1. PHARMACOLOGICAL CHARACTERIZATION OF ADENOSINE RECEPTORS IN BOVINE CHONDROCYTES
Tosi A.1, Varani K.1, Vincenzi F.1, Gessi S.1, Merighi S.1, Fogli E. 1, Sacchetto V. 1, Simioni C. 1, De Mattei M.2, Caruso A.2, Borea P.A.1
1Department of Clinical and Experimental Medicine, Pharmacology Section; 2Department of Morphology and Hystology, University of Ferrara, Italy

2. BINDING THERMODYNAMICS AT THE HUMAN A2B ADENOSINE RECEPTOR
Eleonora Fogli1, Stefania Gessi1, Katia Varani1, Stefania Merighi1, Valeria Sacchetto1, Carolina Simioni1, Edward Leung2, Stephen Mac Lennan2, Pier Andrea Borea1
1Department of Clinical and Experimental Medicine, Pharmacology Unit and Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Italy; 2King Pharm. Research and Development, Inc., Cary, North Carolina

3. ADENOSINE MODULATES VASCULAR ENDOTHELIAL GROWTH FACTOR EXPRESSION VIA HYPOXIA-INDUCIBLE FACTOR-1 IN HUMAN GLIOBLASTOMA CELLS
Valeria Sacchetto1, Stefania Merighi1, Annalisa Benini1, Prisco Mirandola2, Stefania Gessi1, Katia Varani1, Carolina Simioni1, Eleonora Fogli1, Edward Leung3, Stephen Mac Lennan3, Pier Andrea Borea1.
1Dpt of Clin. and Exp. Med., Pharmacol. Unit and Interdisciplinary Center for the Study of Inflammation, Univ. of Ferrara, Italy; 2Dpt of Human Anat., Pharmacol. and For. Med., Univ. of Parma, Italy; 3King Pharm. Research and Development, Inc., Cary, North Carolina

4. ACTIVATED PRESYNAPTIC P2X7 RECEPTORS FUNCTION AS CALCIUM CHANNELS LINKED TO EXOCYTOTIC GLUTAMATE RELEASE
Guarnieri Stefania1, Paluzzi Paola1, Cervetto Chiara1, Alloisio Susanna2, Nobile Mario2, Marcoli Marcoli1, Maura Guido1*
1Dep. Experimental Medicine, Pharmcology and Toxicology Section; *Center of Exellence for Biomedical Research, University of Genoa, Genoa, Italy; 2CNR, Biophysic Intitute, Genoa, Italy

5. ACTIVATED P2X7 RECEPTORS ALLOW CALCIUM ENTRY AND GLUTAMATE EXIT: INVESTIGATION ON TRANSFECTED HEK 293 CELLS
Paluzzi Paola1, Cervetto Chiara1, Guarnieri Stefania1, Alloisio Susanna2, Nobile Mario2, Marcoli Marcoli1, Maura Guido1*
1Dep. Experimental Medicine, Pharmcology and Toxicology Section; *Center of Exellence for Biomedical Research, University of Genoa, Genoa, Italy; 2CNR, Biophysic Intitute, Genoa, Italy

6. EXTRACELLULAR MG2+ MODULATES C-TERMINAL TAIL DEPENDENT P2X7 RECEPTOR FUNCTIONAL PROPERTIES
Susanna Alloisio, Raffaella Barbieri, Luigi Bozzo, Mario Nobile
Institute of Biophysics, CNR, Via De Marini, 6 – 16149 Genoa, Italy

7. ARACHIDONIC ACID POTENTIATES NATIVE AND RECOMBINANT P2X7-MEDIATED ERK1/2, BUT NOT JNK AND P38 PHOSPHORYLATION IN CULTURED CORTICAL ASTROCYTES AND HUMAN EMBRYONIC KIDNEY 293 CELLS
Barbieri Raffaella1, Alloisio Susanna1, Ferroni Stefano2 and Nobile Mario1
1Institute of Biophysics, CNR, 16149 Genoa, Italy; 2Dept. of Human and General Physiology, University of Bologna, 40127 Bologna, Italy

8. PURINERGIC FACILITATION OF PARASYMPATHETIC ACTIVITY IN ISOLATED PIG DETRUSOR: INVOLVEMENT OF PREJUNCTIONAL P2X3 RECEPTORS
D’Agostino G., Condino A.M., Barbieri A. and Tonini M*
Department of Experimental and Applied Pharmacology, School of Pharmacy, University of Pavia, Via Taramelli 14, and *Department of Physiological and Pharmacological Sciences, P.za Botta 10, I-27100 Pavia, Italy

9. ROLE OF P2 PURINERGIC RECEPTORS ON CA1 NEUROTRANSMISSION OF RAT HIPPOCAMPAL SLICES
Traini Chiara , Coppi Elisabetta, Pugliese Anna Maria and Pedata Felicita
Department of Preclinical and Clinical Pharmacology, University of Florence,
Viale Pieraccini 6, 50139 Florence, Italy

10. ROLE OF PKA IN EGFR TRANSACTIVATION INDUCED BY PGE2 IN A431 CELLS
Erika Terzuoli, F. Finetti and M. Ziche
Laboratory of angiogenesis, Department of Molecular Biology, University of Sien

11. INSULIN-LIKE GROWTH FACTOR I (IGF-I) INDUCES HUMAN MU OPIOID RECEPTOR (MOR) EXPRESSION IN DIFFERENTIATED NEURONS: ROLE OF TRANSCRIPTION FACTORS REST AND STAT3
Bedini Andrea, Di Toro Rosanna and Spampinato Santi
Department of Pharmacology and Toxicology – University of Bologna Irnerio 48 – 40126 Bologna – Italy

12. RESISTIN INDUCES VASCULAR INSULIN RESISTANCE THROUGH AN IMPAIRMENT OF AKT/ENOS PHOSPHORYLATIONS
Alba Di Pardo°, Maria Teresa Gentile°, Carmine Vecchione°, Gennaro Marino°, Giovanna Antenucci°, Angelo Maffei°, Giuseppe Lembo° #.
°Department of Angio-Cardio-Neurology, Neuromed Institute, Pozzilli (IS), and #Department of Experimental Medicine, “La Sapienza” University of Rome

13. INTERACTION BETWEEN WNT PATHWAY AND ORPHAN NUCLEAR RECEPTORS
Motolese Marta 1, Orlando Rosamaria 1, Caricasole Andrea 3, Terstappen Georg C.3, Melchiorri Daniela 1, Nicoletti Ferdinando 1,2, Caruso Alessandra 1
1Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”; 2I.N.M. Neuromed , Pozzilli; Italy; 3Sienabiotech s.p.a. Siena

14. STUDY OF SYNTHETIC PEPTIDES DERIVED FROM PKI55, A PKC MODULATOR, IN STIMULATED HUMAN NEUTROPHILS
Sofia Falzarano1, Lara Franceschetti1, Susanna Spisani2, Rita Selvatici1
1Department of Experimental and Diagnostic Medicine, Section of Medical Genetics, University of Ferrara; 2Department of Molecolar Biochemistry and Biology, University of Ferrara

15. THE THYROID DISRUPTOR 1,1,1-TRICHLORO-2,2-BIS(P-CHLOROPHENYL)-ETHANE APPEARS TO BE AN UNCOMPETITIVE INVERSE AGONIST FOR THE THYROTROPIN RECEPTOR
Mario Rossi, Elisa Donati, Antonio Dimida, Eleonora Ferrarini, Patrizia Agretti, Franco Giorgi, Giovanni U. Corsini, Aldo Pinchera, Paolo Vitti, Massimo Tonacchera, and Roberto Maggio
Department of Neuroscience (M.R., E.D., F.G., G.U.C.) and Department of Endocrinology, Centre of Excellence for the Study of Damage to the Nervous and Endocrine Systems Produced by Environmental, Alimentary, and Pharmacological Agents, AmbiSEN (A.D., E.F., P.A., A.P., P.V., M.T.), University of Pisa, Pisa, Department of Experimental Medicine, University of L’Aquila, Italy

16. PHARMACOLOGICAL CHARACTERISATION OF THE UROTENSIN-II RECEPTOR LIGANDS URANTIDE AND UFP-803 IN CHOHUT CELLS
Batuwangala Madura1,3, Camarda Valeria1, Marzola Erika2, McDonald John3, Lambert David G.3, Ng Leong3, Guerrini Remo2, Regoli Domenico1 and Calo’ Girolamo1.
1Dept. of Pharmacology and 2Dept. of Pharmaceutical Sciences, University of Ferrara, 44100 Ferrara, Italy. 3Dept. of Cardiovascular Sciences, Division of Anaesthesia, Pharmacology and Therapeutics, University of Leicester, Leicester, LE2 7LX, UK

17. STIMULATION OF EPHRIN B INDUCES MODIFICATIONS OF HIPPOCAMPAL SYNAPTIC PLASTICITY IN NEONATAL AND ADULT RATS
Piccinin Sonia1; Cinque Carlo1; Laura Calo’1; Patanè Monica1; Melchiorri Daniela1; Bashir Zafar3 ; Eusebi Fabrizio1,2.; Nicoletti Ferdinando1,2
1 Department of Human Physiology and Pharmacology, University La Sapienza of Rome, Italy; 2 I.N.M. Neuromed, Pozzilli, Italy; 3 MRC Centre for synaptic plasticity, Department of Anatomy, University of Bristol, UK

18. PGE2 PROMOTES EGFR TRANSACTIVATION AND SQUAMOUS CELL CARCINOMA GROWTH BY THE NOS AND ERK1/2 PATHWAYS
Raffaella Solito, Marina Ziche and Lucia Morbidelli
Section of Pharmacology, Department of Molecular Biology, University of Siena

19. SELECTIVE H3 RECEPTOR ISOFORMS ACTIVATE AKT/GSK AXIS AND ERK IN RAT CORTICAL NEURONS
Chiara Mariottini1, Gerold Bongers3, Rob Leurs3, Silvia Fossati2 Alberto Chiarugi2, Patrizio Blandina2 and M. Beatrice Passani2
1Dipartimento di Fisiologia, V.le Morgagni 65, Firenze, Italy; 2Dipartimento di Farmacologia Preclinica e Clinica, V.le Pieraccini 6, Firenze, Italy; 3Department of Medicinal Chemistry, Vrije Universiteit, Amsterdam, The Netherlands

20. NITRIC OXIDE/CGMP SIGNALING PATHWAY EXERTS TONIC CONTROL ON INTRAOCULAR PRESSURE (IOP) HOMEOSTASIS IN RABBITS
Bastia Elena, Guzzetta Massimiliano, Biondi Stefano and Impagnatiello Francesco
Nicox Research Institute, Bresso, Milano, Italy

21. THE EFFECTS OF ACETAZOLAMIDE ON CALCIUM ACTIVATED K+ CHANNELS IN SKELETAL MUSCLE ARE MEDIATED BY INTERACTION WITH THE ALPHA SUBUNIT
Mele Antonietta1, Tricarico Domenico1, Latorre Ramon2, Torres Yolima2, Conte Camerino Diana1.
1Dept. of Pharmacobiology, Fac of Pharmacy,University of Bari, Bari Italy; 2Centro de Estudios Cientificos, Valdivia, Chile

22. FLUVASTATIN MAY INDUCE A CHRONIC REDUCTION OF THE STORE OPERATED CALCIUM ENTRY IN STRIATED FIBRES: AN OTHER BRICK IN THE WALL OF THE HYPOLIPEDEMIC DRUGS' MYOTOXICITY?
Rolland Jean-francois, Liantonio Antonella, Conte Camerino Diana
Department Pharmaco-Biology, Faculty of Pharmacy, University of Bari

23. HYDROPHOBICITY OF PHENYLALANINE 1586 WITHIN THE PORE OF THE HUMAN NAV1.4 SODIUM CHANNEL IS A DETERMINANT OF LOCAL ANESTHETIC BINDING
Jean-François Desaphy1, Antonella Dipalma1, Alessia Catalano2, Giovanni Lentini2, Carlo Franchini2, Vincenzo Tortorella2, Diana Conte Camerino1
1Section of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, Via Orabona 4 – campus, 70125 Bari, Italy; 2Department of Medicinal Chemistry, Faculty of Pharmacy, University of Bari

24. STRUCTURAL REQUIREMENTS OF N-BENZYL TOCAINIDE ANALOGS FOR STEREOSELECTIVE AND POTENT BLOCK OF SKELETAL MUSCLE SODIUM CHANNELS
1De Bellis Michela, 1De Luca Annamaria, 2Corbo Filomena, 2Muraglia Marilena, 2Franchini Carlo, 2Tortorella Paolo and 1Conte Camerino Diana
1Unit of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of Bari and 2Department of Medical Chemistry, Faculty of Pharmacy University of Bari, Italy

25. CELLULAR AND SUBCELLULAR LOCALIZATION OF NA+-CA2+ EXCHANGER (NCX) 1, 2 AND 3 IN CENTRAL NERVOUS SYSTEM (CNS)
Magi Simona1, Castaldo Pasqualina1, Salucci Sara3, Gobbi Pietro3, Minelli Andrea2 and Amoroso Salvatore1
1Section of Pharmacology, Department of Neuroscience, University “Politecnica delle Marche”, Ancona and Institute of 2Physiological and 3Morphological Sciences, University of Urbino “Carlo Bo”

26. TRANSPORT OF PYRIDINE NUCLEOTIDES ACROSS THE PLASMA MEMBRANE IN MAMMALIAN CELLS
Emanuela Ercolano, Richard A. Billington, Fabrizio Condorelli, Pier Luigi Canonico, Armando A. Genazzani
DiSCAFF, Università del Piemonte Orientale, Novara

27. SODIUM CALCIUM EXCHANGER AND SODIUM DEPENDENT GLUTAMATE TRANSPORTERS INVOLVEMENT IN ENERGY PRODUCTION, IN RAT HEART
1Castaldo Pasqualina, 2Rodolico Gabriella, 2Piegari Elena, 1Magi Simona, 1Corcione Elisa, 2Berrino Liberato and 1Amoroso Salvatore
1Section of Pharmacology, Department of Neuroscience, Università “Politecnica delle Marche”, Ancona; 2Department of Experimental Medicine, Section of Pharmacology, Second University of Naples

28. TAURINE PREVENTS THE DISUSE-ASSOCIATED ALTERATION OF SOLEUS MUSCLE CALCIUM HOMEOSTASIS IN THE HINDLIMB-UNLOADED RATS
Giannuzzi Viviana, Liantonio Antonella, Desaphy Jean-François, Pierno Sabata, Conte Camerino Diana
Section of Pharmacology, Dept. of Pharmacobiology, University of Bari, Italy

29. EVALUATION OF THE EFFECTS OF A COMBINED CHRONIC TREATMENT WITH ATORVASTATIN AND FENOFIBRATE ON RAT SKELETAL MUSCLE: AN EX VIVO ELECTROPHYSIOLOGICAL AND CYTOFLUORIMETRIC STUDY
Cippone Valentina, Giannuzzi Viviana, Pierno Sabata, Liantonio Antonella, Conte Camerino Diana
Dept. of Pharmacobiology, Section of Pharmacology, Faculty of Pharmacy, University of Bari, Italy

30. PHARMACOLOGICAL TARGETING OF RENAL CLC-K CHLORIDE CHANNELS: LIGANDS STRUCTURAL REQUIREMENTS AND THERAPEUTIC POTENTIAL
Liantonio Antonella1, Picollo Alessandra2, Babini Elena2, De Bellis Michela1, Fracchiolla Giuseppe3, Carbonara Giuseppe3, Tortorella Paolo3, Pusch Michael2, Conte Camerino Diana1
1Section of Pharmacology, Dept. of Pharmacobiology, University of Bari, Italy; 2Institute of Biophysic-CNR, Genova, Italy; 3Dept. of Medicinal Chemistry, University of Bari, Italy

31. ENDOCANNABINOIDS CONTRIBUTE TO THE NEUROPROTECTIVE EFFECTS OF MGLU1 RECEPTOR ANTAGONISTS AGAINST POST-ISCHEMIC NEURONAL DEATH
Landucci Elisa, Scartabelli Tania, Cozzi Andrea, Mannaioni Guido, Moroni Flavio & Pellegrini-Giampietro Domenico
Dipartimento di Farmacologia Preclinica e Clinica, Università di Firenze, Viale Pieraccini 6, 50139 Firenze

32. TRANSFORMING GROWTH FACTOR-B1 PROTECTS RAT CORTICAL NEURONS AGAINST EARLY AND LATE -AMYLOID TOXICITY
Filippo Caraci1, Agata Copani1, Giuseppe Battaglia2, Ferdinando Nicoletti2,3, Maria Angela Sortino4
1Dept. of Pharmaceutical Sciences, University of Catania ; 2I.N.M. Neuromed, Pozzilli, Italy, 3Dept. of Human Physiology and Pharmacology, University of Rome ‘‘La Sapienza’’; 4Dept. of Experimental and Clinical Pharmacology, University of Catania

33. B-AMYLOID EFFECTS IN DIFFERENTIATION AND DEATH OF NEURAL PROGENITOR CELL-DERIVED NEURONS
Calafiore M1, Giuffrida M.L.1, Sortino M.A.2 and Copani A1.
1Department of Pharmaceutical Sciences, 2Department of Experimental and Clinical Pharmacology, University of Catania, Catania

34. DIFFERENTIAL ROLE OF MGLU1 AND MGLU5 RECEPTORS IN RAT HIPPOCAMPAL SLICE MODELS OF ISCHEMIC TOLERANCE
Scartabelli Tania, Landucci Elisa, Moroni Flavio & Pellegrini-Giampietro Domenico.
Dipartimento di Farmacologia Preclinica e Clinica, Università di Firenze, Viale Pieraccini 6, 50139 Firenze

35. REGULATION OF AUTOPHAGY BY THE INOSITOL TRISPHOSPHATE RECEPTOR
Maiuri Maria Chiara1,2, Criollo Alfredo2, Tasdemir Ezgi2, Carnuccio Rosa1, Kroemer Guido2
1Department of Experimental Pharmacology, Faculty of Biotechnological Sciences, University of Naples “Federico II”, Via D. Montesano 49, 80135 Napoli, Italy; 2INSERM U848, University “Paris Sud”, Institut G. Roussy, 39 rue C. Desmoulins, F-94805 Villejuif, France
(Abstract non disponibile su richiesta dell'autore)

36. PERIPHERAL NEUROPATHIES: APOPTOSIS-PREVENTING ACTIVITY OF ACETYL-L-CARNITINE
Di Cesare Mannelli Lorenzo*, Ghelardini C.*, Vivoli E.*, Toscano A.§, Bartolini A*.
*University of Florence, Dept. of Preclinical and Clinical Pharmacology, Viale Pieraccini 6, 50139, Florence, Italy; §University of Florence, Dept. of Anatomy Hystology and Forensic Medicine, Viale Morgagni 85, 50139, Florence, Italy

37. EFFECTS OF COMBINATION TREATMENT WITH AZIDOTHYMIDINE AND PHARMACOLOGICAL INHIBITORS OF NF-KB ON APOPTOTIC CELL DEATH IN UNINFECTED OR VIRUS-INFECTED TRANSFORMED CELL LINES
1Minutolo A. 2Matteucci C. , 1, Balestrieri E. 3 Ascolani A..4 Mastino A. 3,5, Macchi Beatrice
1Department of Experimental Medicine and Biochemical Science, University of Rome “Tor Vergata”, Rome; 2Institute of Neurobiology and Molecular Medicine, C.N.R., Rome; 3 Department of Neuroscience, University of Rome “Tor Vergata”, Rome; 4Department of Microbiological, Genetic and Molecular Sciences, University of Messina, Messina. 5IRCCS Santa Lucia Rome, Italy

38. MODULATION OF BCL-2 EXPRESSION BY GEMCITABINE AND NIMESULIDE IN HUMAN PANCREATIC TUMOR CELL LINES
Longoni Biancamaria, Giovannetti Anna, Bertacca Laura, Navarra Teresa and Mosca Franco
Department of Oncology, Transplantation and Advanced Technologies in Medicine, University of Pisa

39. PROTECTIVE EFFECT OF LEVETIRACETAM VERSUS OXYGEN STRESS -INDUCED CELL DEATH IN PC12 AND IN SH-SY5Y CELL LINES
1Ascolani Arianna, 2Matteucci C, 2Balestrieri E, 3Caltagirone C, 1,3Macchi B
1Department of Neuroscience, University of Rome “Tor Vergata”, Rome, Italy.2 Department of Experimental Medicine and Biochemical Science, University of Rome “Tor Vergata”, Rome, Italy. 3IRCCS S. Lucia Rome, Italy

40. ROLE OF REACTIVE OXYGEN SPECIES (ROS) IN THE ANTIAPOPTOTIC EFFECT OF OXYSTEROLS ON HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS (HUVEC)
Chiara Poggiani, Laura Agnoletto, Federico Cusinato, Lucia Trevisi, Sisto Luciani
Department of Pharmacology and Anaestesiology, University of Padova

41. HYDROGEN PEROXIDE-DEPENDENT ERK1/2 DEPHOSPHORYLATION MEDIATES TOXICITY VIA UPSTREAM INHIBITION OF THE SURVIVAL SIGNALLING IN U937 CELLS EXPOSED TO PEROXYNITRITE
Cerioni Liana and Cantoni Orazio
Institute of Pharmacology and Pharmacognosy, University of Urbino “Carlo Bo”

42. SUBNORMOTHERMIC MACHINE PERFUSION REDUCES NECROSIS AND APOPTOSIS AND IMPROVES ENERGY STATUS DURING PRESERVATION OF STEATOTIC RAT LIVERS: IMPLICATIONS FOR TRANSPLANTATION
1Ferrigno Andrea, 2Rizzo V, 3Carlucci F, 3Tabucchi A, 4Boncompagni E., 1Richelmi P., 5Cillo U, 4Freitas I, 1Vairetti M
1Dept. Int. Med. and Therapeutics and 2Dept. of Biochemistry, IRCCS San Matteo, Univ. of Pavia; 3Dept. Int. Med., Univ. of Siena, 4Dept. of Animal Biology and IGM-CNR, Univ. of Pavia, 5Dept. General Surgery, Univ. of Padua

43. A PATHOGENETIC HYPOTHESIS OF UNVERRICHT-LUNDBORG DISEASE ONSET AND PROGRESSION
Buzzi Andrea b, Franceschetti Silvana a, Sancini Giulio a, Zucchini Silvia b, Paradiso Beatrice b, Magnaghi Giuseppina a, Frassoni Carolina a, Chikhladze Maia a, Avanzini Giuliano a, Simonato Michele b
a Neurological Institute “C. Besta”, Milan, Italy; b University of Ferrara, Italy

44. ANTIAPOPTOTIC EFFECTS OF GREEN TEA POLYPHENOL EPIGALLOCATECHIN-3-GALLATE (EGCG) ON ISCHEMIC INJURY OF THE RAT RETINA
Tamburella Alessandra, Leggio Gian Marco, Drago Filippo
Department of Experimental and Clinical Pharmacology, University of Catania, Catania, Italy
(Abstract non disponibile su richiesta dell'autore)

45. MELANOCORTINS IMPROVE WOUND HEALING IN EXPERIMENTAL BURN INJURY
Bazzani Carla1, Giuliani Daniela1, Mioni Chiara1, Galantucci Maria1, Zaffe Davide2, Minutoli Letteria3, Bitto Alessandra3, Botticelli Annibale R.4, Altavilla Domenica3, Squadrito Francesco3, Guarini Salvatore1
1Dept. Biomedical Sciences, Sect. Pharmacology, and 2Dept. Anatomy and Histology, University of Modena and Reggio Emilia; 3Dept. Clinical Exp. Medicine and Pharmacology, Sect. Pharmacology, University of Messina; 4Dept. Human Pathology, University of Pavia

46. MUSCARINIC CONTROL OF PARASYMPATHETIC ACTIVITY IN ISOLATED PORCINE AIRWAYS: INVOLVEMENT OF M1/M2 MUSCARINIC AUTORECEPTORS
Condino A.M., Barbieri A., Zonta F. and D’Agostino G.
Department of Experimental and Applied Pharmacology, School of Pharmacy, University of Pavia, Via Taramelli 14, I-27100 Pavia, Italy

47. HIERARCHICAL CONTROL OF DOPAMINE NEURON-FIRING PATTERNS BY NEURONAL NICOTINIC RECEPTORS
Mameli-Engvall Monica1,2,3, Evrard Alexis2, Pons Stephanie2, Maskos Uwe2, Svensson H. Torgny1, Changeux Jean-Pierre2, Faure Philippe2
1 Karolinska Institute, Dept. Physiology and Pharmacology, S-17177 Stockholm, Sweden; 2 Institut Pasteur, Unité Récepteurs et Cognition, URA CNRS 2182, Paris Cedex 15, France ; 3 EDX Diagnostics SPA, Sardegna Ricerche, Localita’ Piscinamanna, Ed.3, 09010 Pula, Italy

48. THE RELEASE OF ENDOCANNABINOIDS IN THE CA1 HIPPOCAMPAL AREA IS MODULATED BY MGLU1 RECEPTORS: A PATCH CLAMP STUDY
Baccini Gilda, Landucci Elisa, Moroni Flavio, Pellegrini-Giampietro Domenico & Mannaioni Guido
Dipartimento di Farmacologia Preclinica e Clinica, Università di Firenze, Viale Pieraccini 6, 50139 Firenze

49. EVIDENCE FOR A POSSIBLE INTERACTION BETWEEN CANNABINOID AND SEROTONERGIC SYSTEMS IN MODULATING INHIBITORY SYNAPTIC TRANSMISSION IN BASOLATERAL AMYGDALA
Domenici M.R1., Marsicano G2., Azad S.C.3, Lutz B.4, Popoli P1., Zieglgänsberger W.3, Rammes G.3
1 Dep. Drug Res and Evaluation, Istituto Superiore di Sanità, Rome, Italy; 2Centre de Recherche INSERM François Magendie, Bordeaux, France; 3 Max-Planck Institut for Psychiatry, Munich, Germany; 4Dep of Physiological Chemistry,Johannes Gutenberg University, Mainz, Germany

50. PHARMACOLOGICAL CHARACTERIZATION OF A NEW NON-IMIDAZOLE HISTAMINE H3 ANTAGONIST
Flammini Lisa, Bertoni Simona, Saccani Francesca, Ballabeni Vigilio, Impicciatore Mariannina, Barocelli Elisabetta
Department of Applied Pharmacological, Biological and Chemical Sciences, University of Parma, V.le GP Usberti 27/a, Parma

51. SEROTONIN EFFLUX FROM RAT DORSAL RAPHE NUCLEUS SLICES: MODULATION BY CORTICOTROPIN RELEASING FACTOR
Marino Silvia, Nazzaro Cristiano, Siniscalchi Anna
Department of Clinical and Experimental Medicine University of Ferrara Via Fossato di Mortara, 17-19 44100 Ferrara

52. MONOAMINERGIC CHANGES IN LOCUS COERULEUS AND DORSAL RAPHE NUCLEUS FOLLOWING NORADRENALINE DEPLETION
Teresa Macheda1, Tommaso Cassano1, Maria Grazia Morgese1, Luigia Trabace1, Vincenzo Cuomo2 and Gabriella Gobbi3
1Department of Biomedical Sciences, University of Foggia, Italy; 2Department of Pharmacology and General Physiology, University of Rome, ‘La Sapienza’, Italy; 3Dept. of Psychiatry, McGill University, Montréal, Qc, Canada

53. FUNCTIONAL PROTEOMICS OF NEUROPLASTICITY-RELATED SIGNALING IN A RAT MODEL OF DEPRESSION WITH GENE-ENVIROMENT INTERACTION
Musazzi Laura1, Roberto Giambelli1,2, Daniela Tardito1, Lucia Caffino1, Aram El Khoury3, Aleksander Mathé3, Giorgio Racagni1, Maurizio Popoli1
1Center of Neuropharmacology-Department of Pharmacological Sciences, University of Milano, Italy; 2Department of Experimental and Clinical Pharmacology, School of Medicine, University of Catania, Catania (Italy); 3Karolinska Institutet, Inst. of Clinical Neuroscience, Karolinska Hospital Huddinge, Stockholm (Sweden)

54. ENDOTHELIAL CELLS RESPONSE TO POLYETHYLENE TEREPHTHALATE SURFACES ACTIVATED BY IRRADIATION
Pezzatini Silvia1, Satriano Cristina2, Morbidelli Lucia1, Ziche Marina1
1 Pharmacology section, Dept Molecular Biology, University of Siena, Via A. Moro 2, 53100 Siena, Italy; 2 Laboratory for Molecular Surfaces and Nanotechnologies and CSGI, Dept. of Chemical Sciences, University of Catania, viale A. Doria 6, 95025 Catania, Italy

55. PEROXYNITRITE INACTIVATES HUMAN-TISSUE INHIBITOR OF METALLOPROTEINASE-4 (TIMP-4) FAVOURING CORONARY ENDOTHELIAL CELL MOTILITY
Martina Monti, S. Donnini, L. Morbidelli, and M Ziche
Laboratory of Angiogenesis, Department of Molecular Biology, University of Siena

56. ACE INHIBITOR-INDUCED ANGIOGENESIS IN CORONARY ENDOTHELIUM IS MEDIATED BY FIBROBLAST GROWTH FACTOR-2
Donnini Sandra, Giachetti Antonio, Ziche Marina and Morbidelli Lucia
Laboratory of Angiogenesis, Dept. Molecular Biology, University of Siena, Siena, Italy

57. MEMBRANE PROTEINS INVOLVED IN FLAVONOID TRANSPORT IN ENDOTHELIAL CELLS
Maestro Alessandra*, Terdoslavich Michela+, Petris Gianluca*, Passamonti Sabina+, Decorti Giuliana*
* Department of Biomedical Sciences and +Department of Biochemistry, Biophysics and Chemistry of Macromolecules, University of Trieste, Trieste

58. A NITRIC OXIDE RELEASING PRAVASTATIN DERIVATIVE, NCX 6550, IMPROVES VASCULAR RESPONSE IN HUMAN AND HYPERTENSIVE RAT VESSELS
C. Presotto, D. Miglietta, R. Olivieri, M. Uzzo, T.Vago*, G. Gelpi#, A. Monopoli
Nicox Research Institute, Bresso, Milan, Italy; * Department of Endocrinology, University Hospital “L.Sacco”, Milan; # Division of Cardiovascular Surgery, “L.Sacco” Hospital, Milan
(Abstract non disponibile su richiesta dell'autore)

59. NEBIVOLOL INDUCES NITRIC OXIDE PRODUCTIONE IN THE HEART
A Maffei1, R Poulet1, A. Di Pardo1, R. Carangi1, P. Carullo1, M.T. Gentile1, G Lembo1,2.
1IRCCS Neuromed, Pozzili (IS); 2 La Sapienza University, Rome

60. ROLE OF PROTEIN KINASE C AND RHO KINASE IN THE RAT-SELECTIVE VASOCONSTRICTOR EFFECT OF NORMORMIDE
1Cavalli Maurizio, 2Papparella Italia, 2Ceolotto Giulio, 1Bova Sergio
1Department of Pharmacology and Anesthesiology, University of Padova; 2Department of Clinical and Experimental Medicine, University of Padova

61. HYDROGEN SULPHIDE INVOLVEMENT IN VASCULAR TONE IN DIABETIC RATS
d’Emmanuele di Villa Bianca Roberta, Sorrentino R., Mitidieri E. and Sorrentino R.
Department of Experimental Pharmacology, University of Naples Federico II

62. HYPERGLYCEMIA-MEDIATED OVEREXPRESSION OF CYCLOOXYGENASE-2 (COX-2) PARTICIPATES IN VASCULAR HYPOREACTIVITY OF STREPTOZOTOCIN-INDUCED TYPE I DIABETES
Tarquinio Mariela, Nacci Carmela, De Benedictis Leonarda, Montagnani Monica
Department of Pharmacology and Human Physiology - Medical School - University of Bari, 70124 Bari, ITALY

63. NEUTROPHIL-DEPENDENT CEREBRAL OEDEMA IN NORMAL AND DIABETIC RAT: ROLE OF TRANSCELLULAR SYNTHESIS OF CYSTEINIL LEUKOTRIENES
Brivio Ivan, Buccellati C, Di Gennaro A, Folco G, Sala A.
Center for Cardiopulmonary Pharmacology, Dep. of Pharmacological Sciences, University of Milan

64. ANGIOTENSIN II INVOLVEMENT IN REMODELLING OF CAROTIDS SUBJECTED TO PRESSURE OVERLOAD
Bianco Giuseppe1, Mitidieri Emma2, d’Emmanuele di Villa Bianca Roberta2, Pinto Aldo1, Autore Giuseppina1, Sorrentino Raffaella2
1Dipartimento di Scienze Farmaceutiche, Università di Salerno, Salerno; 2Dipartimento di Farmacologia Sperimentale, Università di Napoli, Federico II

65. EVALUATION OF THE EFFECT OF TWO DIFFERENT DOSES OF ASPIRIN IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFT (CABG)
Brambilla Marta 1, Centenaro Chiara2, Tremoli Elena1,2, Parolari Alessandro2, Camera Marina1,2
1Dept. Pharmacological Sciences, University of Milan; 2Centro Cardiologico Monzino IRCCS, Milan, Italy

66. POLYDEOXYRIBONUCLEOTIDE (PDRN) INCREASES VEGF PRODUCTION AND BLOOD FLOW IN AN EXPERIMENTAL MODEL OF HIND LIMB ISCHEMIA IN RATS
Fiumara Tiziana1, Polito Francesca1, Bitto Alessandra1, Minutoli Letteria1, Di Stefano Vincenzo1, Altavilla Domenica1, Cattarini Giulia2, Caputi Achille P1, Squadrito Francesco1
1Department of Clinical and Experimental Medicine and Pharmacology, University of Messina and 2Mastelli srl, Sanremo, Italy

67. HYDROGEN SULFIDE (H2S) INHIBITS AGGREGATION OF HUMAN PLATELETS
Giovanni Zagli1, Patacchini R.2, Trevisani M.1, Abbate R.1, Cinotti S.1, Gensini GF.1, Masotti G.1 and Geppetti P.1
1Department of Critical Care Medicine & Surgery, University of Florence, Florence, Italy; 2Department of Pharmacology, Chiesi Pharmaceuticals, Parma, Italy

68. SERCA2 PUMP EXPRESSION AND PHOSPHORILATED PHOSPHOLAMBAN IN MECHANICAL-INDUCED VENTRICULAR HYPERTROPHY IN RATS
Popolo Ada, Morello S., 1D’Emmanuele di Villa Bianca R., Marzocco S., 1Sorrentino R., Autore G. and Pinto A.
Department of Pharmaceutical Sciences, University of Salerno; 1Department of Experimental Pharmacology, University of Napoli “Federico II”

69. NITRIC OXIDE DONORS: ANTI-AGGREGATING EFFECTS AND MECHANISMS OF INHIBITION OF PLATELET AGGREGATION
Priora Raffaella, Margaritis A., Frosali S., Summa D., Di Giuseppe D., Di Simplicio P.
Department of Neuroscience, Pharmacology Unit, University of Siena

70. EFFECTS OF HYPERBARIC OXYGEN THERAPY ON THROMBOCYTOPENIA AND PLATELET AGGREGATION DURING AN EXPERIMENTAL MODEL OF MULTIPLE ORGAN FAILURE SYNDROME
Maria Donniacuo 1, B. Rinaldi 2, A. Capuano 2, G. Liguori 2, F. Imperatore 2, S. Cuzzocrea 3, A. Filippelli 2, F. Rossi 2
1 Doctorate in Pharmacological Sciences and Respiratory Physiopathology, Second University of Naples, Italy; 2 Department of Experimental Medicine and Excellence Center of Cardiovascular Disease, Second University of Naples, Italy; 3 Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy

71. PROXIMAL AND DISTAL EFFECTS OF ARTERIOTOMY IN RAT CAROTIDS: AN EXTENSIVE MICROARRAY ANALYSIS OF GENE EXPRESSION
1Finicelli Mauro, 1Forte Amalia, 4De Luca Pasquale, 2Santè Pasquale, 2Quarto Cesare, 3Onorati Francesco, 3Renzulli Attilio, 1Galderisi Umberto, 2Cotrufo Maurizio, 1Cipollaro Marilena, 1Cascino Antonino, 1Rossi Francesco, 1Berrino Liberato
Dept. of 1Exp. Medicine and 2Cardiothoracic Sciences, Second University of Naples; 3Unit of Cardiac Surgery, University Magna Graecia, Catanzaro; 4BIOGEM S.c.a.r.l., Ariano Irpino

72. EFFECT OF CARBON NANOTUBES ON HUMAN PLATELETS
Russier Julie§, Togna Anna Rita§, Togna Giuseppina I§, Serafino Annalucia*, Almairac Robert**, Fiorito Silvana+
§Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”; *Institute of Neurobiology and Molecular Medicine, CNR, Rome; **Laboratoire des Colloides, Verres, et Nanomateriaux,CNRS - University of Montpellier II; +Department of Experimental Medicine University of Rome “La Sapienza” - CNR

73. ANTIATHEROSCLEROTIC PROPERTIES OF EVEROLIMUS: IN VITRO AND IN VIVO STUDIES
S. Bellosta, R. Baetta, N. Ferri, L. Arnaboldi, M. Canavesi, P. Pfister*, A. Granata, R. Dorent*, A Corsini
Department of Pharmacological Sciences, University of Milan, Milan, Italy; *Novartis Pharma AG, Basel, Switzerland

74. INFECTION AND ATHEROSCLEROSIS: SIMVASTATIN LOWERS THE RISK OF DEVELOPING ATHEROSCLEROSIS BY LIMITING COXSACKIEVIRUS B INFECTION AND THE EXPRESSION OF PRO-INFLAMMATORY MARKERS IN HUMAN VASCULAR ENDOTHELIAL CELLS
Elena Ferioli*, Antonella Bottelli*, Giuseppe Armocida*, PierGiulio Conaldi°
*Department of Medicine and Public Health, University of Insubria, Varese, Italy; ° ISMETT, Palermo, Italy

75. IN VIVO STIMULATION OF LXR INCREASES THE EFFLUX POTENTIAL OF SERA AND PROMOTES THE REVERSE CHOLESTEROL TRANSPORT
Zanotti Ilaria, Potì Francesco, Pedrelli Matteo, Favari Elda, Calabresi Laura *, Moleri Elsa *, Bernini Franco
Dept. of Pharmacological and Biological Sciences and Applied Chemistries, University of Parma, Parma, and *Center E. Grossi Paoletti, Dept. of Pharmacological Sciences, University of Milan, Milan

76. ROLE OF MESNA TO REDUCE HOMOCYSTEINE LEVELS THROUGH SH/SS EXCHANGE REACTION: POSSIBLE THERAPEUTICAL APPLICATIONS IN HYPERHOMOCYSTEINEMIC PATIENTS
Di Giuseppe D., Frosali S., Priora R., Margaritis A., Summa D., Di Simplicio P.
Department of Neuroscience, Pharmacology Unit, University of Siena

77. PROTEIN-THIOL SUBSTITUTION OR PROTEIN DETHIOLATION BY SH/SS ECHANGE REACTIONS: THE ALBUMIN MODEL
Domenico Summa, Ottavia S., Priora R., Frosali S., Margaritis A., Di Giuseppe D., Niccolai N., d Paolo Di Simplicio
Department of Neuroscience, Pharmacology Unit, and Dept of Molecular Biology, University of Siena, 53100 Siena, Italy; *Department of Molecular Biology, University of Siena, 53100 Siena, Italy

78. FLAXSEED OIL SUPPLEMENTATION INCREASES PLASMA AND TISSUE CONCENTRATIONS OF ( -3) FATTY ACIDS IN RATS
Notarangelo Francesca§, Avallone Rossella§, Rustichelli Cecilia#, Campioli Enrico§, Braghiroli Daniela#, Baraldi Mario§°
§Department of Biomedical Sciences, #Department of Pharmaceutical Sciences, Via Campi 287, 41100 Modena, Italy, Pharmacology, °National InterUniversity Consortium for the Study of Natural Active Principles (CINSPAN)

79. SYNTHESIS AND PRELIMINARY BIOLOGICAL EVALUATION OF NEW PARTIALLY FLUORINATED THIOL DUAL INHIBITORS OF NEUTRAL ENDOPEPTIDASE 24.11 AND ANGIOTENSIN CONVERTING ENZYME
Simone Tambaro,a Francesca Olimpieri,b Paolo Lazzari,a Alessandro Volonterio,b Barbara Pittau,a Luca Pani,a,c Matteo Zanda,b
a Neuroscienze PharmaNess S.c.a r.l., c/o POLARIS, Edificio 5, Loc.Piscinamanna, 09010 Pula (CA), Italy; b C.N.R. Istituto di Chimica del Riconoscimento Molecolare, Via Mancinelli 7, 20131 Milano, Italy; d C.N.R. Istituto di Tecnologie Biomediche, Sezione di Cagliari, c/o Neuroscienze PharmaNess S.c.a r.l.

80. CARDIOPROTECTIVE ACTIVITY OF SIDENAFIL IN RATS WITH CHRONIC NITRIC OXIDE SYNTHASE INHIBITION
Manfredi Barbara, De Gennaro Colonna Vito, Berti Ferruccio, Rossoni Giuseppe
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Italy

81. NOCICEPTIN/ORPHANIN FQ-INDUCED INHIBITION OF ELECTRICAL ACTIVITY IN DORSAL RAPHE NUCLEUS SLICES FROM NORMAL AND STRESSED RATS
Barbieri Mario, Nazzaro Cristiano, Beani Lorenzo, Siniscalchi Anna
Department of Clinical and Experimental Medicine University of Ferrara, Via Fossato di Mortara, 17-19; 44100 Ferrara

82. PHARMACOLOGICAL CHARACTERIZATION OF THE NOCICEPTIN/ORPHANINN FQ RECEPTOR ANTAGONIST SB-612111: IN VIVO STUDIES
1Rizzi Anna, 1Gavioli Elaine, 1Marzola Giuliano, 1Spagnolo Barbara, 1Zucchini Silvia, 2Ciccocioppo Roberto, 3Trapella Claudio, 1Regoli Domenico and 1Calo’ Girolamo
1Dept. of Pharmacology and 3Dept of Pharmaceutical Science, University of Ferrara, Italy; 2Dept. of Experimental Medicine and Public Health, University of Camerino, Italy

83. FUNCTIONAL ANTAGONISM BETWEEN NOCICEPTIN/ORPHANIN FQ (N/OFQ) AND CRF IN THE RAT BRAIN: EVIDENCE FOR INVOLVEMENT OF THE BED NUCLEUS OF THE STRIA TERMINALIS
Rodi Donata (1), Zucchini Silvia (1), Simonato Michele (1), Cifani Carlo (2), Massi Maurizio (2), Polidori Carlo (2)
1) Department of Clinical and Experimental Medicine, Pharmacology Section, and Neuroscience Centre, University of Ferrara; 2) Department of Experimental Medicine and Publich Health, University of Camerino

84. ANTICONVULSANT EFFECTS OF ORPHANIN FQ ON SEIZURES INDUCED BY PENTYLENETETRAZOLE
Di Giannuario Amalia1, Colucci Mariantonella1, Maione Francesco1,2, Mascolo Nicola2, Pieretti1 Stefano
1Department of Drug Research and Evaluation, Istituto Superiore di Sanità, V.le Regina Elena 299 - 00161 Rome. 2Department of Experimental Pharmacology, University of Naples Federico II, Via Domenico Montesano 49 - 80131 Naples

85. EFFECT OF NOVEL NOCICEPTIN/ORPHANIN FQ-NOP RECEPTOR LIGANDS ON FOOD INTAKE IN WISTAR RATS
Cifani Carlo a, Polidori Carlo a, Calò Girolamo b, Massi Maurizio a
a Department of Experimental Medicine and Public Health, University of Camerino, I-62032, Camerino, Italy; b Department of Experimental and Clinical Medicine, Section of Pharmacology and Neuroscience Center, University of Ferrara, I-44100 Ferrara, Italy

86. CHRONIC I.C.V. TREATMENT WITH [NPHE1, ARG14, LYS15] N/OFQ-NH2 (UFP-101), A POTENT NOP RECEPTOR ANTAGONIST, REVERSES BEHAVIOURAL AND BIOCHEMICAL EFFECTS OF CHRONIC MILD STRESS IN RATS
Vitale Giovanni a, Ruggieri Valentina a, Frigeri Claudio a, Filaferro Monica a, Guerrini Remo b and Maurizio Massi c
a Department of Biomedical Sciences, Section of Pharmacology, University of Modena and Reggio Emilia; b Department of Pharmaceutical Sciences , University of Ferrara; c Department of Pharmacological Sciences and Experimental Medicine, University of Camerino

87. NOCICEPTIN/ORPHANIN FQ AND FOOD INTAKE IN DISEASE-PRONE WOKW AND DISEASE-RESISTANT DA RATS
Cifani Carlo a, Filippetti Roberta a, Kloting Ingrid b, Massi Maurizio a and Polidori Carlo a
a Department of Experimental Medicine and Public Health, University of Camerino, I-62032 Camerino, Italy - b Department of Laboratory Animal Science, Medical Faculty, University of Greifswald, D-17495 Karlsburg, Germany

88. THE NEURODIFFERENTIATIVE EFFECT OF ESTROGEN INVOLVES NUCLEAR RECEPTORS AND IS MEDIATED BY TGF-B
Merlo Sara1,2, Canonico Pier Luigi2, Copani Agata3, Sortino Maria Angela1
Departments of 1Experimental and Clinical Pharmacology and 3Pharmaceutical Sciences, University of Catania, and 2DISCAFF, University of Piemonte Orientale, Novara

89. ERYTHROPOIETIN INHIBTS THE RELEASE, BUT NOT SYNTHESIS, OF CORTICOTROPIN-RELEASING HORMONE FROM RAT HYPOTHALAMIC EXPLANTS IN VITRO
Tringali Giuseppe, Lisi Lucia, Pozzoli Giacomo, Navarra Pierluigi
Institute of Pharmacology, Catholic University Medical School, Rome, Italy

90. NEUROCHEMICAL EFFECTS OF POST-WEANING SOCIAL ISOLATION IN ADULT RAT BRAIN
Colaianna Marilena (a), De Giorgi Angelo (a), Cuomo Vincenzo (b), Trabace Luigia (a)
(a)Dept. Biomedical Sciences, University of Foggia, Foggia, Italy; (b)Dept. of Human Physiology and Pharmacology, Vittorio Espamer, University of Rome La Sapienza, Rome, Italy

91. STRAIN-DEPENDENT LEVELS OF BIOGENIC AMINE IN POST-WEANING SOCIALLY-ISOLATED RATS
Castrignanò Silvia(a), Zotti Margherita(a), Cuomo Vincenzo(b), Trabace Luigia(a)
(a)Dept. of Biomedical Sciences, University of Foggia; (b)Dept. of Human Physiology and Pharmacology, Vittorio Espamer, University of Rome La Sapienza, Rome, Italy

92. SELECTIVE VOLUME REDUCTION OF ANTERIOR CINGULATE CORTEX IN YOUNG ADULT RATS AFTER NEONATAL EXCITOTOXIC LESION OF VENTRAL HIPPOCAMPUS
Gianluca Casu,* Giorgio Marchese,* Paola Casti,* Gabriele Pinna Spada,* Luca Pani,*,§

*Neuroscienze PharmaNess S.c.a r.l., c/o POLARIS, Edificio 5, Loc.Piscinamanna, 09010 Pula (CA), Italy; §C.N.R. Istituto di Tecnologie Biomediche, Sezione di Cagliari, c/o Neuroscienze PharmaNess S.c.a r.l.

93. ACUTE BUT NOT CHRONIC TREATMENT WITH OLANZAPINE REDUCES EXPERIMENTAL ANXIETY IN RATS: POSSIBLE MECHANISMS
Locchi Federica, Rimondini Roberto, Dall’Olio Rossella, Gandolfi Ottavio
Department of Pharmacology, University of Bologna, 40128 Bologna, Italy

94. GENDER DIFFERENCES ON LONG TERM EFFECTS OF RAT PRENATAL STRESS ON DORSAL AND VENTRAL HIPPOCAMPAL METABOTROPIC GLUTAMATE RECEPTORS AND ANXIETY BEHAVIOUR
Zuena Anna Rita1,2, Casolini Paola1, Mairesse Jerome1,2, Cinque Carlo1, Matteucci Patrizia1, Alemà Giovanni Sebastiano1, Morley-Fletcher Sara2, Catalani Assia1, Nicoletti Ferdinando1,3, Maccari Stefania2.
1Dept of Human Physiology and Pharmacology, Univesity of Rome “La Sapienza”, Italy; 2Lab of Perinatal Stress, University of Lille 1, France; 3INM Neuromed, Pozzilli, Italy

95. POST-NATAL REPEATED MILD STRESS INDUCES CHANGES IN BRAIN NAD(P)H RECYCLING IN ADULT MALE MICE: ROLE OF THE OPIOID SYSTEM
Stefano Loizzo, Irene Guarino, Gabriella Galietta, Andrea Fortuna, Alberto Loizzo, Santi Spampinato, Gabriele Campana, Anna Capasso, Flavia Franconi
Section of Drugs and Health for the Child and the Woman, Dept of Drug Research and Evaluation, and National Centre for Rare Diseases, Istituto Superiore di Sanita’, Roma, Dept of Pharmacology, University of Bologna, Dept of Pharmacology, University of Salerno, Dept of Pharmacology and Centre of Excellence for Biotechnology and Biodiversity University of Sassari, and GIOIA Foundation

96. CHANGES IN HIPPOCAMPAL GENE EXPRESSION PROFILE FOLLOWING ACUTE AND CHRONIC STRESS IN THE MOUSE
Ubaldi Massimo1, Lourdusamy Anbarasu1, Soverchia Laura1, Cippitelli Andrea1, Barbara Ruggeri1, Gary Hardiman2, Ciccocioppo Roberto1
1Department of Experimental Medicine and Public Health, University of Camerino Italy; 2Department of Medicine, University of California San Diego, CA, USA

97. TREATMENT OF PREMENSTRUAL SYNDROME WITH CONTINUOUS LOW DOSAGE SERTRALIN
Walter Milano, Emanuela Tammaro*, Luca Milano, Sara Rundle-Smith, Claudio Petrella, Anna Capasso*
Mental Health Operations Unit District 44 ASL Napoli 1 and *Department of Pharmaceutical Sciences, University of Salerno, Italy

98. NOVEL THERAPEUTIC OPPORTUNITIES IN UNIPOLAR DEPRESSION
Mauro Corsi, W.P.
Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithkline S.p.A., Verona, Italy

99. LIFESTYLE INTERVENTIONS ON BODYWEIGHT GAIN OLANZAPINE-INDUCED: RESULT FROM A RANDOMIZED-CONTROLLED TRIAL
Michela Cammarano*, Walter Milano, Margherita Comazzi°, Luca Milano, Claudio Petrella, Anna Capasso*
Unità Operativa Salute Mentale Distretto 44 ASL Napoli1; * Department of Pharmaceutical Sciences, University of Salerno, Italy; ° Unità di Psichiatria Azienda Ospedaliera di Melegnano Milano

100. TOLERABILITY OF ANTIPSYCHOTICS IN CHILDREN AND ADOLESCENTS: A PROSPECTIVE STUDY
Marianna Alacqua1, Gianluca Trifirò1,4, Vincenzo Arcoraci1, Eva Germanò2, Antonella Gagliano2,Mariarosa Siracusano2, Giuseppa Di Vita3, Catalda Gagliano3, Edoardo Spina1, 4
1Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Italy - 2 Division of Child Neurology and Psychiatry, University of Messina, Italy - 3 Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Troina, Italy; 4 IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy

101. PLASMA CONCENTRATIONS OF QUETIAPINE DURING COADMINISTRATION WITH ANTIEPILEPTIC DRUGS IN PSYCHIATRIC PATIENTS
D’Arrigo Concetta1, Migliardi Gaetana1, Santoro Vincenza2, Muscatello Maria Rosaria3, Zoccali Rocco3 and Spina Edoardo1,2
1Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, 2IRCCS Centro Neurolesi “Bonino-Pulejo” and 3Department of Neurosciences, Psychiatric and Anesthesiological Sciences, University of Messina, Messina, Italy

102. POTENTIAL APPLICATION OF TESTOSTERONE METABOLITES IN THE TREATMENT OF ADRENOLEUKODYSTROPHY
Romina Carissimi1, Milena Blasevich1, Marco Cappa2, Graziella Uziel3, Anna Petroni1
1Depart. of Pharmacological Sciences, University of Milan, via Balzaretti 9, 20133 Milan, Italy; 2Depart. of Pediatrics Medicine, Children’s Hospital “Bambino Gesù”, IRCCS, Rome, Italy; 3Child Neurology Dep., Istituto Neurologico “C. Besta”, Milan, Italy

103. DEVELOPMENT OF SPECIFIC BIOMARKERS FOR ALS CLINICAL PROGRESSION: VALIDATION AND POTENTIAL ROLES IN PATHOGENESIS
Bonini Sara A.1, Zhao Zhong2, Lange Dale J3., Ho Lap2, Yemul Shrishailam2, Wang Jun2, Salton Steven4, Memo Maurizio1, Pasinetti Giulio M.2
1 Department of Biomedical Sciences and Biotechnologies, University of Brescia, Brescia, Italy; 2 Department of Psychiatry, 3 Department of Neurology,4 Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA

104. FUNCTIONAL HETEROGENEITY OF HISTAMINERGIC NEURONS SUGGEST INTERESTING APPLICATIONS OF GSK189254, A NOVEL H3 RECEPTOR ANTAGONIST
Patrizia Giannoni1, M.Beatrice Passani1, Daniele Nosi2, Andrew D. Medhurst3, Paul Chazot4, Fiona Shenton4 and Patrizio Blandina1
1Dipartimento di Farmacologia Preclinica and Clinica, 2Dipartimento di Anatomy Universita’ di Firenze Italy, 3Neurology Centre of Excellence for Drug Discovery,GlaxoSmithKline,Essex CM19 5AW, UK, 4Centre for Integrative Neuroscience, School of Biological and Biomedical Sciences, Durham University, UK

105. IMPROVEMENTS IN LONG-TERM MEMORY RETENTION BY INHIBITION OF FATTY ACID AMIDE HYDROLASE (FAAH) ARE MEDIATED BY A-TYPE PEROXISONE PROLIFERATOR-ACTIVATED RECEPTORS (PPARA) AND NOT BY CANNABINOID CB1 RECEPTORS
Mazzola C1, , Medalie J1, Panlilio LV1, Solinas M2, Drago F3, Goldberg SR1 and Yasar S4
1 Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, NIDA, NIH, DHHS, Baltimore, MD, 21224, USA.2 Department Laboratoire de Biologie et Physiologie Cellulaires, CNRS-6187, Université de Poitiers, 86022, Poitiers, France. 3 Department of Experimental and Clinical Pharmacology, Medical School, University of Catania, Italy. 4 Division of Geriatric Medicine, Johns Hopkins Medical School, Baltimore, MD, 21224, USA

106. TRICYCLIC PYRAZOLES. SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL 4,5-DIHYDRO-1H-6-OXA-CYCLOHEPTA[1,2-C]PYRAZOLE-BASED ANALOGUES OF CANNABINOID ANTAGONIST NESS 0327
Christian Dessì,‡, Gabriele Murineddu,† Stefania Ruiu,‡ Giovanni Loriga,† Ilaria Manca,† Paolo Lazzari,‡ Amedeo Pau,† Roberta Reali,‡ Gérard A. Pinna† and Luca Pani‡,§
‡Neuroscienze PharmaNess S.c.a r.l., c/o POLARIS, Edificio 5, Loc.Piscinamanna, 09010 Pula (CA), Italy; †Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, Via F. Muroni 23/A, 07100 Sassari, Italy; §C.N.R. Istituto di Tecnologie Biomediche, Sezione di Cagliari, c/o Neuroscienze PharmaNess S.c.a r.l.

107. EARLY AND LATE POST-MORTEM NEURAL STEM CELLS GROW AND DIFFERENTIATE IN VITRO. A NOVEL SOURCE FOR CELLULAR THERAPY
Laura Madaschi1*, Giovanni Marfia1*, Daniela Cigognini1, Daniele Bottai1,2 , Anna Maria Di Giulio1, Alfredo Gorio1,2
1) Dept. of Medicine, Surgery and Dentistry, Faculty of Medicine, University of Milan, Italy; 2) Clinical Pharmacology IRCCS Humanitas, Milan, Italy; * These two authors equally contributed at this work

108. CALCINEURIN PRIMES GNRH-SECRETING NEURONS FOR MIGRATION
Zaninetti Roberta, Tacchi Sara, Erriquez Jessica, Distasi Carla, Maggi Roberto*, Canonico PierLuigi, Genazzani Armando A.
Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche Farmacologiche, Drug and Food Biotechnology Center, Università degli Studi del Piemonte Orientale “A. Avogadro”, Novara *Laboratorio di Neuroendocrinologia dello Sviluppo, Istituto di Endocrinologia, CEND, Università degli Studi di Milano

109. THE GHB-ANALOGUE, GET 73, PREVENTS EITHER THE DEVELOPMENT OF PREFERENCE FOR SUCROSE IN NON-STRESSED RATS, OR THE REDUCTION OF SUCROSE INTAKE IN CHRONICALLY STRESSED RATS

Tacchi Raffaella1, Ferrari A1, Pinetti D1, Sternieri E1, Bertolini A1, Ottani A2

1Dipartimento Integrato di Servizi Diagnostici e di Laboratorio, Struttura Complessa di Tossicologia e Farmacologia Clinica, Università di Modena e Reggio Emilia; 2Dipartimento di Scienze Biomediche, Sezione di Farmacologia, Università di Modena e Reggio Emilia

110. STANDARDIZED ANALYSIS OF C-FOS MRNA EXPRESSION PATTERN IN RAT BRAIN AUTORADIOGRAPHY USING FREEWARE IMAGING SOFTWARE
Dipasquale Pasqua, Celentano Michele, Righetti Laura, Lucchino Ilaria, Gaetani Silvana and Cuomo Vincenzo
Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”

111. GPR17: A NEW DUAL RECEPTOR FOR BOTH EXTRACELLULAR NUCLEOTIDES AND CYSTEINYL-LEUCOTRIENES INVOLVED IN BRAIN ISCHEMIA
Gelosa Paolo1, Sironi Luigi1, Guerrini Uliano1, Tremoli Elena1,2, Enrico Rovati1, Patrizia Rosa3, Lecca Davide1, Pignieri Alice1, Abbracchio Maria P1* and Cimino Mauro4*
1Department of Pharmacological Sciences, University of Milan, Italy - 2Monzino Cardiologic Centre IRCCS, Milan, Italy - 3CNR Institute of Neuroscience, Cellular and Molecular Pharmacology, Milan, Italy - 4Institute of Pharmacology and Pharmacognosy, University of Urbino, Italy; *equally contributed to the present work

112. APOMORPHINE-INDUCED NEURODEGENERATION IN MONGOLIAN GERBIL HIPPOCAMPUS
Donato Giuseppe1, Russo E.1, De Fazio S.1, De Fazio P.1, Perrotta I.2, De Sarro G.1
1Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Catanzaro, Italy; 2Ecology Department, University of Calabria, Cosenza, Italy

113. BLUNTED HPA AXIS ACTIVITY DURING ISCHEMIA PROTECTS ADULT RATS NEONATALLY EXPOSED TO GLUCOCORTICOIDS AGAINST BRAIN DAMAGE
Cinque Carlo1, Mairesse Jerome3, Casolini Paola1, Domenici Maria Rosaria2, Galluzzo Mariangela2, Musumeci Marco2, Alemà Giovanni Sebastiano1, Zuena Anna Rita1, Matteucci Patrizia1, Maccari Stefania3, Nicoletti Ferdinando1,4, Catalani Assia1
1. Dep. of Human Physiol & Pharmacol, University “Sapienza”, Rome, Italy; 2. Dep. of Pharmacol, Istituto Superiore di Sanità, Rome, Italy; 3. Lab. Perinatal Stress, JE2365. University of Lille 1, 59655 Villeneuve d’Ascq, France; 4. INM Neuromed, Pozzilli, Italy

114. KNOCKING-DOWN AND KNOCKING-OUT OF NCKX2 GENE EXPRESSION EXACERBATE THE BRAIN INSULT INDUCED BY FOCAL ISCHEMIA
Cuomo Ornella, Pignataro G., Gala R., Boscia F., Tortiglione A., Valsecchi V., Di Renzo GF., Lytton J.* and Annunziato L.
Division of Pharmacology, Department of Neuroscience, School of Medicine, , Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy. *Department of Biochemistry and Molecular Biology University of Calgary, Calgary, Alberta, Canada

115. NEUROPROTECTIVE EFFECT OF MELANOCORTINS IN FOCAL CEREBRAL ISCHEMIA
Giuliani Daniela1, Ottani Alessandra1, Mioni Chiara1, Galantucci Maria1, Bazzani Carla1, Zaffe Davide2, Bitto Alessandra3, Minutoli Letteria3, Botticelli Annibale R.4, Altavilla Domenica3, Squadrito Francesco3, Guarini Salvatore1
1Dept. Biomedical Sci., Sect. Pharmacology, and 2Dept. Anatomy and Histology, University of Modena and Reggio Emilia; 3Dept. Clin. Exp. Med. Pharmacol., Sect. Pharmacology, University of Messina; 4Dept. Human Pathology, University of Pavia

116. INDUCTION OF THE WNT INHIBITOR, DICKKOPF-1, IS ASSOCIATED WITH NEURODEGENERATION RELATED TO TEMPORAL LOBE EPILEPSY
Francesca Biagioni1, Carla L. Busceti1, Eleonora Aronica2*, Marianna Storto1, Giuseppe Battaglia1, Filippo S. Giorgi3, Francesco Fornai1,3, Roberto Gradini4, Andrea Caricasole5, Ferdinando Nicoletti1,6, Valeria Bruno1,6
1I.N.M. Neuromed, Pozzilli, Italy; 2Dept. of Neuropathol., Univ. of Amsterdam, The Netherland; 3Dept. of Hum. Morphol., Univ. of Pisa, Italy; 5SienaBiotech, Siena, Italy; 5Dept. of Exp. Med. and 6Hum. Physiol. And Pharmacol. , Univ. “La Sapienza”, Rome, Italy

117. STIMULATION OF PROTEINASE-ACTIVATED RECEPTORS 1 AND 2 INDUCES NEURODEGENERATION IN THE RAT OLFACTORY SYSTEM
Simona Dedoni, Maria C. Olianas, Luciana Garau and Pierluigi Onali
Section of Biochemical Pharmacology, Department of Neuroscience, University of Cagliari, Cagliari, Italy

118. HISTONE DEACETYLASE (HDAC) INHIBITORS REDUCE THE IN VITRO AND IN VIVO NEUROINFLAMMATORY RESPONSE IN MICE
Faraco Giuseppe, Fossati Silvia, Formentini Laura, * Mascagni Paolo, * Fossati Gianluca, * Leoni Flavio, Moroni Flavio e Chiarugi Alberto
Dipartimento di Farmacologia Clinica e Preclinica, Università degli Studi di Firenze *Italfarmaco S.p.a., Milan, Italy

119. NEUROPROTECTION BY 17B-ESTRADIOL IN WHOLE RAT URINARY BLADDER SUBJECTED TO ISCHAEMIA/REPERFUSION INJURY
Valeri Aurora, Pessina F., Sgaragli G.
Dip. Scienze Biomediche, Università degli Studi di Siena, Via Aldo Moro 2 , 53100 Siena

120. HEME OXYGENASE ACTIVITY IN IMMORTALIZED HYPOTHALAMIC NEURONS GT1-7
Mores Nadia, Mancuso Cesare, Errico Stefania, Barone Eugenio, Preziosi Paolo
Istituto di Farmacologia – Facoltà di Medicina e Chirurgia
Università Cattolica del Sacro Cuore - Roma

121. SPINAL CORD INJURY AND NEURAL PRECURSORS. HOMING, FATE AND RECOVERY OF FUNCTION
Bottai Daniele 1,2, Maraschi Laura 1, Di Giulio Anna Maria1 and Gorio Alfredo 1,2
1) Department of Medicine, Surgery and Dentistry, University of Milan, Via A. di Rudinì 8, 20142 Milano, Italy; 2) Clinical Pharmacology IRCCS Humanitas Via Manzoni 56, 20089 Rozzano, Milano, Italy

122. MELATONIN PROTECTS FROM THE LONG-TERM MORPHOLOGICAL AND FUNCTIONAL CONSEQUENCES OF A NEONATAL HYPOXIC-ISCHEMIC BRAIN INJURY IN RATS
Silvia Carloni, Giuseppe Buonocore1, Serafina Perrone1, Mariangela Longini1, Fabrizio Proietti1, Walter Balduini
Istituto di Farmacologia e Farmacognosia, Università degli Studi di Urbino “Carlo Bo”, Via S. Chiara 27, Urbino; 1Dipartimento di Pediatria, Ostetricia e Medicina della Riproduzione, Sezione di Neonatologia Università di Siena, Policlinico Le Scotte Via M. Bracci, Siena

123. PENTOXIFYLLINE AMELIORATES CALCIUM HOMEOSTASIS AND IMPROVES REGENERATION IN SKELETAL MUSCLE OF DYSTROPHIC MDX MICE: A COMPARISON WITH THE EFFECTS OF A COMBINED TREATMENT PREDNISOLONE-TAURINE
Burdi Rosa1, Rolland Jean-François1, Cozzoli Anna1, Giannuzzi Viviana1, Liantonio Antonella1, Camerino Giulia M.1, Andreetta Francesca2, Confalonieri Paolo2, Mangieri Domenica 3, Nico Beatrice3, De Luca Annamaria 1
1Unit of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, Italy; 2Muscular Pathology Unit, National Neurological Institute Carlo Besta, Milan, Italy, 3Department of Human Anatomy and Histology, University of Bari, Italy

124. EFFECT OF A CHRONIC TREATMENT WITH GENTAMICIN ON IN VIVO AND EX VIVO MARKERS OF DYSTROPHIC PROGRESSION IN MDX MOUSE
Cozzoli Anna1, Burdi Rosa1,Cippone Valentina1, Nicchia Grazia P.2, Frigeri Antonio2, Camerino Giulia M.2, Mangieri Domenica3, Nico Beatrice3 and De Luca Annamaria1
1Dept. of Pharmacobiology, Faculty Pharmacy and 2Dept. of General and Environmental Physiology, 3Department of Human Anatomy and Histology, University of Bari, Italy

125. VEGF OVEREXPRESSION VIA ADENO-ASSOCIATED VIRUS GENE TRANSFER PROMOTES SKELETAL MUSCLE REGENERATION AND ENHANCES MUSCLE FUNCTION IN MDX MICE
Di Stefano Vincenzo1, Bitto Alessandra1, Minutoli Letteria1, Altavilla Domenica1, Messina Sonia2, Vita Giuseppe2, Giacca Mauro3, Caputi Achille P.1 and Squadrito Francesco1
1Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, 2Dept of Neurosci, Psych and Anaesthesiol, University of Messina, 3Mol Med Lab, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy

126. POSSIBLE ANTIOXIDANT EFFECT OF SULPHUR MUD- BATH THERAPY IN TREATMENT OF OSTEOARTHROSIS
1,2Costantino Maria, 2Lampa Enrico, 3Giuberti Gaia, 3Caraglia Michele, 3Abbruzzese Alberto, 2Filippelli Amelia
1CE.RI.S.T. (Center of Thermal Researches and Studies srl), Naples, Italy; 2Department of Experimental Medicine–Pharmacological Division, II University of Naples-Italy; 3Department of Biochemistry and Biophysics “F. Cedrangolo” – II University of Naples, Naples, Italy

127. BILIRUBIN MODULATES NEUROTROPHIN REDOX SIGNALING
Mancuso Cesare1, Eboli Maria L.2, Calabrese Vittorio3, Preziosi Paolo1, Galeotti Tommaso2, Pani Giovambattista2.
From the Institutes of 1Pharmacology and 2General Pathology, Catholic University School of Medicine, Largo F. Vito, 1 - 00168 Roma, Italy; 3Dept. of Chemistry, Biochemistry and Mol. Biology Section, Faculty of Medicine, University of Catania, 95100, Catania, Italy

128. A STUDY ON BIOLOGICAL ACTIVITIES OF CYANIDIN-3-O-GLUCOSIDE RELATED TO ITS ANTIOXIDANT PROPERTIES
1Speciale A.,1Cimino F., 1Chirafisi J., 1Cristani M., 2Ermito S., 1Spinzia C., 1Saija A.
1Dept. Farmaco-Biologico, School of Pharmacy, University of Messina - Vill. SS. Annunziata 98168 Messina, Italy. 2Institute of Gynecology and Obstetrics, University of Messina, Italy

129. PROTECTIVE EFFECT OF MN(III) TETRAKIS (4-BENZOIC ACID) PORPHYRIN ON THE INACTIVATION OF PRIMARY ANTIOXIDANT ENZYMES IN KERATINOCYTES BY PHOTODYNAMICALLY GENERATED FREE RADICALS
Carolina Muscoli1, Steven Nistico’2, Rosaria Arcone1, Carmen Colica1, Valeria Visalli1, Domenica Vetrice1, Francesca Casale1, Immacolata Del Vecchio3, Maria Concetta Strongoli3, Vincenzo Mollace1 and Domenicantonio Rotiroti3
1Dept of Pharmacobiol. Sciences, University of Catanzaro Magna Graecia, Italy; 2 School of Medicine, Univesity of Rome “Tor Vergata”; 3ISN-CNR

130. ANTICATARACTOGENIC PROPERTY OF G-GLUTAMYLCYSTEINE ETHYL ESTER IN AN ANIMAL MODEL OF CATARACT
Pannini Simone, Barberi Luigi, Leone Raffaele L, Casini Piero
Department of Farmacology “G. Segre”, University of Siena

131. ASSESSMENT OF BLOOD AND SALIVARY ANTIOXIDANT SYSTEM IN SUBJECTS WITH PERIODONTITIS AND PERI-IMPLANTITIS
Fiaschi Anna Ida, *Ruggero Grazia, De Vuono Giulia, Cerretani Daniela, *Cozzolino Annunziata
Department of Pharmacology “G. Segre”, *Department of Odontostomatologic Science, Maxillo-Facial Surgery Division, University of Siena

132. STATUS OF LIPID PEROXIDATION IN PATIENTS WITH OSTEOARTHRITIS UNDERWENT A TAMMEF SYSTEM
Fiaschi Anna Ida, *Battisti Emilio, *Albanese Antonietta, Cerretani Daniela, Runci Francesco
Department of Pharmacology “G. Segre”, *Centre TAMMEF, University of Siena

133. REPEATED TREATMENT WITH AM404 REDUCES MECHANICAL ALLODYNIA AND THERMAL HYPERALGESIA IN A MODEL OF NEUROPATHIC PAIN WITHOUT CENTRAL EFFECTS
Sasso Oscar, La Rana G., Russo R., D’Agostino G., Iacono A., Meli R. and Calignano A.
Dep Experimental Pharmacology, Faculty of Pharmacy, via D. Montesano 49-Naples

134. ANTIHYPERALGESIC AND ANTIALLODYNIC EFFECT OF PURINERGIC ANTAGONISTS IN A MOUSE MODEL OF MONONEUROPATHY: NEUROINFLAMMATORY INVOLVED MECHANISMS
Trovato Anna Elisa1, Franchi Silvia1, Magnaghi Valerio2, Panerai Alberto E.1, Procacci Patrizia4, Rodella Luigi F.3, Sacerdote Paola1, Valsecchi Anna E.1 and Colleoni Mariapia1
1Dep. Pharmacol. Chem. Med. Toxicol, Univ. of Milan, 2Dep. Endocrinol, Center Excell. Neurodegen. Dis., Univ. of Milan, 3Divis. Anat., Dep. Biomedic. Sci. Biotechnol., Univ. of Brescia, 4Inst. Histol. Embriol. Neurocytol., Univ. of Milan

135. PHYTOESTROGEN GENISTEIN REDUCES NOCICEPTIVE HYPERSENSITIVITY IN THE MOUSE CHRONIC CONSTRICTION INJURY MODEL
Valsecchi Anna E., Franchi Silvia, Panerai Alberto E., Sacerdote Paola, Trovato Anna E. and Colleoni Mariapia
Departement of Pharmacology, Chemoterapy and Medical Toxicology, University of Milan

136. BLOCKADE OF THE TRPV1 RECEPTOR AND OF THE FATTY ACID AMIDE HYDROLASE ENZYME IN A MOUSE MODEL OF NEUROPATHIC PAIN PREVENTS PAIN-LIKE BEHAVIOUR AND CASPASES ACTIVATION
Giordano Catia, Siniscalco Dario, Migliozzi Annalucia, Rossi Francesco, Di Marzo Vincenzo°, Maione Sabatino
Istituto di Chimica Biomolecolare, CNR, Pozzuoli (NA), Italy; Department of Experimental Medicine, section of Pharmacology, Second University of Naples, Via S. Maria di Costantinopoli 16 – 80138 Naples, Italy

137. THE FATTY-ACID AMIDE HYDROLASE INHIBITOR URB597 REDUCES NEUROPATHIC PAIN AFTER ORAL ADMINISTRATION IN MICE
Roberto Russo, Giovanna La Rana, Giuseppe D’Agostino, Oscar Sasso, Jesse LoVerme, Daniele Piomelli and Antonio Malignano
Department of Experimental Pharmacology, University of Naples, Italy.; Department of Pharmacology and the Center for Drug Discovery, University of California, Irvine

138. N-ARACHIDONOYL-SEROTONIN: A FATTY ACID AMIDE HYDROLASE INHIBITOR WITH ANTAGONISTIC ACTIVITY AT TRPV1 RECEPTORS AND ANALGESIC PROPERTIES IN VIVO
Palazzo Enza1, De Petrocellis Luciano2, Petrosino Stefania2, Gatta Luisa1, Guida Francesca1, Ortar Giorgio3, Rossi Francesco1, Maione Sabatino1, Di Marzo Vincenzo2
1Department of Experimental Medicine, Section of Pharmacology “L. Donatelli”, Second University of Naples, via Costantinopoli 16, 80138 Naples. 2Endocannabinoid Research Group, Institutes of Cybernetics and of Biomolecular Chemistry, CNR, Pozzuoli (Naples).3Dipartimento di Studi Farmaceutici, Università di Roma 'La Sapienza”, Roma

139. A NOVEL PHARMACOLOGICAL APPROACH FOR THE TREATMENT OF NEUROPATHIC PAIN: TOLL-LIKE RECEPTOR 4 ANTAGONISTS AS MODULATORS OF ACTIVATED MICROGLIA
Costa Barbara, Comelli Francesca, Peri Francesco, Francesca Granucci, Isabella Bettoni, Rossini Clara, Giagnoni Gabriella
Department of Biotechnology and Bioscience, University of Milano-Bicocca

140. ETHANOL CAUSES NEUROGENIC VASODILATATION BY TRPV1 ACTIVATION AND CGRP RELEASE IN THE TRIGEMINOVASCULAR SYSTEM OF THE GUINEA PIG
S. Benemei1, P. Nicoletti1, M. Trevisani2, M. Manconi3, G. De Siena1, G. Zagli1, J. A. Capone2, P. Geppetti1, L. A. Pini4
1Clinical Pharmacology Unit, Department of Critical care Medicine and Surgery, University of Florence,2Center of Excellence for the Study of Inflammation and Headache Center, University of Ferrara, Ferrara, 4Department of Laboratory Medicine and Forensic Medicine, University of Modena and Reggio Emilia, Italy

141. INSERTION/DELETION POLYMORPHISM OF THE ANGIOTENSIN I-CONVERTING ENZYME GENE IN MIGRAINE PATIENTS
V. Pizza (1), G. Volpe (1), F. Infante (2), G. Schiavo (2), E. Lamaida (1), A. Agresta (1), A. Bisogno (3), A. Bianchi (3), A. Capasso (3)
1) Neurophysiopatology 2) Molecular Biology, S. Luca Hospital, Vallo della Lucania (SA), 3) University of Salerno, Italy

142. GENETIC POLYMORPHISMS AND MIGRAINE
V. Pizza (1), G. Volpe (1), F. Infante (2) E. Lamaida (1), A. Agresta (1), F. Longobardi (3), A. Bisogno (3), A. Bianchi (3), A. Capasso (3)
(1)Neurophysiopatology Service; (2)Molecular Biology Service, S. Luca Hospital, Vallo della Lucania (SA), ASL SA/3; (3)Department of Pharmaceutical Sciences, University of Salerno, Italy.

143. LONG-TERM INTRATHECAL MORPHINE IN PATIENTS WITH CHRONIC NON-CANCER PAIN UP-REGULATES MU OPIOD RECEPTOR GENE EXPRESSION IN LYMPHOCYTES
Gabriele Campana1, William Raffaeli2 Donatella Sarti 2and Santi Spampinato1
1Dept. Of Pharmacology - University of Bologna-Irnerio 48 - 40126 – Bologna; 2 Pain and Palliative Care Unit, Infermi Hospital, Rimini -Via Ovidio - 47900 - Rimini

144. COMPARATIVE PRODUCTION OF THE ACTIVE TRAMADOL METABOLITE O-DESMETHYL-TRAMADOL (M1) IN DOMESTIC ANIMAL SPECIES
Zonca Annalisa*, Cagnardi Petra *, Villa Roberto*, Ravasio Giuliano#, Vettorato Enzo$, Isola Maurizio$, Montesissa Clara§
* Dipartimento di Scienze e Tecnologie Veterinarie per la Sicurezza Alimentare, Milano; §Dipartimento di Sanità Pubblica Patologia Comparata ed Igiene Veterinaria, Padova; #Dipartimento di Scienze Cliniche Veterinarie, Milano; $ Dipartimento di Scienze Cliniche Veterinarie, Padova

145. EFFECT OF UNCONTINGENT AND SUBCHRONIC ADMINISTRATION OF ADDICTIVE DRUGS ON NEURONAL PLASTICITY IN THE RAT NUCLEUS ACCUMBENS
Ibba Federico1, Vinci Stefania1, Spiga Saturnino2, Acquas Elio1, 3 and Di Chiara Gaetano1, 3
1Department of Toxicology and 3Centre of Excellence on Neurobiology of Addiction, University of Cagliari; 2 Department of Animal Biology and Ecology, University of Cagliari

146. TREND OF DRUGS OF ABUSE DETECTION IN THE URINE OF PATIENTS OF THE UNIVERSITY HOSPITAL OF MODENA, DURING THE PERIOD 1997-2006
Coccia Ciro, Ferrari Anna, Castellana Carmela Nives, Poppi Brunella, Pisa Stefania, Bertolini Alfio, Sternieri Emilio
Toxicology and Clinical Pharmacology Section. Department of Laboratory Services University of Modena and Reggio Emilia, Italy

147. DIFFERENCE IN THE DEGREE OF NICOTINE DEPENDENCE AND DEVELOPMENT OF DEPRESSION BETWEEN CANNABIS USERS AND POLIDRUG USERS
Russo Giuseppina A. 1 , Garuana Anna 2, Mannucci Carmen 1, Tedesco Michele 1, Calapai Gioacchino1
1Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, School of Medicine, University of Messina, Italy; 2Territorial Service for Addiction (Ser.T.) of the District of Ribera – Local Sanitary Unit USL n°1, Agrigento (Italy)

148. THE CANNABINOID ANTAGONIST SR 141716A REDUCES THE INCREASE OF EXTRA-CELLULAR DOPAMINE RELEASE IN THE RAT NUCLEUS ACCUMBENS INDUCED BY A NOVEL HIGH PALATABLE FOOD
Melis Tiziana, Sanna Fabrizio, Succu Salvatora, Argiolas Antonio, Melis Maria Rosaria
Beranrd B. Brodie Department of Neurosciences, University of Cagliari, Italy

149. CANNABINOID SELF-ADMINISTRATION IN THE RAT: GENDER DIFFERENCES AND EFFECT OF OVARIECTOMY
Spano M. Sabrina1,3, Fattore Liana2,3, Altea Silvia1, Angius Fabrizio1, Fadda Paola1,3,
Fratta Walter1, 2,3
1Department of Neuroscience, University of Cagliari ; 2Institute of Neuroscience CNR, Section of Cagliari; 3Centre of Excellence "Neurobiology of Dependence", University of Cagliari

150. PSYCHOSIS ONSET: USE OF CANNABIS X COMT GENOTYPE INTERACTION. A CASE-ONLY DESIGN ANALYSIS IN A FIRST-EPISODE PSYCHOSIS SAMPLE
Caterina La Cascia1,2, M.Di Forti2, R.M. Murray2, D.La Barbera1, A.Butt2, V.Mondelli2, J.Eyeson2, S.Navari2, M.Aas2, D.Clifford2, P.Dazzan2, C.Pariante2, C.Morgan2, B.Freeman2, S.Luzi2, D.Dempster2, M.Rivera2, D.Collier2, J.Powell2, G.Cannizzaro3
1Dept. of Clinical Neurosciences, University of Palermo, 2Institute of Psychiatry, King’s College London, UK, 3Dept. of Pharmacological Sciences, University of Palermo

151. FLUMAZENIL SELECTIVELY PREVENTS THE INCREASE IN A4 SUBUNIT GENE EXPRESSION AND AN ASSOCIATED CHANGE IN GABAA RECEPTOR FUNCTION INDUCED BY ETHANOL WITHDRAWAL
Caria Stefania1, Biggio F.1, Gorini G.1, Murru L.1, Sanna E.1,2, Follesa P.1,2,
and Biggio G.1,2
University of Cagliari, Department of Experimental Biology, Section of Neuroscience1; Center of Excellence for the Neurobiology of Dependence2, 09123 Cagliari, Italy

152. PREGNENOLONE SULFATE ENHANCEMENT OF GABA RELEASE IN THE DEVELOPING RAT CEREBELLUM IS MEDIATED BY PRESYNAPTIC NMDARS AND IS MODULATED BY ETHANOL
Mario Carta, L. Murru, F. Virdis, M.D. Brockmann, R. Marras, E. Sanna, G. Biggio.
Dept. Experimental Biology, Sect of Neuroscience, and Center of Excellence for the Neurobiology of Dependence. Cittadella Universitaria, SS 554 Km 4,500, 09042, Monserrato, Cagliari, Italy

153. NEUROSTEROID-MEDIATED INCREASE OF GABAERGIC TONIC INHIBITION IN RAT DENTATE GYRUS GRANULE CELLS BY ETHANOL
G. Talani, S. Zucca, E. Sanna, G. Biggio
Dept. Experimental Biology, Sect. of Neuroscience, and Center of Excellence for the Neurobiology of Drug Dependence, University of Cagliari, Cittadella Universitaria, Monserrato, Cagliari, Italy

154. ACTIVATION OF TRANSIENT RECEPTOR POTENTIAL VANILLOID TYPE 1 (TRPV1) BY ETHANOL: ROLE OF ENDOGENOUS LIPID MEDIATORS
Campi B., Gatti R, Andre E, Geppetti P. & Trevisani M.
Interdisciplinary Centre of Excellence for the Study of Inflammation (ICSI), University of Ferrara, Ferrara, Italy

155. TRANSIENT RECEPTOR POTENTIAL VANILLOID 1, SUBSTANCE P & REACTIVE OXYGEN SPECIES MEDIATE ETHANOL-INDUCED GASTRIC INJURY
Marcello Trevisani1, David Gazzieri1, Selena Harrison2, Graeme S. Cottrell5, Eunice Andre1, Daniela Massi3, Sandra Zecchi4, Giuseppe Lungarella6, Nigel W. Bunnett5, Pierangelo Geppetti1,2
1Center of Excellence for the Study of Inflammation, University of Ferrara; Departments of 2Critical Care Medicine and Surgery, 3Human Pathology and Oncology, and 4Anatomy, University of Florence; 5Departments of Surgery and Physiology, University of San Francisco, 6Department of Physiopathology, University of Siena

156. ETHANOL INDUCED DOPAMINE RELEASE IN THE RAT MESOLIMBIC SYSTEM. ROLE OF ACETHALDEHYDE
Sirca Donatella 1, Mereu Maddalena 1, Golosio Angela 1, Enrico Paolo 2, Marco Diana 1
1)“G. Minardi” Laboratory of Cognitive Neuroscience, Department of Drug Sciences; 2) Department of Biomedical Sciences. University of Sassari, 07100 Sassari, Italy

157. RITIRATO

158. INTERMITTENT INTOXICATION WITH ETHANOL VAPOR INDUCES A LONG-LASTING HYPNOTIC TOLERANCE AND BEHAVIORAL SENSITIVITY IN RAT
Rimondini R. †, Sommer W.*, Heilig M.*, Dall’Olio R. †, Locchi F. †, Gandolfi O†
*Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892; †Department of Pharmacology, University of Bologna, 40128 Bologna, Italy

159. REDUCTION OF ETHANOL DRINKING FOLLOWING CHRONIC ADMINISTRATION OF THE ANTIEPILEPTIC LEVETIRACETAM IN GENETICALLY SELECTED ALCOHOL PREFERRING RATS
Serena Stopponi, Postolache Cristita, Nazzareno Cannella, Daina Economidou, Fedeli Amalia, Maurizio Massi, Ciccocioppo Roberto
University of Camerino, Italy

160. EFFECT OF THE SELECTIVE FATTY ACID AMIDE HYDROLASE INHIBITOR URB597 ON ETHANOL ABUSE RELATED BEHAVIOURS IN THE RAT
Braconi Simone, Piomelli Daniele*, Duranti Andrea§, Tonini Andrea§, Tarzia Giorgio§, Cannella Nazzareno, Massi Maurizio, Ciccocioppo Roberto, Cippitelli Andrea
Department of Experimental Medicine and Public Health, University of Camerino, Italy; *Gillespie Neuroscience Facility, University of California, Irvine, USA; §Institute of Medicinal Chemistry, University of Urbino “ Carlo Bò”, Italy

161. NEUROPEPTIDE S: A NEW NEUROTRASMITTER SYSTEM INVOLVED IN RELAPSE TO ALCOHOL-SEEKING BEHAVIOUR
1Cannella Nazzareno, 1 Economidou Daina, 1Kallupi Marsida, 2Guerrini Remo, 3Calò Girolamo, 1Roberto Ciccocioppo
1Dept. of Experimental Medicine and Public Health, University of Camerino, Italy; 2Dept of Pharmaceutical Science and, 2Dept. of Pharmacology, University of Ferrara, Italy

162. ROLE OF TGF-B ON MAP KINASE PHOSPHORYLATION AND CELL PROLIFERATION IN PRIMARY CULTURES OF HUMAN LUNG FIBROBLAST
Sullo Nikol, Gallelli L., De Nardo M., Orlotti D., Russo M., Marrocco G., D’Agostino B., De Sarro GB., Rossi F.
Department of Experimental Medicine, Sect. of Pharmacology, Faculty of Medicine and Surgery, 2nd University of Naples, via Constantinopoli 16, 80138 Naples, Italy

163. ETHANOL SENSITISES TRPV1-MEDIATED COUGH IN GUINEA PIGS BY A PROTEIN KINASE C-DEPENDENT PATHWAY
Gatti Raffaele1, Andre Eunice1, Campi Barbara1, Geppetti Pierangelo1, 2 and Trevisani Marcello1
1Interdisciplinary Centre of Excellence for the Study of Inflammation (ICSI), University of Ferrara, Ferrara, Italy; 2Department of Critical Care Medicine and Surgery, University of Florence, Florence, Italy

164. THE ROLE OF CERAMIDE PATHWAY IN ASTHMA
Giannini Lucia a, Bani Daniele b, Uliva Caterina a, Marzocca Cosimo a, Comhair Suzy A.A. c, Erzurum Serpil C. c, Li Dechun d, Ndengele Michael d, Salvemini Daniela d, Masini Emanuela a
a Department of Preclinical and Clinical Pharmacology, and b Anatomy, Histology and Forensic Science, Section of Histology, University of Florence, Italy; c Pulmonary, Critical Care Medicine and Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, USA; d Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, St Louis University, St Louis, USA

165. ROLE OF NOCICEPTIN AND ITS RECEPTOR IN ANIMAL MODEL OF ASTHMA
Orlotti Donatella, De Nardo M., Russo M., Sullo N., Marrocco G., Rossi F., D’Agostino B.
Department of Experimental Medicine, Sect. of Pharmacology, Faculty of Medicine and Surgery, 2nd University of Naples, via Constantinopoli 16, 80138 Naples, Italy

166. ACTIVATION OF PROTEASE-ACTIVATED RECEPTOR-2 REDUCES AIRWAYS INFLAMMATION IN EXPERIMENTAL ALLERGIC ASTHMA
Russo Mariangela, Orlotti D., De Nardo M., Marrocco G., Sullo N., Guastafierro MG., Rossi F., D’Agostino B.
Department of Experimental Medicine, Sect. of Pharmacology, Faculty of Medicine and Surgery, 2nd University of Naples, via Constantinopoli 16, 80138 Naples, Italy

167. M3 MUSCARINIC RECEPTORS IN PERIPHERAL LUNG PARENCHIMA OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Vincenzi F.1, Varani K.1, Caramori G.2, Tosi A.1, Gessi S.1, Merighi S.1, Fogli E. 1, Sacchetto V. 1, Simioni C. 1, Papi A.2, Borea P.A.1
Department of Clinical and Experimental Medicine, Pharmacology Section1 and Respiratory Disease Section 2, University of Ferrara, Italy

168. GLYCOGEN SYNTHASE KINASE-3B INHIBITION ATTENUATES THE DEVELOPMENT OF BLEOMYCIN-INDUCED LUNG INJURY
1,2Salvatore Cuzzocrea, 1,2Tiziana Genovese, 1,2Emanuela Mazzon, 3Emanuela Esposito, 1Carmelo Muià, 4Maha Abdelrahman, 1,2Rosanna Di Paola, 2Placido Bramanti, and 4Christoph Thiemermann
1Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy; 2IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy; 3Dipartimento di Farmacologia Sperimentale, Università di Napoli “Federico II”, Italy; 4The William Harvey Research Institute, Centre for Experimental Medicine, Nephrology and Critical Care, St Bartholomew’s and The Royal London School of Medicine and Dentistry, London, UK

169. MODULATION OF THE NON-ADRENERGIC, NON-CHOLINERGIC INHIBITORY SYSTEM BY ADENOSINE A1 AND A3 RECEPTORS IN THE GUINEA-PIG ISOLATED TRACHEA
Dellabianca Antonio*, De Amici Emanuela*, Tonini Stefano*, De Angelis Stefano**, Faniglione Marisa**, Candura Stefano M*, Tonini Marcello**
*Dept. Preventive Occupational and Community Medicine, University of Pavia; **Dept. of Physiological and Pharmacological Sciences, University of Pavia

170. NEW ROLES FOR CYSTEINYL LEUKOTRIENE IN ASTHMA: FROM AIRWAY REMODELLING TO B2-ADRENORECEPTOR DYSFUNCTION
1G.Enrico Rovati, 2Michele Baroffio 1Simona Citro, 1Valèrie Capra, 2Emanuele Crimi, 2Vito Brusisco
1Laboratory of Molecular Pharmacology, Section of Eicosanoid Pharmacology, Dept. of Pharmacological Sciences, University of Milan; and 2 Respiratory Pathophysiology Unit, Dept. of Internal Medicine, University of Genoa

171. SPHINGOSINE-1-PHOSPHATE/SPHINGOSINE KINASE PATHWAY IS INVOLVED IN MOUSE AIRWAY HYPER-RESPONSIVENESS
Fiorentina Roviezzo, A. Di Lorenzo, M. Bucci, V. Brancaleone, L.De Gruttola, V.Vellecco,
F. Rossi, B. D’Agostino and G. Cirino
Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples-Federico II-; Department of Experimental Medicine-Section of Pharmacology, Faculty of Medicine and Surgery, 2nd University of Naples

172. EVIDENCE FOR A ROLE OF ADENOSINE A1 RECEPTOR IN BRONCHIAL
HYPERREACTIVITY OF SENSITIZED WISTAR RATS
Alfieri Alessio and Cicala Carla
Department of Experimental Pharmacology, University of Naples “Federico II”, Naples

173. APP, A NOVEL SELECTIVE ADENOSINE DEAMINASE INHIBITOR, IS EFFECTIVE AGAINST EXPERIMENTAL COLITIS
Antonioli Luca1, Fornai Matteo1, Colucci Rocchina1, Ghisu Narcisa1, Da Settimo Federico2, Natale Gianfranco3, Virdis Agostino4, Breschi Maria Cristina5, Del Tacca Mario1, Blandizzi Corrado1
1Division of Pharmacology and Chemotherapy, 1,4Department of Internal Medicine, 2Department of Pharmaceutical Sciences, 3Department of Human Morphology and Applied Biology, and 5Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy

174. EFFECTS OF THE NON-PEPTIDYL LOW MOLECULAR WEIGHT RADICAL SCAVENGER IAC IN DNBS-INDUCED COLITIS IN RATS
Vasina Valentina*, Broccoli Massimiliano*, Ursino Maria Grazia*, Soleti Antonio#, Paolini Moreno*, De Ponti Fabrizio*
*Department of Pharmacology, Alma Mater Studiorum - University of Bologna, Italy; #Medestea Research, Torino, Italy

175. THE NK1 RECEPTOR ANTAGONIST SSR140333 AMELIORATES EXPERIMENTAL COLITIS IN RATS
Ursino Maria Grazia, Vasina Valentina, Croci Tiziano*, De Ponti Fabrizio
Dept. of Pharmacology, University of Bologna, Bologna, Italy * Sanofi-Aventis Research Centre, Milan, Italy

176. RESPONSIVENESS OF LONGITUDINAL AND CIRCULAR MUSCLE TO RELAXING MEDIATORS IS DIFFERENTIALLY AFFECTED IN RAT HYPERTROPHIED ILEUM
Bertoni Simona, Ghizzardi Paola, Tognolini Massimiliano, Ballabeni Vigilio, Impicciatore Mariannina, Barocelli Elisabetta
Dipartimento di Scienze Farmacologiche, Biologiche e Chimiche Applicate. Università degli Studi di Parma. Viale Usberti 27/a, 43100 Parma, Italy

177. IN RAT ILEUM ADENOSINE DEAMINASE IS NOT ONLY AN ECTO- BUT ALSO AN EXO-ENZYME
Calligaro Giulia, Bin Anna, Giron Maria Cecilia, Gaion Rosa Maria
Department of Pharmacology and Anesthesiology, University of Padova

178. HERPES SIMPLEX VIRUS-1 INFECTION ALTERS THE CARBACHOL- AND KCL-INDUCED CONTRACTIONS IN RAT SMALL INTESTINE
Zoppellaro Chiara1, Brun Paola2, Giron Maria Cecilia1, Bin Anna1, Gaion Rosa Maria1, Castagliuolo Ignazio2
1Department of Pharmacology and Anesthesiology, University of Padova; 2Department of Histology, Microbiology & Medical Biotechnologies, University of Padova

179. ADENOSINE RECEPTORS AND METABOLISM IN THE INTESTINAL TRACT
Bin Anna1, Giron Maria Cecilia1, Calligaro Giulia1, Castagliuolo Ignazio2, Gaion Rosa Maria1
1Department of Pharmacology and Anesthesiology, University of Padova
2Department of Histology, Microbiology and Medical Biotechnology, University of Padova

180. ROLE OF A2A ADENOSINE RECEPTORS IN THE REGULATION OF HUMAN COLON MOTILITY
Fornai Matteo1, Antonioli Luca1, Colucci Rocchina1, Ghisu Narcisa1, Buccianti Piero2, Chiarugi Massimo2, Blandizzi Corrado1, Del Tacca Mario1
1Division of Pharmacology and Chemotherapy, Department of Internal Medicine, and 2Department of Surgery, University of Pisa, Pisa, Italy

181. GENDER-RELATED ROLE OF NITRIC OXIDE IN ELECTRICALLY EVOKED CONTRACTIONS IN HUMAN COLONIC CIRCULAR MUSCLE
Maselli M.A., Trisolini P., Pezzolla F., Demma I., De Ponti F.°
Scientific Institute of Gastroenterology “S. de Bellis”, Castellana Grotte, Bari; °Department of Pharmacology, University of Bologna, Bologna, Italy

182. ROLE OF 5-HT RECEPTORS IN MODULATING PROPULSIVE ACTIVITY AND ACCOMMODATION IN THE GUINEA PIG DISTAL COLON
Balestra Barbara*, Cervio Elisabetta*, Sternini Catia**, De Giorgio Roberto#, Tonini Marcello*
*Dept. of Physiological & Pharmacological Sciences, University of Pavia, **Dept. of Medicine and Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, #Dept. of Internal Medicine & Gastroenterology, University of Bologna, Italy

183. THE EFFECTS OF UFP112, A NOVEL NOCICEPTIN/ORPHANIN FQ-NOP RECEPTOR LIGAND, ON COLONIC PROPULSION AND DEFECATION IN PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS
Broccardo M. a, Agostini S. a, Guerrini R. b, Improta G. a, Linari G. a, Petrella C. a
a Dept. Human Physiology and Pharmacology, University of Rome “Sapienza”, b Dept. Pharmaceutical Sciences and Biotechnology Center, University of Ferrara, Italy

184. EFFECT OF MODELED MICROGRAVITY CONDITIONS ON RAT INTESTINAL TRANSIT
Alessandra T. Peana1, Stefania Marzocco2, Elena Pulighe1, Giuseppe Bianco2, Proto Pippia1, Aldo Pinto2, Giuseppina Autore2
1Department of Drug Science, University of Sassari, via Muroni 23/a, 07100, Sassari; 2Department of Pharmaceutical Science, University of Salerno, via Ponte don Melillo, 84084, Fisciano, Salerno

185. MENOPAUSAL TRANSITION: A POSSIBLE RISK FACTOR FOR NEURODEGENERATIVE EVENTS
Bonomo Sara M.1, Rigamonti Antonello E.1, Giunta Marialuisa1, Galimberti Daniela2, Guaita Antonio3, Gagliano Maria G.4, Müller Eugenio E.1 and Cella Silvano G.1
1Department of Medical Pharmacology and 2Department of Neurological Sciences, Fondazione IRCCS Ospedale Maggiore Policlinico, Milan, Italy; 3Geriatric Institute “Camillo Golgi”, Abbiategrasso, Italy; 4Department of Transfusion Medicine, “San Carlo Borromeo” Hospital, Milan, and CEND, University of Milan

186. EFFECTS OF THE PHYTOESTROGEN GENISTEIN ON SOME PREDICTORS OF CARDIOVASCULAR RISK IN OSTEOPENIC, POSTMENOPAUSAL WOMEN: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY
Marini Herbert1, Minutoli Letteria2, Polito Francesca2, Bitto Alessandra2, Altavilla Domenica2, Frisina Nicola3, D’Anna Rosario4, Lubrano Carla5, Adamo Elena B1, Caputi Achille P.2 and Squadrito Francesco2
1Dept. of Bioch., Phys. and Nutr. Sci., 2Dept. of Clin. and Exp. Med. and Pharm., 3Dept. of Int. Med., 4Dept. of Obst. and Gyn. Sci., Messina; 5 Dept. of Med. Physiop., “La Sapienza” Univ., Rome, Italy

187. IN VITRO AND IN VIVO ANTI-INFLAMMATORY ACTIVITIES OF PSEUDOMORELIN, A GHRELIN-MIMETIC PSEUDOTETRAPEPTIDE
Ghè Corrado, Baragli Alessandra, Arnoletti Elisa, Deghenghi Romano, Muccioli Giampiero
Division of Pharmacology, Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Turin, Italy

188. GHRELIN AND DES-ACYL GHRELIN INDUCE MURINE C2C12 MYOBLASTS DIFFERENTIATION AND FUSION INTO MYOTUBES
Arnoletti Elisa§, Filigheddu Nicoletta*, Ghè Corrado§, Ponzetto Carola ‡, Crepaldi Tiziana, ‡, Graziani Andrea *, Muccioli Giampiero §
§Division of Pharmacology and ‡Anatomy, Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Turin, Italy; *Department of Medical Sciences, University of Piemonte Orientale “Amedeo Avogadro”, Novara, Italy

189. ENDOCRINE AND EXTRAENDOCRINE EFFECTS OF GHRELIN AND NOVEL SYNTHETIC ANALOGS
Bulgarelli Ilaria a, Bresciani Elena a, Tamiazzo Laura a, Rapetti Daniela a, Perrissoud Daniel b, Torsello Antonio a,c and Locatelli Vittorio a,c
a Department of Experimental Medicine, University of Milan Bicocca, Monza, Italy; b Zentaris GmbH, Frankfurt, Germany; c Interdepartmental Center for Bioinformatics and Proteomics, University of Milano-Bicocca, Monza, Italy

190. EFECTS OF IRBESARTAN ON THE MYOCARDIAL ISCHEMIA/REPERFUSION INJURY IN ZDF RATS WITH METABOLIC SYNDROME
Di Filippo Clara1,2, Lampa Enrico1,2, Martella Raffaele3 , Vargiu Giuseppe4, Paizis Georges4, D’Amico Michele 1,2
1Department of Experimental Medicine, Section of Pharmacology L. Donatelli,2”Excellence Centre for Cardiovascular Disease”, and 3Department of Geriatrics and Metabolic Diseases, 2nd University of Naples, Italy. 4Sanofi-Aventis, Milano

191. EFFECTS OF LIPOSOME-ENCAPSULATED PYRAZOLO-PYRIMIDINE DERIVATE ON THE GROWTH OF HUMAN THYROID CANCER CELLS
1Celano Marilena, 1Cosco Donato, 2Navarra Michele, 1Alcaro Stefano, 3Schenone Silvia,1Procopio Samanta, 1Varano Eliana, 4Botta Maurizio, 1Fresta Massimo, 1Russo Diego
1Dip. di Scienze Farmacobiologiche Univ. Catanzaro, 2Dip. Farmacobiologico, Univ. Messina, 3Dip. Scienze Farmaceutiche, Univ. Genova, e 4Dip. Farmaco Chim. Tecnol., Univ. Siena

192. EFFECT OF TESTOSTERONE ON P70S6K PHOSPHORYLATION IN SKELETAL MUSCLE CELL COLTURES
1Maria G. Dattolo, 1Rocco Saviano, 1Giovanna La Rana, 1Antonio Calignano, 2Maria Miniaci and 1Pietro Scotto
1Dept.of Experimental Pharmacology, University of Napoli “Federico II”;2Dept.of Experimental and Clinical Medicine, University of Catanzaro, Italy

193. ENDOGENOUS BENZODIAZEPINES AND INTESTINAL BACTERIAL FLORA IN NORMAL AND PATHOLOGICAL CONDITIONS
Campioli Enrico§, Avallone Rossella§, Ferrieri Antonella§, Baraldi Mario§°
§Department of Biomedical Sciences, Via Campi 287, 41100 Modena, Italy, °National InterUniversity Consortium for the Study of Natural Active Principles (CINSPAN)

194. EFFECTS OF A METHANOLIC EXTRACT OF SEDUM TELEPHIUM IN LPS-ACTIVATED RAT MACROPHAGES
Polito Francesca1, Bitto Alessandra1, Minutoli Letteria1, Fiumara Tiziana1, Giachetti Daniela2, Miraldi Elisabetta2, Biagi Marco2 Squadrito Francesco1, Caputi Achille P.1, Altavilla Domenica1
1Dept of Exp and Clinical Medicine and Pharmacology and 2Dept of Environmental Sci, Section of Pharm Biol, University of Siena, Italy

195. DIFFERENT PHENOTYPES OF MICROGLIA ACTIVATION
Dello Russo Cinzia, Tringali Giuseppe, and Navarra Pierluigi
Istituto di Farmacologia, Università Cattolica del S Cuore, Largo F Vito 1 - Roma

196. MAPPING OF THE HUMAN PROMOTER OF GNB2L1 GENE ENCODING THE RACK1 PROTEIN AND ITS REGULATORY ROLE IN THE IMMUNOSENESCENCE
Del Vecchio Igor1, Zuccotti A.1, Corsini E.2, Racchi M.1, Lucchelli A.1, Govoni S.1
1 Department of Experimental and Applied Pharmacology, University of Pavia, Viale Taramelli 14, 27100 Pavia, Italy; 2 Department of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133 Milan, Italy

197. ANTINFLAMMATORY ACTIVITY AND GASTROPROTECTIVE EFFECT OF THE ANTIOXIDANT COMPOUND IACVITA IN RATS
Zavatti Manuela, Zanoli Paola, Montanari Caterina, Vezzalini Francesca and Baraldi Mario
Department of Biomedical Sciences, Section of Pharmacology and National InterUniversity Consortium for the Study of Natural Active Principles (CINSPAN), University of Modena and Reggio Emilia, Modena, Italy

198. THE GLUCOCORTICOID-INDUCED LEUCINE ZIPPER (GILZ) PROTECTS AGAINST DNBS-INDUCED COLITIS DEVELOPMENT
Velardi Enrico1, Donato Valerio1, Bruscoli Stefano1, Mazzon Emanuela2, Cannarile Lorenza1, Cuzzocrea Salvatore2 and Riccardi Carlo1
1 Dept. Clinical and Experimental Medicine, Sect. Pharmacology, Perugia University Medical School, 06122, Perugia, and 2 Dept Clinical and Experimental Medicine and Pharmacology, Messina University Medicine School, Torre Biologica, Policlinico Universitario, 98123, Italy

199. MUCIN DEPLETED FOCI (MDF) ARE USEFUL BIOMARKERS TO STUDY INFLAMMATION-INDUCED COLON CARCINOGENESIS IN RODENTS
Femia A. Pietro, Dolara Piero, Tarquini Elena, Salvadori Maddalena and Caderni Giovanna
Department of Pharmacology University of Florence, Florence, Italy

200. LOCAL ADMINISTRATION OF PALMITOYLETHANOLAMIDE REDUCES CHRONIC GRANULOMA-ASSOCIATED ANGIOGENESIS IN RAT
D’Amico Alessandra, De Filippis D., Iuvone T.
1Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy

201. CONTRIBUTION OF A4B1 INTEGRIN TO THE ANTIALLERGIC EFFECT OF LEVOCABASTINE IN EXPERIMENTAL CONJUNCTIVITIS
Spartà Antonino M, Qasem Ahmed R, Bucolo Claudio, Baiula Monica, Govoni Paolo, Fascì Domenico, Spampinato Santi
Department of Pharmacology, University of Bologna

202. PROTECTION AGAINST UVB-INDUCED DAMAGE IN RABBIT EYE BY 4-COUMARIC ACID
Lodovici Maura 1, Morbidelli Lucia 2, Akpan Victor 1, Ziche Marina2 and Dolara Piero 1
1Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139, Florence (Italy); 2Department of Molecular Biology, University of Siena, Via A. Moro 2, 53100 Siena (Italy)

203. CT327, A NOVEL THERAPEUTIC AGENT FOR TOPICAL TREATMENT OF PSORIASIS
Barone Domenico, Bertarione Rava Rossa Luisa, Traversa Silvio, Mainero Valentina, Oderda Cecilia, Pincelli Carlo*, Marconi Alessandra*, and Fumero Silvano
Creabilis therapeutics SpA, Via Ribes, 5 – 10010 Colleretto Giacosa (TO), Italy; *University of Modena e Reggio Emilia, Via del Pozzo, 71 – 41100 Modena, Italy

204. ROLE OF PEROXISOME PROLIFERATORS ACTIVATED RECEPTORS ALPHA (PPAR-A) IN ACUTE PANCREATITIS INDUCED BY CERULEAN
1Angelina De Sarro, 1,2Emanuela Mazzon,1,2Tiziana Genovese, 1,2Rosanna Di Paola, 1Carmelo Muià, 1Giuseppe Malleo, 3‡Emanuela Esposito, 1,2Achille P. Caputi and 1,2Salvatore Cuzzocrea
1Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy; 2IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy; 3Dipartimento di Farmacologia Sperimentale, Università di Napoli “Federico II”, Napoli, Italy

205. ANALYSIS OF THE THYMIDYLATE SYNTHASE GENE STRUCTURE IN COLORECTAL CANCER PATIENTS, AND ITS POSSIBLE RELATION WITH THE 5-FLUOROURACIL DRUG RESPONSE
Rosario Sanguedolce1, Gaspare Gulotta2, Massimo Cajozzo3, Antonino Agrusa2, Salvatore Feo4, Giorgio Sanguedolce1 and Anna Calascibetta1
1Dipartimento di Scienze Farmacologiche, 2Chirurgia Generale e d’Urgenza, 3Dipartimento di Discipline Chirurgiche ed Oncologiche, 4DOSAC. University of Studies of Palermo

206. IRINOTECAN METRONOMIC CHEMOTHERAPY IN METASTATIC COLORECTAL CANCER PATIENTS: A PHARMACOKINETIC AND PHARMACODYNAMIC STUDY
Bocci Guido1, Allegrini Giacomo2, Fioravanti Anna1, Orlandi Paola1, Loupakis Fotios2, Barletta M. Teresa2, Di Paolo Antonello1, Falcone Alfredo2, Danesi Romano1, Del Tacca Mario1
1Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa; 2Division of Medical Oncology, General Hospital, Livorno

207. ADENOSINE RECEPTOR A3: ROLE AND EXPRESSION IN HUMAN THYROID CANCER
Morello Silvana, Petrella A., Festa M., Popolo A., Parente L., Chiappetta G.* and Pinto A.
Department of Pharmaceutical Sciences, University of Salerno, Italy; *Tumor Institute, Fondazione Senatore G. Pascale, Naples, Italy

208. ANTIMETASTATIC EFFECT OF A NOVEL NON COMPETITIVE CXCR1/CXCR2 INHIBITOR IN HUMAN MELANOMA
*Bruno Annalisa, *Mosca M., *Buanne P., °Del Bufalo D., °Desideri M., °Giorgini S., §Ruco L., *Allegretti M., *Gloaguen I., *Bizzarri C., * Melillo G., *Bertini R. and °Zupi G.
*Dompé pha.r.ma s.p.a., via Campo di Pile, 67100 L’AQUILA, ITALY; °Regina Elena Cancer Institute, via delle Messi d’Oro 156, 00158 ROME, ITALY; § S.Andrea Hospital, University La Sapienza, via di Grottarossa 1035, 00189 ROME, ITALY

209. PHARMACOKINETICS OF CISPLATIN DURING INTRAPERITONEAL HYPERTHERMIC CHEMOTHERAPY PERFUSION (IHCP) IN PATIENTS WITH PERITONEAL CARCINOMATOSIS
*Cerretani Daniela, *Ferraro Maria Teresa, *Fiaschi Anna Ida, *Miceli Giovanni Battista,**Cioppa Tommaso, **Marrelli Daniele,**Corso Giovanni,**Pedrazzani Corrado,**Roviello Franco
*Department of Pharmacology “G. Segre”, University of Siena; **Department of Human Patology and Oncology, Unit of Surgical Oncolgy, University of Siena

210. EFFECTS OF ZOLEDRONIC ACID ON CATHEPSIN K CIRCULATING LEVELS IN PATIENTS WITH BONE METASTASIS
Tumminello Francesca M¹., Badalamenti Giuseppe², Incorvaia Lorena², Fulfaro Fabio² Crescimanno Marilena¹, Flandina Carla¹, Gebbia Nicola² and Leto Gaetano¹
¹Lab. Chemioter. Sperimentale and ²U.O. di Oncologia Medica, Dipartimento di Discipline Chirurgiche ed Oncologiche; Policlinico Universitario P. Giaccone, 90127 Palermo, Italy

211. THERAPEUTIC DRUG MONITORING OF ANTIRETROVIRAL AGENTS: DETERMINATION OF PLASMA CONCENTRATIONS BY MEANS OF A HIGH-PRESSURE LIQUID CHROMATOGRAPHIC TECHNIQUE
Pinetti Diego i, Motta Alice ii, Gallesi Daniela i, Guaraldi Giovanni ii
i Toxicology and Clinical Pharmacology, Department of Laboratory Services, University of Modena and Reggio Emilia; ii Department of Medicine and Medicine Specialities, University of Modena and Reggio Emilia

212. H2S AND NO AFFECT INTRACELLULAR KILLING OF CANDIDA ALBICANS MODULATING GSH LEVELS
Grosso S.1, Caronno A.1, Lucini V.1, Pannacci M.1, Sullo N.2 and Scaglione F.1
1Department of Pharmacology, University of Milan, Milan, Italy; 2Depatment of Experimental Medicine- Section of Pharmacology, II University of Naples, Naples, Italy

213. PHARMACOKINETIC/PHARMACODYNAMIC OF MACROLIDES IN AN IN VIVO MODEL OF CHLAMYDIA PNEUMONIAE'S PNEUMONIA
Caronno Alessia, Lucini Valeria, Grosso Silvia, Pannacci Marilou, Scaglione Francesco
Department of Pharmacology, University of Milan, Milan, Italy

214. BIOAVAILABILITY IMPROVEMENT OF POLYMYXIN B BY CALCIUM ALGINATE/CHITOSAN MICROPARTICLES
Rossi Tiziana°, Baggio Giosuè°, Coppi Andrea°, Bruni Elisa°, Ruberto Antonio°, Iannuccelli Valentina* And Coppi Gilberto*
University of Modena and Reggio Emilia- Italy: °Department of Biomedical Sciences- Section of Pharmacology; * Department of Pharmaceutical Sciences, 287 G. Campi st 41100 Modena Italy

215. ATORVASTATIN TREATMENT INFLUENCES POLYMORPHONUCLEAR LEUKOCYTE FUNCTION: A LONGITUDINAL STUDY
Anna Loraschi, Schembri L., Maio R.C., Marino F., Cosentino M., Guasti L., Rasini E., Legnaro M., Colombo C., Cereda E., Cimpanelli M., Castiglioni L., Tozzi M.*, Castelli P.*, Venco A., Lecchini S.
Department of Clinical Medicine, Section of Experimental and Clinical Pharmacology and *Department of Surgical Surgical Science, University of Insubria, Varese, Italy

216. TREATMENT WITH SIMVASTATIN MODIFIES AT1R EXPRESSION AND FUNCTION IN POLYMORPHONUCLEAR LEUKOCYTE OF HIGH CARDIOVASCULAR RISK SUBJECTS: A LONGITUDINAL STUDY
Maio Ramona Consuelo, Marino F., Guasti L., Cosentino M., Rasini E., Ferrari M., Cimpanelli M.G., Loraschi A., Legnaro M., Cereda E., Crespi C., Venco A., Lecchini S.
Department of Clinical Medicine, Section of Experimental and Clinical Pharmacology, University of Insubria, Varese

217. EFFECTS OF ATORVASTATIN TREATMENT ON THE MODULATION OF LEUKOCYTE FUNCTION IN PATIENTS UNDERGOING PERIPHERAL VASCULAR INTERVENTION: A LONGITUDINAL STUDY
Schembri Laura, Loraschi A., Maio R.C., Marino F., Cosentino M.,, Guasti L., Rasini E., Legnaro M., Colombo C., Cereda E., Cimpanelli M., Castiglioni L., Tozzi M.1, Castelli P. 1, Venco A., Lecchini S.
Department of Clinical Medicine, Section of Experimental and Clinical Pharmacology and 1Department of Surgical Sciences, University of Insubria, Varese, Italy

218. ATORVASTATIN AND MINOCYCLINE, EFFECTIVE COMBINATION IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
Luccarini Ilaria a, Biagioli Tiziana b, Ballerini Clara b, Biamonte Filippo c, Bellucci Arianna d, Fiorentini Anna a and Casamenti Fiorella a.
aDept of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy. bDept of Neurology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.cDept of Neuroscience, University Campus Bio-Medico of Rome, Italy. dDept Biomed. and Biotechnol. Sci., University of Brescia, Viale Europa 11, 25123 Brescia, Italy

219. IL-2 INDUCES AN ALTERED CD4/CD8 RATIO OF SPLENIC T LYMPHOCYTES FROM TRANSGENIC MICE OVEREXPRESSING THE GLUCOCORTICOID-INDUCED PROTEIN GILZ
Nicola Pozzesi, Carlo Riccardi, Domenico V. Delfino
Section of Pharmacology, Toxicology and Chemotherapy, Department of Clinical and Experimental Medicine, University of Perugia Medical School, Perugia, Italy

220. OUT OF FRAME BCR-ABL FUSION PEPTIDES AS TARGETS OF THE IMMUNOTHERAPY IN CHRONIC MYELOGENOUS LEUKEMIA
Casnici Claudia, Crotta Katia, Lattuada Donatella, Mastrotto Cristina, Volpe Gisella*, Panuzzo Cristina*, Kuka Mirala*, Saglio Giuseppe*, Marelli Ornella
Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy; *Department of Clinical and Biological Science, University of Turin, Turin, Italy

221. EXPRESSION OF THE ANG II TYPE 1 RECEPTOR ON HUMAN CD4+CD25+HI REGULATORY T CELLS
Rasini Emanuela, Marino F., Guasti L., Ferrari M., Legnaro M. Schembri L., Venco A., Lecchini S., Cosentino M.
Department of Clinical Medicine, University of Insubria, Varese, Italy

222. EFFECT OF DIFFERENT MENTHA PIPERITA VARIETIES ON PROLIFERATION AND CYTOKINE PRODUCTION IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS
Carcano Elena, Cosentino Marco, Bombelli Raffaella, Luini Alessandra, Marino Franca, *Colombo Maria L., #Conti Ario, Lecchini Sergio
Dept. Clinical Medicine, Sect. Clin. Exp. Pharmacology, University of Insubria, Varese, I, *Dept. Pharm. Sci. Technol., University of Turin, I, and #Alpine Foundation for Life Sciences, Olivone, CH

223. MODIFIED A-GALACTOSYL CERAMIDE ANALOGS FOR STIMULATING INKT CELLS: A PHARMACOLOGICAL CHARACTERIZATION
Fallarini Silvia1, Panza L.1, Compostella F.2, Ronchetti F.2, De Libero G.3, Lombardi G.1
1DISCAFF Department, University of “Piemonte Orientale”, Novara, Italy; 2Department of Chemistry, Biochemistry and Biotechnology for Medicine, University of Milano, Milano, Italy; 3Experimental Immunology, Department of Research, University Hospital, Basel, Switzerland

224. A TUSCAN OLIVE OIL EXTRACT INHIBITS NUCLEAR FACTOR-KAPPA B ACTIVATION IN MONOCYTE/MACROPHAGES FROM HEALTHY DONORS
Bardelli Claudio1, Gunella Gabriele1, Amoruso Angela1, Brunelleschi Sandra1, Romani Annalisa2, Ieri Francesca2, Coinu Rita3 & Franconi Flavia3
1Dept. Medical Sciences, University “A. Avogadro”, Novara (Italy); 2Dept. Pharmacological Chemistry, University of Florence (Italy); 3Center of Excellence for Biotechnology Development and Biodiversity Research, University of Sassari (Italy)

225. QUALITY OF LIFE OF PEDIATRIC PATIENTS WITH ATTENTION DEFICIT HYPERACTIVITY DISORDER AND OPPOSITIVE DEFIANT DISORDER: AN ITALIAN DOUBLE-BLIND PLACEBO-CONTROLLED STUDY WITH ATOMOXETINE
Curatolo Paolo1; Mancini Francesca2; Dell’Agnello Grazia2
1Neuropsychiatria Infantile Clinica Sant’Alessandro, Rome, Italy; 2Eli Lilly Italia

226. EVENING AND EARLY MORNING ADMINISTRATION OF ATOMOZETINE IN ADHD CHILDREN: A COMPARISON
Kelsey Douglas1; Sutton Virginia1; Lewis Donald2; Schuh Kory1; Sumner Calvin1; Quintana Humberto3; Dell’Agnello Grazia4; Frediani Sonia4; Rossi Andrea4
1Lilly Research Laboratories,Indianapolis,IN; 2Monarch Medical Research,Norfolk,VA; 3Louisiana State University Health Science Center,New Orleans,LA; 4Eli Lilly Italia

227. SAFETY AND TOLERABILITY OF DULOXETINE IN THE TREATMENT OF MAJOR DEPRESSIVE DISORDER: ANALYSIS OF POOLED DATA FROM EIGHT PLACEBO-CONTROLLED CLINICAL TRIALS
Barraco Alessandra, Mancini Michele, Rossi Andrea
Eli Lilly Italia S.p.A.

228. THE NEW ANTIDEPRESSANT DULOXETINE: CARDIOVASCULAR EFFECTS
Mancini Michele, Barraco Alessandra, Rossi Andrea
Eli Lilly Italia S.p.A.

229. THE MANAGEMENT OF BIPOLAR MANIA: A NATIONAL SURVEY OF BASELINE DATA FROM THE EMBLEM STUDY
Bellantuono Cesario1, Rossi Andrea2, Barraco Alessandra2, Goetz Iris3, Mancini Michele2 for the Italian EMBLEM study group
1Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Italy; 2Eli Lilly Italia S.p.A. for the Italian EMBLEM study group; 3Eli Lilly and Company, Windlesham, UK

230. EUROPEAN MANIA IN BIPOLAR LONGITUDINAL EVALUATION OF MEDICATION (EMBLEM) STUDY: RESULTS OF THE ACUTE 12-WEEK PHASE IN ITALY BY REGIONAL LOCATION (NORTH, CENTRE AND SOUTH)
Rossi Andrea1, Barraco Alessandra1, Goetz Iris2, Mancini Michele1 for the Italian EMBLEM study group
1Eli Lilly Italia S.p.A.; 2Eli Lilly and Company, Windlesham, UK

231. EFFECTIVENESS OF ANTIPSYCHOTIC TREATMENT IN OUTPATIENTS WITH SCHIZOPHRENIA: 36- MONTH RESULTS FROM THE SCHIZOPHRENIA OUTPATIENTS HEALTH OUTCOMES (SOHO) STUDY
Novick Diego (1), Haro Josè M. (2), Brown James (1), Suarez Diego (2), Rossi Andrea (3), Frediani Sonia (3), Ratcliffe Mark C. (1), Scatigna Marco(3) and the SOHO Study Group (4)
(1) Eli Lilly and Company, Windlesham, UK (2) Unità ricerca e sviluppo, San Joan de Deu-SSM, Sant Boi, Barcellona, Spagna (3) Eli illy Italia S.p.A. (4) Alonso J (SP), Gasquet I (FR), Haro JM (SP) Jones PB (UK), Knapp M (UK), Lepine JP (FR), Naber D (DE), Slooff CJ (NL)

232. TOLERABILITY OF OUTPATIENT ANTIPSYCHOTIC TREATMENT: 36-MONTH RESULTS FROM THE EUROPEAN SCHIZOPHRENIA OUTPATIENTS HEALTH OUTCOMES (SOHO) STUDY
Novick Diego (1), Haro Josè M (2), Suarez Diego (2), Bushe Chris (3), Lepine Antoine (4), Rossi Andrea (5), Frediani Sonia (5) Scatigna Marco (5) and the SOHO Study Group (6)
(1) Eli Lilly and Company, Windlesham, UK (2) Unità ricerca e sviluppo, San Joan de Deu-SSM, Sant Boi, Barcellona, Spagna (3) Eli Lilly and Company, Basingstoke, UK; (4) Hôpital Fernand Widal Parigi Cedex 10 (5) Eli Lilly Italia S.p.A. (6) Alonso J (SP), Gasquet I (FR), Haro JM (SP) Jones PB (UK), Knapp M (UK), Lepine JP (FR), Naber D (DE), Slooff CJ (NL)

233. THERAPEUTIC MONITORING OF CLOZAPINE, ABCB1 GENOTYPING AND RESPONSE TO TREATMENT IN PSYCHOTIC PATIENTS
Lastella Marianna*, Consoli Giorgio°, Amatori Federica*, Catena Mario°, Ciapparelli Antonio°, Ciofi Laura*, Golia Francesca°, Carmassi Claudia°, Danesi Romano*, Dell’Osso Liliana°, Del Tacca Mario*, Di Paolo Antonello*
*Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa; °Psychiatric Clinic, Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa

234. ESSENTIAL TREMOR IS RESPONSIVE TO COMBINED TOPIRAMATE AND DECLORAZEPAM TREATMENT
Siniscalchi Antonio,1 Gallelli Luca,2 Borner Perrone Ina,2 Davoli Alessandro,2 De Sarro Giovambattista2
1Department of Neuroscience, Neurology Division, “Annunziata” Hospital, Cosenza, Italy; 2Chair of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy

235. THERAPEUTIC DRUG MONITORING OF GENTAMICIN IN NEWBORNS: OUR EXPERIENCE
Martinelli Valentina, Serpi Antonella*, Carta Paolo, Fanos Vassilios*, Del Zompo Maria, Testa Marcella*
Section of Clinical Pharmacology, Department of Neurosciences “B.B. Brodie”, University of Cagliari; *Institute of Neonatal Pathology and Intensive Therapy, University of Cagliari

236. PHASE II MARKER LESION STUDY OF 6-WEEK INTRAVESICAL GEMCITABINE INSTILLATION IN PATIENTS WITH LOW-RISK SUPERFICIAL BLADDER CANCER
Brausi Maurizio 1, Giussani Laura 2, Altieri Vincenzo 3, Rigatti Patrizio 4, Gontero Paolo 5, Bertelli Lorenzo 6, Rossi Andrea 6, Langer Frank 7, Russo Francesca 6, Bono Aldo2
1 Divisione di Urologia AUSL, Modena, 2 Divisione di Urologia Ospedale di Circolo e Fondazione Macchi, Varese, 3Clinica Urologia Azienda Universitaria Policlinico Federico II , Napoli, 4Clinica Urologia Università Vita e Salute, Ospedale S. Raffaele, Milano, 5Clinica di Urologia Ospedale Maggiore della Carità, Novara, 6Eli Lilly Italia; 7Eli Lilly EuMed

237. COMPARISON BETWEEN DIFFERENT TOPICAL HYPOTENSIVE DRUGS IN TWO EXPERIMENTAL MODELS OF GLAUCOMA IN THE RABBIT
*Fabrizi Francesca, °Giambene Barbara, °Galassi Gianfranco, *Uliva Caterina, §Ongini Ennio, *Masini Emanuela
*Department of Preclinical and Clinical Pharmacology; University of Florence;°Department of Oto-neuro-ophthalmological Sciences, University of Florence and §NicOx Research Institute, Milan, Italy

238. PLASMA LEVELS OF ARGININE AND LACTATE IN REHABILITATION PATIENTS WITH SPINAL CORD INJURY AND PRESSURE ULCERS
Verri Manuela*, Aquilani R.^, Boschi F.*, Dossena M.*, Iadarola P.°, Viglio S.°, Pastoris O.*
*Department of Physiological & Pharmacological Sciences; °Department of Biochemistry “A. Castellani”, University of Pavia, Pavia, Italy; ^IRCCS “S. Maugeri” Foundation, Montescano, Italy

239. SILDENAFIL CITRARE VERSUS TADALAFIL FOR ED TREATMENT: PREFERENCE OF ITALIAN PATIENTS AND REASONS OF THEIR CHOICE
Fusco Ferdinando, Lembo, Antonio 1, Ludovico Giuseppe M 2, Pirozzi Farina Furio 3, Montorsi Francesco 4, Menchini Fabris Fabrizio 5, Sicuteri Riccardo 6, Rossi Andrea 6, Gentilella Raffaella 6, Mirone Vincenzo
Clinica Urologica, Università Federico II, Napoli; 1 Div. Urologia, Ospedali Riuniti di Bergamo; 2 Unità di Urologia Operativa, Ospedale Civile, Monopoli, Bari; 3 Università Di Sassari, Clinica Urologica; 4 Reparto di Urologia, Ospedale S. Raffaele, Milano; 5 Unità di Andrologia, Università di Pisa, Pisa; 6 Eli Lilly Italia

240. THE MAGNITUDE OF INHIBITORY DRUG INTERACTIONS IS DEPENDENT ON LIVER FUNCTIONAL STATUS
Pegoraro Paola1, De Martin Sara1, Orlando Rocco2, and Palatini Pietro1
1Department of Pharmacology and Anaesthesiology, and of 2Medical and Surgical Sciences, University of Padova, Italy

241. GABAPENTIN-INDUCED RHABDOMYOLYSIS: A CASE REPORT
Tuccori Marco1,2, Lombardo Giuseppe2, Lapi Francesco1,4, Vannacci Alfredo1,4, Blandizzi Corrado1,4, Mugelli Alessandro1,4, Del Tacca Mario1,2
1Tuscan Regional Center for Pharmacovigilance; 2Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa – Pisa, Italy; 3Intensive Care Unit - Hospital of Empoli, Florence – Italy; 4Department of Preclinical and Clinical Pharmacology - University of Florence, Florence – Italy

242. ANTICOAGULANTS AND DRUGS AT INTERACTION RISK
Marianna Alacqua1, Gianluca Trifirò1,4, Salvatore Moretti3, Michele Tari3, Mariella Galdo3, Ugo Tari3, Achille P Caputi1,4, UVEC group3, Vincenzo Arcoraci1
1Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Italy - 2 Division of Child Neurology and Psychiatry, University of Messina, Italy - 3 “Caserta 1” Local Health Service, Caserta, Italy - 4 IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy

243. VIGILANCE SYSTEM FOR UNDESIRABLE EFFECTS OF COSMETIC PRODUCTS (COSMETOVIGILANCE) IN EUROPE
Sportiello Liberata1 and Sautebin Lidia1,2
1Department of Experimental Pharmacology, 2Pharmacoeconomic and Pharmacoutilization Research Centre, Faculty of Pharmacy, University of Naples Federico II, Naples, Italy

244. NOTIFICATION OF UNDESIRABLE EFFECTS OF COSMETIC PRODUCTS BY PHARMACISTS AND DERMATOLOGISTS: A PILOT PROJECT
Sautebin Lidia
Department of Experimental Pharmacology, Pharmacoeconomic and Pharmacoutilization Research Centre, Faculty of Pharmacy, University of Naples Federico II, Naples, Italy

245. GENDER DIFFERENCE IN ADVERSE DRUG REACTIONS: ANALYSIS OF SPONTANEOUS REPORTS OF AN ITALIAN INTERREGIONAL DATABASE (GIF)
Francesco Salvo (1), Paola Maria Cutroneo (1), Ilaria Meneghelli (2), Domenico Motola (3), Mario Del Tacca (4), Barbara Ros (5), Annalisa Capuano (6), Olivia Leoni, and Giovanni Polimeri (1)
(1) Dep. Clin Experim Med and Pharmacol, University of Messina, Italy - (2) Clinical Pharmacology Unit, University of Verona, Italy - (3) Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Italy - (4) Division of Pharmacology and Chemotherapy, University of Pisa, Italy; (5) Pharmaceutical Service of Friuli Venezia Giulia Health Department, Trieste, Italy - (6) Department of Experimental Medicine, Second University of Naples, Italy - (7) Lombardy Centre of Pharmacovigilance, Milan, Italy

246. GENDER AND AGE-RELATED DRUG PRESCRIPTION PATTERNS IN THE VARESE LOCAL HEALTH AUTHORITY
Leoni Olivia1, Banfi Fabio2, Soma Renato1, Manfredi Luca1, Oria Cristina1, Roi Cinzia1
1PAC Department, Varese Local Health Authority, Italy; 2Health Managed, Varese Local Health Authority, Italy

247. THE PHARMACOLOGICAL CONSULTATION SERVICE AS A VALID TOOL FOR DEVELOPING A CORRECT DRUG APPROACH: "THE POPPERS' CASE"
Stochino M. Erminia, Asuni Carlo, Carta Paolo, Del Zompo Maria
Drug Information Centre, Section of Clinical Pharmacology, Department of Neurosciences “B.B. Brodie”, University of Cagliari

248. ADVERSE REACTIONS TO CONTRAST MEDIA: AN ANALYSIS FROM SPONTANEOUS REPORTING DATA
Paola Cutroneo1, Giovanni Polimeni1,2, Roberto Curcuruto1, Alessandra Russo1, Gioacchino Calapai1, Achille P. Caputi1
1Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy; 2Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Centro Neurolesi "Bonino-Pulejo," Messina, Italy

249. REGIONAL SURVEILLANCE OF EMERGENCY DEPARTMENT VISITS FOR OUTPATIENT ADVERSE DRUG EVENTS
M. Gallo, L. Ferrante, M.L. Illiano, F. Russo, R. Annibale, A. Filippelli, F. Rossi, A. Captano
Department of Experimental Medicine, Section of Pharmacology “Leonardo Donatelli”. Center of Pharmacosurveillance and Pharmacoepidemiology, Faculty of Medicine and Surgery, Second University of Naples, Italy

250. PHARMACOVIGILANCE TEACHING IN THE EUROPEAN FACULTIES OF PHARMACY
Rossi Antonietta1, Pergola Carlo1 and Sautebin Lidia1,2
1Department of Experimental Pharmacology, 2Pharmacoeconomic and Pharmacoutilization Research Centre, Faculty of Pharmacy, University of Naples Federico II, Naples, Italy.

251. PROMOTING CONTINUING EDUCATION IN PHARMACOVIGILANCE: THE EXPERIENCE OF "PHARMASEARCH", A NETWORK OF GENERAL PRACTITIONERS REPORTING ADVERSE DRUG REACTIONS
Catania Maria A1., Salvo Francesco1, Oteri Alessandro1, Polimeni Giovanni1,5, Russo Alessandra1, Giustini Saffi E.2, Sessa Aurelio2, Tuccori Marco3, Martelli Antonietta4, Del Tacca Mario3, Caputi Achille P.1,5
1University of Messina; 2Area Pharmasearch, SIMG; 3University of Pisa; 4University of Genova; 5IRCCS Neurolesi “Bonino-Pulejo”, Messina

252. THE BLINK PROJECT: A NEW BIOMEDICAL RESEARCHERS' DATABASE (WWW.DOYOUBLINK.NET)
Busconi Pietro1, Ferranti Stefano2, Ceserani Ida3, Pistotti Vanna4, Casale Federico3, Caglioti Luciano5, Biggio Giovanni3, Garattini Silvio4
1Promotore, Fondazione Schering, Italy – 2Sviluppo tecnico database, New! S.a.s., Milano, Italy; 3Società Italiana di Farmacologia, Milano, Italy - 4Istituto di Ricerche Farmacologiche “Mario Negri”, Italy - 5Università "La Sapienza", Roma, Italy

253. ON PARENTERAL FORMULATIONS AND GOLDEN STANDARDS FOR QUALITY AND SAFETY
Naccari C. a, Giovinazzo C. a, Saija A. a, Tomaino A. a
a Dept. Farmaco-Biologico, Faculty of Pharmacy, University of Messina, Contrada Annunziata, 98168 Messina, Italy; b Faculty of Pharmacy, University of Messina, Contrada Annunziata, 98168 Italy

254. CENTRAL EFFECTS OF A NEW SECOISOPIMARANE DITERPENOID FROM AERIAL PARTS OF SALVIA CINNABARINA
Francesco Maione1,2, Mariantonella Colucci2, Angela Bisio3, Romussi Giovanni3, Stefano Pieretti2, Amalia Di Giannuario2, Maria C. Bonito1,2, Nicola Mascolo1
1Department of Experimental Pharmacology, University of Naples “Federico II, Naples; 2Department of Drug Research and Evaluation, Italian National Institute of Health, Rome; 3Department of Chemistry and Pharmaceutical Technology and Alimentary, University of Genoa, Genoa

255. IN VITRO ANTIOXIDANT ACTIVITY OF AGED EXTRACTS OF SOME ITALIAN SPONTANEOUS ALLIUM SPECIES
Nencini Cristina, Micheli Lucia, Giorgi Giorgio, Franchi Gian Gabriele
Department of Pharmacology “Giorgio Segre”, University of Siena

256. EFFECT OF ALLIUM NEAPOLITANUM ON LIVER INJURY INDUCED BY ETHANOL IN RATS
Nencini Cristina, Franchi Gian Gabriele, Giorgi Giorgio, Micheli Lucia.
Department of Pharmacology “Giorgio Segre”, University of Siena

257. ANTIOXIDANT PROPERTIES OF INFUSIONS FROM LEAVES AND INFLORESCENCES OF ACHILLEA MILLEFOLIUM SSP. COLLINA B. BY USE OF CHEMICAL AND BIOLOGICAL ASSAYS
Raffaella Bombelli1, A. Luini1, A. Giorgi2, G. Licheri2, E. Carcano1, F. Marino1, M.Cosentino1, M. Cocucci2, S. Lecchini1
1Dipartimento di Medicina Clinica, Sezione di Farmacologia Sperimentale e Clinica, Università degli Studi dell’Insubria, Varese and 2Dipartimento di Produzione Vegetale, Università degli Studi di Milano, Milano

258. IN VITRO ANTIOXIDANT, ANTIMUTAGEN AND ANTI-INFLAMMATORY ACTIVITY OF EXTRACTS AND STILBENES FROM GLYCYRRHIZA GLABRA LEAVES
1CRISTANI M., 1SAIJA A., 1D’ARRIGO M., 1NACCARI C., 2RUBERTO G., 2BIONDI D.M., 1TROMBETTA D.
1Dept. Farmaco-Biologico, School of Pharmacy, University of Messina, Italy - 2CNR Institute of Biomolecular Chemistry - Catania, Valverde, Catania, Italy

259. PROTECTIVE EFFECT OF HYPERICUM PERFORATUM IN ZYMOSAN-INDUCED MULTIPLE ORGAN DYSFUNCTION SYNDROME
1Angelina De Sarro, 1,2Emanuela Mazzon, 1,2Rosanna Di Paola, 1Carmelo Muià, 1,2Tiziana Genovese, 2Placido Bramanti, 3Emanuela Esposito, 4Marta Menegazzi, 3Rosaria Meli, 4Hisanori Suzuki, and 1,2Salvatore Cuzzocrea
1Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy; 2IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy; 3Dipartimento di Farmacologia Sperimentale, Università di Napoli “Federico II”, Napoli, Italy; 4Department of Neuroscience and Vision, University of Verona, Verona, Italy

260. INHIBITION OF HUMAN CAMP PHOSPHODIESTERASES AS A MECHANISM OF THE SPASMOLYTIC EFFECT OF MATRICARIA RECUTITA L. WATER EXTRACT
Dell’Agli Mario, Dal Cero Esther, Maschi Omar, Bosisio Enrica
Department of Pharmacological Sciences, Faculty of Pharmacy, University of Milan, Italy

261. PHENYLPROPANOID RICH ESSENTIAL OILS AS POTENTIAL ANTITHROMBOTICS ENDOWED WITH GASTROPROTECTIVE EFFECTS
Tognolini Massimiliano 1, Barocelli Elisabetta 1, Bertoni Simona 1, Impicciatore Mariannina 1, Bruni Renato 2, Ballabeni Vigilio 1
1Dept of pharmacological, biological and applied chemical sciences. University of Parma. Viale Usberti 27/a, 43100 Parma, Italy; 2Dept of evolutionary and functional biology. University of Parma. Viale Usberti 11/a, 43100 Parma, Italy

262. BIOLOGICAL ACTIVITY OF BERGAMOT PEEL EXTRACTS (CITRUS BERGAMIA RISSO)
Trombetta D., D’Arrigo M., Ginestra G., Arcoraci T., Mandalari G., Saija A., Cristani M.
Dept. Farmaco-Biologico, School of Pharmacy, University of Messina - Vill. SS. Annunziata 98168 Messina, Italy

263. EVIDENCE TO IMPLICATE PHOSPHO-AKT (P-AKT) IN THE MECHANISMS UNDERLYING NEUROPROTECTION AFFORDED BY THE ESSENTIAL OIL OF BERGAMOT AGAINST EXCITOTOXICITY IN VITRO
Maida Simona1, Fratto Vincenza, Navarra Michele1, Bagetta Giacinto2 and Corasaniti M.Tiziana1
1Department of Pharmacobiological Sciences, University “Magna Graecia” of Catanzaro, Catanzaro, Italy; 2Department of Pharmacobiology and University Centre of Adaptive Disorders and Headache (UCADH), section of Neuropharmacology of Normal and Pathological Neuronal Plasticity, University of Calabria, Rende (CS), Italy

264. THE PROTECTIVE EFFECT OF BERGAMOT OIL NON VOLATILE FRACTION ON LOX-1 EXPRESSION IN BALLOON INJURY-RELATED NEOINTIMA FORMATION
Iolanda Sacco1, E Palma1, F Sculco1, C. Colica1, V Visalli1, S Muscoli3, S Ragusa1, L Mondello4, D. Rotiroti1, F Romeo3, V Mollace1,2
1Faculty of Pharmacy, University “Magna Graecia” of Catanzaro, Italy; 2San Raffaele Pisana IRCCS, Rome, Italy; 3Chair of Cardiology, University of Rome “Tor Vergata”, Rome, Italy; 4Faculty of Pharmacy, University of Messina, Italy

265. VASCULAR ACTIVITY OF ISOLATES FROM THE HYACINTHACEAE OF SOUTH AFRICA
Ferrara Antonella, F Fusi, C Koorbanally, NR Crouch, DA Mulholland & G Sgaragli

Dipartimento di Scienze Biomediche, Università degli Studi di Siena, via A. Moro 2, 53100 Siena, email: ferrara14@unisi.it

266. OLYMORPHISMS OF THE ABCB1 GENE PREDICT DRUG RESISTANCE IN EPILEPTIC PATIENTS
Lastella Marianna*, Danesi Romano*, Cascio Elisa*, Jensen Stella§ , Iudice Alfonso§,
Murri Luigi§ , Del Tacca Mario*, Di Paolo Antonello*
*Division of Pharmacology and Chemotherapy, Department of Internal Medicine;
§Division of Neurology, Department of Neurosciences - University of Pisa

267. HERPES SIMPLEX VECTORS EXPRESSING FGF-2 AND BDNF PROMPT NEURONOGENESIS AND EXERT DISEASE-MODIFYING EFFECTS IN A MODEL OF TEMPORAL LOBE EPILEPSY
Mazzuferi Manuela,1 Paradiso Beatrice,1 Marconi Peggy,1 Zucchini Silvia,1 Elena Berto,1 Binaschi Anna,1 Bozac Aleksandra,1 Buzzi Andrea,1 Magri Eros,1 Navarro Mora Graciela,2 Rodi Donata,1 Volpi Ilaria,1 Fabene Paolo F.,2 Marzola Andrea,1 Manservigi Roberto,1 Simonato Michele 1
1University of Ferrara,2University of Verona, Italy

268. ALZHEIMER'S DISEASE: ASSOCIATION STUDY BETWEEN RESPONSE TO CHOLINESTERASE INHIBITORS AND CANDIDATE GENES IN A SARDINIAN SAMPLE
Squassina Alessio1, Congiu Donatella1, Manconi Francesca1, Putzu Paolo F2, Chillotti Caterina1, Del Zompo Maria1, Piccardi Mariapaola1
1Unit of Clinical Pharmacology, Department of Neurosciences ‘‘B. B. Brodie’’, University of Cagliari, 2Division of Geriatrics, Local Health Agency 8, Cagliari, Italy

269. IMPACT OF CYP3A4 AND CYP3A5 POLYMORPHISMS ON CLINICAL OUTCOME OF DONEPEZIL IN ALZHEIMER'S DISEASE PATIENTS
T. Paoletti1, M.G. Scordo2, G. Miglio1, M.L. Villa3, M.L. Dahl2, G. Lombardi1
1 DISCAFF Department, University of “Piemonte Orientale Amedeo Avogadro”, Novara, Italy; 2 Department of Medical Sciences, Clinical Pharmacology, Uppsala University Hospital, Uppsala, Sweden; 3 Geriatric Clinical Unit, “ Ospedale Maggiore della Carità”, Novara, Italy

270. ROLE OF POLYMORPHISMS OF THE UGT1A9 GENE IN COMT INHIBITOR-INDUCED HEPATOTOXICITY IN PARKINSON'S DISEASE: A CLINICAL STUDY
1Marco Ferrari, 1Marco Cosentino, 1Franca Marino, 1Giorgio Bono, 2Emilia Martignoni, 3,4Giuseppe Nappi, 1Sergio Lecchini
1Dept. Clin. Med., University of Insubria, Varese, 2Dept. Med. Sci., University of Piemonte Orientale “Amedeo Avogadro”, Novara and Dept. Neurorehabil. Mov. Disord., “Salvatore Maugeri” Foundation, Scientific Institute of Veruno, NO, 3Dept. of Neurol. Otorhinolaryngol., University “La Sapienza”, Rome, and 4I.R.C.C.S. C. Mondino, Pavia, Italy

271. GENETIC POLYMORHISMS OF SEROTONIN TRANSPORTER AND MONOAMINE OXIDASE; AND RESPONSE TO SSRI ANTIDEPRESSANT DRUGS IN TERMINAL CANCER PATIENTS
Schillani Giulia, Capozzo Marianna, Conte Anna Maria, De Vanna Maurizio, Giraldi Tullio
Department of Biomedical Sciences, University of Triest

272. LITHIUM RESPONSE: ASSOCIATION STUDY WITH CANDIDATE GENES
Manchia Mirko, Squassina Alessio, Lampus Simona, Ardau Raffaella, Chillotti Caterina, Del Zompo Maria, Severino Giovanni
Section of Clinical Pharmacology, Department of Neurosciences “B.B. Brodie”, University of Cagliari

273. PHARMACOGENOMICS AND TRIPTANS: A PILOT STUDY OF ASSOCIATION BETWEEN CLINICAL RESPONSE TO RIZATRIPTAN AND SOME CANDIDATE GENES
Asuni Carlo, Stochino M. Erminia, Congiu Donatella, Cherchi Alessandra, Piccardi M. Paola, Del Zompo Maria
Headache Centre, Section of Clinical Pharmacology, Department of Neurosciences “B.B. Brodie”, University of Cagliari

274. SYNERGISTIC CYTOTOXICITY OF OXALIPLATIN AND PEMETREXED IN COLON CANCER CELLS: CELLULAR AND MOLECULAR MECHANISMS
Sara Nannizzi, Elisa Giovannetti, Valentina Mey, Simona Ricciardi, Mario Del Tacca, Romano Danesi
Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa

275. MOLECULAR MECHANISMS UNDERLYING THE SYNERGISTIC INTERACTION OF THE EGFR TYROSINE KINASE INHIBITOR ERLOTINIB WITH THE MULTITARGETED ANTIFOLATE PEMETREXED IN NON-SMALL CELL LUNG CANCER CELLS
Giovannetti Elisa,1,2 Smid Kees,1 Mey Valentina,2 Tekle Christina,1 Nannizzi Sara,2 Rodriguez José A,1 Ricciardi Simona,2 Del Tacca Mario ,2 Giaccone Giuseppe,1Danesi Romano,2 Peters Godefridus J1
1Dept. Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands; 2Dept. Internal Medicine, Div. Pharmacology and Chemotherapy, University of Pisa, Italy

276. PHARMACOGENETIC EVALUATION OF AURORA A KINASE IN COLORECTAL CANCERS
Amatori Federica Maria*, Boldrini L§, Di Paolo A*, Lastella M*, Fontanini G§, Del Tacca M*, Danesi R*.
* Division of Pharmacology and Chemotherapy, Department of Internal Medicine; §Division of Pathology, Department of General Surgery, University of Pisa

277. EPIGENETIC MECHANISMS OF SENSITIVITY TO IRINOTECAN IN COLORECTAL CANCER CELL LINES
Crea Francesco, Giovannetti Elisa, Mey Valentina, Nannizzi Sara, Ricciardi Simona, Danesi Romano, Del Tacca Mario
Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy

278. GENETIC POLYMORPHISMS IN DNA REPAIR GENES AND THEIR IMPACT ON SUSCEPTIBILITY TO MULTIPLE MYELOMA
Sabrina ANGELINI1, Cantelli-Forti Giorgio1, Carolina Terragna2, Matteo Renzulli2, Michele Cavo2, Patrizia Hrelia1
1. Department of Pharmacology, University of Bologna; 2. Institute of Haematology and Medical Oncology “Seragnoli”, University of Bologna
(Abstract non disponibile su richiesta dell'autore)

279. GENETIC POLYMORPHISM OF BLEOMYCIN HYDROLASE: A NEW BIOMARKER FOR HUMAN MUTAGEN SENSITIVITY
Maffei Francesca1, Carbone Fabio1, Angelini Sabrina1, Cantelli Forti Giorgio1, Norppa Hannu2, Hrelia Patrizia1
1 Department of Pharmacology, University of Bologna, Via Irnerio 48 40126 Bologna, Italy; 2 Finnish Institute of Occupational Health, Topeliuksenkatu 41 aA, FI-00250 Helsinki, Finland

280. DNA VACCINE STRATEGY AGAINST CHRONIC B-CELL LYMPHOMA: ANTI-IDIOTYPIC CDR3 VACCINATION
Schirru Cristina1, Maullu Carlo1, Deidda Federico1, Rinaldi Monica3, Signori Emanuela2,3, Massi Emanuela2, Chiarella Pieranna1,2, Marelli Ornella4, Tonon Giancarlo1 and Fazio Vito Michele2,3
1 Bioker S.r.l. Polaris Loc.piscinamanna Pula (CA); 2 CIR, Section of Molecular Medicine and Biotechnology, University "Campus Bio-Medico", Rome, Italy; 3 Institute of Neurobiology and Molecular Medicine, CNR Rome, Italy; 4 Dipartimento Di Farmacologia, Chemioterapia E Tossicologia Medica, Università di Milano