS IN HEMIPARKINSONIAN
RATS
Nicola Simola a, Sandro Fenu a, Pier G. Baraldi b, Mojgan A. Tabrizi
b and Micaela Morelli a
aDepartment of Toxicology and Centre of Excellence for Neurobiology
of Dependence, University of Cagliari, Cagliari, Italy; bDepartment
of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy
107. ANALYSYS OF THE MPP+ UPTAKE IN MESENCEPHALIC
CELL CULTURES FROM CYP 2E1 KNOCK-OUT MICE
Caramelli Andrea, Pardini Carla, Viaggi Cristina, Vaglini Francesca,
Sgadò Paola,
Corsini Giovanni U.
Dip. di Neuroscienze Sez. Farmacol. Università di Pisa
(Abstract non disponibile su richiesta dell'autore)
108. EFFECTS
OF DIRECT AND INDIRECT CANNABINOID RECEPTOR AGONISTS ON LEVODOPA-INDUCED
DYSKINESIAS IN A RAT MODEL OF PARKINSON’S DISEASE
Maria Grazia Morgese1,3, Tommaso Cassano1, Luigia Trabace1, Vincenzo
Cuomo2, Andrea Giuffrida3
1Department of Biomedical Sciences, University of Foggia, Italy;
2Department of Pharmacology and General Physiology, University of
Rome, ‘La Sapienza’, Italy; 3Department of Pharmacology,
University of Texas Health Science Center at San Antonio, Texas,
U.S.A
109. THE
NITRIC OXIDE-RELEASING DERIVATIVE OF FLURBIPROFEN HCT1026 DECREASES
VULNERABILITY OF NIGROSTRIATAL DOPAMINERGIC NEURONS TO MPTP VIA
A SWITCH OF GLIA PROINFLAMMATORY PHENOTYPE: IMPLICATIONS FOR TREATMENT
OF PARKINSON’S DISEASE
Francesca L’Episcopo1, Nuccio Testa1, Salvo Caniglia1, Cataldo
Tirolo1, Giovanna Giaquinta1, Paolo Arcieri1, Pier-Andrea Serra2,
Gianfranco Bazzu2, Morale Maria C1, Francesco Impagnatiello3, Marchetti
Bianca1,2
1Neuropharmacology, OASI Institute Researc and Care (IRCCS)
Troina (EN), Italy and 2Department of Pharmacology, University of
Sassari, Medical School, Sassari, Italy, and 3Nicox Research Institute,
Bresso, Milano, Italy
110. NEUROINFLAMMATORY
RESPONSE IN THE ACUTE MPTP RODENT MODEL OF PARKINSON’S DISEASE:
TIME-DEPENDENT CORRELATION WITH HISTOPATHOLOGICAL, NEUROCHEMICAL
AND BEHAVIORAL RESPONSE TO NIGROSTRIATAL INJURY AND REPAIR
Francesca L’Episcopo1, Giuliana Salani 2, Pier-Andrea Serra3,
Salvo Caniglia1, Cataldo Tirolo1, Giovanna Giaquinta1, Nuccio Testa1,
Gaia Rocchitta3, Giammario Calia3, Antonio Manca3, Maria C Morale1
Stefano Pluchino2, Gianvito Martino3, Bianca Marchetti1,2
1Neuropharmacology, OASI Institute for Research and Care (IRCCS)
Troina (EN), Italy; 2Neuroimmunology Unit, Department of Neurology
and Physiology, San Raffaele Scientific Institute, Milano, and 3Dept.
Pharmacology, University of Sassari Medical School, Sassari, Italy
111. S100B
PROTEIN PROMOTES TAU PROTEIN HYPERPHOSPHORILATION THROUGH DKK-1
PROTEIN UP-REGULATION AND RELATIVE WNT PATHWAY DISRUPTION IN CULTURED
HUMAN NEURONS
Esposito Giuseppe 1, Scuderi Caterina 1, 4, De Filippis Daniele
2, Iuvone Teresa 2, Savani Claudia 1, 5, Lu Jie 3, Sheen Volney
3 and Steardo Luca 1
1 Department of Human Physiology and Pharmacology “Vittorio
Erspamer”, University of Rome “La Sapienza” -
2 Department of Experimental Pharmacology, University of Naples
Federico II.
3 Department of Neurology, Beth Israel Deaconess Medical Center,
Harvard Medical School, Boston
4 Department of Pharmacological Sciences, University of Palermo.
5 Department of Human Physiology and Pharmacology, University of
Bari
112. AMYLOID
PRECURSOR PROTEIN AND PRESENILIN1 INTERACT WITH THE ADAPTOR GRB2
AND MODULATE ERK1,2 SIGNALING
Mario Nizzari1, Valentina Venezia1, Emanuela Repetto1, Valentina
Caorsi2, Raffaella Magrassi2, Maria Cristina Gagliani3, Tullio Florio1,
Gennaro Schettini1, Carlo Tacchetti3, Tommaso Russo4, Alberto Diaspro2
and Claudio Russo5
1Dip. Oncologia, Biologia e Genetica, Università di Genova,
2 Dip. Fisica, Università di Genova, 3Dip.Medicina Sperimentale,
Università di Genova, 4 Dip.Biochimica, Università
di Napoli Federico II, 5Dip. Scienze per la Salute, Università
del Molise
113. NITRIC
OXIDE AND DOPAMINERGIC SYSTEM: NEUROCHEMICAL INTERACTIONS IN ß-AMYLOID
INJECTED RATS
Schiavone Stefania (a), Lanni Cristina (b), Cuomo Vincenzo (c),
Trabace Luigia(a), Govoni Stefano (b)
(a) Dept. Biomedical Sciences, University of Foggia, Foggia,
Italy; (b) Dept. of Experimental and Applied Pharmacology, University
of Pavia, Pavia, Italy; (c) Dept. of Human Physiology and Pharmacology,
Vittorio Espamer, University of Rome La Sapienza, Rome, Italy
114. ALTERATIONS
OF TAU PROTEIN AND EFFECT OF LITHIUM SALTS TREATMENT ON TgCRND8
MICE
Rosi Maria Cristina, Grossi Cristina, Fiorentini Anna, Luccarini
Ilaria and Casamenti Fiorella
Department of Pharmacology, University of Florence, Viale Pieraccini
6, 50139 Florence, Italy
115. LONG-TERM
TREATMENT WITH CHF5074, A NOVEL GAMMA-SECRETASE MODULATOR, MARKEDLY
REDUCES BRAIN B-AMYLOID IN A TRANSGENIC MOUSE MODEL OF ALZHEIMER’S
DISEASE
Imbimbo Bruno P.1, Del Giudice Elda2, Miccichè Flavia2, Colavito
Davide2, D'Arrigo Antonello2, Dalle Carbonare Maurizio2, Villetti
Gino1, Facchinetti Fabrizio1, Volta Roberta1, Pietrini Vladimiro,3
Baroc Maria F.3, Leon Alberta2
1Research & Development, Chiesi Farmaceutici, Via Palermo
26/A, 43100 Parma; 2Research & Innovation, Via Svizzera 16,
35127 Padua; 3Department of Neurosciences, Neurology Section, University
of Parma, 43100 Parma
116. ANGIOGENESIS
IN NEURODEGENERATIVE PROCESSES: LOSS OF REGULATORY AB FUNCTION CONTRIBUTES
TO ENDOTHELIAL DEGENERATION
Donnini Sandra, Cantara Silvia, Giachetti Antonio, Ziche Marina
Pharmacology Section, Dept. Molecular Biology, University of
Siena, Italy
117. THE
BH4 DOMAIN OF BCL-XL COUNTERACTS BETA AMYLOID PEPTIDE TOXICITY ON
CAPILLARY ENDOTHELIUM
RAFFAELLA SOLITO, SANDRA DONNINI, SILVIA CANTARA, ANTONIO
GIACHETTI, AND MARINA ZICHE
Section of Pharmacology, Department of Molecular Biology, University
of Siena
118. MITOCHONDRIAL
DYSFUNCTIONS IN A TRANSGENIC MURINE MODEL OF ALZHEIMER’S DISEASE
1Cassano Tommaso, 2Serviddio G., 2Bellanti F., 2Tamborra R., 1Macheda
T., 1Morgese M.G., 1Trabace L., 3Oddo S., 3LaFerla F.M., 4Cuomo
V. and 2Vendemiale G.
1Dept. of Biochemical Sciences Univ. of Foggia, Italy; 2Dept.
of Medical and Occupational Sciences, Univ. of Foggia, Italy; 3Dept.
of Neurobiology and Behavior, Univ. of California, Irvine, U.S.;
4Dept. of Human Physiology and Pharmacology, Univ. of Rome “La
Sapienza”, Italy
119. GLIA
MEDIATES NEUROPROTECTION BY ESTROGEN AGAINST ß-AMYLOID TOXICITY:
EFFECT AMPLIFIED BY ESTROGEN RECEPTOR OVEREXPRESSION
CARBONARO VIVIANA1, FRASCA GIUSEPPINA1, MERLO SARA1, CARACI FILIPPO2,
COPANI AGATA2, SORTINO MARIA ANGELA2
Departments of 1Experimental and Clinical Pharmacology and 2Pharmaceutical
Sciences, University of Catania
120. CANNABIDIOL
IN VIVO SUPPRESSES Aß INDUCED REACTIVE GLIOSIS
Scuderi Caterina 1,2, Esposito Giuseppe 1, Savani Claudia 1,4, De
Filippis Daniele 2, Iuvone Teresa 2, Steardo Luca 1
1 Department of Human Physiology and Pharmacology “Vittorio
Erspamer”, University of Rome “La Sapienza” -
2 Department of Pharmacological Sciences, University of Palermo.
3 Department of Experimental Pharmacology, University of Naples
Federico II. 4 Department of Human Physiology and Pharmacology,
University of Bari
121. IN
VIVO CHARACTERIZATION OF DKK-1 EXPRESSION IN TRANSGENIC ANIMAL MODELS
OF ALZHEIMER’S DISEASE
Fiorentini Anna, Rosi Maria Cristina, Luccarini Ilaria, Grossi Cristina
and Casamenti Fiorella
Department of Pharmacology, University of Florence, Viale Pieraccini
6, 50139 Florence, Italy
122. IN
VIVO EFFECT OF CLIOQUINOL TREATMENT IN A MOUSE MODEL OF ALZHEIMER’S
DISEASE
Grossi Cristina, Rosi Maria Cristina, Fiorentini Anna, Luccarini
Ilaria and Casamenti Fiorella
Department of Pharmacology, University of Florence, Viale Pieraccini
6, 50139 Florence, Italy
123. LONG-TERM
TREATMENT WITH A NEW ANTI-OLIGOMERIC B-AMYLOID VACCINE MARKEDLY
REDUCES BRAIN B-AMYLOID LOAD IN A TRANSGENIC MOUSE MODEL OF ALZHEIMER’S
DISEASE
Imbimbo Bruno P.1, Pietrini Vladimiro,2 Baroc Maria F.2, Del Giudice
Elda3, Miccichè Flavia3, Colavito Davide3, D'Arrigo Antonello3,
Dalle Carbonare Maurizio3, Leon Alberta3, Villetti Gino1, Facchinetti
Fabrizio1, Moretto Nadia4, Ottonello Simone4
1Chiesi Farmaceutici, Via Palermo 26/A, Parma; 2Department of
Neurosciences, University of Parma, Parma; 3Research & Innovation,
Via Svizzera 16, Padua; 4Department of Biochemistry and Molecular
Biology, University of Parma, Viale G.P. Usberti 23/A, Parma
124. DISCOVERY
OF A SERIES OF MOLECULES ACTING AS POTENT ALPHA7 NACHR AGONISTS
WITH PRO-COGNITIVE AND NEUROPROTECTIVE PROPERTIES
C. SCALI1, M. GIANFRIDDO1, H. BOTHMANN1 , E. DIODATO1 , U. ZANELLI1,
A. CARICASOLE1, G. GAVIRAGHI1, J. DUNLOP2, R. RONCARATI1, and G.
C. TERSTAPPEN1
1Siena Biotech SpA, Siena, ITALY, 2 Wyeth Research, Princeton,
NJ, USA
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125. PERIAQUEDUCTAL
GREY METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 7 AND 8 SHOW OPPOSITE
ACTIONS ON AMINO ACID RELEASE, NOCICEPTIVE BEHAVIOUR AND ROSTRAL
VENTROMEDIAL MEDULLA ON AND OFF CELL ACTIVITY
Marabese Ida, Rossi Francesca, Palazzo Enza, Vita Daniela, Maria
Antonietta Scafuro, de Novellis Vito, Maione Sabatino
Department of Experimental Medicine, Section of Pharmacology
“L. Donatelli”, The Second University of Naples, via
Costantinopoli 16, 80138 Naples
126. ROLE
OF THE TYPE 2 AND 3 INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR IN MUSCARINIC
ANTINOCICEPTION IN MICE
VIVOLI E, GALEOTTI N., NORCINI M., GHELARDINI, C., BARTOLINI A.
Department of Pharmacology – Viale G. Pieraccini, 6, 50139
– Florence
127. INVOLVEMENT
OF TYPE 1 AND 3 RYANODINE RECEPTOR IN MOUSE MUSCARINIC ANTINOCICEPTION
NORCINI M., GALEOTTI N., VIVOLI E., GHELARDINI, C., BARTOLINI A.
Department of Pharmacology – Viale G. Pieraccini, 6, 50139
– Florence
128. DETECTION
AND QUANTIFICATION OF ENDOGENOUS N/OFQ IN THE RAT CEREBROSPINAL
FLUID, UNDER BASAL AND STIMULATED CONDITIONS
Lopetuso Giuseppe, Romualdi Patrizia, Candeletti Sanzio
Dip. Farmacologia - Università degli Studi di Bologna
129. IMPAIRED
NOCICEPTION IN MICE LACKING THE PROKINETICIN RECEPTOR 2 (PKR2)
Lattanzi Roberta, Giannini Elisa, Melchiorri Pietro and Negri Lucia
Department of Human Physiology and Pharmacology, University
of Rome “La Sapienza”, Italy
130. THE
CENTRAL ANTINOCICEPTIVE EFFECT OF N-ARACHIDONOYL-PHENOLAMINE (AM404):
IMPLICATION OF OPIOIDERGIC AND SEROTONERGIC SYSTEMS
Ruggieri Valentina a, Vitale Giovanni a, Pini Luigi A. b and Sandrini
Maurizio a
a Sect. of Pharmacology, Dept. of Biomedical Sciences, University
of Modena and Reggio E. b Clinical Pharmacology Unit, University
of Modena and Reggio E
131. 2-CHLORO-2’-C-METHYL-N6-CYCLOPENTYLADENOSINE,
A HIGHLY SELECTIVE ADENOSINE A1 RECEPTOR AGONIST, HAS ANTINOCICEPTIVE
ACTIVITY IN THE RAT
Gatta Luisa, Palazzo Enza, de Novellis Vito, Rossi Francesco, Daniela
Vita, Maione Sabatino
Department of Experimental Medicine, Section of Pharmacology
“L. Donatelli”, The Second University of Naples, via
Costantinopoli 16, 80138 Naples
132. 2-CHLORO-2’-C-METHYL-N6-CYCLOPENTYLADENOSINE,
A HIGHLY SELECTIVE ADENOSINE A1 RECEPTOR AGONIST, MODULATES THE
ONGOING AND TAIL FLICK –RELATED ACTIVITY OF RVM ON AND OFF
CELLS
Guida Francesca, Rossi Francesca, Vita Daniela, Marabese Ida, de
NovellisVito, Maione Sabatino
Department of Experimental Medicine, Section of Pharmacology
“L. Donatelli”, The Second University of Naples, via
Costantinopoli 16, 80138 Naples
133. NGF-INDUCED
NEURITE OUTGROWTH INHIBITION AND PAIN CONTROL
Restivo Alessandra, Salvati P. and Caccia
C.,
Discovery, Newron Pharmaceuticals SpA, Bresso (MI), Italy
134. ANALGESIC
EFFECTS OF NEW PIRIDAZIONE DERIVATIVES
Pieretti Stefano1, Colucci Mariantonella1, Di Giannuario Amalia1,
Francesco Maione1,2, Giovannoni Maria Paola 3, Biancalani Claudio
3 and Dal Piaz Vittorio 3
1Department of Drug Research and Evaluation, Italian National
Institute of Health, Rome; 2Department of Experimental Pharmacology,
University of Naples, “Federico II”; 3Department of
Pharmaceutical Sciences, University of Florence
135. THE
PROTECTIVE EFFECT OF OLIVE OIL PHENOLS HYDROXYTYROSOL AND OLEUROPEIN
ON MORPHINE TOLERANCE
Carolina Muscoli1,2, A Procopio1, D. Ventrice1, M. Oliverio1, M.
Arbitrio3, M. Rizzo1, N. Costa1, R. Arcone1, S. Giovanni4, D. Rotiroti1,
G. Nistico’5, Daniela Salvemini6 and Vincenzo Mollace1
1Dept. of Pharmacobiol. Sciences, University of Catanzaro Magna
Graecia, Italy; 2San Raffaele Pisana IRCCS, Rome, Italy; 3 ISN-CNR;
4 Dept. of Chemistry, University of Calabria, Italy; 5Dept. of Biology,
Univerity of “Tor Vergata”, Italy; 6 Dept. of Int. Med,
Division of Pulmonary, Critical Care and Sleep Medicine, Saint Louis
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136. NEUROPEPTIDE
S STIMULATES LOCOMOTOR ACTIVITY AND WAKEFULNESS AND EVOKES ANXIOLYTIC-LIKE
EFFECTS IN MICE
1Vergura Raffaella, 1Rizzi Anna, 1Marzola Giuliano, 2Guerrini Remo,
2Salvadori Severo, 1Regoli Domenico and 1Calo’ Girolamo.
1Dept. of Pharmacology and 2Dept of Pharmaceutical Science,
University of Ferrara, Italy
137. REPEATED
RESTRAINT STRESS AND ANXIOLYTIC DRUGS DIFFERENTIALLY MODULATE LATENT
INHIBITION IN C57BL6 MICE
Stefania Marcello a, Raymond Mongeau b, Jacob Sparre Andersen c,
Luca Pani d,a
a Neuroscienze Pharmaness S.c.a.r.l., Cagliari. b NeuroPsychoPharmacologie,
Faculté de Médecine Pitié-Salpêtrière,
Paris, France. c Tofla Teld, Copenhagen, Denmark. d Istitute of
Biomedical Technologies, C.N.R., Milano
138. CENTRAL
ADMINISTRATION OF NEUROPEPTIDE S (NPS) INHIBITS PALATABLE FOOD INTAKE
IN THE RAT
Fedeli Amalia, Economidou Daina, Braconi Simone, Cippitelli Andrea,
Massi Maurizio, Ciccocioppo Roberto
Department of Experimental Medicine and Public Health, University
of Camerino, Italy
139. QUINPIROLE-INDUCED
COMPULSIVE DRINKING IN RATS IS INFLUENCED BY MANIPULATION OF BEHAVIORAL
COST
Milella Michele S., Amato Davide, Badiani Aldo, Nencini Paolo
Department of Human Phisiology and Pharmachology, University
of Rome Sapienza
140. DISTURBANCES
OF EATING BEHAVIOR DURING WORKPLACE SUFFERING
W. Milano, C. Petrella, A. Capasso*.
Mental Health Operations Unit District 44 ASL Napoli 1 and *Department
of Pharmaceutical Sciences, University of Salerno, Italy
141. EFFECTS
OF SYSTEMIC MPTP ADMINISTRATION ON BEHAVIOR AND DOPAMINE CHANGES
IN DIALYSATE FROM THE STRIATUM OF FREELY MOVING MICE
Antonio Manca a, Gianfranco Bazzua, Giammario Calia a, Giulia Puggioni
a, Gaia Rocchitta a, Sonia Dedola a, Rossana Mighelia, Pier Andrea
Serra a
a Department of Pharmacology, Medical School, University of
Sassari, Viale S. Pietro 43/b, 07100, Sassari, Italy
142. ROLE
OF DOPAMINE D2-LIKE RECEPTORS IN THE MICROSTRUCTURE OF LICKING FOR
WATER AND SODIUM CHLORIDE SOLUTIONS IN WATER DEPRIVED RATS
Paolo S. D'Aquila, Davide Carta, Maria G. Casula, Bonaria Dore,
Emanuele Murgia, Gino Serra
Department of Drug Sciences, University of Sassari, Sassari,
Italy
143. SINGLE,
INTENSE PRENATAL STRESS CAN DIFFERENTLY AFFECT EMOTIONAL BEHAVIOUR
ACCORDING TO THE NATURE OF THE TASK. INFLUENCE OF METYRAPONE
Noto Giovanna, Plescia Fulvio, Cannizzaro Emanuele, Gagliano Mauro.,
Provenzano Giuseppa Maria and Cannizzaro Carla
Department of Pharmacological Sciences, University of Palermo, Italy
144. MANIPULATIONS
OF GLUCOCORTICOID INDUCED STRESS RESPONSE MAY DIFFERENTLY AFFECT
THE ACQUISITION OF A REWARD-FACILITATED SPATIAL/VISUAL LEARNING
TASK
Barrile Vita, Plescia Fulvio, Cannizzaro Gaspare, La Barbera Marco,
Mantia Giacoma and Cannizzaro Carla
Department of Pharmacological Sciences, University of Palermo
145. BEHAVIOURAL
EFFECTS INDUCED BY CHRONIC TREATMENT WITH EPIGALLOCATECHIN GALLATE
(EGCG), THE MAJOR CATECHIN OF GREEN TEA, IN SPONTANEOUSLY HYPERTENSIVE
RAT (SHR)
LEMOLI Mariangela, MONTAGNANI Monica and DE SALVIA Maria Antonietta
Dept. Pharmacology and Human Physiology, Medical School, University
of Bari, Piazza G. Cesare, 70124 Bari, Italy
146. IMPACT
OF ANTIPSYCHOTIC TREATMENTS OF BEHAVIORAL ALTERATIONS INDUCED BY
PARADOXICAL SLEEP DEPRIVATION
Frau Roberto1, Orrù Marco1, Mereu Giampaolo3, Gessa Gian
Luigi1, Marrosu Francesco2 Bortolato Marco2
1Dept. of Neuroscience “Bernard B. Brodie”. University
of Cagliari, Cagliari, Italy
2Dept. of Cardiovascular and Neurological Science. University of
Cagliari, Cagliari, Italy
3Dept. of Experimental Biology “B. Loddo”. University
of Cagliari, Cagliari, Italy
147. ROLE
OF GABAB RECEPTORS IN THE BALANCE OF EPILEPTIC AND PSYCHOTIC-LIKE
PHENOMENA IN DBA/2J MICE
Bortolato Marco1, Frau Roberto2, Orrù Marco2, Piras Anna
Paola2, Gessa Gian Luigi2, Castelli Maria Paola2, Mereu Giampaolo3,
Marrosu Francesco1
1Dept. of Cardiovascular and Neurological Science. University
of Cagliari, Cagliari, Italy
2Dept. of Neuroscience “Bernard B. Brodie”. University
of Cagliari, Cagliari, Italy
3Dept. of Experimental Biology “B.Loddo”. University
of Cagliari, Cagliari, Italy
148. TRAINING-ASSOCIATED
EMOTIONAL AROUSAL DIFFERENTIALLY MODULATES CANNABINOID EFFECTS ON
OBJECT RECOGNITION MEMORY
Patrizia Campolongo1-2, Sergio Scaccianoce1, Antonella Modafferi1,
Viviana Trezza1, Benno Roozendaal3, Gustav Schelling4, James L McGaugh3
and Vincenzo Cuomo1
1Dept. of Human Physiology and Pharmacology, Univ. of Rome “La
Sapienza”, Rome, Italy;
2Dept. of Biochemical Sciences, Univ. of Foggia, Foggia, Italy;
3Center for the Neurobiology of Learning and Memory, Univ. of California,
Irvine, USA; 4Dept. of Anaesthesiology, Ludwig-Maximilians-University,
Munich, Germany
149. GENDER-RELATED
EFFECTS OF PREGS ON EMOTIONALITY, LEARNING AND MEMORY PERFORMANCE
IN ADULT RATS
Diliberto Irene, Plescia Fulvio, Cannizzaro Gaspare, Mantia Giacoma,
Provenzano Giuseppa Maria and Cannizzaro Carla
Department of Pharmacological Sciences, University of Palermo
150. USE
OF ENERGY DRINKS IN ASSOCIATION WITH ALCOHOLIC BEVERAGES IN A COHORT
OF STUDENTS OF THE SCHOOL OF MEDICINE OF THE UNIVERSITY OF MESSINA
Oteri A, Salvo F, Caputi AP, Calapai G
Department of Clinical and Experimental Medicine and Pharmacology,
University of Messina
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151. GAMMA
HYDROXYBUTIRATE (GHB) MODULATES NPY – Y1 RECEPTOR SIGNALLING
IN THE AMYGDALA OF TRANSGENIC MICE THROUGH GABAB RECEPTOR IN A NEUROSTEROIDS
INDEPENDENT MANNER
Mele P. a, Serra M. b,c,d, Pisu M.G. b,d, Eva C. a, Biggio G b,c,d.
a Dep. Of Anatomy, Pharmacology and Forensic Medicine, Section
of Pharmacology, University of Turin, Italy. b Dep. of Experimental
Biology, Sec. of Neuroscience, University of Cagliari, Cagliari,
Italy. c Center of Excellence for the Neurobiology of Dependence,
University of Cagliari, Cagliari, Italy. d C.N.R. Institute of Neuroscience,
Cagliari, Italy
152. MAPPING
BRAIN ACTIVITY FOLLOWING GAMMA-HYDROXYBUTYRIC ACID ADMINISTRATION
USING FUNCTIONAL MAGNETIC RESONANCE IMAGING IN RATS
Muntoni Anna Lisa1, Lu Hanbing2, Scholl Clara A.2, Pistis Marco3,
Stein Elliot A.2
1CNR Institute of Neuroscience and 3Department of Neuroscience,
University of Cagliari, Italy
2Neuroimaging Research Branch, National Institute on Drug Abuse,
NIH, Baltimore, USA
153. ENDOCANNABINOID
SYSTEM AND NICOTINE WITHDRAWAL SIGNS IN MICE
Mannucci Carmen a, Pieratti Antonella a, Russo Giuseppina a, Caputi
Achille P. a, Calapai Gioacchino a
a Department of Clinical and Experimental Medicine and Pharmacology,
Section of Pharmacology, School of Medicine, University of Messina,
Italy
154. SMOKING
CESSATION AFTER THE INTRODUCTION OF THE LAW BANNING SMOKING IN PUBLIC
PLACES IN ITALY: A ONE-YEAR FOLLOW-UP STUDY
Maria Caterina Grassi*, Domenico Enea**, Paolo Nencini*
*Department of Human Physiology and Pharmacology “V. Erspamer”.
**Centro Policlinico Senza Fumo, “Sapienza” University
of Rome, Italy
155. SMOKING
CESSATION AND BODY WEIGHT
Maria Caterina Grassi*, Domenico Enea**, Rosanna Marchetti**, Flavia
Temperilli***, Francesca Villarosa***, Paolo Nencini *, Massimo
Cuzzolaro ***
*Department of Human Physiology “V.Erspamer”, **Centro
Policlinico Senza Fumo, ***Department of Clinical Medicine, “Sapienza”
University of Rome, Italy
156. PRELIMINARY
RESULTS IN PIVOTAL STUDY ON BIOMARKERS RELATED TO SMOKING HABITS
Gioacchino Calapai a, Stefania Morandi b, Carmen Mannucci a, Alfredo
Nunziata b, Achille Caputi a e Antonella Bassi b
a Department of Clinical and Experimental Medicine and Pharmacology,
University of Messina - b BAT Italia S.p.A. R&D Via Amsterdam147,
Rome
157. ALTERED
EXPRESSION OF METABOTROPIC GLUTAMATE RECEPTORS IN THE NUCLEUS ACCUMBENS
DURING OPIATE DEPENDENCE AND WITHDRAWAL IN THE RAT
Modafferi Antonella M.E1., Diana Marco2, Scaccianoce Sergio1
1Dept. of Human Physiology and Pharmacology - University of
Rome La Sapienza; 2 Dept. of Drug Sciences - University of Sassari
158. TIME-DEPENDENT
MORPHOLOGICAL AND BIOCHEMICAL CHANGES DURING MORPHINE WITHDRAWAL
IN THE RAT NUCLEUS ACCUMBENS
Vinci Stefania1, Marinelli Angela2, Olla Alessia2, Ibba Federico1,
Diana Marco3, Spiga Saturnino2, Acquas Elio1,4
1Department of Toxicology and 4Centre of Excellence on Neurobiology
of Addiction, University of Cagliari; 2 Department of Animal Biology
and Ecology, University of Cagliari; 3Department of Drug Sciences
, University of Sassari
159. RECIPROCAL
EFFECTS OF RESPONSE CONTINGENT AND NON-CONTINGENT INTRAVENOUS HEROIN
ON IN VIVO NUCLEUS ACCUMBENS SHELL VERSUS CORE DOPAMINE: A REPEATED
SAMPLING MICRODIALYSIS STUDY
Cacciapaglia1 Fabio, Lecca Daniele1,2, Valentini Valentina1,2 and
Di Chiara Gaetano1,2,3
1Department of Toxicology, 2Centre of Excellence for Studies
on Addictions and 3Institute of Neuroscience, Consiglio Nazionale
delle Ricerche (CNR), University of Cagliari, Italy
160. ROLE
OF DOPAMINE D1 RECEPTOR IN MORPHINE- AND LITHIUM-INDUCED CONDITIONED
SACCHARIN AVOIDANCE
Nicola Simola, Sandro Fenu, Emilia Rivas and Gaetano Di Chiara
Department of Toxicology and Centre of Excellence for Neurobiology
of Dependence, University of Cagliari, Cagliari, Italy
161. DISSOCIATION
IN THE MODULATORY EFFECTS OF ENVIRONMENT ON HEROIN-INDUCED PSYCHOMOTOR
SENSITIZATION VS. HEROIN SELF-ADMINISTRATION
Michele Celentano, Daniele Caprioli, Paolo Nencini, Aldo Badiani
Department of Human Physiology and Pharmacology, University
of Rome Sapienza
162. METHADONE
AND BUPRENORPHINE MAINTENANCE EFFECTS ON IMMUNE SYSTEM FUNCTION:
COMPARISON WITH UNTREATED HEROIN ADDICTCS
Somaini Lorenzo1, Franchi Silvia2, Leccese Vincenzo1, Gerra Gilberto3,
Panerai Alberto E2, Sacerdote Paola2
1 Addiction Treatment Centre, Health Local Unit ASL 12 Biella.
2 Department of Pharmacology, via Vanvitelli 32, 20129 Milano. 3
Health Local Unit AUSL Parma
163. THE
ROLE OF LIVER CYTOCHROME ISOFORMS ON BUPRENORPHINE METABOLISM AND
IT’S CLINICAL RELEVANCE
Somaini Lorenzo1, Gola Mauro2
1 Addiction Treatment Centre, Health Local Unit ASL 12 Biella.
2 Laboratory of Pharmacogenetics Lugano (CH)
164. ANABOLIC
ANDROGENIC STEROIDS INFLUENCE THE EXPRESSION OF BRAIN NERVE GROWTH
FACTOR IN THE RAT
Carretta Maria Teresa*, D’Amico Danilo*, Pace Stefania, Modafferi
Antonella M.E., Salemi Marisa, Togna Giuseppina I., Scaccianoce
Sergio
Dept. of Human Physiology and Pharmacology - University of Rome
La Sapienza
165. NANOMOLAR
CONCENTRATIONS OF ANABOLIC-ANDROGENIC STEROIDS AMPLIFY EXCITOTOXIC
NEURONAL DEATH IN MIXED MOUSE CORTICAL CULTURES
Rosamaria Orlando1*, Alessandra Caruso1*, Gemma Molinaro2, Marta
Motolese1, Francesco Matrisciano 1, Giuseppina Togna1, Daniela Melchiorri1,
Ferdinando Nicoletti1,2 and Valeria Bruno1,2
1Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy;
2Department of Human Physiology and Pharmacology, University of
Rome “La Sapienza”, Rome, Italy
166. EFFECT
OF NANDROLONE AND STANOZOLOL ON PRO-INFLAMMATORY CYTOKINE PRODUCTION
BY HUMAN MACROPHAGES
Trefiletti Giuliana*, Togna Anna Rita*, Pacifici Roberta**, Bacosi
Antonella**, Di Carlo Simonetta** and Togna Giuseppina I.*
* Department of Human Physiology and Pharmacology, University
of Rome “La Sapienza”
** Department of Therapeutic Research and Medicines Evaluation,
Istituto Superiore di Sanità, Rome
167. THE
K-OPIOID RECEPTOR AGONIST U-69593 PREVENTS COCAINE-INDUCED DARPP-32
PHOSPHORYLATION AT THR34 IN THE RAT BRAIN
D'Addario C, Di Benedetto M, Candeletti S, Romualdi P
Dept of Pharmacology - University of Bologna - via Irnerio 48,
40126 BOLOGNA
168. FACILITATION
OF CONDITIONED REINSTATEMENT OF COCAINE-SEEKING FOLLOWING CENTRAL
ADMINISTRATION OF NEUROPEPTIDE S
Marsida Kallupi, Daina Economidou, Nazzareno Cannella, Serena Stopponi,
Roberto Ciccocioppo
Department of Experimental Medicine and Public Health, University
of Camerino, Italy
169. ENVIRONMENTAL
MODULATION OF COCAINE AND AMPHETAMINE SELF ADMINISTRATION
Daniele Caprioli, Michele Celentano, Paolo Nencini, Aldo Badiani
Department of Human Physiology and Pharmacology, University
of Rome La Sapienza
170. INCREASED
TOXICITY OF COCAINE ADULTERATED WITH ATROPINE: EFFICACY OF DIAZEPAM
Zani Alessia, Braida Daniela, Rossoni Giuseppe, Gori Enzoa, CapurroValeria,
Sala Mariaelvina
Department of Pharmacology, Chemotherapy and Medical Toxicology,
and a Behavioural Pharmacology and Drug Dependence Center, University
of Milan, Via Vanvitelli 32, 20129, Milan, Italy
171. ROLE
OF CREB IN THE PRODYNORPHIN GENE EXPRESSION REGULATION BY MDMA
Di Benedetto M, Porticella E, D´Addario C, Candeletti S, Romualdi
P
Dept of Pharmacology - University of Bologna - via Irnerio 48,
40126 BOLOGNA
172. 3,4-METHYLENDIOXYMETHAMPHETAMINE
(ECSTASY) INDUCES FORMATION OF REACTIVE OXYGEN SPECIES AND TAU PROTEIN
PHOSPHORYLATION IN THE HIPPOCAMPUS
Carla L. Busceti1, Francesca Biagioni1, Barbara Riozzi1, Marianna
Storto1, Giuseppe Battaglia1, Francesco Fornai1,3, Valeria Bruno1,5,
Ferdinando Nicoletti1,5
1I.N.M. Neuromed, Pozzilli, Italy; 2Dept. of Neuropathol., Univ.
of Amsterdam, The Netherland; 3Dept. of Hum. Morphol. and Applied
Biol., Univ. of Pisa, Italy; 4SienaBiotech, Siena, Italy; 5Dept.
of Hum. Physiol. and Pharmacol., Univ. “La Sapienza”,
Rome, Italy
173. PHARMACOLOGICAL
AND TOXICOLOGICAL PROPERTIES OF SMART DRUGS
Oteri A a, Calapai G a, Pichini S b, Zuccaro P b, Palmi I b, Caputi
AP a,c
aDepartment of Clinical and Experimental Medicine and Pharmacology,
University of Messina. bIstituto Superiore di Sanità, Rome.
cIRCCS Centro Neurolesi ‘‘Bonino-Pulejo’’,
Messina, Italy |
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FARMACOLOGIA DELL’APPARATO DIGERENTE |
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174. INHIBITORY MODULATION
OF THE NON-ADRENERGIC NON-CHOLINERGIC RELAXATION OF THE RAT GASTRIC
FUNDUS BY NOCICEPTIN/ORPHANIN FQ AND RELATED PEPTIDES
Currò D., De Marco T., Martucci D. and Preziosi P.
Institute of Pharmacology, School of Medicine, Catholic University
of the Sacred Heart, Rome, Italy
(Abstract non disponibile su richiesta del'autore)
175. NOCICEPTIN/ORPHANIN
FQ PREVENTS GASTRIC DAMAGE INDUCED BY ACUTE STRESS IN THE RAT BY
ACTING IN THE PERIPHERY
Giuseppina MORINI a, Daniela GRANDI a, Elvira SOLENGHI a, Remo GUERRINI
b, Carlo POLIDORI c & Maurizio MASSI c
aDepartment of Human Anatomy, Pharmacology and Forensic Medicine,
University of Parma, PARMA; bDepartment of Pharmaceutical Sciences
and Biotechnology Center, University of Ferrara, FERRARA; cDepartment
of Experimental Medicine and Public Health, University of Camerino,
CAMERINO
176. GASTROPROTECTIVE
EFFECTS OF THE SELECTIVE HISTAMINE H3 RECEPTOR AGONISTS METHIMEPIP
AND IMMETHRIDINE
1Adami Maristella, 1Guaita Elena, 2de Esch Iwan JP, 2Leurs Rob,
3Stark Holger and 1Coruzzi Gabriella
1Department of Human Anatomy, Pharmacology and Forensic Medicine,
University of Parma, Italy; 2LACDR, Department of Medicinal Chemistry,
Vrije Universiteit Amsterdam, The Netherlands; 3Institut für
Pharmazeutische Chemie, J W Goethe-Universität, Frankfurt,
Germany
177. THE
GASTRIC EFFECTS OF UFP 112, A NEW NOP RECEPTOR AGONIST, IN PHYSIOLOGICAL
AND PATHOLOGICAL CONDITIONS
Petrella Carla a, Agostini S. a, Broccardo M.a, Guerrini R. b, Improta
G. a , Morini G. c
a Dept. Human Physiology and Pharmacology University of Rome
“La Sapienza”, b Dept. Pharmaceutical Sciences and Biotechnology
Center, University of Ferrara, c Dept. of Human Anatomy, Pharmacology
and Forensis Medicine, University of Parma –ITALY
178. EFFECTS
OF CYCLOOXYGENASE INHIBITORS ON MOLECULAR MECHANISMS IMPLICATED
IN GASTRIC ULCER HEALING
Colucci Rocchina1, Ghisu Narcisa1, Antonioli Luca1, Fornai Matteo1,
Bernardini Nunzia2, Ippolito Chiara2, Natale Gianfranco2, Del Tacca
Mario1, Blandizzi Corrado 1
1Division of Pharmacology and Chemotherapy, Department of Internal
Medicine, 2Department of Human Morphology and Applied Biology, University
of Pisa, Italy
179. DUAL
EFFECTS OF TICLOPIDINE DURING FORMATION AND HEALING OF ETHANOL-INDUCED
GASTRIC LESIONS IN THE RAT: COMPARISON WITH ASPIRIN
D. Rapetti1, F. Guidobono2, A. Soglian3, V. Locatelli1, V. De Luca2,
V. Sibilia2
1Department of Experimental Medicine, University of Milano-
Bicocca, Monza, Italy
2Department of Pharmacology, Chemotherapy and Medical Tossicology,
University of Milan, Italy
3Medical Department, Pharmaceutical Division, Bayer HealthCare,
Milan, Italy
180. INVOLVEMENT
OF PKC IN THE ADAPTIVE CHANGES OF OPIOID RECEPTORS IN THE MYENTERIC
PLEXUS AFTER CHRONIC SYMPATHETIC DENERVATION
1Zanetti Elena, 1Oldrini Rita, 2Pascale Alessia, 1Canciani Luca,
1Giuliani Daniela, 2Amadio Marialaura, 3Chiaravalli Annamaria, 1Giaroni
Cristina, 1Lecchini Sergio, 1Frigo Gianmario.
1Clinical and Applied Pharmacology Interuniversity Centre, University
of Insubria and University of Pavia; 2Experimental and Applied Pharmacology
Dept, University of Pavia; 3Dept. of Surgical Pathology Ospedale
di Circolo of Varese
181. ALTERED
EXPRESSION AND PHOSPHORYLATION OF NMDA NR1 SUBUNITS IN THE MYENTERIC
PLEXUS DURING HYPOXIA-HYPOGLICAEMIA
1Giaroni Cristina, 1Zanetti Elena, 1Giuliani Daniela, 1Oldrini Rita,
1Bianchi Francesca, 1Moro Elisabetta, 2Trinchera Marco, 1Crema Francesca,
1Lecchini Sergio, 1Frigo Gianmario
1Clinical and Applied Pharmacology Interuniversity Centre, Universities
of Insubria and Pavia, 2Department of Experimental and Clinical
Biomedical Sciences, University of Insubria
182. MELATONIN
REVERSES LPS-INDUCED GASTRO-INTESTINAL MOTILITY DISTURBANCES THROUGH
THE INHIBITION OF OXIDATIVE STRESS
De Filippis Daniele1, Esposito G3, D’Amico A1, De Man JG2,
De Winter BY2, Steardo L3, Iuvone T1
1Department of Experimental Pharmacology, Faculty of Pharmacy,
University of Naples Federico II, Via D. Montesano 49, 80131 Naples,
Italy. 2Division of Gastroenterology, Faculty of Medicine, University
of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium. 3Department
of Human Physiology and Pharmacology “Vittorio Erspamer”Faculty
of Pharmacy University of Rome “La Sapienza” Piazza
A. Moro 5, 00151 Roma (Italy)
183. THE
CANNABINOID WIN 55212 INHIBITS PANCREATIC AMYLASE SECRETION VIA
CHOLINERGIC SUPPRESSION
Agostini Simona, Broccardo M., Improta G., Petrella C., Linari G.
Dept. of Human Physiology and Pharmacology. University “La
Sapienza”, Rome
184. SERA
OF CELIAC PATIENTS WITH NEUROLOGICAL DISORDERS EVOKE A MITOCHONDRIAL-DEPENDENT
APOPTOSIS IN HUMAN SH-Sy5Y NEUROBLASTOMA CELLS
Cervio Elisabetta*, Volta Umberto°, Verri Manuela*, Boschi Federica*,
Pastoris Ornella*, Granito Alessandro°, De Giorgio Roberto ^,
Tonini Marcello *
*Dept of Phys & Pharm Sci, Univ Pavia; Dept of °Int
Med, Cardioangiol, Hepatol & ^Int Med & Gastroenterol, Univ
of Bologna, Italy
185. EXPRESSION
AND function OF THE BRADYKININ B1 RECEPTOR IN NORMAL AND INFLAMED
HUMAN GALLBLADDER
Eunice Andre1, David Gazzieri1, Elisabetta Bardella1, Juliano Ferreira3,
Marcelo A. Mori4, Michael Bader4, João B.Calixto5, Roberto
De Giorgio6, Roberto Corinaldesi6, Pierangelo Geppetti1 and Marcello
Trevisani1
1Pharmacology Unit, University of Ferrara, 3Dep. of Chemistry,
Universidade Federal de Santa Maria, 4Max Delbrück Center for
Molecular Medicine, Berlin-Buch, 5Dep. of Pharmacology, Universidade
Federal de Santa Catarina, Florianópolis, 6 Dep. Int. Med.
and Gastroent., University of Bologna
186. A
COMMUNITY PHARMACIES SURVEY ON PREVALENCE OF CONSTIPATION AND RISK
FACTORS FOR LAXATIVE USE IN THE LOCAL HEALTH DISTRICTS OF VERBANIA
AND MESSINA
Ilaria Morreale (1), Francesco Salvo (1), Giovanni Polimeni (1),
Ilaria Morreale (1), Elena Vighi (2), Laura Poggi (2), Giuliana
Dossi (2), Alfina Rossitto (3), Angelina De Sarro (1), Gioacchino
Calapai (1), Achille Patrizio Caputi (1)
(1) Dep. Clin Experim Med and Pharmacol, University of Messina,
Italy. (2) Local Health District N. 14 (Verbano/Cusino/Ossola),
Verbania, Italy |
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FARMACOLOGIA DEL METABOLISMO E DEL SISTEMA
ENDOCRINO |
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187. EXENATIDE
ACHIEVED EQUIVALENT GLYCEMIC CONTROL TO INSULIN GLARGINE WITH WEIGHT
REDUCTION, INDEPENDENTLY FROM BASELINE BMI, IN METFORMIN AND SULFONYLUREA-TREATED
TYPE-2 DIABETES
Heine Robert J.1; Van Gaal Luc F.2; Johns Don3; Mihm Michael J.
3; Gentilella Raffaella 4; Widel Mario H. 3; Brodows Robert G.3
1 Diabetes Center, Department of Endocrinology, VU University
Medical Center, Amsterdam, The Netherlands; 2 Department of Diabetology,
Metabolism and Clinical Nutrition, Faculty of Medicine, University
Hospital Antwerp, Belgium; 3Lilly Research Laboratories, Eli Lilly
and Company, Indianapolis, IN, USA; 4Eli Lilly Italy, Florence,
Italy
188. EFFECTS
OF EXENATIDE COMPARED WITH TWICE-DAILY BIPHASIC INSULIN ASPART IN
PATIENTS WITH TYPE 2 DIABETES USING METFORMIN AND A SULPHONYLUREA
Nauck Michael A. 1, Duran Garcia Santiago 2, Kim Dennis 3, Johns
Don 4, Gentilella Raffaella 5, Festa Andreas 4, Trautmann Michael
4
1 Clinical Diabetology, Diabeteszentrum Bad Lauterberg, Germany,
2 Cátedra de Endocrinología, Hospital de Valme, Seville,
Spain, 3 Amylin Pharmaceuticals, Inc., San Diego, United States,
4 Lilly Research Laboratories, Eli Lilly and Company, Indianapolis,
United States; 5 Eli Lilly Italy, Florence, Italy
189. A
COMPARISON OF EXENATIDE AND INSULIN GLARGINE IN PATIENTS USING A
SINGLE ORAL ANTIDIABETIC AGENT
Barnett Anthony H. 1, Trautmann Michael 2, Burger Jude 3, Johns
Don 3, Kim Dennis 4, Brodows Robert 3, Gentilella Raffaella 5, Festa
Andreas 2, Roberts Anthony 2
1 Department of Diabetes/Endocrinology, Birmingham Heartlands
Hospital, United Kingdom, 2 Eli Lilly and Company, Hamburg, Germany,
3 Eli Lilly and Company, Indianapolis, United States, 4 Amylin Pharmaceuticals,
Inc., San Diego, United States; 5 Eli Lilly Italy, Florence, Italy
190. SAFETY
AND EFFICACY OF EXENATIDE OVER 16 WEEKS IN PATIENTS WITH TYPE 2
DIABETES MELLITUS USING A THIAZOLIDINEDIONE WITH OR WITHOUT METFORMIN
Zinman Bernard 1, Hoogwerf Byron 2, Duran Garcia Santiago 3, Milton
Denai 4, Giaconia Joseph 4, Kim Dennis 5, Gentilella Raffaella 6,
Trautmann Michael 7, Brodows Robert 4
1 Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto,
Canada, 2 Department of Endocrinology, Cleveland Clinic Foundation,
Cleveland, USA, 3 Cátedra de Endocrinología, Hospital
de Valme, Sevilla, Spain, 4 Eli Lilly and Company, Indianapolis,
USA, 5 Amylin Pharmaceuticals, Inc., San Diego, USA, 6 Eli Lilly
Italy, Florence, Italy, 7 Eli Lilly and Company, Hamburg, Germany
191. BETA-CELL FUNCTION IS MARKEDLY REDUCED
IN WOMEN WITH PREVIOUS GESTATIONAL DIABETES
Canu Silvia1, Franconi Flavia1, Tesi Federica2, Seghieri Giuseppe2
1Dpt. of Pharmacology, University of Sassari, Italy. 2Dpt. of
Internal Medicine, Spedali Riuniti, Pistoia
(Abstract non disponibile su richiesta del'autore)
192. CONCENTRATION OF BRAIN NATRIURETIC
PEPTIDE IN WOMEN WITH GESTATIONAL DIABETES
2Campesi Ilaria, 1Tesi Federica, 1Gironi Alfredo, 2Canu Silvia,
2De Bellis Alessandra, 1Anichini Roberto, 1Seghieri Giuseppe, 2Franconi
Flavia
1Dpt. of Internal Medicine, Spedali Riuniti, Pistoia, 2Dpt.
of Pharmacology, University of Sassari, Italy
(Abstract non disponibile su richiesta del'autore)
193. BIOCHEMICAL
MECHANISMS UNDERLYING ENDOCANNABINOID DYSREGULATION IN THE PANCREAS
AND ADIPOSE TISSUE OF HIGH FAT DIET-FED MICE
Isabelle Matias1, Katarzyna Starowicz1, Luigia Cristino2, Alessandro
Racioppi1
and Vincenzo Di Marzo1
1,2Endocannabinoid Research Group, 1Institute of Biomolecular
Chemistry and 2Institute of Cybernetics, Consiglio Nazionale delle
Ricerche, Pozzuoli (NA), Italy
194. GHRELIN
AND DES-ACYL GHRELIN INHIBIT ISOPROTERENOL-INDUCED LIPOLYSIS IN
RAT ADIPOCYTES THROUGH ACTIVATION OF PHOSPHODIESTERASE 3B
Baragli Alessandra, Ghè Corrado, Arnoletti Elisa, Muccioli
Giampiero
Division of Pharmacology, Department of Anatomy, Pharmacology
and Forensic Medicine, University of Turin, Turin, Italy
195. PHARMACOLOGICAL
MODULATION OF METABOLIC, HORMONAL, AND INFLAMMATORY ALTERATIONS
IN AN EXPERIMENTAL MODEL OF HEPATIC STEATOSIS
1Iacono Anna, 1,4Esposito Emanuela, 1Mattace Raso Giuseppina, 2Bianco
Giuseppe, 3,4Cuzzocrea Salvatore, 1Meli Rosaria
1Department of Experimental Pharmacology, University of Naples
“Federico II”, Naples; 2Department of Pharmaceutical
Sciences, University of Salerno; 3Department of Clinical and Experimental
Medicine and Pharmacology, School of Medicine, University of Messina,
Messina; 4IRCCS Centro Neurolesi "Bonino-Pulejo," Messina,
Italy |
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FARMACOLOGIA DELLA DISFUNZIONE ERETTILE |
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196. INVOLVEMENT
OF MITOGEN-ACTIVATED PROTEIN KINASES (MAPKS) DURING TESTICULAR ISCHEMIA-REPERFUSION
INJURY IN NUCLEAR FACTOR-kB KNOCK-OUT MICE
Minutoli Letteria1, Bitto Alessandra1, Polito Francesca1, Fiumara
Tiziana1, Squadrito Francesco1, Mioni Chiara 2, Antonuccio Pietro3,
Romeo Carmelo3, Marini Herbert4, Guarini Salvatore 2Caputi Achille
P.1 and Altavilla Domenica1.
1Department of Clinical and Experimental Medicine and Pharmacology,
Univ of Messina 2Dept of of Biomed Sci, Univ of Modena and Reggio
Emilia, 3Department of Med and Surg Pediatric Sci, 4 Dept of Biochem,
Physiol and Nutr Sci, University of Messina, Italy
197. STIMULATION
OF DOPAMINE RECEPTORS IN THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS
OF MALE RATS INDUCES PENILE ERECTION AND INCREASES EXTRA-CELLULAR
DOPAMINE IN THE NUCLEUS ACCUMBENS: INVOLVEMENT OF CENTRAL OXYTOCIN
Succu Salvatora, Sanna Fabrizio, Melis Tiziana, Argiolas Antonio,
Melis Maria Rosaria
Bernard B. Brodie Department of Neuroscience, University of
Cagliari, Italy
198. INFLUENCE
OF A CANNABINOID CB1 RECEPTOR ANTAGONIST, SR141716, ON SEXUAL BEHAVIOR
OF MALE RATS
Zanoli Paola, Zavatti Manuela, Montanari Caterina, Rivasi Marianna,
Poggioli Rosanna and Benelli Augusta
Department of Biomedical Sciences, Section of Pharmacology,
University of Modena and Reggio Emilia, Modena, Italy
199. HYDROGEN
SULFIDE (H2S) RELAXES HUMAN AND RABBIT CORPUS CAVERNOSUM IN VITRO
Romina Nassini1, Patacchini R.2, Materazzi S.1 , Mondaini N.1, Natali
A.1, Geppetti P.1 and Harrison S.1.
1Department of Critical Care Medicine & Surgery, University
of Florence, Florence, Italy; and 2Department of Pharmacology, Chiesi
Pharmaceuticals, Parma, Italy; Florence, Italy
200. EURYCOMA
LONGIFOLIA IMPROVES COPULATORY ACTIVITY OF SEXUALLY SLUGGISH RATS
Montanari Caterina, Zavatti Manuela, Zanoli Paola and Baraldi Mario
Dept. of Biomedical Sciences, Section of Pharmacology and National
InterUniversity Consortium for the Study of Natural Active Principles
(CINSPAN), University of Modena and Reggio Emilia, Modena, Italy
201. THE
TIGHT-SKIN MICE AS A GENETIC MODEL OF PEYRONIE’S–LIKE
DISEASE
1,2Roberta d’Emmanuele di Villa Bianca, 1,2Sorrentino R.,
3Lungarella G., 1Longo N., 1Imbimbo C. 1Mirone V. 1,2Cirino G.
1Center for Preclinical and Clinical Research in Sexual Medicine
(CIRMS), 2Department of Experimental Pharmacology, University of
Naples Federico II, 3Departement of Physiopathology, Experimental
Medicine and Public Health, University of Siena |
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FARMACOLOGIA DELL’INFIAMMAZIONE |
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202. PHARMACOLOGICAL
ACTIVITY OF SELECTIVE COX-1 AND COX-2 INHIBITORS IN ENDOTHELIAL
CELLS
Bolego Chiara, Buccellati Carola, Folco Giancarlo, Sala Angelo
Department of Pharmacological Sciences, University of Milan,
via Balzaretti 9, 20133 Milan Italy
203. ROLE
OF FGFR1 IN THE ANGIOGENIC RESPONSE INDUCED BY PGE2
Finetti Federica, Ziche Marina and Donnini Sandra
Pharmacology section, Department of Molecular Biology, University
of Siena
204. TIME
COURSE OF BRAIN PGE2 LEVEL AND SYNTHESIS PATHWAY IN LPS- FEVERED
RATS
di Matteo Anna, Bartella Cristina, Mangano Giorgina, Apicella Claudia,
Mancini Francesca, Coletta Isabella, Guglielmotti Angelo, Polenzani
Lorenzo
Angelini Farmaceutici – ACRAF S.p.A Piazzale della Stazione
S.Palomba-Pomezia Italy
205. BRAIN
PROSTANOIDS PROFILE IN CONTROL AND LPS-TREATED RATS
Bartella Cristina, Garrone Beatrice, Basta Francesco, De Santi Stefano,
Vitiello Marco, Coletta Isabella, Guglielmotti Angelo, Polenzani
Lorenzo
Angelini Farmaceutici – ACRAF S.P.A Piazzale della Stazione
S.Palomba-Pomezia Italy
206. CYSTEINYL
LEUKOTRIENES IN HUMAN ENDOTHELIAL CELLS: SYNTHESIS AND ACTIVITIES
Chiara Carnini, Maria Rosa Accomazzo, Emanuele Borroni, Laura Vitellaro-Zuccarelli,
Giancarlo Folco, Gianenrico Rovati, Angelo Sala
Department of Pharmacological Sciences, Department of Biomolecular
Sciences and Biotechnology, and Center for Cardiopulmonary Pharmacology,
University of Milan, 20133 Milan, Italy
207. NITRIC-OXIDE
SCAVENGING PROPERTIES OF NOVEL ORGANIC COMPOUNDS CONTAINING COBALT(II)
AND RUTHENIUM(III)
1Cantore Miriam, 2Valtancoli Barbara, 3Cinci Lorenzo, 2Bencini Andrea,
1Ciuffi Mario and 1Failli Paola
Depts. of: 1Preclinical & Clinical Pharmacology, 2Chemistry
and 3Anatomy, Histology & Forensic Medicine, University of Florence,
Italy
208. INHIBITION
OF NITRIC OXIDE PATHWAY BY AN ACETONIC EXTRACT FROM FEIJOA SELLOWIANA
BERG. FRUITS
Rossi Antonietta1,2, Pergola Carlo1, Formisano Carmen3, Guerriere
Luisa3 and Sautebin Lidia1
1Department of Experimental Pharmacology, University of Naples
Federico II, Naples, Italy; 2IRCCS Centro Neurolesi “Bonino-Pulejo”,
University of Messina, Messina, Italy; 3Department of Chemistry
of Natural Products, University of Naples Federico II, Naples, Italy
209. NCX 2057, A NITRIC OXIDE-DERIVATIVE
OF FERULIC ACID, EXERTS ANTI-INFLAMMATORY ACTIVITY IN IN-VITRO AND
IN-VIVO MODELS
Ronchetti Daniela, Borghi Valentina, Biondi Stefano and Impagnatiello
Francesco Nicox Research Institute, Bresso, Milan, Italy
(Abstract non disponibile su richiesta dell'autore)
210. NCX
4040, A NITRIC OXIDE-DONATING ASPIRIN DERIVATIVE WITH IMPROVED ANTI-INFLAMMATORY
PROPERTIES
Paola Anzellotti, Luigia Di Francesco, Stefania Tacconelli and Paola
Patrignani
Department of Medicine and Center of Excellence on Aging, School
of Medicine, “G. d’Annunzio” University; †“G.
d’Annunzio” University Foundation, Ce.S.I
211. EVIDENCE
OF CYTOKINES LEVELS MODULATION IN RAT SERUM EXERTED BY IACVITA,
A NEW ANTIOXIDANT COMPUND
Ricchi Lucia, Corsi Lorenzo, Geminiani Elisa, Baraldi Mario
Dip. Scienze Biomediche Università degli Studi di Modena
e Reggio Emilia
CINSPAN Consorzio Interuniversitario Nazionale per lo Studio dei
Principi Attivi Naturali
212. RAPID
RELEASE OF ANNEXIN A1 FOLLOWING HEAT-SHOCK RESPONSE IN LPS-STIMULATED
MACROPHAGES
Michela Festa, Luca Parente, Roderick J. Flower*, Mauro Perretti*,
Fulvio D’Acquisto* , Simona F. Ercolino
Department of Pharmaceutical Sciences, University of Salerno,
Salerno, Italy. *William Harvey Research Institute, Dept. of Biochemical
Pharmacology, Charterhouse Square, London, England
213. ESTROGEN
RECEPTOR ANTAGONIST ICI 182,780 INHIBITS THE ANTI-INFLAMMATORY EFFECT
OF GLUCOCORTICOIDS
1,2Salvatore Cuzzocrea, 3Stefano Bruscoli, 1Concetta Crisafulli,
1,2Emanuela Mazzon, 3Massimiliano Agostini, 1Carmelo Muià,
2,4Emanuela Esposito, 3Rosa Di Virgilio, 4Rosaria Meli, 5Elisabetta
Vegeto, 5Adriana Maggi and 3Carlo Riccardi
1Department of Clinical and Experimental Medicine and Pharmacology,
University of Messina, Italy; 2IRCCS Centro Neurolesi "Bonino-Pulejo",
Messina, Italy; 3Department of Cinical and Experimental Medicine,
Pharmacology, University of Perugia, Italy; 4Department of Experimental
Pharmacology, University of Naples “Federico II”, Naples
Italy; 5Department of Pharmacological Sciences, University of Milan,
Italy
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CHEMIOTERAPIA ANTIBATTERICA, ANTIVIRALE ED
ANTINEOPLASTICA |
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214. SYNERGISTIC
CYTOTOXICITY AND PHARMACOGENETICS OF GEMCITABINE AND ZD6474 IN BLADDER
CANCER CELL LINES
Mey Valentina, Giovannetti Elisa, Nannizzi Sara, Ricciardi Simona,
Danesi Romano,
Del Tacca Mario
Division of Pharmacology and Chemotherapy, Department of Internal
Medicine,
University of Pisa
215. SYNERGISTIC
CYTOTOXICITY, INHIBITION OF AKT AND C-KIT PHOSPHORYLATION, MODULATION
OF GENE EXPRESSION BY SORAFENIB AND GEMCITABINE IN HUMAN PANCREATIC
CANCER CELLS
Simona Ricciardi, Elisa Giovannetti, Sara Nannizzi, Valentina Mey,
Giuseppe Pasqualetti, Romano Danesi, Mario Del Tacca
Division of Pharmacology and Chemotherapy, Department of Internal
Medicine, University of Pisa
216. INHIBITION
OF STAT3 INCREASES DOXORUBICIN SENSITIVITY IN A HUMAN METASTATIC
BREAST CANCER CELL LINE
Roberta Molteni, Raffaella Ravizza, Marzia Bruna Gariboldi and Elena
Monti
Dept. of Structural and Functional Biology, Università
degli Studi dell’Insubria
217. IN
VITRON STUDY OF THE INTERACTION BETWEEN GEMCITABINE AND SORAFENIB
IN NON SMALL CELL LUNG CANCER (NSCLC) A549 CELL LINE
Pasqualetti Giuseppe, Ricciardi Simona, Nannizzi Sara, Mey Valentina,
Elisa Giovannetti, Danesi Romano, Del Tacca Mario
Division of Pharmacology and Chemotherapy, Department of Internal
Medicine - University of Pisa
218. IN
VITRO AND IN VIVO ANTINEOPLASTIC EFFECTS OF A NOVEL PLATINUM BIOCONJUGATE
USING A BIOCOMPATIBLE POLYMERIC MATRIX
Marzia Bruna Gariboldi, Elisabetta Gabano1, Katia Sparnacci1, Michele
Laus1, Domenico Osella1, Raffaella Ravizza, Roberta Molteni and
Elena Monti
DBSF – Pharmacology Section, University of Insubria, Busto
Arsizio (VA). 1Dipartimento di Scienze dell’Ambiente e della
Vita, Università del Piemonte Orientale “A. Avogadro”,
Alessandria
219. TOXICOLOGICAL
EVALUATION OF MEPACRINE AND INTERFERON a-2A ON U87-MG AND VERO CELL
COLTURE
Coppi Andrea, Baggio Giosue’, Bruni Elisa and Rossi Tiziana
University of Modena and Reggio Emilia- Italy: Departmentof
Biomedical Sciences-Section of Pharmacology; 287 G. Campi st 41100
Modena Italy
220. PRO-OXIDANT
AND ANTITUMOR EFFECTS OF CURCUMIN AND N-ETHYLMALEIMIDE IN THE HA22T/VGH
MODEL OF OVERT HEPATOCELLULAR CARCINOMA
Carina Valeria, Labbozzetta M., Poma P., Alaimo A., Maurici A.,
Inguglia L., Notarbartolo M., D’Alessandro N.
Dipartimento di Scienze Farmacologiche, Università di
Palermo
221. HDAC
INHIBITORS RESTORE THE p53 PATHWAY IN NEUROBLASTOMA CELLS
Ilaria Gnemmi, Fabrizio Condorelli, Armando A. Genazzani and Pier
Luigi Canonico
DiSCAFF&DFB Center, Università del Piemonte Orientale,
Novara, Italy
222. TEMPERATURE
INFLUENCE ON CELLULAR UPTAKE, DNA PLATINATION AND ANTIPROLIFERATIVE
ACTIVITY OF PLATINUM(II) DRUGS
Colangelo Donato a, Gabano Elisabetta b, Osella Domenico b, Viano
Ilario a
aDept. Medical Sciences, Via Solaroli 17 I-28100 Novara, bDept.
of Ambiental and Life Sciences, via Bellini 25/G, I-15100 Alessandria,
Università del Piemonte Orientale “A. Avogadro”,
Italy
223. INHIBITION
OF P-GP/ATPASE ACTIVITY OF RAT SMALL INTESTINE MEMBRANE VESICLES
BY THE NOVEL, DIHYDROPYRIDINE MDR REVERTER DP7
Alderighi Daniela, Sgaragli T., Dragoni S., Frosini M., Valoti M.,
Saponara S., Fusi F., Shah A., Kawasae M., Motohashi N., Molnar
J., Sgaragli G
Dipartimento di scienze biomediche, Università Degli
Studi di Siena via A. Moro 2, 53100 Siena
224. HIGH
ENERGY SHOCK WAVES INCREASE PACLITAXEL EFFICACY IN A SYNGENIC MODEL
OF BREAST CANCER
Canaparo Roberto1,2, Serpe Loredana2, Eandi Mario2, Zara Gian Paolo2,
Berta Laura1, Frairia Roberto1
1Department of Clinical Pathophysiology, University of Torino, Torino,
Italy. 2Department of Anatomy, Pharmacology and Forensic Medicine,
University of Torino, Torino, Italy
225. EVALUATION
OF SYNTHETIC “TUBULYSIN U” INDUCED CYTOTOXICITY IN HL60,
C6, PC12 AND ECV304 CELL LINES
Ilaria Manca, a Monica Sani, b,c Angela Sanna, a Giacomo Fossati,
b Paolo Lazzari, a Florent Huguenot, b Luca Pani, a,d Matteo Zanda
b
aNeuroscienze PharmaNess S.c.a r.l., c/o POLARIS, Edificio 5, Loc.Piscinamanna,
09010 Pula (CA), Italy. bC.N.R. Istituto di Chimica del Riconoscimento
Molecolare, Via Mancinelli 7, 20131 Milano, Italy. cKemoTech srl,
Unità Operativa di Milano, Via Mancinelli 7, 20131 Milano,
Italy. dC.N.R. Istituto di Tecnologie Biomediche, Sezione di Cagliari,
c/o Neuroscienze PharmaNess S.c.a r.l.
226. ANTHOCYANIDINS
MODULATE THE CYTOTOXICITY OF IRINOTECAN AND OXALIPLATIN IN HUMAN
COLON ADENOCARCINOMA CELLS
Cvorovic Jovana, Candussio Luigi, Maestro Alessandra, Bartoli Fiora,
Decorti Giuliana
Department of Biomedical Sciences, University of Trieste, Via
Giorgieri 7, Trieste
227. PRELIMINARY
RESULTS ON ANTIPROLIFERATIVE EFFECT OF NEW DEACETILASE INHIBITORS
ON HUMAN LEUKEMIA CELL LINES
Vitali Federica a, Turriziani Mario b, D’Alfonso Rossella
b, Lombardo Marco b, Valenti Sergio c, Mai Antonello c, Tita Beatrice
a
aDepartment of Human Physiology and Pharmacology, University
of Rome “Sapienza”. bDepartment of Internal Medicine,
University of Rome “Tor Vergata”. cDepartment of Pharmaceutical
Studies, University of Rome “Sapienza”
228. TOPICAL
ADMINISTRATION OF RESVERATROL AS PRE- AND ANTINEOPLASTIC AGENT
Berta GN, Mognetti B, Barberis A, Marinos L, Di Carlo F.
Department of Clinical and Biological Sciences, University of
Turin, I-10043 Orbassano, Italy |
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DEI FARMACI |
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229. EFFECT
OF TOPIRAMATE TREATMENT IN A PATIENT AFFECTED BY SYMPTOMATIC TRIGEMINAL
NEURALGIA
Gallelli Luca,1 Siniscalchi Antonio,2 Borner Perrone Ina,1 Davoli
Alessandro,1 De Sarro Giovambattista1
1Chair of Pharmacology, Department of Experimental and Clinical
Medicine, Faculty of Medicine, University Magna Graecia of Catanzaro,
Italy.
2Department of Neuroscience, Neurology Division, “Annunziata”
Hospital, Cosenza, Italy
230. PHARMACOKINETICS
OF TRAMADOL AND OF ITS METABOLITE N-DESMETHYLTRAMADOL IN FASTING
AND FED HORSES, AFTER SINGLE ORAL ADMINISTRATION
Buti Deanna, Saccomanni Giuseppe*, Sgorbini Micaela, Mengozzi Grazia,
Manera Clementina* and Giorgi Mario
Departments of Veterinary Clinics V.le delle Piagge 2 56124
Pisa, Italy. *Pharmaceutical Science Via Bonanno 6 56126 Pisa, Italy
231. ADMINISTRATION
OF ORAL SUSTAINED-RELEASE TABLET FORMULATION OF TRAMADOL IN HORSES:
PHARMACOKINETICS OF THE PARENTAL DRUG AND OF N-DESMETHYLTRAMADOL
Magnani Francesca, Saccomanni Giuseppe*, Casini Lucia**, Soldani
Giulio, Manera Clementina* and Giorgi Mario
Departments of Vetrinary Clinics V.le delle Piagge 2 56124 Pisa,
*Pharmaceutical Science V. Bonanno 6 56126 Pisa and **Animal Productions,
S. Piero a Grado, 56010 Pisa, Italy
232. HIGH
HOMOCYSTEINE PLASMA LEVELS IN PATIENTS TREATED WITH ANTIEPILEPTIC
DRUGS
Siniscalchi Antonio,1 Liotti Alessandra,2 Gallelli Luca,2 Davoli
Alessandro,2 Marigliano Norma M,2 De Sarro Giovambattista2
1Department of Neuroscience, Neurology Division, “Annunziata”
Hospital, Cosenza, Italy
2Chair of Pharmacology, Department of Experimental and Clinical
Medicine, Faculty of Medicine, University Magna Graecia of Catanzaro,
Italy
233. PHARMACOKINETICS
OF INDOMETHACIN IN CHRONIC MIGRAINE PATIENTS AFTER WITHDRAWAL OF
THE OVERUSED COMBINATION OF INDOMETHACIN, PROCHLORPERAZINE, AND
CAFFEINE
Ferrari Anna, Gallesi Daniela, Sances Grazia*, Pinetti Diego, Bertolini
Alfio, Sternieri Emilio
Toxicology and Clinical Pharmacology Section, Headache Centre,
University Centre for Adaptive Disorders and Headache, Section Modena
II. University of Modena and Reggio Emilia, Italy
*Headache Unit, IRCCS C. Mondino, University of Pavia, Italy
234. VARIABILITY
OF ORAL SUMATRIPTAN PHARMACOKINETICS IN MIGRAINE PATIENTS
Coccia Ciro, Pinetti Diego, Bertolini Alfio, Sternieri Emilio, Ferrari
Anna
Toxicology and Clinical Pharmacology Section, Headache Centre,
University Centre for Adaptive Disorders and Headache, Section Modena
II. University of Modena and Reggio Emilia, Italy
235. HORMONAL
INDEX OF WELL-BEING IN WOMEN AFFECTED BY MEDICATION OVERUSE HEADACHE
(MOH)
Monnazzi Paola, Simeoni Simona, Martelletti Paolo* and Patacchioli
Francesca Romana.
Dept Human Physiology and Pharmacology “V. Erspamer”,
*Internal Medicine, 2nd School of Medicine, University of Rome La
Sapienza, Italy
236. LONG-TERM
EFFICACY OF ANTIHYPERTENSIVE THERAPY IN OLD-AGE PATIENTS WITH ESSENTIAL
HYPERTENSION
Alicandri Carlo1, Parini Francesca1,2, Valenti Luigi P.1, Parrinello
Giovanni3, Spano PierFranco2, Sigala Sandra1,2
1Division of Medicine, Istituto Clinico Città di Brescia,
Brescia, Italy; 2Section of Pharmacology, Dept of Biomed Sci and
Biotec, University of Brescia Medical School, Brescia, Italy; 3
Medical Statistic Unit, Dept of Biomed Sci and Biotec, University
of Brescia Medical School, Brescia, Italy
237. THE
ROLE OF CYP3A5 IN METHADONE METHABOLISM: A CASE REPORT
De Fazio Salvatore1, Scordo MariaGabriella2, Gallelli Luca1, Marigliano
Norma M1, Ferreri Ibbadu Guido1, Rende Pierandrea1, De Sarro Giovambattista1
1Chair of Pharmacology, Department of Experimental and Clinical
Medicine, Faculty of Medicine, University of Catanzaro, Via T. Campanella
115, 88100 Catanzaro, Italy
2Department of Medical Sciences, Clinical Pharmacology; Uppsala
University, Akademiska sjukhuset, Ing. 61, 75185 Uppsala, Sweden
238. MANAGEMENT
OF LITHIUM THERAPY DURING PREGNANCY
Lampus Simona, Serio Stefania, Chillotti Caterina, Del Zompo Maria,
Ardau Raffaella
Clinical Psychopharmacology Center, Section of Clinical Pharmacology,
Department of Neurosciences "B. B. Brodie", University
of Cagliari
239. A
NEW APOMORPHINE FORMULATION FOR ORAL ADMINISTRATION
Zara GP1, Cattaldo S4, Cavalli R2, Calderoni S4, Muntoni E1, Gasco
MR5, Mauro A3-4, Eandi M1
1Dipartimento Anatomia Farmacologia e Medicina Legale, 2Dipartimento
di Scienze e Tecnologia del Farmaco, 3Dipartimento di Neuroscienze,
Università di Torino Italy - 4IRRCS Istituto Auxologico Italiano,
Piancavallo Italy – 5Nanovector s.r.l. Torino Italy |
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FARMACOVIGILANZA, FARMACOEPIDEMIOLOGIA E
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240. INVESTIGATION
ON THE OPPORTUNITY IN INITIATING TREATMENT FOR HEPATITIS C VIRUS
(HCV) INFECTION AMONG DRUG USERS
Mattioli Francesca, Montinaro Eleonora*, Ducci Elena*, Martelli
Antonietta
Department of Internal Medicine, Pharmacology Unit, University
of Genoa, I-16132 Genoa, Italy
*Valbisagno Drug Dependence Service (SerT) of Genoa
241. REPORTS
OF ADVERSE REACTIONS TO ANTIBIOTICS IN THE TUSCAN PHARMASEARCH DATABASE
Montagnani Sabrina 1, Tuccori Marco 1, Giustini Saffi E 2, Salvetti
Andrea 2, Blandizzi Corrado 1, Del Tacca Mario1
1 Tuscan Regional Center for Pharmacovigilance - Division of
Pharmacology and Chemotherapy, Department of Internal Medicine,
University of Pisa – Pisa, Italy
2 Italian Society of General Medicine (SIMG) – Florence, Italy
242. RETROSPECTIVE
EVALUATION OF ANTIDEPRESSANTS SIDE EFFECTS
De Fazio Salvatore, Gareri Pietro, Palleria Caterina, Gallelli Luca,
De Sarro Giovambattista
Chair of Pharmacology, School of Medicine, University “Magna
Graecia” of Catanzaro, “Mater Domini” University
Hospital, Via T. Campanella 115, 88100 Catanzaro, Italy
243. GUIDELINES
ON THE CLINICAL USE OF CLOZAPINE
Ligas Franca, Ardau Raffaella, Chillotti Caterina, Del Zompo Maria
Clinical Psychopharmacology Centre, Section of Clinical Pharmacology,
Department of Neurosciences “B.B. Brodie”, University
of Cagliari
244. OBSERVATIONAL
STUDY COMPARING THE SAFETY OF TYPICAL AND ATYPICAL ANTIPSYCHOTIC
DRUGS IN PATIENTS AFFECTED BY DEMENTIA WITH BEHAVIOURAL AND PSYCHOLOGICAL
SYMPTOMS OF DEMENTIA (BPSD)
A. Capuano, S. Potenza, L. Ferrante, M. Gallo, B. Rinaldi, A. Filippelli,
F. Rossi
Department of Experimental Medicine, Section of Pharmacology “Leonardo
Donatelli”. Center of Pharmacosurveillance and Pharmacoepidemiology,
Faculty of Medicine and Surgery, Second University of Naples, Italy
245. PRESCRIBING
PATTERN OF ANTI-PARKINSON DRUGS IN SOUTHERN ITALY: CROSS-SECTIONAL
ANALYSIS IN THE YEARS 2003-5
Gianluca Trifirò1,5, Rodolfo Savica2, Letterio Morgante2,
Michele Tari3 , Salvatore Moretti3, Nicola Vanacore4, Edoardo Spina1,5,
Vincenzo Arcoraci1 and Achille P Caputi1,5
1Department of Clinical and Experimental Medicine and Pharmacology,
Pharmacology Unit, University of Messina, Italy; 2Department of
Neuroscience, Psychiatry and Anaesthesiology, University of Messina,
Italy; 3 Caserta-1 Local Health Service, Caserta – Italy;4
National Centre for Epidemiology Surveillance and Health Promotion.
National Institute of Health, Rome, Italy; 5 IRCCS Centro Neurolesi
"Bonino-Pulejo", Messina, Italy
246.
USE OF HERBAL PRODUCTS IN CHILDREN: RISKS AND BENEFITS
Stefano Loizzo1,2, AnnaLivia Loizzo3, Anna Capasso4, Alberto Loizzo1
1Dept of Drug Research and Evaluation and 2Dept of Cell Biology
and Neurosciences, Istituto Superiore di Sanita’, Roma, Italy;
3Dept of Paediatric Neuropsychiatry, University of Roma Tor Vergata,
Roma, Italy, 4Dept of Pharmacology, University of Salerno, Salerno,
Italy
247. KNOWLEDGE
AND USE OF HERBAL DRUGS IN PREGNANCY
1Micheli Lucia, 1Nencini Cristina, 1Franchi Gian Gabriele, 2Urso
Renato and 1, 2Giorgi Giorgio
1Department of Pharmacology “Giorgio Segre”, University
of Siena. 2Centro Regionale di Farmacovigilanza, Area Vasta Sud-
Est (Siena), Regione Toscana
248. DRUGS
AND HERBAL PRODUCTS IN HOSPITAL PRACTICE: USE AND POTENTIAL INTERACTIONS
Stocco Andrea1, Gallo Umberto2, Bano Francesca2, Bin Anna1, Grion
Anna Maria2, Ori Carlo1, Gaion Rosa Maria1, Giron Maria Cecilia1
1Department of Pharmacology and Anesthesiology, University of
Padova. 2Department of Pharmaceutical Care, ULSS 16 – Padova
249. KNOWLEDGES
ABOUT HERBAL PRODUCTS AMONG SUBJECTS ON WARFARIN THERAPY AND PATIENT-PHYSICIAN
RELATIONSHIP
Laura Cuzzolin1, Francesco Francini-Pesenti2, Silvana Zaffani1,
Filippo Brocadello2, Vittorio Pengo3, Antonella Bassi4, Giuseppina
Benoni1
1Department of Medicine & Public Health-Section of Pharmacology,
University of Verona, Italy; 2Clinical Nutrition Unit, Hospital
of Padua, Italy; 3Clinical Cardiology-Thrombosis Centre, University
of Padua, Italy; 4Department of Clinical and Experimental Medicine,
University of Verona, Italy
250. ATTITUDES,
KNOWLEDGE AND USE OF HERBAL PRODUCTS AMONG PREGNANT WOMEN: A PILOT
SURVEY IN TUSCANY
Alfredo Vannacci, Francesco Lapi, Maria Morsuillo, Martina Moschini,
Fabrizio Cipollinic, Marina Di Pirro, Enrica Cecchia, Grazia Banchelli,
Fabio Firenzuoli, Alessandro Mugelli
Department of Preclinical and Clinical Pharmacology, University
of Florence, Italy aEmergency Department, Prato Hospital, ASL 4,
Italy; bCentre of Natural Medicine, ASL 11, Empoli, Italy; cDepartment
of Statistical Sciences, University of Florence, Italy
251. SURVEILLANCE
AND INFORMATION ON HERBAL MEDICINES USE OF IN PREGNANCY IN THE SICILY
REGION
Pieratti Antonella1, Calapai Gioacchino1, Corsello Salvatore2, Mirabile
Marianna2, Fava Giuseppina1, Caputi Achille P1
1) Department of Clinical and Experimental Medicine and Pharmacology,
University of Messina. 2) U.O.C. of Ginecology and Obstetrics, Hospital
S.S. Salvatore, Paternò, Catania |
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TOSSICOLOGIA SPERIMENTALE E CLINICA |
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252. NEUROCHEMICAL
MODULATION AND BEHAVIOURAL CHANGE AFTER NEONATAL ADMINISTRATION
OF PYRETHROIDS IN ANIMAL MODEL
Nasuti Cinzia Carla1, Gabbianelli Rosita2, Di Stefano Antonio3,
Cantalamessa Franco1.
1Department of Experimental Medicine and Public, University
of Camerino, 62032 Camerino (MC). 2Department of Biology M.C.A.,
University of Camerino, 62032 Camerino (MC). 3Department of Drug
Science, University of “G. D’Annunzio”, 66100
Chieti (CH)
253. ROLE
OF BRAIN RENIN ANGIOTENSIN SYSTEM IN THE ACUTE HYPERTENSIVE RESPONSE
TO INTRACEREBROVENTRICULAR CADMIUM
Varoni M.Vittoria, Palomba Domenico, Anania Vittorio, Demontis M.Piera
D.B.A - Division of Pharmacology, Faculty of Veterinary Medicine
– University of Sassari
254. CANCER
CHEMOPREVENTION: MANIPULATION OF XENOBIOTIC METABOLIZING ENZYMES
BY GLUCORAPHASATIN AND GLUCORAPHENIN FOUND IN BRASSICACEAE
Barbara Bonamassa1, Jessica Barillari2, Donatella Canistro1, Laura
Pozzetti1, Andrea Sapone1, Renato Iori 2, Gian Luigi Biagi1 and
Moreno Paolini1
1Department of Pharmacology, Molecular Toxicology Unit, Alma
Mater Studiorum - University of Bologna, Via Irnerio 48 - 40126
Bologna, Italy. 2Agricultural Research Council - Research Institute
for Industrial Crops (CRA-ISCI), via Corticella 133, Bologna, Italy
255. EFFECTS
OF PCB101, PCB118, PCB138 AND PCB153 ALONE AND IN MIXTURE IN MCF-7
BREAST CANCER CELLS: POSSIBLE MECHANISM OF ACTION
Chiesara Enzo, Marabini L., Radice S.
Department of Pharmacology, Chemoterapy and Medical Toxicology
“E. Trabucchi”, University of Milan, Via Vanvitelli
32, 20129, Milan
256. DOES
ACETYLSALYCILIC ACID INTERFERE WITH LIVER DIMETHYLBENZANTHRACENE(DMBA)-
METABOLISM? STUDY IN A RAT MODEL OF DMBA-INDUCED MAMMARY CARCINOGENESIS
Racca Silvia1, Spaccamiglio Angela1, Dacasto Mauro2, Carletti Monica2,
Nebbia Carlo2, Abbadessa Giuliana1, Di Carlo Francesco1
1Department of Clinical and Biological Sciences, University
of Turin, Orbassano (TO); 2Department of Animal Pathology, Division
of Pharmacology and Toxicology, University of Turin, Grugliasco
(TO)
257. EFFECT
OF ISOTHIAZOLINONES ON REDOX OMEOSTASIS OF RAT ERYTHROCYTES
*Frosali Simona, *Priora R., *Margaritis A., § Di Stefano A.,
*Di Giuseppe D., *Summa D., *Di Simplicio P.
* Department of Neuroscience, Pharmacology Unit, University
of Siena. § Department of Molecular Biology, University of
Siena
258. VERMINOSIDE
AND VERBASCOSIDE FROM KIGELIA AFRICANA: CYTOTOXIC AND GENOTOXIC
EFFECTS IN HUMAN LYMPHOCYTES
Santoro A., Bianco G., Picerno P., Aquino R.P., Marzocco S., Autore
Giuseppina, Gazzerro P., Lioi M.B.1, Bifulco M.
Dipartimento di Scienze Farmaceutiche, Università di
Salerno, Fisciano Italy. 1Dipartimento di Scienze delle Produzioni
Animali, Università della Basilicata, Potenza Italy
259. DNA
FRAGMENTATION IN PERIPHERAL BLOOD LYMPHOCYTES OF PATIENTS WITH LIVER
CIRRHOSIS RELATED TO ALCOHOL ABUSE OR TO HEPATITIS B OR C VIRUSES
Grossi Sarah, Mattioli Francesca, Manfredi Valeria, Sumberaz Alessandro*,
Testino Gianni*, Martelli Antonietta
Department of internal Medicine, Pharmacology Unit, University
of Genoa, I-16132 Genoa, Italy. * Gastreoenterology Unit –
St. Martino Hospital – Genoa
260. EFFECTS
OF DP7 ON HUMAN AND RAT LIVER CYP-DEPENDENT ACTIVITIES: A KINETIC
STUDY
D’Elia Paolo, Dragoni S., De Matteis F., Valoti M., Kawase
M., Shah A., Motohashi N., Molnar J., Sgaragli G.
Dipartimento Scienze Biomediche, Università degli Studi
di Siena, via A. Moro 2, 53100 Siena
261. FORMATION
OF DNA-DAMAGING N-NITROSO COMPOUNDS FROM THE INTERACTION OF CALCIUM-CHANNEL
BLOCKERS WITH NITRITE
Robbiano Luigi, Gosmar Marzia, Martelli Antonietta
Department of Internal Medicine, Pharmacology Unit, University
of Genoa, I-16132 Genoa, Italy
262. LOW-LEVEL
LEAD, CADMIUM AND VANADIUM: “IN VITRO” EVALUATION OF
THEIR GENOTOXIC POTENTIAL AS INFLUENCED BY COPPER, ZINC OR SELENIUM
Volpe Anna R., Cesare Patrizia, Aimola Pierpaolo, and Carmignani
Marco
Section of Pharmacology and Toxicology, Department of Basic
and Applied Biology, University of L’Aquila, Via Vetoio 2,
67010 Coppito (L’Aquila), Italy
263. INHIBITORY
ENZYMATIC ACTIVITY OF SEMICARBAZIDE
Mastrangelo Sabina1, Evandri Maria Grazia2, Maranghi Francesca3,
Mantovani Alberto3, Bolle Paola1
1 Department of Human Physiology and Pharmacology, “Sapienza”
University of Rome; 2 Italian Medicines Agency, Rome; 3 Department
of Food Safety and Veterinary Public Health, Italian National Health
Institute, Rome
264. IN
VITRO EFFECTS OF TWO OVER-THE-COUNTER BLEACHING PRODUCTS ON GINGIVAL
EPITHELIUM AND DENTAL RESTORATIVE MATERIAL
F. CIMINO, A. TOMAINO, A. SPECIALE, M. CRISTANI, D. TROMBETTA, A.
SAIJA
1Dept. Farmaco-Biologico, School of Pharmacy, University of
Messina, Italy
265. HUMAN
UMBILICAL CORD-DERIVED HEMATOPOIETIC STEM CELLS IN CYTO- AND GENO-TOXICITY
STUDIES: RESULTS WITH CADMIUM AND CHROMIUM COMPOUNDS
Carmignani Marco, Aimola Pierpaolo, Cesare Patrizia, Orsini Federica
and Volpe Anna R.
Section of Pharmacology and Toxicology, Department of Basic
and Applied Biology, University of L’Aquila, Via Vetoio 2,
67010 Coppito (L’Aquila), Italy
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GENICA |
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266. SEROTONIN
TRANSPORTER 5HTTLPR POLYMORPHISM, CLINICAL VARIANTS AND SYMPTOM
SEVERITY IN PATIENTS WITH IRRITABLE BOWEL SYNDROME
Ghisu Narcisa1, Colucci Rocchina1, Bellini Massimo2, Rossi Giuseppe3,
Blandizzi Corrado1, Gori Giovanni1, Marchi Santino 2, Tonini Marcello4,
Del Tacca Mario1
1Division of Pharmacology and Chemotherapy and 2Gastrointestinal
Unit, Department of Internal Medicine, University of Pisa, Italy;
3Institute of Clinical Physiology-C.N.R., Italy; 4Department of
Physiological and Pharmacological Sciences, University of Pavia,
Italy
267. ADVERSE
EFFECTS OF AZATHIOPRINE IN PEDIATRIC PATIENTS WITH INFLAMMATORY
BOWEL DISEASE AND MULTILOCUS GENOTYPES OF ENZYMES INVOLVED IN THE
METABOLISM OF THIOPURINES
STOCCO Gabriele1,2, MARTELOSSI Stefano1, BARABINO Arrigo3, DECORTI
Giuliana2, BARTOLI Fiora1, VENTURA Alessandro1
1) University of Trieste, Department of Sciences of Reproduction
and Development and I.R.C.C.S. “Burlo Garofolo” Trieste,
Pediatric Clinic – 2) University of Trieste, Department of
Biomedical Sciences – 3) I.R.C.C.S. “G. Gaslini”,
Genova
268. CORTICOSENSITIVITY
IN INFLAMMATORY BOWEL DISEASE: ROLE OF GLUCOCORTICOID RECEPTOR POLYMORPHISMS
De Iudicibus S.1, 2, Stocco G.1, 2, Drigo I.1, 2, Norbedo S.2, Bartoli
F.1, Decorti G.1, 2, Martelossi S.2, Ventura A.2
1 Department of Biomedical Sciences, University of Trieste.
2 Department of Paediatrics, I.R.C.C.S. Burlo Garofolo Trieste
269. EVIDENCE
OF AN INCREASE OF THE ACTIVE METABOLITES OF THIOPURINES INDUCED
BY AMINOSALICYLATES IN INFLAMMATORY BOWEL DISEASE
Marino S.1, 2, Stocco G.1, 2, Pozzi E.3, Martelossi S.2, Lionetti
P.3, Malusà N. 4, Decorti G.1, 2 Bartoli F.1, Ventura A.2
1 Department of Biomedical Sciences, University of Trieste.
2 Department of Paediatrics, I.R.C.C.S. Burlo Garofolo Trieste.
3 Research Children’s Hospital ‘Meyer’, Florence.
4 Department of Prevention, Azienda Sanitaria 1, Trieste
270. INFLUENCE
OF THIOPURINE METHYLTRANSFERASE GENOTYPE AND PHENOTYPE ON ADVERSE
EVENTS AND EFFICACY OF AZATHIOPRINE IN RHEUMATOLOGIC AND GASTROENTEROLOGIC
PATIENTS
Gori Giovanni1, Colucci Rocchina1, Ghisu Narcisa1, Fornai Matteo1,
Tani Chiara2, Mosca Marta2, Ceccarelli Linda3, Blandizzi Corrado1,
Costa Francesco3, Marchi Santino3, Bombardieri Stefano2, Del Tacca
Mario1
1Division of Pharmacology and Chemotherapy, 2Gastroenterology
Unit, and 3Rheumatology Unit, Department of Internal Medicine, University
of Pisa, Pisa, Italy
271. IDENTIFICATION
OF MUTATIONS IN HERG AND KCNE2 GENES ASSOCIATED WITH ARRHYTHMIA
IN PATIENTS TREATED WITH MACROLIDES
Pannacci Marilou1, Sullo Nikol2, Caronno Alessia1, Lucini Valeria1,
Grosso Silvia1, Francesco Scaglione1
1Department of Pharmacology, University of Milan, Milan, Italy.
2Department of Experimental Medicine- Section of Pharmacology, 2nd
University of Naples, Naples, Italy
272. AN
ALLELIC VARIANT OF NA+/CA++ EXCHANGER PROMOTER REGION, A2689C, PLAYS
A ROLE IN DIASTOLIC BLOOD PRESSURE RESPONSE TO B-BLOCKERS AND DIHYDROPYRIDINE
CA++ ANTAGONISTS TREATMENT IN HYPERTENSIVE PATIENTS
Valentina Trimarco*, Alessandro Bellis**, Marina Marino**, Bruna
Gigante**, Nicola De Luca**, Bruno Trimarco**, Lucio Annunziato*,
Gianfranco Di Renzo*
*Division of Pharmacology, Dept. of Neuroscience, Federico II
University of Naples, Naples, Italy. ** Dept. of Cardiovascular
and Immunological Sciences, Federico II University of Naples, Naples,
Italy
273. DISTRIBUTION
OF CYP3A5 AND MDR-1 SINGLE NUCLEOTIDE POLYMORPHISMS IN CAUCASIAN
LIVER TRANSPLANT PATIENTS
Provenzani Alessio1, Poma P2., Labbozzetta M2., Notarbartolo M2.,
Di Stefano R1., Triolo F3., Vizzini G4., Gridelli B5., D’Alessandro
N2.
1Department of Clinical Pharmacy - ISMETT, 2Department of Pharmacological
Sciences - Università di Palermo, 3Regenerative Medicine
and Cell Therapy Unit - ISMETT, 4Department of Medicine - ISMETT,
5Department of Abdominal Surgery and Transplantation - ISMETT |
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FARMACI INNOVATIVI DI ORIGINE BIOTECNOLOGICA |
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274. PROLONGING
THE ACTION OF RECOMBINANT HUMAN GROWTH HORMONE BY MONOPEGYLATION
OF MUTEINS
Caboi Francesca*, Bossi Michele*, Crobu Davide*, Cabras Alba*, Scaramuzza
Silvia* and Taylor Geoffrey*
*Bio-Ker s.r.l. c/o Scientific and technologic Park of Sardinia
Polaris, Loc. Piscinamanna Pula (Cagliari)
275. NOVEL
G-CSF MUTANT FOR CONJUGATION
Salis Barbara, Caboi Francesca, Pitzalis Sabrina, Maullu Carlo,
Sergi Mauro, Sollai Luigi, Taylor Geoffrey
Bio-Ker s.r.l. c/o Scientific and technologic Park of Sardinia
Polaris, Loc. Piscinamanna Pula (Cagliari)
276. NEW
LONG LASTING PEGylated-hGH
Selis Fabio*, Scaramazza Silvia*, Contis Manuela*, Pasut Gianfranco+,
Veronese Francesco+, Schrepfer Rodolfo*
*Bioker S.r.l. c\o Polaris-Loc Piscinamanna, Pula (CA). + Università
degli Studi di Padova, Dipartimento di Scienze Farmaceutiche
277. SILICA
MICROPARTICLES FOR THE CONTROLLED RELEASE OF HUMAN GROWTH HORMONE
Sergi Mauro*, Morpurgo Margherita+, Selis Fabio*, Parisi Laura+,
Concas Danilo*, Marongiu Christian*, Schrepfer Rodolfo*, Tonon Giancarlo*
*Bioker S.r.l. c\o Polaris-Loc Piscinamanna, Pula (CA)
+Università degli Studi di Padova, Dipartimento di Scienze
Farmaceutiche
278. INHIBITION
OF NF-kB ACTIVATION BY DECOY ODN RELEASED FROM LIPOSOMES IN ACTIVATED
MACROPHAGES
De Stefano Daniela1, Maiuri Maria C1., Simeon Vittorio1, De Rosa
Giuseppe2, LaGuardia Valeria2, Carnuccio Rosa1
1Department of Experimental Pharmacology; 2Department of Pharmaceutical
Sciences; University of Naples “Federico II”, Via D.
Montesano n 49, 80131 Naples, Italy
279.
OSTEOGENIC DIFFERENTIATION OF HUMAN ADIPOSE-DERIVED STEM
CELLS (hASC)
de Girolamo L1;2, Sartori M1, Bastoni S3 and Brini AT1
1 Medical Pharmacology Department, Faculty of Medicine, University
of Milan.
2 IRCCS Galeazzi Orthopedic Institute, Milan. 3 Orthopedic and Traumatological
Institute, Faculty of Medicine, University of Milan
280. IN
VITRO EFFECTS OF ANTI-INFLAMMATORY DRUGS INCORPORATED IN SOLID LIPID
NANOPARTICLES ON HUMAN PERIPHERAL MONONUCLEAR BLOOD CELLS FROM IBD
PATIENTS
Serpe Loredana1, Canaparo Roberto2, Daperno Marco3, Eandi Mario1,
Gasco Maria Rosa4 and Zara Gian Paolo1
1Department of Anatomy, Pharmacology and Forensic Medicine,
University of Torino, Torino, 2Department of Clinical Pathophysiology,
University of Torino, Torino, 3Department of Gastroenterology, Mauriziano
Hospital, Torino, 4Nanovector s.r.l, Torino
281. PEGYLATION
OF RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR (R-H-G-CSF)
PRODUCED IN ESCHERICHIA COLI: A NEW DRUG TO OVERCOME NEUTROPENIA
Bonatesta Rosa Rita *, Caboi Francesca*, Sergi Mauro*, Sollai Luigi*,
Onali Pierluigi+, Schrepfer Rodolfo* and Tonon Giancarlo*
*Bioker S.r.l. c\o Polaris-Loc Piscinamanna, Pula (CA). + Università
degli Studi di Cagliari, Dipartimento di Neuroscienze
282. EMEA AND EMERGING THERAPIES AND TECHNOLOGIES:
ACTIVITY OF THE INNOVATION TASK FORCE
Roberto De Lisa, Daniela Ranzani, Laurent Brassart, Isabelle Moulon,
Marisa Papaluca Amati
EMEA European Medicines’ Agency
(Abstract non disponibile su richiesta del'autore) |
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283. INDIPENDENT
DRUG INFORMATION AND PRESCIBING APPROPRIATENESS: A CHANCE FOR HEALTH
PROFESSIONALS AND PATIENTS
Luppino Maria R1,3, Alacqua Marianna1,3, Catania Maria A1,3, Fava
Giuseppina1,3, Gentile Marianna1,3, Oteri Alessandro1,3, Polimeni
Giovanni1,2,3, Russo Alessandra1,3, Aliferopulos Harilaos3, Genovese
Rosalia3, Sgroi Carmela3, Silvestro Anna3, Zangla Antonella3, Caputi
Achille P1,2,3
1University of Messina - 2IRCSS “Bonino-Pulejo”,
Messina - 3Messina Provincial Drug Information Center
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