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33°
Congresso Nazionale
della Società Italiana di Farmacologia
Cagliari, 6-9 Giugno 2007
Fiera della Sardegna |
Sessione Posters
8 Giugno
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Cliccare sul titolo di ciascun poster per aprire il relativo
abstract in PDF
POSTERS - 8 Giugno ore 13.00-15.00 |
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RECETTORI E MECCANISMI DI TRASDUZIONE DEL
SEGNALE |
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1. PHARMACOLOGICAL
CHARACTERIZATION OF ADENOSINE RECEPTORS IN BOVINE CHONDROCYTES
Tosi A.1, Varani K.1, Vincenzi F.1, Gessi S.1, Merighi S.1, Fogli
E. 1, Sacchetto V. 1, Simioni C. 1, De Mattei M.2, Caruso A.2, Borea
P.A.1
1Department of Clinical and Experimental Medicine, Pharmacology
Section; 2Department of Morphology and Hystology, University of
Ferrara, Italy
2. BINDING
THERMODYNAMICS AT THE HUMAN A2B ADENOSINE RECEPTOR
Eleonora Fogli1, Stefania Gessi1, Katia Varani1, Stefania Merighi1,
Valeria Sacchetto1, Carolina Simioni1, Edward Leung2, Stephen Mac
Lennan2, Pier Andrea Borea1
1Department of Clinical and Experimental Medicine, Pharmacology
Unit and Interdisciplinary Center for the Study of Inflammation,
University of Ferrara, Italy; 2King Pharm. Research and Development,
Inc., Cary, North Carolina
3. ADENOSINE
MODULATES VASCULAR ENDOTHELIAL GROWTH FACTOR EXPRESSION VIA HYPOXIA-INDUCIBLE
FACTOR-1 IN HUMAN GLIOBLASTOMA CELLS
Valeria Sacchetto1, Stefania Merighi1, Annalisa Benini1, Prisco
Mirandola2, Stefania Gessi1, Katia Varani1, Carolina Simioni1, Eleonora
Fogli1, Edward Leung3, Stephen Mac Lennan3, Pier Andrea Borea1.
1Dpt of Clin. and Exp. Med., Pharmacol. Unit and Interdisciplinary
Center for the Study of Inflammation, Univ. of Ferrara, Italy; 2Dpt
of Human Anat., Pharmacol. and For. Med., Univ. of Parma, Italy;
3King Pharm. Research and Development, Inc., Cary, North Carolina
4. ACTIVATED
PRESYNAPTIC P2X7 RECEPTORS FUNCTION AS CALCIUM CHANNELS LINKED TO
EXOCYTOTIC GLUTAMATE RELEASE
Guarnieri Stefania1, Paluzzi Paola1, Cervetto Chiara1, Alloisio
Susanna2, Nobile Mario2, Marcoli Marcoli1, Maura Guido1*
1Dep. Experimental Medicine, Pharmcology and Toxicology Section;
*Center of Exellence for Biomedical Research, University of Genoa,
Genoa, Italy; 2CNR, Biophysic Intitute, Genoa, Italy
5. ACTIVATED
P2X7 RECEPTORS ALLOW CALCIUM ENTRY AND GLUTAMATE EXIT: INVESTIGATION
ON TRANSFECTED HEK 293 CELLS
Paluzzi Paola1, Cervetto Chiara1, Guarnieri Stefania1, Alloisio
Susanna2, Nobile Mario2, Marcoli Marcoli1, Maura Guido1*
1Dep. Experimental Medicine, Pharmcology and Toxicology Section;
*Center of Exellence for Biomedical Research, University of Genoa,
Genoa, Italy; 2CNR, Biophysic Intitute, Genoa, Italy
6. EXTRACELLULAR
MG2+ MODULATES C-TERMINAL TAIL DEPENDENT P2X7 RECEPTOR FUNCTIONAL
PROPERTIES
Susanna Alloisio, Raffaella Barbieri, Luigi Bozzo, Mario Nobile
Institute of Biophysics, CNR, Via De Marini, 6 – 16149
Genoa, Italy
7. ARACHIDONIC
ACID POTENTIATES NATIVE AND RECOMBINANT P2X7-MEDIATED ERK1/2, BUT
NOT JNK AND P38 PHOSPHORYLATION IN CULTURED CORTICAL ASTROCYTES
AND HUMAN EMBRYONIC KIDNEY 293 CELLS
Barbieri Raffaella1, Alloisio Susanna1, Ferroni Stefano2 and Nobile
Mario1
1Institute of Biophysics, CNR, 16149 Genoa, Italy; 2Dept. of
Human and General Physiology, University of Bologna, 40127 Bologna,
Italy
8. PURINERGIC
FACILITATION OF PARASYMPATHETIC ACTIVITY IN ISOLATED PIG DETRUSOR:
INVOLVEMENT OF PREJUNCTIONAL P2X3 RECEPTORS
D’Agostino G., Condino A.M., Barbieri A. and Tonini M*
Department of Experimental and Applied Pharmacology, School
of Pharmacy, University of Pavia, Via Taramelli 14, and *Department
of Physiological and Pharmacological Sciences, P.za Botta 10, I-27100
Pavia, Italy
9. ROLE
OF P2 PURINERGIC RECEPTORS ON CA1 NEUROTRANSMISSION OF RAT HIPPOCAMPAL
SLICES
Traini Chiara , Coppi Elisabetta, Pugliese Anna Maria and Pedata
Felicita
Department of Preclinical and Clinical Pharmacology, University
of Florence,
Viale Pieraccini 6, 50139 Florence, Italy
10. ROLE
OF PKA IN EGFR TRANSACTIVATION INDUCED BY PGE2 IN A431 CELLS
Erika Terzuoli, F. Finetti and M. Ziche
Laboratory of angiogenesis, Department of Molecular Biology,
University of Sien
11. INSULIN-LIKE
GROWTH FACTOR I (IGF-I) INDUCES HUMAN MU OPIOID RECEPTOR (MOR) EXPRESSION
IN DIFFERENTIATED NEURONS: ROLE OF TRANSCRIPTION FACTORS REST AND
STAT3
Bedini Andrea, Di Toro Rosanna and Spampinato Santi
Department of Pharmacology and Toxicology – University
of Bologna Irnerio 48 – 40126 Bologna – Italy
12. RESISTIN
INDUCES VASCULAR INSULIN RESISTANCE THROUGH AN IMPAIRMENT OF AKT/ENOS
PHOSPHORYLATIONS
Alba Di Pardo°, Maria Teresa Gentile°, Carmine Vecchione°,
Gennaro Marino°, Giovanna Antenucci°, Angelo Maffei°,
Giuseppe Lembo° #.
°Department of Angio-Cardio-Neurology, Neuromed Institute,
Pozzilli (IS), and #Department of Experimental Medicine, “La
Sapienza” University of Rome
13. INTERACTION
BETWEEN WNT PATHWAY AND ORPHAN NUCLEAR RECEPTORS
Motolese Marta 1, Orlando Rosamaria 1, Caricasole Andrea 3, Terstappen
Georg C.3, Melchiorri Daniela 1, Nicoletti Ferdinando 1,2, Caruso
Alessandra 1
1Department of Human Physiology and Pharmacology, University
of Rome “La Sapienza”; 2I.N.M. Neuromed , Pozzilli;
Italy; 3Sienabiotech s.p.a. Siena
14. STUDY
OF SYNTHETIC PEPTIDES DERIVED FROM PKI55, A PKC MODULATOR, IN STIMULATED
HUMAN NEUTROPHILS
Sofia Falzarano1, Lara Franceschetti1, Susanna Spisani2, Rita Selvatici1
1Department of Experimental and Diagnostic Medicine, Section
of Medical Genetics, University of Ferrara; 2Department of Molecolar
Biochemistry and Biology, University of Ferrara
15. THE
THYROID DISRUPTOR 1,1,1-TRICHLORO-2,2-BIS(P-CHLOROPHENYL)-ETHANE
APPEARS TO BE AN UNCOMPETITIVE INVERSE AGONIST FOR THE THYROTROPIN
RECEPTOR
Mario Rossi, Elisa Donati, Antonio Dimida, Eleonora Ferrarini, Patrizia
Agretti, Franco Giorgi, Giovanni U. Corsini, Aldo Pinchera, Paolo
Vitti, Massimo Tonacchera, and Roberto Maggio
Department of Neuroscience (M.R., E.D., F.G., G.U.C.) and Department
of Endocrinology, Centre of Excellence for the Study of Damage to
the Nervous and Endocrine Systems Produced by Environmental, Alimentary,
and Pharmacological Agents, AmbiSEN (A.D., E.F., P.A., A.P., P.V.,
M.T.), University of Pisa, Pisa, Department of Experimental Medicine,
University of L’Aquila, Italy
16. PHARMACOLOGICAL
CHARACTERISATION OF THE UROTENSIN-II RECEPTOR LIGANDS URANTIDE AND
UFP-803 IN CHOHUT CELLS
Batuwangala Madura1,3, Camarda Valeria1, Marzola Erika2, McDonald
John3, Lambert David G.3, Ng Leong3, Guerrini Remo2, Regoli Domenico1
and Calo’ Girolamo1.
1Dept. of Pharmacology and 2Dept. of Pharmaceutical Sciences,
University of Ferrara, 44100 Ferrara, Italy. 3Dept. of Cardiovascular
Sciences, Division of Anaesthesia, Pharmacology and Therapeutics,
University of Leicester, Leicester, LE2 7LX, UK
17. STIMULATION
OF EPHRIN B INDUCES MODIFICATIONS OF HIPPOCAMPAL SYNAPTIC PLASTICITY
IN NEONATAL AND ADULT RATS
Piccinin Sonia1; Cinque Carlo1; Laura Calo’1; Patanè
Monica1; Melchiorri Daniela1; Bashir Zafar3 ; Eusebi Fabrizio1,2.;
Nicoletti Ferdinando1,2
1 Department of Human Physiology and Pharmacology, University
La Sapienza of Rome, Italy; 2 I.N.M. Neuromed, Pozzilli, Italy;
3 MRC Centre for synaptic plasticity, Department of Anatomy, University
of Bristol, UK
18. PGE2
PROMOTES EGFR TRANSACTIVATION AND SQUAMOUS CELL CARCINOMA GROWTH
BY THE NOS AND ERK1/2 PATHWAYS
Raffaella Solito, Marina Ziche and Lucia Morbidelli
Section of Pharmacology, Department of Molecular Biology, University
of Siena
19. SELECTIVE
H3 RECEPTOR ISOFORMS ACTIVATE AKT/GSK AXIS AND ERK IN RAT CORTICAL
NEURONS
Chiara Mariottini1, Gerold Bongers3, Rob Leurs3, Silvia Fossati2
Alberto Chiarugi2, Patrizio Blandina2 and M. Beatrice Passani2
1Dipartimento di Fisiologia, V.le Morgagni 65, Firenze, Italy;
2Dipartimento di Farmacologia Preclinica e Clinica, V.le Pieraccini
6, Firenze, Italy; 3Department of Medicinal Chemistry, Vrije Universiteit,
Amsterdam, The Netherlands
20. NITRIC
OXIDE/CGMP SIGNALING PATHWAY EXERTS TONIC CONTROL ON INTRAOCULAR
PRESSURE (IOP) HOMEOSTASIS IN RABBITS
Bastia Elena, Guzzetta Massimiliano, Biondi Stefano and Impagnatiello
Francesco
Nicox Research Institute, Bresso, Milano, Italy
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I CANALI IONICI ED I MECCANISMI DI TRASPORTO
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21. THE
EFFECTS OF ACETAZOLAMIDE ON CALCIUM ACTIVATED K+ CHANNELS IN SKELETAL
MUSCLE ARE MEDIATED BY INTERACTION WITH THE ALPHA SUBUNIT
Mele Antonietta1, Tricarico Domenico1, Latorre Ramon2, Torres Yolima2,
Conte Camerino Diana1.
1Dept. of Pharmacobiology, Fac of Pharmacy,University of Bari,
Bari Italy; 2Centro de Estudios Cientificos, Valdivia, Chile
22. FLUVASTATIN
MAY INDUCE A CHRONIC REDUCTION OF THE STORE OPERATED CALCIUM ENTRY
IN STRIATED FIBRES: AN OTHER BRICK IN THE WALL OF THE HYPOLIPEDEMIC
DRUGS' MYOTOXICITY?
Rolland Jean-francois, Liantonio Antonella, Conte Camerino Diana
Department Pharmaco-Biology, Faculty of Pharmacy, University
of Bari
23. HYDROPHOBICITY
OF PHENYLALANINE 1586 WITHIN THE PORE OF THE HUMAN NAV1.4 SODIUM
CHANNEL IS A DETERMINANT OF LOCAL ANESTHETIC BINDING
Jean-François Desaphy1, Antonella Dipalma1, Alessia Catalano2,
Giovanni Lentini2, Carlo Franchini2, Vincenzo Tortorella2, Diana
Conte Camerino1
1Section of Pharmacology, Department of Pharmacobiology, Faculty
of Pharmacy, University of Bari, Via Orabona 4 – campus, 70125
Bari, Italy; 2Department of Medicinal Chemistry, Faculty of Pharmacy,
University of Bari
24. STRUCTURAL
REQUIREMENTS OF N-BENZYL TOCAINIDE ANALOGS FOR STEREOSELECTIVE AND
POTENT BLOCK OF SKELETAL MUSCLE SODIUM CHANNELS
1De Bellis Michela, 1De Luca Annamaria, 2Corbo Filomena, 2Muraglia
Marilena, 2Franchini Carlo, 2Tortorella Paolo and 1Conte Camerino
Diana
1Unit of Pharmacology, Department of Pharmacobiology, Faculty
of Pharmacy, University of Bari and 2Department of Medical Chemistry,
Faculty of Pharmacy University of Bari, Italy
25. CELLULAR
AND SUBCELLULAR LOCALIZATION OF NA+-CA2+ EXCHANGER (NCX) 1, 2 AND
3 IN CENTRAL NERVOUS SYSTEM (CNS)
Magi Simona1, Castaldo Pasqualina1, Salucci Sara3, Gobbi Pietro3,
Minelli Andrea2 and Amoroso Salvatore1
1Section of Pharmacology, Department of Neuroscience, University
“Politecnica delle Marche”, Ancona and Institute of
2Physiological and 3Morphological Sciences, University of Urbino
“Carlo Bo”
26. TRANSPORT
OF PYRIDINE NUCLEOTIDES ACROSS THE PLASMA MEMBRANE IN MAMMALIAN
CELLS
Emanuela Ercolano, Richard A. Billington, Fabrizio Condorelli, Pier
Luigi Canonico, Armando A. Genazzani
DiSCAFF, Università del Piemonte Orientale, Novara
27. SODIUM
CALCIUM EXCHANGER AND SODIUM DEPENDENT GLUTAMATE TRANSPORTERS INVOLVEMENT
IN ENERGY PRODUCTION, IN RAT HEART
1Castaldo Pasqualina, 2Rodolico Gabriella, 2Piegari Elena, 1Magi
Simona, 1Corcione Elisa, 2Berrino Liberato and 1Amoroso Salvatore
1Section of Pharmacology, Department of Neuroscience, Università
“Politecnica delle Marche”, Ancona; 2Department of Experimental
Medicine, Section of Pharmacology, Second University of Naples
28. TAURINE
PREVENTS THE DISUSE-ASSOCIATED ALTERATION OF SOLEUS MUSCLE CALCIUM
HOMEOSTASIS IN THE HINDLIMB-UNLOADED RATS
Giannuzzi Viviana, Liantonio Antonella, Desaphy Jean-François,
Pierno Sabata, Conte Camerino Diana
Section of Pharmacology, Dept. of Pharmacobiology, University
of Bari, Italy
29. EVALUATION
OF THE EFFECTS OF A COMBINED CHRONIC TREATMENT WITH ATORVASTATIN
AND FENOFIBRATE ON RAT SKELETAL MUSCLE: AN EX VIVO ELECTROPHYSIOLOGICAL
AND CYTOFLUORIMETRIC STUDY
Cippone Valentina, Giannuzzi Viviana, Pierno Sabata, Liantonio Antonella,
Conte Camerino Diana
Dept. of Pharmacobiology, Section of Pharmacology, Faculty of
Pharmacy, University of Bari, Italy
30. PHARMACOLOGICAL
TARGETING OF RENAL CLC-K CHLORIDE CHANNELS: LIGANDS STRUCTURAL REQUIREMENTS
AND THERAPEUTIC POTENTIAL
Liantonio Antonella1, Picollo Alessandra2, Babini Elena2, De Bellis
Michela1, Fracchiolla Giuseppe3, Carbonara Giuseppe3, Tortorella
Paolo3, Pusch Michael2, Conte Camerino Diana1
1Section of Pharmacology, Dept. of Pharmacobiology, University
of Bari, Italy; 2Institute of Biophysic-CNR, Genova, Italy; 3Dept.
of Medicinal Chemistry, University of Bari, Italy |
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CONTROLLO FARMACOLOGICO DEI PROCESSI DI MORTE
E PROLIFERAZIONE CELLULARE |
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31. ENDOCANNABINOIDS
CONTRIBUTE TO THE NEUROPROTECTIVE EFFECTS OF MGLU1 RECEPTOR ANTAGONISTS
AGAINST POST-ISCHEMIC NEURONAL DEATH
Landucci Elisa, Scartabelli Tania, Cozzi Andrea, Mannaioni Guido,
Moroni Flavio & Pellegrini-Giampietro Domenico
Dipartimento di Farmacologia Preclinica e Clinica, Università
di Firenze, Viale Pieraccini 6, 50139 Firenze
32. TRANSFORMING
GROWTH FACTOR-B1 PROTECTS RAT CORTICAL NEURONS AGAINST EARLY AND
LATE -AMYLOID TOXICITY
Filippo Caraci1, Agata Copani1, Giuseppe Battaglia2, Ferdinando
Nicoletti2,3, Maria Angela Sortino4
1Dept. of Pharmaceutical Sciences, University of Catania ; 2I.N.M.
Neuromed, Pozzilli, Italy, 3Dept. of Human Physiology and Pharmacology,
University of Rome ‘‘La Sapienza’’; 4Dept.
of Experimental and Clinical Pharmacology, University of Catania
33. B-AMYLOID
EFFECTS IN DIFFERENTIATION AND DEATH OF NEURAL PROGENITOR CELL-DERIVED
NEURONS
Calafiore M1, Giuffrida M.L.1, Sortino M.A.2 and Copani A1.
1Department of Pharmaceutical Sciences, 2Department of Experimental
and Clinical Pharmacology, University of Catania, Catania
34. DIFFERENTIAL
ROLE OF MGLU1 AND MGLU5 RECEPTORS IN RAT HIPPOCAMPAL SLICE MODELS
OF ISCHEMIC TOLERANCE
Scartabelli Tania, Landucci Elisa, Moroni Flavio & Pellegrini-Giampietro
Domenico.
Dipartimento di Farmacologia Preclinica e Clinica, Università
di Firenze, Viale Pieraccini 6, 50139 Firenze
35. REGULATION OF AUTOPHAGY BY THE INOSITOL
TRISPHOSPHATE RECEPTOR
Maiuri Maria Chiara1,2, Criollo Alfredo2, Tasdemir Ezgi2, Carnuccio
Rosa1, Kroemer Guido2
1Department of Experimental Pharmacology, Faculty of Biotechnological
Sciences, University of Naples “Federico II”, Via D.
Montesano 49, 80135 Napoli, Italy; 2INSERM U848, University “Paris
Sud”, Institut G. Roussy, 39 rue C. Desmoulins, F-94805 Villejuif,
France
(Abstract non disponibile su richiesta dell'autore)
36. PERIPHERAL
NEUROPATHIES: APOPTOSIS-PREVENTING ACTIVITY OF ACETYL-L-CARNITINE
Di Cesare Mannelli Lorenzo*, Ghelardini C.*, Vivoli E.*, Toscano
A.§, Bartolini A*.
*University of Florence, Dept. of Preclinical and Clinical Pharmacology,
Viale Pieraccini 6, 50139, Florence, Italy; §University of
Florence, Dept. of Anatomy Hystology and Forensic Medicine, Viale
Morgagni 85, 50139, Florence, Italy
37. EFFECTS
OF COMBINATION TREATMENT WITH AZIDOTHYMIDINE AND PHARMACOLOGICAL
INHIBITORS OF NF-KB ON APOPTOTIC CELL DEATH IN UNINFECTED OR VIRUS-INFECTED
TRANSFORMED CELL LINES
1Minutolo A. 2Matteucci C. , 1, Balestrieri E. 3 Ascolani A..4 Mastino
A. 3,5, Macchi Beatrice
1Department of Experimental Medicine and Biochemical Science,
University of Rome “Tor Vergata”, Rome; 2Institute of
Neurobiology and Molecular Medicine, C.N.R., Rome; 3 Department
of Neuroscience, University of Rome “Tor Vergata”, Rome;
4Department of Microbiological, Genetic and Molecular Sciences,
University of Messina, Messina. 5IRCCS Santa Lucia Rome, Italy
38. MODULATION
OF BCL-2 EXPRESSION BY GEMCITABINE AND NIMESULIDE IN HUMAN PANCREATIC
TUMOR CELL LINES
Longoni Biancamaria, Giovannetti Anna, Bertacca Laura, Navarra Teresa
and Mosca Franco
Department of Oncology, Transplantation and Advanced Technologies
in Medicine, University of Pisa
39. PROTECTIVE
EFFECT OF LEVETIRACETAM VERSUS OXYGEN STRESS -INDUCED CELL DEATH
IN PC12 AND IN SH-SY5Y CELL LINES
1Ascolani Arianna, 2Matteucci C, 2Balestrieri E, 3Caltagirone C,
1,3Macchi B
1Department of Neuroscience, University of Rome “Tor Vergata”,
Rome, Italy.2 Department of Experimental Medicine and Biochemical
Science, University of Rome “Tor Vergata”, Rome, Italy.
3IRCCS S. Lucia Rome, Italy
40. ROLE
OF REACTIVE OXYGEN SPECIES (ROS) IN THE ANTIAPOPTOTIC EFFECT OF
OXYSTEROLS ON HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS (HUVEC)
Chiara Poggiani, Laura Agnoletto, Federico Cusinato, Lucia Trevisi,
Sisto Luciani
Department of Pharmacology and Anaestesiology, University of
Padova
41. HYDROGEN
PEROXIDE-DEPENDENT ERK1/2 DEPHOSPHORYLATION MEDIATES TOXICITY VIA
UPSTREAM INHIBITION OF THE SURVIVAL SIGNALLING IN U937 CELLS EXPOSED
TO PEROXYNITRITE
Cerioni Liana and Cantoni Orazio
Institute of Pharmacology and Pharmacognosy, University of Urbino
“Carlo Bo”
42. SUBNORMOTHERMIC
MACHINE PERFUSION REDUCES NECROSIS AND APOPTOSIS AND IMPROVES ENERGY
STATUS DURING PRESERVATION OF STEATOTIC RAT LIVERS: IMPLICATIONS
FOR TRANSPLANTATION
1Ferrigno Andrea, 2Rizzo V, 3Carlucci F, 3Tabucchi A, 4Boncompagni
E., 1Richelmi P., 5Cillo U, 4Freitas I, 1Vairetti M
1Dept. Int. Med. and Therapeutics and 2Dept. of Biochemistry,
IRCCS San Matteo, Univ. of Pavia; 3Dept. Int. Med., Univ. of Siena,
4Dept. of Animal Biology and IGM-CNR, Univ. of Pavia, 5Dept. General
Surgery, Univ. of Padua
43. A
PATHOGENETIC HYPOTHESIS OF UNVERRICHT-LUNDBORG DISEASE ONSET AND
PROGRESSION
Buzzi Andrea b, Franceschetti Silvana a, Sancini Giulio a, Zucchini
Silvia b, Paradiso Beatrice b, Magnaghi Giuseppina a, Frassoni Carolina
a, Chikhladze Maia a, Avanzini Giuliano a, Simonato Michele b
a Neurological Institute “C. Besta”, Milan, Italy;
b University of Ferrara, Italy
44. ANTIAPOPTOTIC EFFECTS OF GREEN TEA POLYPHENOL
EPIGALLOCATECHIN-3-GALLATE (EGCG) ON ISCHEMIC INJURY OF THE RAT
RETINA
Tamburella Alessandra, Leggio Gian Marco, Drago Filippo
Department of Experimental and Clinical Pharmacology, University
of Catania, Catania, Italy
(Abstract non disponibile su richiesta dell'autore)
45. MELANOCORTINS
IMPROVE WOUND HEALING IN EXPERIMENTAL BURN INJURY
Bazzani Carla1, Giuliani Daniela1, Mioni Chiara1, Galantucci Maria1,
Zaffe Davide2, Minutoli Letteria3, Bitto Alessandra3, Botticelli
Annibale R.4, Altavilla Domenica3, Squadrito Francesco3, Guarini
Salvatore1
1Dept. Biomedical Sciences, Sect. Pharmacology, and 2Dept. Anatomy
and Histology, University of Modena and Reggio Emilia; 3Dept. Clinical
Exp. Medicine and Pharmacology, Sect. Pharmacology, University of
Messina; 4Dept. Human Pathology, University of Pavia |
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FARMACOLOGIA DELLA TRASMISSIONE SINAPTICA |
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46. MUSCARINIC
CONTROL OF PARASYMPATHETIC ACTIVITY IN ISOLATED PORCINE AIRWAYS:
INVOLVEMENT OF M1/M2 MUSCARINIC AUTORECEPTORS
Condino A.M., Barbieri A., Zonta F. and D’Agostino G.
Department of Experimental and Applied Pharmacology, School
of Pharmacy, University of Pavia, Via Taramelli 14, I-27100 Pavia,
Italy
47. HIERARCHICAL
CONTROL OF DOPAMINE NEURON-FIRING PATTERNS BY NEURONAL NICOTINIC
RECEPTORS
Mameli-Engvall Monica1,2,3, Evrard Alexis2, Pons Stephanie2, Maskos
Uwe2, Svensson H. Torgny1, Changeux Jean-Pierre2, Faure Philippe2
1 Karolinska Institute, Dept. Physiology and Pharmacology, S-17177
Stockholm, Sweden; 2 Institut Pasteur, Unité Récepteurs
et Cognition, URA CNRS 2182, Paris Cedex 15, France ; 3 EDX Diagnostics
SPA, Sardegna Ricerche, Localita’ Piscinamanna, Ed.3, 09010
Pula, Italy
48. THE
RELEASE OF ENDOCANNABINOIDS IN THE CA1 HIPPOCAMPAL AREA IS MODULATED
BY MGLU1 RECEPTORS: A PATCH CLAMP STUDY
Baccini Gilda, Landucci Elisa, Moroni Flavio, Pellegrini-Giampietro
Domenico & Mannaioni Guido
Dipartimento di Farmacologia Preclinica e Clinica, Università
di Firenze, Viale Pieraccini 6, 50139 Firenze
49. EVIDENCE
FOR A POSSIBLE INTERACTION BETWEEN CANNABINOID AND SEROTONERGIC
SYSTEMS IN MODULATING INHIBITORY SYNAPTIC TRANSMISSION IN BASOLATERAL
AMYGDALA
Domenici M.R1., Marsicano G2., Azad S.C.3, Lutz B.4, Popoli P1.,
Zieglgänsberger W.3, Rammes G.3
1 Dep. Drug Res and Evaluation, Istituto Superiore di Sanità,
Rome, Italy; 2Centre de Recherche INSERM François Magendie,
Bordeaux, France; 3 Max-Planck Institut for Psychiatry, Munich,
Germany; 4Dep of Physiological Chemistry,Johannes Gutenberg University,
Mainz, Germany
50. PHARMACOLOGICAL
CHARACTERIZATION OF A NEW NON-IMIDAZOLE HISTAMINE H3 ANTAGONIST
Flammini Lisa, Bertoni Simona, Saccani Francesca, Ballabeni Vigilio,
Impicciatore Mariannina, Barocelli Elisabetta
Department of Applied Pharmacological, Biological and Chemical
Sciences, University of Parma, V.le GP Usberti 27/a, Parma
51. SEROTONIN
EFFLUX FROM RAT DORSAL RAPHE NUCLEUS SLICES: MODULATION BY CORTICOTROPIN
RELEASING FACTOR
Marino Silvia, Nazzaro Cristiano, Siniscalchi Anna
Department of Clinical and Experimental Medicine University
of Ferrara Via Fossato di Mortara, 17-19 44100 Ferrara
52. MONOAMINERGIC
CHANGES IN LOCUS COERULEUS AND DORSAL RAPHE NUCLEUS FOLLOWING NORADRENALINE
DEPLETION
Teresa Macheda1, Tommaso Cassano1, Maria Grazia Morgese1, Luigia
Trabace1, Vincenzo Cuomo2 and Gabriella Gobbi3
1Department of Biomedical Sciences, University of Foggia, Italy;
2Department of Pharmacology and General Physiology, University of
Rome, ‘La Sapienza’, Italy; 3Dept. of Psychiatry, McGill
University, Montréal, Qc, Canada
53. FUNCTIONAL
PROTEOMICS OF NEUROPLASTICITY-RELATED SIGNALING IN A RAT MODEL OF
DEPRESSION WITH GENE-ENVIROMENT INTERACTION
Musazzi Laura1, Roberto Giambelli1,2, Daniela Tardito1, Lucia Caffino1,
Aram El Khoury3, Aleksander Mathé3, Giorgio Racagni1, Maurizio
Popoli1
1Center of Neuropharmacology-Department of Pharmacological Sciences,
University of Milano, Italy; 2Department of Experimental and Clinical
Pharmacology, School of Medicine, University of Catania, Catania
(Italy); 3Karolinska Institutet, Inst. of Clinical Neuroscience,
Karolinska Hospital Huddinge, Stockholm (Sweden) |
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FARMACOLOGIA CARDIOVASCOLARE |
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54. ENDOTHELIAL
CELLS RESPONSE TO POLYETHYLENE TEREPHTHALATE SURFACES ACTIVATED
BY IRRADIATION
Pezzatini Silvia1, Satriano Cristina2, Morbidelli Lucia1, Ziche
Marina1
1 Pharmacology section, Dept Molecular Biology, University of
Siena, Via A. Moro 2, 53100 Siena, Italy; 2 Laboratory for Molecular
Surfaces and Nanotechnologies and CSGI, Dept. of Chemical Sciences,
University of Catania, viale A. Doria 6, 95025 Catania, Italy
55. PEROXYNITRITE
INACTIVATES HUMAN-TISSUE INHIBITOR OF METALLOPROTEINASE-4 (TIMP-4)
FAVOURING CORONARY ENDOTHELIAL CELL MOTILITY
Martina Monti, S. Donnini, L. Morbidelli, and M Ziche
Laboratory of Angiogenesis, Department of Molecular Biology,
University of Siena
56. ACE
INHIBITOR-INDUCED ANGIOGENESIS IN CORONARY ENDOTHELIUM IS MEDIATED
BY FIBROBLAST GROWTH FACTOR-2
Donnini Sandra, Giachetti Antonio, Ziche Marina and Morbidelli Lucia
Laboratory of Angiogenesis, Dept. Molecular Biology, University
of Siena, Siena, Italy
57. MEMBRANE
PROTEINS INVOLVED IN FLAVONOID TRANSPORT IN ENDOTHELIAL CELLS
Maestro Alessandra*, Terdoslavich Michela+, Petris Gianluca*, Passamonti
Sabina+, Decorti Giuliana*
* Department of Biomedical Sciences and +Department of Biochemistry,
Biophysics and Chemistry of Macromolecules, University of Trieste,
Trieste
58. A NITRIC OXIDE RELEASING PRAVASTATIN
DERIVATIVE, NCX 6550, IMPROVES VASCULAR RESPONSE IN HUMAN AND HYPERTENSIVE
RAT VESSELS
C. Presotto, D. Miglietta, R. Olivieri, M. Uzzo, T.Vago*, G. Gelpi#,
A. Monopoli
Nicox Research Institute, Bresso, Milan, Italy; * Department
of Endocrinology, University Hospital “L.Sacco”, Milan;
# Division of Cardiovascular Surgery, “L.Sacco” Hospital,
Milan
(Abstract non disponibile su richiesta dell'autore)
59. NEBIVOLOL
INDUCES NITRIC OXIDE PRODUCTIONE IN THE HEART
A Maffei1, R Poulet1, A. Di Pardo1, R. Carangi1, P. Carullo1, M.T.
Gentile1, G Lembo1,2.
1IRCCS Neuromed, Pozzili (IS); 2 La Sapienza University, Rome
60. ROLE
OF PROTEIN KINASE C AND RHO KINASE IN THE RAT-SELECTIVE VASOCONSTRICTOR
EFFECT OF NORMORMIDE
1Cavalli Maurizio, 2Papparella Italia, 2Ceolotto Giulio, 1Bova Sergio
1Department of Pharmacology and Anesthesiology, University of
Padova; 2Department of Clinical and Experimental Medicine, University
of Padova
61. HYDROGEN
SULPHIDE INVOLVEMENT IN VASCULAR TONE IN DIABETIC RATS
d’Emmanuele di Villa Bianca Roberta, Sorrentino R., Mitidieri
E. and Sorrentino R.
Department of Experimental Pharmacology, University of Naples
Federico II
62. HYPERGLYCEMIA-MEDIATED
OVEREXPRESSION OF CYCLOOXYGENASE-2 (COX-2) PARTICIPATES IN VASCULAR
HYPOREACTIVITY OF STREPTOZOTOCIN-INDUCED TYPE I DIABETES
Tarquinio Mariela, Nacci Carmela, De Benedictis Leonarda, Montagnani
Monica
Department of Pharmacology and Human Physiology - Medical School
- University of Bari, 70124 Bari, ITALY
63. NEUTROPHIL-DEPENDENT
CEREBRAL OEDEMA IN NORMAL AND DIABETIC RAT: ROLE OF TRANSCELLULAR
SYNTHESIS OF CYSTEINIL LEUKOTRIENES
Brivio Ivan, Buccellati C, Di Gennaro A, Folco G, Sala A.
Center for Cardiopulmonary Pharmacology, Dep. of Pharmacological
Sciences, University of Milan
64. ANGIOTENSIN
II INVOLVEMENT IN REMODELLING OF CAROTIDS SUBJECTED TO PRESSURE
OVERLOAD
Bianco Giuseppe1, Mitidieri Emma2, d’Emmanuele di Villa Bianca
Roberta2, Pinto Aldo1, Autore Giuseppina1, Sorrentino Raffaella2
1Dipartimento di Scienze Farmaceutiche, Università di
Salerno, Salerno; 2Dipartimento di Farmacologia Sperimentale, Università
di Napoli, Federico II
65. EVALUATION
OF THE EFFECT OF TWO DIFFERENT DOSES OF ASPIRIN IN PATIENTS UNDERGOING
CORONARY ARTERY BYPASS GRAFT (CABG)
Brambilla Marta 1, Centenaro Chiara2, Tremoli Elena1,2, Parolari
Alessandro2, Camera Marina1,2
1Dept. Pharmacological Sciences, University of Milan; 2Centro
Cardiologico Monzino IRCCS, Milan, Italy
66. POLYDEOXYRIBONUCLEOTIDE
(PDRN) INCREASES VEGF PRODUCTION AND BLOOD FLOW IN AN EXPERIMENTAL
MODEL OF HIND LIMB ISCHEMIA IN RATS
Fiumara Tiziana1, Polito Francesca1, Bitto Alessandra1, Minutoli
Letteria1, Di Stefano Vincenzo1, Altavilla Domenica1, Cattarini
Giulia2, Caputi Achille P1, Squadrito Francesco1
1Department of Clinical and Experimental Medicine and Pharmacology,
University of Messina and 2Mastelli srl, Sanremo, Italy
67. HYDROGEN
SULFIDE (H2S) INHIBITS AGGREGATION OF HUMAN PLATELETS
Giovanni Zagli1, Patacchini R.2, Trevisani M.1, Abbate R.1, Cinotti
S.1, Gensini GF.1, Masotti G.1 and Geppetti P.1
1Department of Critical Care Medicine & Surgery, University
of Florence, Florence, Italy; 2Department of Pharmacology, Chiesi
Pharmaceuticals, Parma, Italy
68. SERCA2
PUMP EXPRESSION AND PHOSPHORILATED PHOSPHOLAMBAN IN MECHANICAL-INDUCED
VENTRICULAR HYPERTROPHY IN RATS
Popolo Ada, Morello S., 1D’Emmanuele di Villa Bianca R., Marzocco
S., 1Sorrentino R., Autore G. and Pinto A.
Department of Pharmaceutical Sciences, University of Salerno; 1Department
of Experimental Pharmacology, University of Napoli “Federico
II”
69. NITRIC
OXIDE DONORS: ANTI-AGGREGATING EFFECTS AND MECHANISMS OF INHIBITION
OF PLATELET AGGREGATION
Priora Raffaella, Margaritis A., Frosali S., Summa D., Di Giuseppe
D., Di Simplicio P.
Department of Neuroscience, Pharmacology Unit, University of
Siena
70. EFFECTS
OF HYPERBARIC OXYGEN THERAPY ON THROMBOCYTOPENIA AND PLATELET AGGREGATION
DURING AN EXPERIMENTAL MODEL OF MULTIPLE ORGAN FAILURE SYNDROME
Maria Donniacuo 1, B. Rinaldi 2, A. Capuano 2, G. Liguori 2, F.
Imperatore 2, S. Cuzzocrea 3, A. Filippelli 2, F. Rossi 2
1 Doctorate in Pharmacological Sciences and Respiratory Physiopathology,
Second University of Naples, Italy; 2 Department of Experimental
Medicine and Excellence Center of Cardiovascular Disease, Second
University of Naples, Italy; 3 Department of Clinical and Experimental
Medicine and Pharmacology, University of Messina, Italy
71. PROXIMAL
AND DISTAL EFFECTS OF ARTERIOTOMY IN RAT CAROTIDS: AN EXTENSIVE
MICROARRAY ANALYSIS OF GENE EXPRESSION
1Finicelli Mauro, 1Forte Amalia, 4De Luca Pasquale, 2Santè
Pasquale, 2Quarto Cesare, 3Onorati Francesco, 3Renzulli Attilio,
1Galderisi Umberto, 2Cotrufo Maurizio, 1Cipollaro Marilena, 1Cascino
Antonino, 1Rossi Francesco, 1Berrino Liberato
Dept. of 1Exp. Medicine and 2Cardiothoracic Sciences, Second
University of Naples; 3Unit of Cardiac Surgery, University Magna
Graecia, Catanzaro; 4BIOGEM S.c.a.r.l., Ariano Irpino
72. EFFECT
OF CARBON NANOTUBES ON HUMAN PLATELETS
Russier Julie§, Togna Anna Rita§, Togna Giuseppina I§,
Serafino Annalucia*, Almairac Robert**, Fiorito Silvana+
§Department of Human Physiology and Pharmacology, University
of Rome “La Sapienza”; *Institute of Neurobiology and
Molecular Medicine, CNR, Rome; **Laboratoire des Colloides, Verres,
et Nanomateriaux,CNRS - University of Montpellier II; +Department
of Experimental Medicine University of Rome “La Sapienza”
- CNR |
6 |
FARMACI PER LA RIDUZIONE DEL RISCHIO CARDIOVASCOLARE |
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73. ANTIATHEROSCLEROTIC
PROPERTIES OF EVEROLIMUS: IN VITRO AND IN VIVO STUDIES
S. Bellosta, R. Baetta, N. Ferri, L. Arnaboldi, M. Canavesi, P.
Pfister*, A. Granata, R. Dorent*, A Corsini
Department of Pharmacological Sciences, University of Milan,
Milan, Italy; *Novartis Pharma AG, Basel, Switzerland
74. INFECTION
AND ATHEROSCLEROSIS: SIMVASTATIN LOWERS THE RISK OF DEVELOPING ATHEROSCLEROSIS
BY LIMITING COXSACKIEVIRUS B INFECTION AND THE EXPRESSION OF PRO-INFLAMMATORY
MARKERS IN HUMAN VASCULAR ENDOTHELIAL CELLS
Elena Ferioli*, Antonella Bottelli*, Giuseppe Armocida*, PierGiulio
Conaldi°
*Department of Medicine and Public Health, University of Insubria,
Varese, Italy; ° ISMETT, Palermo, Italy
75. IN
VIVO STIMULATION OF LXR INCREASES THE EFFLUX POTENTIAL OF SERA AND
PROMOTES THE REVERSE CHOLESTEROL TRANSPORT
Zanotti Ilaria, Potì Francesco, Pedrelli Matteo, Favari Elda,
Calabresi Laura *, Moleri Elsa *, Bernini Franco
Dept. of Pharmacological and Biological Sciences and Applied
Chemistries, University of Parma, Parma, and *Center E. Grossi Paoletti,
Dept. of Pharmacological Sciences, University of Milan, Milan
76. ROLE
OF MESNA TO REDUCE HOMOCYSTEINE LEVELS THROUGH SH/SS EXCHANGE REACTION:
POSSIBLE THERAPEUTICAL APPLICATIONS IN HYPERHOMOCYSTEINEMIC PATIENTS
Di Giuseppe D., Frosali S., Priora R., Margaritis A., Summa D.,
Di Simplicio P.
Department of Neuroscience, Pharmacology Unit, University of
Siena
77. PROTEIN-THIOL
SUBSTITUTION OR PROTEIN DETHIOLATION BY SH/SS ECHANGE REACTIONS:
THE ALBUMIN MODEL
Domenico Summa, Ottavia S., Priora R., Frosali S., Margaritis A.,
Di Giuseppe D., Niccolai N., d Paolo Di Simplicio
Department of Neuroscience, Pharmacology Unit, and Dept of Molecular
Biology, University of Siena, 53100 Siena, Italy; *Department of
Molecular Biology, University of Siena, 53100 Siena, Italy
78. FLAXSEED
OIL SUPPLEMENTATION INCREASES PLASMA AND TISSUE CONCENTRATIONS OF
( -3) FATTY ACIDS IN RATS
Notarangelo Francesca§, Avallone Rossella§, Rustichelli
Cecilia#, Campioli Enrico§, Braghiroli Daniela#, Baraldi Mario§°
§Department of Biomedical Sciences, #Department of Pharmaceutical
Sciences, Via Campi 287, 41100 Modena, Italy, Pharmacology, °National
InterUniversity Consortium for the Study of Natural Active Principles
(CINSPAN)
79. SYNTHESIS
AND PRELIMINARY BIOLOGICAL EVALUATION OF NEW PARTIALLY FLUORINATED
THIOL DUAL INHIBITORS OF NEUTRAL ENDOPEPTIDASE 24.11 AND ANGIOTENSIN
CONVERTING ENZYME
Simone Tambaro,a Francesca Olimpieri,b Paolo Lazzari,a Alessandro
Volonterio,b Barbara Pittau,a Luca Pani,a,c Matteo Zanda,b
a Neuroscienze PharmaNess S.c.a r.l., c/o POLARIS, Edificio
5, Loc.Piscinamanna, 09010 Pula (CA), Italy; b C.N.R. Istituto di
Chimica del Riconoscimento Molecolare, Via Mancinelli 7, 20131 Milano,
Italy; d C.N.R. Istituto di Tecnologie Biomediche, Sezione di Cagliari,
c/o Neuroscienze PharmaNess S.c.a r.l.
80. CARDIOPROTECTIVE
ACTIVITY OF SIDENAFIL IN RATS WITH CHRONIC NITRIC OXIDE SYNTHASE
INHIBITION
Manfredi Barbara, De Gennaro Colonna Vito, Berti Ferruccio, Rossoni
Giuseppe
Department of Pharmacology, Chemotherapy and Medical Toxicology,
University of Milan, Italy |
7 |
FARMACOLOGIA DEL SISTEMA NERVOSO |
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81. NOCICEPTIN/ORPHANIN
FQ-INDUCED INHIBITION OF ELECTRICAL ACTIVITY IN DORSAL RAPHE NUCLEUS
SLICES FROM NORMAL AND STRESSED RATS
Barbieri Mario, Nazzaro Cristiano, Beani Lorenzo, Siniscalchi Anna
Department of Clinical and Experimental Medicine University
of Ferrara, Via Fossato di Mortara, 17-19; 44100 Ferrara
82. PHARMACOLOGICAL
CHARACTERIZATION OF THE NOCICEPTIN/ORPHANINN FQ RECEPTOR ANTAGONIST
SB-612111: IN VIVO STUDIES
1Rizzi Anna, 1Gavioli Elaine, 1Marzola Giuliano, 1Spagnolo Barbara,
1Zucchini Silvia, 2Ciccocioppo Roberto, 3Trapella Claudio, 1Regoli
Domenico and 1Calo’ Girolamo
1Dept. of Pharmacology and 3Dept of Pharmaceutical Science,
University of Ferrara, Italy; 2Dept. of Experimental Medicine and
Public Health, University of Camerino, Italy
83. FUNCTIONAL
ANTAGONISM BETWEEN NOCICEPTIN/ORPHANIN FQ (N/OFQ) AND CRF IN THE
RAT BRAIN: EVIDENCE FOR INVOLVEMENT OF THE BED NUCLEUS OF THE STRIA
TERMINALIS
Rodi Donata (1), Zucchini Silvia (1), Simonato Michele (1), Cifani
Carlo (2), Massi Maurizio (2), Polidori Carlo (2)
1) Department of Clinical and Experimental Medicine, Pharmacology
Section, and Neuroscience Centre, University of Ferrara; 2) Department
of Experimental Medicine and Publich Health, University of Camerino
84. ANTICONVULSANT
EFFECTS OF ORPHANIN FQ ON SEIZURES INDUCED BY PENTYLENETETRAZOLE
Di Giannuario Amalia1, Colucci Mariantonella1, Maione Francesco1,2,
Mascolo Nicola2, Pieretti1 Stefano
1Department of Drug Research and Evaluation, Istituto Superiore
di Sanità, V.le Regina Elena 299 - 00161 Rome. 2Department
of Experimental Pharmacology, University of Naples Federico II,
Via Domenico Montesano 49 - 80131 Naples
85. EFFECT
OF NOVEL NOCICEPTIN/ORPHANIN FQ-NOP RECEPTOR LIGANDS ON FOOD INTAKE
IN WISTAR RATS
Cifani Carlo a, Polidori Carlo a, Calò Girolamo b, Massi
Maurizio a
a Department of Experimental Medicine and Public Health, University
of Camerino, I-62032, Camerino, Italy; b Department of Experimental
and Clinical Medicine, Section of Pharmacology and Neuroscience
Center, University of Ferrara, I-44100 Ferrara, Italy
86. CHRONIC
I.C.V. TREATMENT WITH [NPHE1, ARG14, LYS15] N/OFQ-NH2 (UFP-101),
A POTENT NOP RECEPTOR ANTAGONIST, REVERSES BEHAVIOURAL AND BIOCHEMICAL
EFFECTS OF CHRONIC MILD STRESS IN RATS
Vitale Giovanni a, Ruggieri Valentina a, Frigeri Claudio a, Filaferro
Monica a, Guerrini Remo b and Maurizio Massi c
a Department of Biomedical Sciences, Section of Pharmacology,
University of Modena and Reggio Emilia; b Department of Pharmaceutical
Sciences , University of Ferrara; c Department of Pharmacological
Sciences and Experimental Medicine, University of Camerino
87. NOCICEPTIN/ORPHANIN
FQ AND FOOD INTAKE IN DISEASE-PRONE WOKW AND DISEASE-RESISTANT DA
RATS
Cifani Carlo a, Filippetti Roberta a, Kloting Ingrid b, Massi Maurizio
a and Polidori Carlo a
a Department of Experimental Medicine and Public Health, University
of Camerino, I-62032 Camerino, Italy - b Department of Laboratory
Animal Science, Medical Faculty, University of Greifswald, D-17495
Karlsburg, Germany
88. THE
NEURODIFFERENTIATIVE EFFECT OF ESTROGEN INVOLVES NUCLEAR RECEPTORS
AND IS MEDIATED BY TGF-B
Merlo Sara1,2, Canonico Pier Luigi2, Copani Agata3, Sortino Maria
Angela1
Departments of 1Experimental and Clinical Pharmacology and 3Pharmaceutical
Sciences, University of Catania, and 2DISCAFF, University of Piemonte
Orientale, Novara
89. ERYTHROPOIETIN
INHIBTS THE RELEASE, BUT NOT SYNTHESIS, OF CORTICOTROPIN-RELEASING
HORMONE FROM RAT HYPOTHALAMIC EXPLANTS IN VITRO
Tringali Giuseppe, Lisi Lucia, Pozzoli Giacomo, Navarra Pierluigi
Institute of Pharmacology, Catholic University Medical School,
Rome, Italy
90. NEUROCHEMICAL
EFFECTS OF POST-WEANING SOCIAL ISOLATION IN ADULT RAT BRAIN
Colaianna Marilena (a), De Giorgi Angelo (a), Cuomo Vincenzo (b),
Trabace Luigia (a)
(a)Dept. Biomedical Sciences, University of Foggia, Foggia,
Italy; (b)Dept. of Human Physiology and Pharmacology, Vittorio Espamer,
University of Rome La Sapienza, Rome, Italy
91. STRAIN-DEPENDENT
LEVELS OF BIOGENIC AMINE IN POST-WEANING SOCIALLY-ISOLATED RATS
Castrignanò Silvia(a), Zotti Margherita(a), Cuomo Vincenzo(b),
Trabace Luigia(a)
(a)Dept. of Biomedical Sciences, University of Foggia; (b)Dept.
of Human Physiology and Pharmacology, Vittorio Espamer, University
of Rome La Sapienza, Rome, Italy
92. SELECTIVE
VOLUME REDUCTION OF ANTERIOR CINGULATE CORTEX IN YOUNG ADULT RATS
AFTER NEONATAL EXCITOTOXIC LESION OF VENTRAL HIPPOCAMPUS
Gianluca Casu,* Giorgio Marchese,* Paola Casti,* Gabriele Pinna
Spada,* Luca Pani,*,§
*Neuroscienze PharmaNess S.c.a r.l., c/o POLARIS,
Edificio 5, Loc.Piscinamanna, 09010 Pula (CA), Italy; §C.N.R.
Istituto di Tecnologie Biomediche, Sezione di Cagliari, c/o Neuroscienze
PharmaNess S.c.a r.l.
93. ACUTE
BUT NOT CHRONIC TREATMENT WITH OLANZAPINE REDUCES EXPERIMENTAL ANXIETY
IN RATS: POSSIBLE MECHANISMS
Locchi Federica, Rimondini Roberto, Dall’Olio Rossella, Gandolfi
Ottavio
Department of Pharmacology, University of Bologna, 40128 Bologna,
Italy
94. GENDER
DIFFERENCES ON LONG TERM EFFECTS OF RAT PRENATAL STRESS ON DORSAL
AND VENTRAL HIPPOCAMPAL METABOTROPIC GLUTAMATE RECEPTORS AND ANXIETY
BEHAVIOUR
Zuena Anna Rita1,2, Casolini Paola1, Mairesse Jerome1,2, Cinque
Carlo1, Matteucci Patrizia1, Alemà Giovanni Sebastiano1,
Morley-Fletcher Sara2, Catalani Assia1, Nicoletti Ferdinando1,3,
Maccari Stefania2.
1Dept of Human Physiology and Pharmacology, Univesity of Rome
“La Sapienza”, Italy; 2Lab of Perinatal Stress, University
of Lille 1, France; 3INM Neuromed, Pozzilli, Italy
95. POST-NATAL
REPEATED MILD STRESS INDUCES CHANGES IN BRAIN NAD(P)H RECYCLING
IN ADULT MALE MICE: ROLE OF THE OPIOID SYSTEM
Stefano Loizzo, Irene Guarino, Gabriella Galietta, Andrea Fortuna,
Alberto Loizzo, Santi Spampinato, Gabriele Campana, Anna Capasso,
Flavia Franconi
Section of Drugs and Health for the Child and the Woman, Dept
of Drug Research and Evaluation, and National Centre for Rare Diseases,
Istituto Superiore di Sanita’, Roma, Dept of Pharmacology,
University of Bologna, Dept of Pharmacology, University of Salerno,
Dept of Pharmacology and Centre of Excellence for Biotechnology
and Biodiversity University of Sassari, and GIOIA Foundation
96. CHANGES
IN HIPPOCAMPAL GENE EXPRESSION PROFILE FOLLOWING ACUTE AND CHRONIC
STRESS IN THE MOUSE
Ubaldi Massimo1, Lourdusamy Anbarasu1, Soverchia Laura1, Cippitelli
Andrea1, Barbara Ruggeri1, Gary Hardiman2, Ciccocioppo Roberto1
1Department of Experimental Medicine and Public Health, University
of Camerino Italy; 2Department of Medicine, University of California
San Diego, CA, USA
97. TREATMENT
OF PREMENSTRUAL SYNDROME WITH CONTINUOUS LOW DOSAGE SERTRALIN
Walter Milano, Emanuela Tammaro*, Luca Milano, Sara Rundle-Smith,
Claudio Petrella, Anna Capasso*
Mental Health Operations Unit District 44 ASL Napoli 1 and *Department
of Pharmaceutical Sciences, University of Salerno, Italy
98. NOVEL
THERAPEUTIC OPPORTUNITIES IN UNIPOLAR DEPRESSION
Mauro Corsi, W.P.
Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithkline
S.p.A., Verona, Italy
99. LIFESTYLE
INTERVENTIONS ON BODYWEIGHT GAIN OLANZAPINE-INDUCED: RESULT FROM
A RANDOMIZED-CONTROLLED TRIAL
Michela Cammarano*, Walter Milano, Margherita Comazzi°, Luca
Milano, Claudio Petrella, Anna Capasso*
Unità Operativa Salute Mentale Distretto 44 ASL Napoli1;
* Department of Pharmaceutical Sciences, University of Salerno,
Italy; ° Unità di Psichiatria Azienda Ospedaliera di
Melegnano Milano
100. TOLERABILITY
OF ANTIPSYCHOTICS IN CHILDREN AND ADOLESCENTS: A PROSPECTIVE STUDY
Marianna Alacqua1, Gianluca Trifirò1,4, Vincenzo Arcoraci1,
Eva Germanò2, Antonella Gagliano2,Mariarosa Siracusano2,
Giuseppa Di Vita3, Catalda Gagliano3, Edoardo Spina1, 4
1Department of Clinical and Experimental Medicine and Pharmacology,
Pharmacology Unit, University of Messina, Italy - 2 Division of
Child Neurology and Psychiatry, University of Messina, Italy - 3
Oasi Institute for Research on Mental Retardation and Brain Aging
(IRCCS), Troina, Italy; 4 IRCCS Centro Neurolesi "Bonino-Pulejo",
Messina, Italy
101. PLASMA
CONCENTRATIONS OF QUETIAPINE DURING COADMINISTRATION WITH ANTIEPILEPTIC
DRUGS IN PSYCHIATRIC PATIENTS
D’Arrigo Concetta1, Migliardi Gaetana1, Santoro Vincenza2,
Muscatello Maria Rosaria3, Zoccali Rocco3 and Spina Edoardo1,2
1Section of Pharmacology, Department of Clinical and Experimental
Medicine and Pharmacology, 2IRCCS Centro Neurolesi “Bonino-Pulejo”
and 3Department of Neurosciences, Psychiatric and Anesthesiological
Sciences, University of Messina, Messina, Italy
102. POTENTIAL
APPLICATION OF TESTOSTERONE METABOLITES IN THE TREATMENT OF ADRENOLEUKODYSTROPHY
Romina Carissimi1, Milena Blasevich1, Marco Cappa2, Graziella Uziel3,
Anna Petroni1
1Depart. of Pharmacological Sciences, University of Milan, via
Balzaretti 9, 20133 Milan, Italy; 2Depart. of Pediatrics Medicine,
Children’s Hospital “Bambino Gesù”, IRCCS,
Rome, Italy; 3Child Neurology Dep., Istituto Neurologico “C.
Besta”, Milan, Italy
103. DEVELOPMENT
OF SPECIFIC BIOMARKERS FOR ALS CLINICAL PROGRESSION: VALIDATION
AND POTENTIAL ROLES IN PATHOGENESIS
Bonini Sara A.1, Zhao Zhong2, Lange Dale J3., Ho Lap2, Yemul Shrishailam2,
Wang Jun2, Salton Steven4, Memo Maurizio1, Pasinetti Giulio M.2
1 Department of Biomedical Sciences and Biotechnologies, University
of Brescia, Brescia, Italy; 2 Department of Psychiatry, 3 Department
of Neurology,4 Department of Neuroscience, Mount Sinai School of
Medicine, New York, New York, USA
104. FUNCTIONAL
HETEROGENEITY OF HISTAMINERGIC NEURONS SUGGEST INTERESTING APPLICATIONS
OF GSK189254, A NOVEL H3 RECEPTOR ANTAGONIST
Patrizia Giannoni1, M.Beatrice Passani1, Daniele Nosi2, Andrew D.
Medhurst3, Paul Chazot4, Fiona Shenton4 and Patrizio Blandina1
1Dipartimento di Farmacologia Preclinica and Clinica, 2Dipartimento
di Anatomy Universita’ di Firenze Italy, 3Neurology Centre
of Excellence for Drug Discovery,GlaxoSmithKline,Essex CM19 5AW,
UK, 4Centre for Integrative Neuroscience, School of Biological and
Biomedical Sciences, Durham University, UK
105. IMPROVEMENTS
IN LONG-TERM MEMORY RETENTION BY INHIBITION OF FATTY ACID AMIDE
HYDROLASE (FAAH) ARE MEDIATED BY A-TYPE PEROXISONE PROLIFERATOR-ACTIVATED
RECEPTORS (PPARA) AND NOT BY CANNABINOID CB1 RECEPTORS
Mazzola C1, , Medalie J1, Panlilio LV1, Solinas M2, Drago F3, Goldberg
SR1 and Yasar S4
1 Preclinical Pharmacology Section, Behavioral Neuroscience
Research Branch, Intramural Research Program, NIDA, NIH, DHHS, Baltimore,
MD, 21224, USA.2 Department Laboratoire de Biologie et Physiologie
Cellulaires, CNRS-6187, Université de Poitiers, 86022, Poitiers,
France. 3 Department of Experimental and Clinical Pharmacology,
Medical School, University of Catania, Italy. 4 Division of Geriatric
Medicine, Johns Hopkins Medical School, Baltimore, MD, 21224, USA
106. TRICYCLIC
PYRAZOLES. SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL 4,5-DIHYDRO-1H-6-OXA-CYCLOHEPTA[1,2-C]PYRAZOLE-BASED
ANALOGUES OF CANNABINOID ANTAGONIST NESS 0327
Christian Dessì,‡, Gabriele Murineddu,† Stefania
Ruiu,‡ Giovanni Loriga,† Ilaria Manca,† Paolo
Lazzari,‡ Amedeo Pau,† Roberta Reali,‡ Gérard
A. Pinna† and Luca Pani‡,§
‡Neuroscienze PharmaNess S.c.a r.l., c/o POLARIS, Edificio
5, Loc.Piscinamanna, 09010 Pula (CA), Italy; †Dipartimento
Farmaco Chimico Tossicologico, Università di Sassari, Via
F. Muroni 23/A, 07100 Sassari, Italy; §C.N.R. Istituto di Tecnologie
Biomediche, Sezione di Cagliari, c/o Neuroscienze PharmaNess S.c.a
r.l.
107. EARLY
AND LATE POST-MORTEM NEURAL STEM CELLS GROW AND DIFFERENTIATE IN
VITRO. A NOVEL SOURCE FOR CELLULAR THERAPY
Laura Madaschi1*, Giovanni Marfia1*, Daniela Cigognini1, Daniele
Bottai1,2 , Anna Maria Di Giulio1, Alfredo Gorio1,2
1) Dept. of Medicine, Surgery and Dentistry, Faculty of Medicine,
University of Milan, Italy; 2) Clinical Pharmacology IRCCS Humanitas,
Milan, Italy; * These two authors equally contributed at this work
108. CALCINEURIN
PRIMES GNRH-SECRETING NEURONS FOR MIGRATION
Zaninetti Roberta, Tacchi Sara, Erriquez Jessica, Distasi Carla,
Maggi Roberto*, Canonico PierLuigi, Genazzani Armando A.
Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche
Farmacologiche, Drug and Food Biotechnology Center, Università
degli Studi del Piemonte Orientale “A. Avogadro”, Novara
*Laboratorio di Neuroendocrinologia dello Sviluppo, Istituto di
Endocrinologia, CEND, Università degli Studi di Milano
109. THE
GHB-ANALOGUE, GET 73, PREVENTS EITHER THE DEVELOPMENT OF PREFERENCE
FOR SUCROSE IN NON-STRESSED RATS, OR THE REDUCTION OF SUCROSE INTAKE
IN CHRONICALLY STRESSED RATS
Tacchi Raffaella1, Ferrari A1, Pinetti D1, Sternieri
E1, Bertolini A1, Ottani A2
1Dipartimento Integrato di Servizi Diagnostici
e di Laboratorio, Struttura Complessa di Tossicologia e Farmacologia
Clinica, Università di Modena e Reggio Emilia; 2Dipartimento
di Scienze Biomediche, Sezione di Farmacologia, Università
di Modena e Reggio Emilia
110. STANDARDIZED
ANALYSIS OF C-FOS MRNA EXPRESSION PATTERN IN RAT BRAIN AUTORADIOGRAPHY
USING FREEWARE IMAGING SOFTWARE
Dipasquale Pasqua, Celentano Michele, Righetti Laura, Lucchino Ilaria,
Gaetani Silvana and Cuomo Vincenzo
Department of Human Physiology and Pharmacology, University
of Rome “La Sapienza” |
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FARMACOLOGIA DEI PROCESSI DEGENERATIVI |
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111. GPR17:
A NEW DUAL RECEPTOR FOR BOTH EXTRACELLULAR NUCLEOTIDES AND CYSTEINYL-LEUCOTRIENES
INVOLVED IN BRAIN ISCHEMIA
Gelosa Paolo1, Sironi Luigi1, Guerrini Uliano1, Tremoli Elena1,2,
Enrico Rovati1, Patrizia Rosa3, Lecca Davide1, Pignieri Alice1,
Abbracchio Maria P1* and Cimino Mauro4*
1Department of Pharmacological Sciences, University of Milan,
Italy - 2Monzino Cardiologic Centre IRCCS, Milan, Italy - 3CNR Institute
of Neuroscience, Cellular and Molecular Pharmacology, Milan, Italy
- 4Institute of Pharmacology and Pharmacognosy, University of Urbino,
Italy; *equally contributed to the present work
112. APOMORPHINE-INDUCED
NEURODEGENERATION IN MONGOLIAN GERBIL HIPPOCAMPUS
Donato Giuseppe1, Russo E.1, De Fazio S.1, De Fazio P.1, Perrotta
I.2, De Sarro G.1
1Department of Experimental and Clinical Medicine, Faculty of
Medicine and Surgery, University of Catanzaro, Catanzaro, Italy;
2Ecology Department, University of Calabria, Cosenza, Italy
113. BLUNTED
HPA AXIS ACTIVITY DURING ISCHEMIA PROTECTS ADULT RATS NEONATALLY
EXPOSED TO GLUCOCORTICOIDS AGAINST BRAIN DAMAGE
Cinque Carlo1, Mairesse Jerome3, Casolini Paola1, Domenici Maria
Rosaria2, Galluzzo Mariangela2, Musumeci Marco2, Alemà Giovanni
Sebastiano1, Zuena Anna Rita1, Matteucci Patrizia1, Maccari Stefania3,
Nicoletti Ferdinando1,4, Catalani Assia1
1. Dep. of Human Physiol & Pharmacol, University “Sapienza”,
Rome, Italy; 2. Dep. of Pharmacol, Istituto Superiore di Sanità,
Rome, Italy; 3. Lab. Perinatal Stress, JE2365. University of Lille
1, 59655 Villeneuve d’Ascq, France; 4. INM Neuromed, Pozzilli,
Italy
114. KNOCKING-DOWN
AND KNOCKING-OUT OF NCKX2 GENE EXPRESSION EXACERBATE THE BRAIN INSULT
INDUCED BY FOCAL ISCHEMIA
Cuomo Ornella, Pignataro G., Gala R., Boscia F., Tortiglione A.,
Valsecchi V., Di Renzo GF., Lytton J.* and Annunziato L.
Division of Pharmacology, Department of Neuroscience, School
of Medicine, , Federico II University of Naples, Via S. Pansini
5, 80131 Naples, Italy. *Department of Biochemistry and Molecular
Biology University of Calgary, Calgary, Alberta, Canada
115. NEUROPROTECTIVE
EFFECT OF MELANOCORTINS IN FOCAL CEREBRAL ISCHEMIA
Giuliani Daniela1, Ottani Alessandra1, Mioni Chiara1, Galantucci
Maria1, Bazzani Carla1, Zaffe Davide2, Bitto Alessandra3, Minutoli
Letteria3, Botticelli Annibale R.4, Altavilla Domenica3, Squadrito
Francesco3, Guarini Salvatore1
1Dept. Biomedical Sci., Sect. Pharmacology, and 2Dept. Anatomy
and Histology, University of Modena and Reggio Emilia; 3Dept. Clin.
Exp. Med. Pharmacol., Sect. Pharmacology, University of Messina;
4Dept. Human Pathology, University of Pavia
116. INDUCTION
OF THE WNT INHIBITOR, DICKKOPF-1, IS ASSOCIATED WITH NEURODEGENERATION
RELATED TO TEMPORAL LOBE EPILEPSY
Francesca Biagioni1, Carla L. Busceti1, Eleonora Aronica2*, Marianna
Storto1, Giuseppe Battaglia1, Filippo S. Giorgi3, Francesco Fornai1,3,
Roberto Gradini4, Andrea Caricasole5, Ferdinando Nicoletti1,6, Valeria
Bruno1,6
1I.N.M. Neuromed, Pozzilli, Italy; 2Dept. of Neuropathol., Univ.
of Amsterdam, The Netherland; 3Dept. of Hum. Morphol., Univ. of
Pisa, Italy; 5SienaBiotech, Siena, Italy; 5Dept. of Exp. Med. and
6Hum. Physiol. And Pharmacol. , Univ. “La Sapienza”,
Rome, Italy
117. STIMULATION
OF PROTEINASE-ACTIVATED RECEPTORS 1 AND 2 INDUCES NEURODEGENERATION
IN THE RAT OLFACTORY SYSTEM
Simona Dedoni, Maria C. Olianas, Luciana Garau and Pierluigi Onali
Section of Biochemical Pharmacology, Department of Neuroscience,
University of Cagliari, Cagliari, Italy
118. HISTONE
DEACETYLASE (HDAC) INHIBITORS REDUCE THE IN VITRO AND IN VIVO NEUROINFLAMMATORY
RESPONSE IN MICE
Faraco Giuseppe, Fossati Silvia, Formentini Laura, * Mascagni Paolo,
* Fossati Gianluca, * Leoni Flavio, Moroni Flavio e Chiarugi Alberto
Dipartimento di Farmacologia Clinica e Preclinica, Università
degli Studi di Firenze *Italfarmaco S.p.a., Milan, Italy
119. NEUROPROTECTION
BY 17B-ESTRADIOL IN WHOLE RAT URINARY BLADDER SUBJECTED TO ISCHAEMIA/REPERFUSION
INJURY
Valeri Aurora, Pessina F., Sgaragli G.
Dip. Scienze Biomediche, Università degli Studi di Siena,
Via Aldo Moro 2 , 53100 Siena
120. HEME
OXYGENASE ACTIVITY IN IMMORTALIZED HYPOTHALAMIC NEURONS GT1-7
Mores Nadia, Mancuso Cesare, Errico Stefania, Barone Eugenio, Preziosi
Paolo
Istituto di Farmacologia – Facoltà di Medicina
e Chirurgia
Università Cattolica del Sacro Cuore - Roma
121. SPINAL
CORD INJURY AND NEURAL PRECURSORS. HOMING, FATE AND RECOVERY OF
FUNCTION
Bottai Daniele 1,2, Maraschi Laura 1, Di Giulio Anna Maria1 and
Gorio Alfredo 1,2
1) Department of Medicine, Surgery and Dentistry, University
of Milan, Via A. di Rudinì 8, 20142 Milano, Italy; 2) Clinical
Pharmacology IRCCS Humanitas Via Manzoni 56, 20089 Rozzano, Milano,
Italy
122. MELATONIN
PROTECTS FROM THE LONG-TERM MORPHOLOGICAL AND FUNCTIONAL CONSEQUENCES
OF A NEONATAL HYPOXIC-ISCHEMIC BRAIN INJURY IN RATS
Silvia Carloni, Giuseppe Buonocore1, Serafina Perrone1, Mariangela
Longini1, Fabrizio Proietti1, Walter Balduini
Istituto di Farmacologia e Farmacognosia, Università
degli Studi di Urbino “Carlo Bo”, Via S. Chiara 27,
Urbino; 1Dipartimento di Pediatria, Ostetricia e Medicina della
Riproduzione, Sezione di Neonatologia Università di Siena,
Policlinico Le Scotte Via M. Bracci, Siena
123. PENTOXIFYLLINE
AMELIORATES CALCIUM HOMEOSTASIS AND IMPROVES REGENERATION IN SKELETAL
MUSCLE OF DYSTROPHIC MDX MICE: A COMPARISON WITH THE EFFECTS OF
A COMBINED TREATMENT PREDNISOLONE-TAURINE
Burdi Rosa1, Rolland Jean-François1, Cozzoli Anna1, Giannuzzi
Viviana1, Liantonio Antonella1, Camerino Giulia M.1, Andreetta Francesca2,
Confalonieri Paolo2, Mangieri Domenica 3, Nico Beatrice3, De Luca
Annamaria 1
1Unit of Pharmacology, Department of Pharmacobiology, Faculty
of Pharmacy, University of Bari, Italy; 2Muscular Pathology Unit,
National Neurological Institute Carlo Besta, Milan, Italy, 3Department
of Human Anatomy and Histology, University of Bari, Italy
124. EFFECT
OF A CHRONIC TREATMENT WITH GENTAMICIN ON IN VIVO AND EX VIVO MARKERS
OF DYSTROPHIC PROGRESSION IN MDX MOUSE
Cozzoli Anna1, Burdi Rosa1,Cippone Valentina1, Nicchia Grazia P.2,
Frigeri Antonio2, Camerino Giulia M.2, Mangieri Domenica3, Nico
Beatrice3 and De Luca Annamaria1
1Dept. of Pharmacobiology, Faculty Pharmacy and 2Dept. of General
and Environmental Physiology, 3Department of Human Anatomy and Histology,
University of Bari, Italy
125. VEGF
OVEREXPRESSION VIA ADENO-ASSOCIATED VIRUS GENE TRANSFER PROMOTES
SKELETAL MUSCLE REGENERATION AND ENHANCES MUSCLE FUNCTION IN MDX
MICE
Di Stefano Vincenzo1, Bitto Alessandra1, Minutoli Letteria1, Altavilla
Domenica1, Messina Sonia2, Vita Giuseppe2, Giacca Mauro3, Caputi
Achille P.1 and Squadrito Francesco1
1Department of Clinical and Experimental Medicine and Pharmacology,
University of Messina, 2Dept of Neurosci, Psych and Anaesthesiol,
University of Messina, 3Mol Med Lab, International Centre for Genetic
Engineering and Biotechnology (ICGEB), Trieste, Italy
126. POSSIBLE
ANTIOXIDANT EFFECT OF SULPHUR MUD- BATH THERAPY IN TREATMENT OF
OSTEOARTHROSIS
1,2Costantino Maria, 2Lampa Enrico, 3Giuberti Gaia, 3Caraglia Michele,
3Abbruzzese Alberto, 2Filippelli Amelia
1CE.RI.S.T. (Center of Thermal Researches and Studies srl),
Naples, Italy; 2Department of Experimental Medicine–Pharmacological
Division, II University of Naples-Italy; 3Department of Biochemistry
and Biophysics “F. Cedrangolo” – II University
of Naples, Naples, Italy
127. BILIRUBIN
MODULATES NEUROTROPHIN REDOX SIGNALING
Mancuso Cesare1, Eboli Maria L.2, Calabrese Vittorio3, Preziosi
Paolo1, Galeotti Tommaso2, Pani Giovambattista2.
From the Institutes of 1Pharmacology and 2General Pathology,
Catholic University School of Medicine, Largo F. Vito, 1 - 00168
Roma, Italy; 3Dept. of Chemistry, Biochemistry and Mol. Biology
Section, Faculty of Medicine, University of Catania, 95100, Catania,
Italy
128. A
STUDY ON BIOLOGICAL ACTIVITIES OF CYANIDIN-3-O-GLUCOSIDE RELATED
TO ITS ANTIOXIDANT PROPERTIES
1Speciale A.,1Cimino F., 1Chirafisi J., 1Cristani M., 2Ermito S.,
1Spinzia C., 1Saija A.
1Dept. Farmaco-Biologico, School of Pharmacy, University of
Messina - Vill. SS. Annunziata 98168 Messina, Italy. 2Institute
of Gynecology and Obstetrics, University of Messina, Italy
129. PROTECTIVE
EFFECT OF MN(III) TETRAKIS (4-BENZOIC ACID) PORPHYRIN ON THE INACTIVATION
OF PRIMARY ANTIOXIDANT ENZYMES IN KERATINOCYTES BY PHOTODYNAMICALLY
GENERATED FREE RADICALS
Carolina Muscoli1, Steven Nistico’2, Rosaria Arcone1, Carmen
Colica1, Valeria Visalli1, Domenica Vetrice1, Francesca Casale1,
Immacolata Del Vecchio3, Maria Concetta Strongoli3, Vincenzo Mollace1
and Domenicantonio Rotiroti3
1Dept of Pharmacobiol. Sciences, University of Catanzaro Magna
Graecia, Italy; 2 School of Medicine, Univesity of Rome “Tor
Vergata”; 3ISN-CNR
130. ANTICATARACTOGENIC
PROPERTY OF G-GLUTAMYLCYSTEINE ETHYL ESTER IN AN ANIMAL MODEL OF
CATARACT
Pannini Simone, Barberi Luigi, Leone Raffaele L, Casini Piero
Department of Farmacology “G. Segre”, University
of Siena
131. ASSESSMENT
OF BLOOD AND SALIVARY ANTIOXIDANT SYSTEM IN SUBJECTS WITH PERIODONTITIS
AND PERI-IMPLANTITIS
Fiaschi Anna Ida, *Ruggero Grazia, De Vuono Giulia, Cerretani Daniela,
*Cozzolino Annunziata
Department of Pharmacology “G. Segre”, *Department
of Odontostomatologic Science, Maxillo-Facial Surgery Division,
University of Siena
132. STATUS
OF LIPID PEROXIDATION IN PATIENTS WITH OSTEOARTHRITIS UNDERWENT
A TAMMEF SYSTEM
Fiaschi Anna Ida, *Battisti Emilio, *Albanese Antonietta, Cerretani
Daniela, Runci Francesco
Department of Pharmacology “G. Segre”, *Centre TAMMEF,
University of Siena |
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FARMACOLOGIA DEL DOLORE |
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133. REPEATED
TREATMENT WITH AM404 REDUCES MECHANICAL ALLODYNIA AND THERMAL HYPERALGESIA
IN A MODEL OF NEUROPATHIC PAIN WITHOUT CENTRAL EFFECTS
Sasso Oscar, La Rana G., Russo R., D’Agostino G., Iacono A.,
Meli R. and Calignano A.
Dep Experimental Pharmacology, Faculty of Pharmacy, via D. Montesano
49-Naples
134. ANTIHYPERALGESIC
AND ANTIALLODYNIC EFFECT OF PURINERGIC ANTAGONISTS IN A MOUSE MODEL
OF MONONEUROPATHY: NEUROINFLAMMATORY INVOLVED MECHANISMS
Trovato Anna Elisa1, Franchi Silvia1, Magnaghi Valerio2, Panerai
Alberto E.1, Procacci Patrizia4, Rodella Luigi F.3, Sacerdote Paola1,
Valsecchi Anna E.1 and Colleoni Mariapia1
1Dep. Pharmacol. Chem. Med. Toxicol, Univ. of Milan, 2Dep. Endocrinol,
Center Excell. Neurodegen. Dis., Univ. of Milan, 3Divis. Anat.,
Dep. Biomedic. Sci. Biotechnol., Univ. of Brescia, 4Inst. Histol.
Embriol. Neurocytol., Univ. of Milan
135. PHYTOESTROGEN
GENISTEIN REDUCES NOCICEPTIVE HYPERSENSITIVITY IN THE MOUSE CHRONIC
CONSTRICTION INJURY MODEL
Valsecchi Anna E., Franchi Silvia, Panerai Alberto E., Sacerdote
Paola, Trovato Anna E. and Colleoni Mariapia
Departement of Pharmacology, Chemoterapy and Medical Toxicology,
University of Milan
136. BLOCKADE
OF THE TRPV1 RECEPTOR AND OF THE FATTY ACID AMIDE HYDROLASE ENZYME
IN A MOUSE MODEL OF NEUROPATHIC PAIN PREVENTS PAIN-LIKE BEHAVIOUR
AND CASPASES ACTIVATION
Giordano Catia, Siniscalco Dario, Migliozzi Annalucia, Rossi Francesco,
Di Marzo Vincenzo°, Maione Sabatino
Istituto di Chimica Biomolecolare, CNR, Pozzuoli (NA), Italy;
Department of Experimental Medicine, section of Pharmacology, Second
University of Naples, Via S. Maria di Costantinopoli 16 –
80138 Naples, Italy
137. THE
FATTY-ACID AMIDE HYDROLASE INHIBITOR URB597 REDUCES NEUROPATHIC
PAIN AFTER ORAL ADMINISTRATION IN MICE
Roberto Russo, Giovanna La Rana, Giuseppe D’Agostino, Oscar
Sasso, Jesse LoVerme, Daniele Piomelli and Antonio Malignano
Department of Experimental Pharmacology, University of Naples,
Italy.; Department of Pharmacology and the Center for Drug Discovery,
University of California, Irvine
138. N-ARACHIDONOYL-SEROTONIN:
A FATTY ACID AMIDE HYDROLASE INHIBITOR WITH ANTAGONISTIC ACTIVITY
AT TRPV1 RECEPTORS AND ANALGESIC PROPERTIES IN VIVO
Palazzo Enza1, De Petrocellis Luciano2, Petrosino Stefania2, Gatta
Luisa1, Guida Francesca1, Ortar Giorgio3, Rossi Francesco1, Maione
Sabatino1, Di Marzo Vincenzo2
1Department of Experimental Medicine, Section of Pharmacology
“L. Donatelli”, Second University of Naples, via Costantinopoli
16, 80138 Naples. 2Endocannabinoid Research Group, Institutes of
Cybernetics and of Biomolecular Chemistry, CNR, Pozzuoli (Naples).3Dipartimento
di Studi Farmaceutici, Università di Roma 'La Sapienza”,
Roma
139. A
NOVEL PHARMACOLOGICAL APPROACH FOR THE TREATMENT OF NEUROPATHIC
PAIN: TOLL-LIKE RECEPTOR 4 ANTAGONISTS AS MODULATORS OF ACTIVATED
MICROGLIA
Costa Barbara, Comelli Francesca, Peri Francesco, Francesca Granucci,
Isabella Bettoni, Rossini Clara, Giagnoni Gabriella
Department of Biotechnology and Bioscience, University of Milano-Bicocca
140. ETHANOL
CAUSES NEUROGENIC VASODILATATION BY TRPV1 ACTIVATION AND CGRP RELEASE
IN THE TRIGEMINOVASCULAR SYSTEM OF THE GUINEA PIG
S. Benemei1, P. Nicoletti1, M. Trevisani2, M. Manconi3, G. De Siena1,
G. Zagli1, J. A. Capone2, P. Geppetti1, L. A. Pini4
1Clinical Pharmacology Unit, Department of Critical care Medicine
and Surgery, University of Florence,2Center of Excellence for the
Study of Inflammation and Headache Center, University of Ferrara,
Ferrara, 4Department of Laboratory Medicine and Forensic Medicine,
University of Modena and Reggio Emilia, Italy
141. INSERTION/DELETION
POLYMORPHISM OF THE ANGIOTENSIN I-CONVERTING ENZYME GENE IN MIGRAINE
PATIENTS
V. Pizza (1), G. Volpe (1), F. Infante (2), G. Schiavo (2), E. Lamaida
(1), A. Agresta (1), A. Bisogno (3), A. Bianchi (3), A. Capasso
(3)
1) Neurophysiopatology 2) Molecular Biology, S. Luca Hospital,
Vallo della Lucania (SA), 3) University of Salerno, Italy
142. GENETIC
POLYMORPHISMS AND MIGRAINE
V. Pizza (1), G. Volpe (1), F. Infante (2) E. Lamaida (1), A. Agresta
(1), F. Longobardi (3), A. Bisogno (3), A. Bianchi (3), A. Capasso
(3)
(1)Neurophysiopatology Service; (2)Molecular Biology Service,
S. Luca Hospital, Vallo della Lucania (SA), ASL SA/3; (3)Department
of Pharmaceutical Sciences, University of Salerno, Italy.
143. LONG-TERM
INTRATHECAL MORPHINE IN PATIENTS WITH CHRONIC NON-CANCER PAIN UP-REGULATES
MU OPIOD RECEPTOR GENE EXPRESSION IN LYMPHOCYTES
Gabriele Campana1, William Raffaeli2 Donatella Sarti 2and Santi
Spampinato1
1Dept. Of Pharmacology - University of Bologna-Irnerio 48 -
40126 – Bologna; 2 Pain and Palliative Care Unit, Infermi
Hospital, Rimini -Via Ovidio - 47900 - Rimini
144. COMPARATIVE
PRODUCTION OF THE ACTIVE TRAMADOL METABOLITE O-DESMETHYL-TRAMADOL
(M1) IN DOMESTIC ANIMAL SPECIES
Zonca Annalisa*, Cagnardi Petra *, Villa Roberto*, Ravasio Giuliano#,
Vettorato Enzo$, Isola Maurizio$, Montesissa Clara§
* Dipartimento di Scienze e Tecnologie Veterinarie per la Sicurezza
Alimentare, Milano; §Dipartimento di Sanità Pubblica
Patologia Comparata ed Igiene Veterinaria, Padova; #Dipartimento
di Scienze Cliniche Veterinarie, Milano; $ Dipartimento di Scienze
Cliniche Veterinarie, Padova |
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SOSTANZE D'ABUSO |
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145. EFFECT
OF UNCONTINGENT AND SUBCHRONIC ADMINISTRATION OF ADDICTIVE DRUGS
ON NEURONAL PLASTICITY IN THE RAT NUCLEUS ACCUMBENS
Ibba Federico1, Vinci Stefania1, Spiga Saturnino2, Acquas Elio1,
3 and Di Chiara Gaetano1, 3
1Department of Toxicology and 3Centre of Excellence on Neurobiology
of Addiction, University of Cagliari; 2 Department of Animal Biology
and Ecology, University of Cagliari
146. TREND
OF DRUGS OF ABUSE DETECTION IN THE URINE OF PATIENTS OF THE UNIVERSITY
HOSPITAL OF MODENA, DURING THE PERIOD 1997-2006
Coccia Ciro, Ferrari Anna, Castellana Carmela Nives, Poppi Brunella,
Pisa Stefania, Bertolini Alfio, Sternieri Emilio
Toxicology and Clinical Pharmacology Section. Department of
Laboratory Services University of Modena and Reggio Emilia, Italy
147. DIFFERENCE
IN THE DEGREE OF NICOTINE DEPENDENCE AND DEVELOPMENT OF DEPRESSION
BETWEEN CANNABIS USERS AND POLIDRUG USERS
Russo Giuseppina A. 1 , Garuana Anna 2, Mannucci Carmen 1, Tedesco
Michele 1, Calapai Gioacchino1
1Department of Clinical and Experimental Medicine and Pharmacology,
Section of Pharmacology, School of Medicine, University of Messina,
Italy; 2Territorial Service for Addiction (Ser.T.) of the District
of Ribera – Local Sanitary Unit USL n°1, Agrigento (Italy)
148. THE
CANNABINOID ANTAGONIST SR 141716A REDUCES THE INCREASE OF EXTRA-CELLULAR
DOPAMINE RELEASE IN THE RAT NUCLEUS ACCUMBENS INDUCED BY A NOVEL
HIGH PALATABLE FOOD
Melis Tiziana, Sanna Fabrizio, Succu Salvatora, Argiolas Antonio,
Melis Maria Rosaria
Beranrd B. Brodie Department of Neurosciences, University of
Cagliari, Italy
149. CANNABINOID
SELF-ADMINISTRATION IN THE RAT: GENDER DIFFERENCES AND EFFECT OF
OVARIECTOMY
Spano M. Sabrina1,3, Fattore Liana2,3, Altea Silvia1, Angius Fabrizio1,
Fadda Paola1,3,
Fratta Walter1, 2,3
1Department of Neuroscience, University of Cagliari ; 2Institute
of Neuroscience CNR, Section of Cagliari; 3Centre of Excellence
"Neurobiology of Dependence", University of Cagliari
150. PSYCHOSIS
ONSET: USE OF CANNABIS X COMT GENOTYPE INTERACTION. A CASE-ONLY
DESIGN ANALYSIS IN A FIRST-EPISODE PSYCHOSIS SAMPLE
Caterina La Cascia1,2, M.Di Forti2, R.M. Murray2, D.La Barbera1,
A.Butt2, V.Mondelli2, J.Eyeson2, S.Navari2, M.Aas2, D.Clifford2,
P.Dazzan2, C.Pariante2, C.Morgan2, B.Freeman2, S.Luzi2, D.Dempster2,
M.Rivera2, D.Collier2, J.Powell2, G.Cannizzaro3
1Dept. of Clinical Neurosciences, University of Palermo, 2Institute
of Psychiatry, King’s College London, UK, 3Dept. of Pharmacological
Sciences, University of Palermo
151. FLUMAZENIL
SELECTIVELY PREVENTS THE INCREASE IN A4 SUBUNIT GENE EXPRESSION
AND AN ASSOCIATED CHANGE IN GABAA RECEPTOR FUNCTION INDUCED BY ETHANOL
WITHDRAWAL
Caria Stefania1, Biggio F.1, Gorini G.1, Murru L.1, Sanna E.1,2,
Follesa P.1,2,
and Biggio G.1,2
University of Cagliari, Department of Experimental Biology,
Section of Neuroscience1; Center of Excellence for the Neurobiology
of Dependence2, 09123 Cagliari, Italy
152. PREGNENOLONE
SULFATE ENHANCEMENT OF GABA RELEASE IN THE DEVELOPING RAT CEREBELLUM
IS MEDIATED BY PRESYNAPTIC NMDARS AND IS MODULATED BY ETHANOL
Mario Carta, L. Murru, F. Virdis, M.D. Brockmann, R. Marras, E.
Sanna, G. Biggio.
Dept. Experimental Biology, Sect of Neuroscience, and Center
of Excellence for the Neurobiology of Dependence. Cittadella Universitaria,
SS 554 Km 4,500, 09042, Monserrato, Cagliari, Italy
153. NEUROSTEROID-MEDIATED
INCREASE OF GABAERGIC TONIC INHIBITION IN RAT DENTATE GYRUS GRANULE
CELLS BY ETHANOL
G. Talani, S. Zucca, E. Sanna, G. Biggio
Dept. Experimental Biology, Sect. of Neuroscience, and Center
of Excellence for the Neurobiology of Drug Dependence, University
of Cagliari, Cittadella Universitaria, Monserrato, Cagliari, Italy
154. ACTIVATION
OF TRANSIENT RECEPTOR POTENTIAL VANILLOID TYPE 1 (TRPV1) BY ETHANOL:
ROLE OF ENDOGENOUS LIPID MEDIATORS
Campi B., Gatti R, Andre E, Geppetti P. & Trevisani M.
Interdisciplinary Centre of Excellence for the Study of Inflammation
(ICSI), University of Ferrara, Ferrara, Italy
155. TRANSIENT
RECEPTOR POTENTIAL VANILLOID 1, SUBSTANCE P & REACTIVE OXYGEN
SPECIES MEDIATE ETHANOL-INDUCED GASTRIC INJURY
Marcello Trevisani1, David Gazzieri1, Selena Harrison2, Graeme S.
Cottrell5, Eunice Andre1, Daniela Massi3, Sandra Zecchi4, Giuseppe
Lungarella6, Nigel W. Bunnett5, Pierangelo Geppetti1,2
1Center of Excellence for the Study of Inflammation, University
of Ferrara; Departments of 2Critical Care Medicine and Surgery,
3Human Pathology and Oncology, and 4Anatomy, University of Florence;
5Departments of Surgery and Physiology, University of San Francisco,
6Department of Physiopathology, University of Siena
156. ETHANOL
INDUCED DOPAMINE RELEASE IN THE RAT MESOLIMBIC SYSTEM. ROLE OF ACETHALDEHYDE
Sirca Donatella 1, Mereu Maddalena 1, Golosio Angela 1, Enrico Paolo
2, Marco Diana 1
1)“G. Minardi” Laboratory of Cognitive Neuroscience,
Department of Drug Sciences; 2) Department of Biomedical Sciences.
University of Sassari, 07100 Sassari, Italy
157. RITIRATO
158. INTERMITTENT
INTOXICATION WITH ETHANOL VAPOR INDUCES A LONG-LASTING HYPNOTIC
TOLERANCE AND BEHAVIORAL SENSITIVITY IN RAT
Rimondini R. †, Sommer W.*, Heilig M.*, Dall’Olio R.
†, Locchi F. †, Gandolfi O†
*Laboratory of Clinical and Translational Studies, National
Institute on Alcohol Abuse and Alcoholism, National Institutes of
Health, Bethesda, MD 20892; †Department of Pharmacology, University
of Bologna, 40128 Bologna, Italy
159. REDUCTION
OF ETHANOL DRINKING FOLLOWING CHRONIC ADMINISTRATION OF THE ANTIEPILEPTIC
LEVETIRACETAM IN GENETICALLY SELECTED ALCOHOL PREFERRING RATS
Serena Stopponi, Postolache Cristita, Nazzareno Cannella, Daina
Economidou, Fedeli Amalia, Maurizio Massi, Ciccocioppo Roberto
University of Camerino, Italy
160. EFFECT
OF THE SELECTIVE FATTY ACID AMIDE HYDROLASE INHIBITOR URB597 ON
ETHANOL ABUSE RELATED BEHAVIOURS IN THE RAT
Braconi Simone, Piomelli Daniele*, Duranti Andrea§, Tonini
Andrea§, Tarzia Giorgio§, Cannella Nazzareno, Massi Maurizio,
Ciccocioppo Roberto, Cippitelli Andrea
Department of Experimental Medicine and Public Health, University
of Camerino, Italy; *Gillespie Neuroscience Facility, University
of California, Irvine, USA; §Institute of Medicinal Chemistry,
University of Urbino “ Carlo Bò”, Italy
161. NEUROPEPTIDE
S: A NEW NEUROTRASMITTER SYSTEM INVOLVED IN RELAPSE TO ALCOHOL-SEEKING
BEHAVIOUR
1Cannella Nazzareno, 1 Economidou Daina, 1Kallupi Marsida, 2Guerrini
Remo, 3Calò Girolamo, 1Roberto Ciccocioppo
1Dept. of Experimental Medicine and Public Health, University
of Camerino, Italy; 2Dept of Pharmaceutical Science and, 2Dept.
of Pharmacology, University of Ferrara, Italy |
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162. ROLE
OF TGF-B ON MAP KINASE PHOSPHORYLATION AND CELL PROLIFERATION IN
PRIMARY CULTURES OF HUMAN LUNG FIBROBLAST
Sullo Nikol, Gallelli L., De Nardo M., Orlotti D., Russo M., Marrocco
G., D’Agostino B., De Sarro GB., Rossi F.
Department of Experimental Medicine, Sect. of Pharmacology,
Faculty of Medicine and Surgery, 2nd University of Naples, via Constantinopoli
16, 80138 Naples, Italy
163. ETHANOL
SENSITISES TRPV1-MEDIATED COUGH IN GUINEA PIGS BY A PROTEIN KINASE
C-DEPENDENT PATHWAY
Gatti Raffaele1, Andre Eunice1, Campi Barbara1, Geppetti Pierangelo1,
2 and Trevisani Marcello1
1Interdisciplinary Centre of Excellence for the Study of Inflammation
(ICSI), University of Ferrara, Ferrara, Italy; 2Department of Critical
Care Medicine and Surgery, University of Florence, Florence, Italy
164. THE
ROLE OF CERAMIDE PATHWAY IN ASTHMA
Giannini Lucia a, Bani Daniele b, Uliva Caterina a, Marzocca Cosimo
a, Comhair Suzy A.A. c, Erzurum Serpil C. c, Li Dechun d, Ndengele
Michael d, Salvemini Daniela d, Masini Emanuela a
a Department of Preclinical and Clinical Pharmacology, and b
Anatomy, Histology and Forensic Science, Section of Histology, University
of Florence, Italy; c Pulmonary, Critical Care Medicine and Cancer
Biology, The Lerner Research Institute, The Cleveland Clinic Foundation,
Cleveland, USA; d Internal Medicine, Division of Pulmonary, Critical
Care and Sleep Medicine, St Louis University, St Louis, USA
165. ROLE
OF NOCICEPTIN AND ITS RECEPTOR IN ANIMAL MODEL OF ASTHMA
Orlotti Donatella, De Nardo M., Russo M., Sullo N., Marrocco G.,
Rossi F., D’Agostino B.
Department of Experimental Medicine, Sect. of Pharmacology,
Faculty of Medicine and Surgery, 2nd University of Naples, via Constantinopoli
16, 80138 Naples, Italy
166. ACTIVATION
OF PROTEASE-ACTIVATED RECEPTOR-2 REDUCES AIRWAYS INFLAMMATION IN
EXPERIMENTAL ALLERGIC ASTHMA
Russo Mariangela, Orlotti D., De Nardo M., Marrocco G., Sullo N.,
Guastafierro MG., Rossi F., D’Agostino B.
Department of Experimental Medicine, Sect. of Pharmacology,
Faculty of Medicine and Surgery, 2nd University of Naples, via Constantinopoli
16, 80138 Naples, Italy
167. M3
MUSCARINIC RECEPTORS IN PERIPHERAL LUNG PARENCHIMA OF PATIENTS WITH
CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Vincenzi F.1, Varani K.1, Caramori G.2, Tosi A.1, Gessi S.1, Merighi
S.1, Fogli E. 1, Sacchetto V. 1, Simioni C. 1, Papi A.2, Borea P.A.1
Department of Clinical and Experimental Medicine, Pharmacology
Section1 and Respiratory Disease Section 2, University of Ferrara,
Italy
168. GLYCOGEN
SYNTHASE KINASE-3B INHIBITION ATTENUATES THE DEVELOPMENT OF BLEOMYCIN-INDUCED
LUNG INJURY
1,2Salvatore Cuzzocrea, 1,2Tiziana Genovese, 1,2Emanuela Mazzon,
3Emanuela Esposito, 1Carmelo Muià, 4Maha Abdelrahman, 1,2Rosanna
Di Paola, 2Placido Bramanti, and 4Christoph Thiemermann
1Department of Clinical and Experimental Medicine and Pharmacology,
School of Medicine, University of Messina, Italy; 2IRCCS Centro
Neurolesi "Bonino-Pulejo", Messina, Italy; 3Dipartimento
di Farmacologia Sperimentale, Università di Napoli “Federico
II”, Italy; 4The William Harvey Research Institute, Centre
for Experimental Medicine, Nephrology and Critical Care, St
Bartholomew’s and The Royal London School of Medicine and
Dentistry, London, UK
169. MODULATION
OF THE NON-ADRENERGIC, NON-CHOLINERGIC INHIBITORY SYSTEM BY ADENOSINE
A1 AND A3 RECEPTORS IN THE GUINEA-PIG ISOLATED TRACHEA
Dellabianca Antonio*, De Amici Emanuela*, Tonini Stefano*, De Angelis
Stefano**, Faniglione Marisa**, Candura Stefano M*, Tonini Marcello**
*Dept. Preventive Occupational and Community Medicine, University
of Pavia; **Dept. of Physiological and Pharmacological Sciences,
University of Pavia
170. NEW
ROLES FOR CYSTEINYL LEUKOTRIENE IN ASTHMA: FROM AIRWAY REMODELLING
TO B2-ADRENORECEPTOR DYSFUNCTION
1G.Enrico Rovati, 2Michele Baroffio 1Simona Citro, 1Valèrie
Capra, 2Emanuele Crimi, 2Vito Brusisco
1Laboratory of Molecular Pharmacology, Section of Eicosanoid
Pharmacology, Dept. of Pharmacological Sciences, University of Milan;
and 2 Respiratory Pathophysiology Unit, Dept. of Internal Medicine,
University of Genoa
171. SPHINGOSINE-1-PHOSPHATE/SPHINGOSINE
KINASE PATHWAY IS INVOLVED IN MOUSE AIRWAY HYPER-RESPONSIVENESS
Fiorentina Roviezzo, A. Di Lorenzo, M. Bucci, V. Brancaleone, L.De
Gruttola, V.Vellecco,
F. Rossi, B. D’Agostino and G. Cirino
Department of Experimental Pharmacology, Faculty of Pharmacy,
University of Naples-Federico II-; Department of Experimental Medicine-Section
of Pharmacology, Faculty of Medicine and Surgery, 2nd University
of Naples
172. EVIDENCE
FOR A ROLE OF ADENOSINE A1 RECEPTOR IN BRONCHIAL
HYPERREACTIVITY OF SENSITIZED WISTAR RATS
Alfieri Alessio and Cicala Carla
Department of Experimental Pharmacology, University of Naples “Federico
II”, Naples
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173. APP,
A NOVEL SELECTIVE ADENOSINE DEAMINASE INHIBITOR, IS EFFECTIVE AGAINST
EXPERIMENTAL COLITIS
Antonioli Luca1, Fornai Matteo1, Colucci Rocchina1, Ghisu Narcisa1,
Da Settimo Federico2, Natale Gianfranco3, Virdis Agostino4, Breschi
Maria Cristina5, Del Tacca Mario1, Blandizzi Corrado1
1Division of Pharmacology and Chemotherapy, 1,4Department of
Internal Medicine, 2Department of Pharmaceutical Sciences, 3Department
of Human Morphology and Applied Biology, and 5Department of Psychiatry,
Neurobiology, Pharmacology and Biotechnology, University of Pisa,
Pisa, Italy
174. EFFECTS
OF THE NON-PEPTIDYL LOW MOLECULAR WEIGHT RADICAL SCAVENGER IAC IN
DNBS-INDUCED COLITIS IN RATS
Vasina Valentina*, Broccoli Massimiliano*, Ursino Maria Grazia*,
Soleti Antonio#, Paolini Moreno*, De Ponti Fabrizio*
*Department of Pharmacology, Alma Mater Studiorum - University
of Bologna, Italy; #Medestea Research, Torino, Italy
175. THE
NK1 RECEPTOR ANTAGONIST SSR140333 AMELIORATES EXPERIMENTAL COLITIS
IN RATS
Ursino Maria Grazia, Vasina Valentina, Croci Tiziano*, De Ponti
Fabrizio
Dept. of Pharmacology, University of Bologna, Bologna, Italy
* Sanofi-Aventis Research Centre, Milan, Italy
176. RESPONSIVENESS
OF LONGITUDINAL AND CIRCULAR MUSCLE TO RELAXING MEDIATORS IS DIFFERENTIALLY
AFFECTED IN RAT HYPERTROPHIED ILEUM
Bertoni Simona, Ghizzardi Paola, Tognolini Massimiliano, Ballabeni
Vigilio, Impicciatore Mariannina, Barocelli Elisabetta
Dipartimento di Scienze Farmacologiche, Biologiche e Chimiche
Applicate. Università degli Studi di Parma. Viale Usberti
27/a, 43100 Parma, Italy
177. IN
RAT ILEUM ADENOSINE DEAMINASE IS NOT ONLY AN ECTO- BUT ALSO AN EXO-ENZYME
Calligaro Giulia, Bin Anna, Giron Maria Cecilia, Gaion Rosa Maria
Department of Pharmacology and Anesthesiology, University of
Padova
178. HERPES
SIMPLEX VIRUS-1 INFECTION ALTERS THE CARBACHOL- AND KCL-INDUCED
CONTRACTIONS IN RAT SMALL INTESTINE
Zoppellaro Chiara1, Brun Paola2, Giron Maria Cecilia1, Bin Anna1,
Gaion Rosa Maria1, Castagliuolo Ignazio2
1Department of Pharmacology and Anesthesiology, University of
Padova; 2Department of Histology, Microbiology & Medical Biotechnologies,
University of Padova
179. ADENOSINE
RECEPTORS AND METABOLISM IN THE INTESTINAL TRACT
Bin Anna1, Giron Maria Cecilia1, Calligaro Giulia1, Castagliuolo
Ignazio2, Gaion Rosa Maria1
1Department of Pharmacology and Anesthesiology, University of
Padova
2Department of Histology, Microbiology and Medical Biotechnology,
University of Padova
180. ROLE
OF A2A ADENOSINE RECEPTORS IN THE REGULATION OF HUMAN COLON MOTILITY
Fornai Matteo1, Antonioli Luca1, Colucci Rocchina1, Ghisu Narcisa1,
Buccianti Piero2, Chiarugi Massimo2, Blandizzi Corrado1, Del Tacca
Mario1
1Division of Pharmacology and Chemotherapy, Department of Internal
Medicine, and 2Department of Surgery, University of Pisa, Pisa,
Italy
181. GENDER-RELATED
ROLE OF NITRIC OXIDE IN ELECTRICALLY EVOKED CONTRACTIONS IN HUMAN
COLONIC CIRCULAR MUSCLE
Maselli M.A., Trisolini P., Pezzolla F., Demma I., De Ponti F.°
Scientific Institute of Gastroenterology “S. de Bellis”,
Castellana Grotte, Bari; °Department of Pharmacology, University
of Bologna, Bologna, Italy
182. ROLE
OF 5-HT RECEPTORS IN MODULATING PROPULSIVE ACTIVITY AND ACCOMMODATION
IN THE GUINEA PIG DISTAL COLON
Balestra Barbara*, Cervio Elisabetta*, Sternini Catia**, De Giorgio
Roberto#, Tonini Marcello*
*Dept. of Physiological & Pharmacological Sciences, University
of Pavia, **Dept. of Medicine and Neurobiology, David Geffen School
of Medicine, University of California, Los Angeles, #Dept. of Internal
Medicine & Gastroenterology, University of Bologna, Italy
183. THE
EFFECTS OF UFP112, A NOVEL NOCICEPTIN/ORPHANIN FQ-NOP RECEPTOR LIGAND,
ON COLONIC PROPULSION AND DEFECATION IN PHYSIOLOGICAL AND PATHOLOGICAL
CONDITIONS
Broccardo M. a, Agostini S. a, Guerrini R. b, Improta G. a, Linari
G. a, Petrella C. a
a Dept. Human Physiology and Pharmacology, University of Rome
“Sapienza”, b Dept. Pharmaceutical Sciences and Biotechnology
Center, University of Ferrara, Italy
184. EFFECT
OF MODELED MICROGRAVITY CONDITIONS ON RAT INTESTINAL TRANSIT
Alessandra T. Peana1, Stefania Marzocco2, Elena Pulighe1, Giuseppe
Bianco2, Proto Pippia1, Aldo Pinto2, Giuseppina Autore2
1Department of Drug Science, University of Sassari, via Muroni
23/a, 07100, Sassari; 2Department of Pharmaceutical Science, University
of Salerno, via Ponte don Melillo, 84084, Fisciano, Salerno |
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FARMACOLOGIA DEL METABOLISMO E DEL SISTEMA
ENDOCRINO |
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185. MENOPAUSAL
TRANSITION: A POSSIBLE RISK FACTOR FOR NEURODEGENERATIVE EVENTS
Bonomo Sara M.1, Rigamonti Antonello E.1, Giunta Marialuisa1, Galimberti
Daniela2, Guaita Antonio3, Gagliano Maria G.4, Müller Eugenio
E.1 and Cella Silvano G.1
1Department of Medical Pharmacology and 2Department of Neurological
Sciences, Fondazione IRCCS Ospedale Maggiore Policlinico, Milan,
Italy; 3Geriatric Institute “Camillo Golgi”, Abbiategrasso,
Italy; 4Department of Transfusion Medicine, “San Carlo Borromeo”
Hospital, Milan, and CEND, University of Milan
186. EFFECTS
OF THE PHYTOESTROGEN GENISTEIN ON SOME PREDICTORS OF CARDIOVASCULAR
RISK IN OSTEOPENIC, POSTMENOPAUSAL WOMEN: A RANDOMIZED, DOUBLE-BLIND,
PLACEBO-CONTROLLED STUDY
Marini Herbert1, Minutoli Letteria2, Polito Francesca2, Bitto Alessandra2,
Altavilla Domenica2, Frisina Nicola3, D’Anna Rosario4, Lubrano
Carla5, Adamo Elena B1, Caputi Achille P.2 and Squadrito Francesco2
1Dept. of Bioch., Phys. and Nutr. Sci., 2Dept. of Clin. and
Exp. Med. and Pharm., 3Dept. of Int. Med., 4Dept. of Obst. and Gyn.
Sci., Messina; 5 Dept. of Med. Physiop., “La Sapienza”
Univ., Rome, Italy
187. IN
VITRO AND IN VIVO ANTI-INFLAMMATORY ACTIVITIES OF PSEUDOMORELIN,
A GHRELIN-MIMETIC PSEUDOTETRAPEPTIDE
Ghè Corrado, Baragli Alessandra, Arnoletti Elisa, Deghenghi
Romano, Muccioli Giampiero
Division of Pharmacology, Department of Anatomy, Pharmacology
and Forensic Medicine, University of Turin, Turin, Italy
188. GHRELIN
AND DES-ACYL GHRELIN INDUCE MURINE C2C12 MYOBLASTS DIFFERENTIATION
AND FUSION INTO MYOTUBES
Arnoletti Elisa§, Filigheddu Nicoletta*, Ghè Corrado§,
Ponzetto Carola ‡, Crepaldi Tiziana, ‡, Graziani Andrea
*, Muccioli Giampiero §
§Division of Pharmacology and ‡Anatomy, Department
of Anatomy, Pharmacology and Forensic Medicine, University of Turin,
Turin, Italy; *Department of Medical Sciences, University of Piemonte
Orientale “Amedeo Avogadro”, Novara, Italy
189. ENDOCRINE
AND EXTRAENDOCRINE EFFECTS OF GHRELIN AND NOVEL SYNTHETIC ANALOGS
Bulgarelli Ilaria a, Bresciani Elena a, Tamiazzo Laura a, Rapetti
Daniela a, Perrissoud Daniel b, Torsello Antonio a,c and Locatelli
Vittorio a,c
a Department of Experimental Medicine, University of Milan Bicocca,
Monza, Italy; b Zentaris GmbH, Frankfurt, Germany; c Interdepartmental
Center for Bioinformatics and Proteomics, University of Milano-Bicocca,
Monza, Italy
190. EFECTS
OF IRBESARTAN ON THE MYOCARDIAL ISCHEMIA/REPERFUSION INJURY IN ZDF
RATS WITH METABOLIC SYNDROME
Di Filippo Clara1,2, Lampa Enrico1,2, Martella Raffaele3 , Vargiu
Giuseppe4, Paizis Georges4, D’Amico Michele 1,2
1Department of Experimental Medicine, Section of Pharmacology
L. Donatelli,2”Excellence Centre for Cardiovascular Disease”,
and 3Department of Geriatrics and Metabolic Diseases, 2nd University
of Naples, Italy. 4Sanofi-Aventis, Milano
191. EFFECTS
OF LIPOSOME-ENCAPSULATED PYRAZOLO-PYRIMIDINE DERIVATE ON THE GROWTH
OF HUMAN THYROID CANCER CELLS
1Celano Marilena, 1Cosco Donato, 2Navarra Michele, 1Alcaro Stefano,
3Schenone Silvia,1Procopio Samanta, 1Varano Eliana, 4Botta Maurizio,
1Fresta Massimo, 1Russo Diego
1Dip. di Scienze Farmacobiologiche Univ. Catanzaro, 2Dip. Farmacobiologico,
Univ. Messina, 3Dip. Scienze Farmaceutiche, Univ. Genova, e 4Dip.
Farmaco Chim. Tecnol., Univ. Siena
192. EFFECT
OF TESTOSTERONE ON P70S6K PHOSPHORYLATION IN SKELETAL MUSCLE CELL
COLTURES
1Maria G. Dattolo, 1Rocco Saviano, 1Giovanna La Rana, 1Antonio Calignano,
2Maria Miniaci and 1Pietro Scotto
1Dept.of Experimental Pharmacology, University of Napoli “Federico
II”;2Dept.of Experimental and Clinical Medicine, University
of Catanzaro, Italy
193. ENDOGENOUS
BENZODIAZEPINES AND INTESTINAL BACTERIAL FLORA IN NORMAL AND PATHOLOGICAL
CONDITIONS
Campioli Enrico§, Avallone Rossella§, Ferrieri Antonella§,
Baraldi Mario§°
§Department of Biomedical Sciences, Via Campi 287, 41100
Modena, Italy, °National InterUniversity Consortium for the
Study of Natural Active Principles (CINSPAN) |
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FARMACOLOGIA DELL'INFIAMMAZIONE |
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194. EFFECTS
OF A METHANOLIC EXTRACT OF SEDUM TELEPHIUM IN LPS-ACTIVATED RAT
MACROPHAGES
Polito Francesca1, Bitto Alessandra1, Minutoli Letteria1, Fiumara
Tiziana1, Giachetti Daniela2, Miraldi Elisabetta2, Biagi Marco2
Squadrito Francesco1, Caputi Achille P.1, Altavilla Domenica1
1Dept of Exp and Clinical Medicine and Pharmacology and 2Dept
of Environmental Sci, Section of Pharm Biol, University of Siena,
Italy
195. DIFFERENT
PHENOTYPES OF MICROGLIA ACTIVATION
Dello Russo Cinzia, Tringali Giuseppe, and Navarra Pierluigi
Istituto di Farmacologia, Università Cattolica del S
Cuore, Largo F Vito 1 - Roma
196. MAPPING
OF THE HUMAN PROMOTER OF GNB2L1 GENE ENCODING THE RACK1 PROTEIN
AND ITS REGULATORY ROLE IN THE IMMUNOSENESCENCE
Del Vecchio Igor1, Zuccotti A.1, Corsini E.2, Racchi M.1, Lucchelli
A.1, Govoni S.1
1 Department of Experimental and Applied Pharmacology, University
of Pavia, Viale Taramelli 14, 27100 Pavia, Italy; 2 Department of
Pharmacological Sciences, University of Milano, Via Balzaretti 9,
20133 Milan, Italy
197. ANTINFLAMMATORY
ACTIVITY AND GASTROPROTECTIVE EFFECT OF THE ANTIOXIDANT COMPOUND
IACVITA IN RATS
Zavatti Manuela, Zanoli Paola, Montanari Caterina, Vezzalini Francesca
and Baraldi Mario
Department of Biomedical Sciences, Section of Pharmacology and
National InterUniversity Consortium for the Study of Natural Active
Principles (CINSPAN), University of Modena and Reggio Emilia, Modena,
Italy
198. THE
GLUCOCORTICOID-INDUCED LEUCINE ZIPPER (GILZ) PROTECTS AGAINST DNBS-INDUCED
COLITIS DEVELOPMENT
Velardi Enrico1, Donato Valerio1, Bruscoli Stefano1, Mazzon Emanuela2,
Cannarile Lorenza1, Cuzzocrea Salvatore2 and Riccardi Carlo1
1 Dept. Clinical and Experimental Medicine, Sect. Pharmacology,
Perugia University Medical School, 06122, Perugia, and 2 Dept Clinical
and Experimental Medicine and Pharmacology, Messina University Medicine
School, Torre Biologica, Policlinico Universitario, 98123, Italy
199. MUCIN
DEPLETED FOCI (MDF) ARE USEFUL BIOMARKERS TO STUDY INFLAMMATION-INDUCED
COLON CARCINOGENESIS IN RODENTS
Femia A. Pietro, Dolara Piero, Tarquini Elena, Salvadori Maddalena
and Caderni Giovanna
Department of Pharmacology University of Florence, Florence,
Italy
200. LOCAL
ADMINISTRATION OF PALMITOYLETHANOLAMIDE REDUCES CHRONIC GRANULOMA-ASSOCIATED
ANGIOGENESIS IN RAT
D’Amico Alessandra, De Filippis D., Iuvone T.
1Department of Experimental Pharmacology, Faculty of Pharmacy,
University of Naples Federico II, Via D. Montesano 49, 80131 Naples,
Italy
201. CONTRIBUTION
OF A4B1 INTEGRIN TO THE ANTIALLERGIC EFFECT OF LEVOCABASTINE IN
EXPERIMENTAL CONJUNCTIVITIS
Spartà Antonino M, Qasem Ahmed R, Bucolo Claudio, Baiula
Monica, Govoni Paolo, Fascì Domenico, Spampinato Santi
Department of Pharmacology, University of Bologna
202. PROTECTION
AGAINST UVB-INDUCED DAMAGE IN RABBIT EYE BY 4-COUMARIC ACID
Lodovici Maura 1, Morbidelli Lucia 2, Akpan Victor 1, Ziche Marina2
and Dolara Piero 1
1Department of Pharmacology, University of Florence, Viale Pieraccini
6, 50139, Florence (Italy); 2Department of Molecular Biology, University
of Siena, Via A. Moro 2, 53100 Siena (Italy)
203. CT327,
A NOVEL THERAPEUTIC AGENT FOR TOPICAL TREATMENT OF PSORIASIS
Barone Domenico, Bertarione Rava Rossa Luisa, Traversa Silvio, Mainero
Valentina, Oderda Cecilia, Pincelli Carlo*, Marconi Alessandra*,
and Fumero Silvano
Creabilis therapeutics SpA, Via Ribes, 5 – 10010 Colleretto
Giacosa (TO), Italy; *University of Modena e Reggio Emilia, Via
del Pozzo, 71 – 41100 Modena, Italy
204. ROLE
OF PEROXISOME PROLIFERATORS ACTIVATED RECEPTORS ALPHA (PPAR-A) IN
ACUTE PANCREATITIS INDUCED BY CERULEAN
1Angelina De Sarro, 1,2Emanuela Mazzon,1,2Tiziana Genovese, 1,2Rosanna
Di Paola, 1Carmelo Muià, 1Giuseppe Malleo, 3‡Emanuela
Esposito, 1,2Achille P. Caputi and 1,2Salvatore Cuzzocrea
1Department of Clinical and Experimental Medicine and Pharmacology,
School of Medicine, University of Messina, Italy; 2IRCCS Centro
Neurolesi "Bonino-Pulejo", Messina, Italy; 3Dipartimento
di Farmacologia Sperimentale, Università di Napoli “Federico
II”, Napoli, Italy |
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CHEMIOTERAPIA ANTIBATTERICA, ANTIVIRALE ED
ANTINEOPLASTICA |
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205. ANALYSIS
OF THE THYMIDYLATE SYNTHASE GENE STRUCTURE IN COLORECTAL CANCER
PATIENTS, AND ITS POSSIBLE RELATION WITH THE 5-FLUOROURACIL DRUG
RESPONSE
Rosario Sanguedolce1, Gaspare Gulotta2, Massimo Cajozzo3, Antonino
Agrusa2, Salvatore Feo4, Giorgio Sanguedolce1 and Anna Calascibetta1
1Dipartimento di Scienze Farmacologiche, 2Chirurgia Generale
e d’Urgenza, 3Dipartimento di Discipline Chirurgiche ed Oncologiche,
4DOSAC. University of Studies of Palermo
206. IRINOTECAN
METRONOMIC CHEMOTHERAPY IN METASTATIC COLORECTAL CANCER PATIENTS:
A PHARMACOKINETIC AND PHARMACODYNAMIC STUDY
Bocci Guido1, Allegrini Giacomo2, Fioravanti Anna1, Orlandi Paola1,
Loupakis Fotios2, Barletta M. Teresa2, Di Paolo Antonello1, Falcone
Alfredo2, Danesi Romano1, Del Tacca Mario1
1Division of Pharmacology and Chemotherapy, Department of Internal
Medicine, University of Pisa, Pisa; 2Division of Medical Oncology,
General Hospital, Livorno
207. ADENOSINE
RECEPTOR A3: ROLE AND EXPRESSION IN HUMAN THYROID CANCER
Morello Silvana, Petrella A., Festa M., Popolo A., Parente L., Chiappetta
G.* and Pinto A.
Department of Pharmaceutical Sciences, University of Salerno,
Italy; *Tumor Institute, Fondazione Senatore G. Pascale, Naples,
Italy
208. ANTIMETASTATIC
EFFECT OF A NOVEL NON COMPETITIVE CXCR1/CXCR2 INHIBITOR IN HUMAN
MELANOMA
*Bruno Annalisa, *Mosca M., *Buanne P., °Del Bufalo D., °Desideri
M., °Giorgini S., §Ruco L., *Allegretti M., *Gloaguen I.,
*Bizzarri C., * Melillo G., *Bertini R. and °Zupi G.
*Dompé pha.r.ma s.p.a., via Campo di Pile, 67100 L’AQUILA,
ITALY; °Regina Elena Cancer Institute, via delle Messi d’Oro
156, 00158 ROME, ITALY; § S.Andrea Hospital, University La
Sapienza, via di Grottarossa 1035, 00189 ROME, ITALY
209. PHARMACOKINETICS
OF CISPLATIN DURING INTRAPERITONEAL HYPERTHERMIC CHEMOTHERAPY PERFUSION
(IHCP) IN PATIENTS WITH PERITONEAL CARCINOMATOSIS
*Cerretani Daniela, *Ferraro Maria Teresa, *Fiaschi Anna Ida, *Miceli
Giovanni Battista,**Cioppa Tommaso, **Marrelli Daniele,**Corso Giovanni,**Pedrazzani
Corrado,**Roviello Franco
*Department of Pharmacology “G. Segre”, University
of Siena; **Department of Human Patology and Oncology, Unit of Surgical
Oncolgy, University of Siena
210. EFFECTS
OF ZOLEDRONIC ACID ON CATHEPSIN K CIRCULATING LEVELS IN PATIENTS
WITH BONE METASTASIS
Tumminello Francesca M¹., Badalamenti Giuseppe², Incorvaia
Lorena², Fulfaro Fabio² Crescimanno Marilena¹, Flandina
Carla¹, Gebbia Nicola² and Leto Gaetano¹
¹Lab. Chemioter. Sperimentale and ²U.O. di Oncologia
Medica, Dipartimento di Discipline Chirurgiche ed Oncologiche; Policlinico
Universitario P. Giaccone, 90127 Palermo, Italy
211. THERAPEUTIC
DRUG MONITORING OF ANTIRETROVIRAL AGENTS: DETERMINATION OF PLASMA
CONCENTRATIONS BY MEANS OF A HIGH-PRESSURE LIQUID CHROMATOGRAPHIC
TECHNIQUE
Pinetti Diego i, Motta Alice ii, Gallesi Daniela i, Guaraldi Giovanni
ii
i Toxicology and Clinical Pharmacology, Department of Laboratory
Services, University of Modena and Reggio Emilia; ii Department
of Medicine and Medicine Specialities, University of Modena and
Reggio Emilia
212. H2S
AND NO AFFECT INTRACELLULAR KILLING OF CANDIDA ALBICANS MODULATING
GSH LEVELS
Grosso S.1, Caronno A.1, Lucini V.1, Pannacci M.1, Sullo N.2 and
Scaglione F.1
1Department of Pharmacology, University of Milan, Milan, Italy;
2Depatment of Experimental Medicine- Section of Pharmacology, II
University of Naples, Naples, Italy
213. PHARMACOKINETIC/PHARMACODYNAMIC
OF MACROLIDES IN AN IN VIVO MODEL OF CHLAMYDIA PNEUMONIAE'S PNEUMONIA
Caronno Alessia, Lucini Valeria, Grosso Silvia, Pannacci Marilou,
Scaglione Francesco
Department of Pharmacology, University of Milan, Milan, Italy
214. BIOAVAILABILITY
IMPROVEMENT OF POLYMYXIN B BY CALCIUM ALGINATE/CHITOSAN MICROPARTICLES
Rossi Tiziana°, Baggio Giosuè°, Coppi Andrea°,
Bruni Elisa°, Ruberto Antonio°, Iannuccelli Valentina* And
Coppi Gilberto*
University of Modena and Reggio Emilia- Italy: °Department
of Biomedical Sciences- Section of Pharmacology; * Department of
Pharmaceutical Sciences, 287 G. Campi st 41100 Modena Italy |
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IMMUNOFARMACOLOGIA |
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215. ATORVASTATIN
TREATMENT INFLUENCES POLYMORPHONUCLEAR LEUKOCYTE FUNCTION: A LONGITUDINAL
STUDY
Anna Loraschi, Schembri L., Maio R.C., Marino F., Cosentino M.,
Guasti L., Rasini E., Legnaro M., Colombo C., Cereda E., Cimpanelli
M., Castiglioni L., Tozzi M.*, Castelli P.*, Venco A., Lecchini
S.
Department of Clinical Medicine, Section of Experimental and
Clinical Pharmacology and *Department of Surgical Surgical Science,
University of Insubria, Varese, Italy
216. TREATMENT
WITH SIMVASTATIN MODIFIES AT1R EXPRESSION AND FUNCTION IN POLYMORPHONUCLEAR
LEUKOCYTE OF HIGH CARDIOVASCULAR RISK SUBJECTS: A LONGITUDINAL STUDY
Maio Ramona Consuelo, Marino F., Guasti L., Cosentino M., Rasini
E., Ferrari M., Cimpanelli M.G., Loraschi A., Legnaro M., Cereda
E., Crespi C., Venco A., Lecchini S.
Department of Clinical Medicine, Section of Experimental and
Clinical Pharmacology, University of Insubria, Varese
217. EFFECTS
OF ATORVASTATIN TREATMENT ON THE MODULATION OF LEUKOCYTE FUNCTION
IN PATIENTS UNDERGOING PERIPHERAL VASCULAR INTERVENTION: A LONGITUDINAL
STUDY
Schembri Laura, Loraschi A., Maio R.C., Marino F., Cosentino M.,,
Guasti L., Rasini E., Legnaro M., Colombo C., Cereda E., Cimpanelli
M., Castiglioni L., Tozzi M.1, Castelli P. 1, Venco A., Lecchini
S.
Department of Clinical Medicine, Section of Experimental and
Clinical Pharmacology and 1Department of Surgical Sciences, University
of Insubria, Varese, Italy
218. ATORVASTATIN
AND MINOCYCLINE, EFFECTIVE COMBINATION IN EXPERIMENTAL AUTOIMMUNE
ENCEPHALOMYELITIS
Luccarini Ilaria a, Biagioli Tiziana b, Ballerini Clara b, Biamonte
Filippo c, Bellucci Arianna d, Fiorentini Anna a and Casamenti Fiorella
a.
aDept of Pharmacology, University of Florence, Viale Pieraccini
6, 50139 Florence, Italy. bDept of Neurology, University of Florence,
Viale Pieraccini 6, 50139 Florence, Italy.cDept of Neuroscience,
University Campus Bio-Medico of Rome, Italy. dDept Biomed. and Biotechnol.
Sci., University of Brescia, Viale Europa 11, 25123 Brescia, Italy
219. IL-2
INDUCES AN ALTERED CD4/CD8 RATIO OF SPLENIC T LYMPHOCYTES FROM TRANSGENIC
MICE OVEREXPRESSING THE GLUCOCORTICOID-INDUCED PROTEIN GILZ
Nicola Pozzesi, Carlo Riccardi, Domenico V. Delfino
Section of Pharmacology, Toxicology and Chemotherapy, Department
of Clinical and Experimental Medicine, University of Perugia Medical
School, Perugia, Italy
220. OUT
OF FRAME BCR-ABL FUSION PEPTIDES AS TARGETS OF THE IMMUNOTHERAPY
IN CHRONIC MYELOGENOUS LEUKEMIA
Casnici Claudia, Crotta Katia, Lattuada Donatella, Mastrotto Cristina,
Volpe Gisella*, Panuzzo Cristina*, Kuka Mirala*, Saglio Giuseppe*,
Marelli Ornella
Department of Pharmacology, School of Medicine, University of
Milan, Milan, Italy; *Department of Clinical and Biological Science,
University of Turin, Turin, Italy
221. EXPRESSION
OF THE ANG II TYPE 1 RECEPTOR ON HUMAN CD4+CD25+HI REGULATORY T
CELLS
Rasini Emanuela, Marino F., Guasti L., Ferrari M., Legnaro M. Schembri
L., Venco A., Lecchini S., Cosentino M.
Department of Clinical Medicine, University of Insubria, Varese,
Italy
222. EFFECT
OF DIFFERENT MENTHA PIPERITA VARIETIES ON PROLIFERATION AND CYTOKINE
PRODUCTION IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS
Carcano Elena, Cosentino Marco, Bombelli Raffaella, Luini Alessandra,
Marino Franca, *Colombo Maria L., #Conti Ario, Lecchini Sergio
Dept. Clinical Medicine, Sect. Clin. Exp. Pharmacology, University
of Insubria, Varese, I, *Dept. Pharm. Sci. Technol., University
of Turin, I, and #Alpine Foundation for Life Sciences, Olivone,
CH
223. MODIFIED
A-GALACTOSYL CERAMIDE ANALOGS FOR STIMULATING INKT CELLS: A PHARMACOLOGICAL
CHARACTERIZATION
Fallarini Silvia1, Panza L.1, Compostella F.2, Ronchetti F.2, De
Libero G.3, Lombardi G.1
1DISCAFF Department, University of “Piemonte Orientale”,
Novara, Italy; 2Department of Chemistry, Biochemistry and Biotechnology
for Medicine, University of Milano, Milano, Italy; 3Experimental
Immunology, Department of Research, University Hospital, Basel,
Switzerland
224. A
TUSCAN OLIVE OIL EXTRACT INHIBITS NUCLEAR FACTOR-KAPPA B ACTIVATION
IN MONOCYTE/MACROPHAGES FROM HEALTHY DONORS
Bardelli Claudio1, Gunella Gabriele1, Amoruso Angela1, Brunelleschi
Sandra1, Romani Annalisa2, Ieri Francesca2, Coinu Rita3 & Franconi
Flavia3
1Dept. Medical Sciences, University “A. Avogadro”,
Novara (Italy); 2Dept. Pharmacological Chemistry, University of
Florence (Italy); 3Center of Excellence for Biotechnology Development
and Biodiversity Research, University of Sassari (Italy) |
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FARMACOLOGIA CLINICA E SPERIMENTAZIONE CLINICA
DEI FARMACI |
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225. QUALITY
OF LIFE OF PEDIATRIC PATIENTS WITH ATTENTION DEFICIT HYPERACTIVITY
DISORDER AND OPPOSITIVE DEFIANT DISORDER: AN ITALIAN DOUBLE-BLIND
PLACEBO-CONTROLLED STUDY WITH ATOMOXETINE
Curatolo Paolo1; Mancini Francesca2; Dell’Agnello Grazia2
1Neuropsychiatria Infantile Clinica Sant’Alessandro, Rome,
Italy; 2Eli Lilly Italia
226. EVENING
AND EARLY MORNING ADMINISTRATION OF ATOMOZETINE IN ADHD CHILDREN:
A COMPARISON
Kelsey Douglas1; Sutton Virginia1; Lewis Donald2; Schuh Kory1; Sumner
Calvin1; Quintana Humberto3; Dell’Agnello Grazia4; Frediani
Sonia4; Rossi Andrea4
1Lilly Research Laboratories,Indianapolis,IN; 2Monarch Medical
Research,Norfolk,VA; 3Louisiana State University Health Science
Center,New Orleans,LA; 4Eli Lilly Italia
227.
SAFETY AND TOLERABILITY OF DULOXETINE IN THE TREATMENT OF
MAJOR DEPRESSIVE DISORDER: ANALYSIS OF POOLED DATA FROM EIGHT PLACEBO-CONTROLLED
CLINICAL TRIALS
Barraco Alessandra, Mancini Michele, Rossi Andrea
Eli Lilly Italia S.p.A.
228. THE
NEW ANTIDEPRESSANT DULOXETINE: CARDIOVASCULAR EFFECTS
Mancini Michele, Barraco Alessandra, Rossi Andrea
Eli Lilly Italia S.p.A.
229. THE
MANAGEMENT OF BIPOLAR MANIA: A NATIONAL SURVEY OF BASELINE DATA
FROM THE EMBLEM STUDY
Bellantuono Cesario1, Rossi Andrea2, Barraco Alessandra2, Goetz
Iris3, Mancini Michele2 for the Italian EMBLEM study group
1Department of Medicine and Public Health, Section of Psychiatry
and Clinical Psychology, University of Verona, Italy; 2Eli Lilly
Italia S.p.A. for the Italian EMBLEM study group; 3Eli Lilly and
Company, Windlesham, UK
230. EUROPEAN
MANIA IN BIPOLAR LONGITUDINAL EVALUATION OF MEDICATION (EMBLEM)
STUDY: RESULTS OF THE ACUTE 12-WEEK PHASE IN ITALY BY REGIONAL LOCATION
(NORTH, CENTRE AND SOUTH)
Rossi Andrea1, Barraco Alessandra1, Goetz Iris2, Mancini Michele1
for the Italian EMBLEM study group
1Eli Lilly Italia S.p.A.; 2Eli Lilly and Company, Windlesham,
UK
231. EFFECTIVENESS
OF ANTIPSYCHOTIC TREATMENT IN OUTPATIENTS WITH SCHIZOPHRENIA: 36-
MONTH RESULTS FROM THE SCHIZOPHRENIA OUTPATIENTS HEALTH OUTCOMES
(SOHO) STUDY
Novick Diego (1), Haro Josè M. (2), Brown James (1), Suarez
Diego (2), Rossi Andrea (3), Frediani Sonia (3), Ratcliffe Mark
C. (1), Scatigna Marco(3) and the SOHO Study Group (4)
(1) Eli Lilly and Company, Windlesham, UK (2) Unità ricerca
e sviluppo, San Joan de Deu-SSM, Sant Boi, Barcellona, Spagna (3)
Eli illy Italia S.p.A. (4) Alonso J (SP), Gasquet I (FR), Haro JM
(SP) Jones PB (UK), Knapp M (UK), Lepine JP (FR), Naber D (DE),
Slooff CJ (NL)
232. TOLERABILITY
OF OUTPATIENT ANTIPSYCHOTIC TREATMENT: 36-MONTH RESULTS FROM THE
EUROPEAN SCHIZOPHRENIA OUTPATIENTS HEALTH OUTCOMES (SOHO) STUDY
Novick Diego (1), Haro Josè M (2), Suarez Diego (2), Bushe
Chris (3), Lepine Antoine (4), Rossi Andrea (5), Frediani Sonia
(5) Scatigna Marco (5) and the SOHO Study Group (6)
(1) Eli Lilly and Company, Windlesham, UK (2) Unità ricerca
e sviluppo, San Joan de Deu-SSM, Sant Boi, Barcellona, Spagna (3)
Eli Lilly and Company, Basingstoke, UK; (4) Hôpital Fernand
Widal Parigi Cedex 10 (5) Eli Lilly Italia S.p.A. (6) Alonso J (SP),
Gasquet I (FR), Haro JM (SP) Jones PB (UK), Knapp M (UK), Lepine
JP (FR), Naber D (DE), Slooff CJ (NL)
233. THERAPEUTIC
MONITORING OF CLOZAPINE, ABCB1 GENOTYPING AND RESPONSE TO TREATMENT
IN PSYCHOTIC PATIENTS
Lastella Marianna*, Consoli Giorgio°, Amatori Federica*, Catena
Mario°, Ciapparelli Antonio°, Ciofi Laura*, Golia Francesca°,
Carmassi Claudia°, Danesi Romano*, Dell’Osso Liliana°,
Del Tacca Mario*, Di Paolo Antonello*
*Division of Pharmacology and Chemotherapy, Department of Internal
Medicine, University of Pisa; °Psychiatric Clinic, Department
of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University
of Pisa, Pisa
234. ESSENTIAL
TREMOR IS RESPONSIVE TO COMBINED TOPIRAMATE AND DECLORAZEPAM TREATMENT
Siniscalchi Antonio,1 Gallelli Luca,2 Borner Perrone Ina,2 Davoli
Alessandro,2 De Sarro Giovambattista2
1Department of Neuroscience, Neurology Division, “Annunziata”
Hospital, Cosenza, Italy; 2Chair of Pharmacology, Department of
Experimental and Clinical Medicine, Faculty of Medicine, University
Magna Graecia of Catanzaro, Catanzaro, Italy
235. THERAPEUTIC
DRUG MONITORING OF GENTAMICIN IN NEWBORNS: OUR EXPERIENCE
Martinelli Valentina, Serpi Antonella*, Carta Paolo, Fanos Vassilios*,
Del Zompo Maria, Testa Marcella*
Section of Clinical Pharmacology, Department of Neurosciences
“B.B. Brodie”, University of Cagliari; *Institute of
Neonatal Pathology and Intensive Therapy, University of Cagliari
236. PHASE
II MARKER LESION STUDY OF 6-WEEK INTRAVESICAL GEMCITABINE INSTILLATION
IN PATIENTS WITH LOW-RISK SUPERFICIAL BLADDER CANCER
Brausi Maurizio 1, Giussani Laura 2, Altieri Vincenzo 3, Rigatti
Patrizio 4, Gontero Paolo 5, Bertelli Lorenzo 6, Rossi Andrea 6,
Langer Frank 7, Russo Francesca 6, Bono Aldo2
1 Divisione di Urologia AUSL, Modena, 2 Divisione di Urologia
Ospedale di Circolo e Fondazione Macchi, Varese, 3Clinica Urologia
Azienda Universitaria Policlinico Federico II , Napoli, 4Clinica
Urologia Università Vita e Salute, Ospedale S. Raffaele,
Milano, 5Clinica di Urologia Ospedale Maggiore della Carità,
Novara, 6Eli Lilly Italia; 7Eli Lilly EuMed
237. COMPARISON
BETWEEN DIFFERENT TOPICAL HYPOTENSIVE DRUGS IN TWO EXPERIMENTAL
MODELS OF GLAUCOMA IN THE RABBIT
*Fabrizi Francesca, °Giambene Barbara, °Galassi Gianfranco,
*Uliva Caterina, §Ongini Ennio, *Masini Emanuela
*Department of Preclinical and Clinical Pharmacology; University
of Florence;°Department of Oto-neuro-ophthalmological Sciences,
University of Florence and §NicOx Research Institute, Milan,
Italy
238. PLASMA
LEVELS OF ARGININE AND LACTATE IN REHABILITATION PATIENTS WITH SPINAL
CORD INJURY AND PRESSURE ULCERS
Verri Manuela*, Aquilani R.^, Boschi F.*, Dossena M.*, Iadarola
P.°, Viglio S.°, Pastoris O.*
*Department of Physiological & Pharmacological Sciences;
°Department of Biochemistry “A. Castellani”, University
of Pavia, Pavia, Italy; ^IRCCS “S. Maugeri” Foundation,
Montescano, Italy
239. SILDENAFIL
CITRARE VERSUS TADALAFIL FOR ED TREATMENT: PREFERENCE OF ITALIAN
PATIENTS AND REASONS OF THEIR CHOICE
Fusco Ferdinando, Lembo, Antonio 1, Ludovico Giuseppe M 2, Pirozzi
Farina Furio 3, Montorsi Francesco 4, Menchini Fabris Fabrizio 5,
Sicuteri Riccardo 6, Rossi Andrea 6, Gentilella Raffaella 6, Mirone
Vincenzo
Clinica Urologica, Università Federico II, Napoli; 1
Div. Urologia, Ospedali Riuniti di Bergamo; 2 Unità di Urologia
Operativa, Ospedale Civile, Monopoli, Bari; 3 Università
Di Sassari, Clinica Urologica; 4 Reparto di Urologia, Ospedale S.
Raffaele, Milano; 5 Unità di Andrologia, Università
di Pisa, Pisa; 6 Eli Lilly Italia
240. THE
MAGNITUDE OF INHIBITORY DRUG INTERACTIONS IS DEPENDENT ON LIVER
FUNCTIONAL STATUS
Pegoraro Paola1, De Martin Sara1, Orlando Rocco2, and Palatini Pietro1
1Department of Pharmacology and Anaesthesiology, and of 2Medical
and Surgical Sciences, University of Padova, Italy |
20 |
FARMACOVIGILANZA, FARMACOEPIDEMIOLOGIA E
FARMACOECONOMIA |
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241. GABAPENTIN-INDUCED
RHABDOMYOLYSIS: A CASE REPORT
Tuccori Marco1,2, Lombardo Giuseppe2, Lapi Francesco1,4, Vannacci
Alfredo1,4, Blandizzi Corrado1,4, Mugelli Alessandro1,4, Del Tacca
Mario1,2
1Tuscan Regional Center for Pharmacovigilance; 2Division of
Pharmacology and Chemotherapy, Department of Internal Medicine,
University of Pisa – Pisa, Italy; 3Intensive Care Unit - Hospital
of Empoli, Florence – Italy; 4Department of Preclinical and
Clinical Pharmacology - University of Florence, Florence –
Italy
242. ANTICOAGULANTS
AND DRUGS AT INTERACTION RISK
Marianna Alacqua1, Gianluca Trifirò1,4, Salvatore Moretti3,
Michele Tari3, Mariella Galdo3, Ugo Tari3, Achille P Caputi1,4,
UVEC group3, Vincenzo Arcoraci1
1Department of Clinical and Experimental Medicine and Pharmacology,
Pharmacology Unit, University of Messina, Italy - 2 Division of
Child Neurology and Psychiatry, University of Messina, Italy - 3
“Caserta 1” Local Health Service, Caserta, Italy - 4
IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy
243. VIGILANCE
SYSTEM FOR UNDESIRABLE EFFECTS OF COSMETIC PRODUCTS (COSMETOVIGILANCE)
IN EUROPE
Sportiello Liberata1 and Sautebin Lidia1,2
1Department of Experimental Pharmacology, 2Pharmacoeconomic
and Pharmacoutilization Research Centre, Faculty of Pharmacy, University
of Naples Federico II, Naples, Italy
244. NOTIFICATION
OF UNDESIRABLE EFFECTS OF COSMETIC PRODUCTS BY PHARMACISTS AND DERMATOLOGISTS:
A PILOT PROJECT
Sautebin Lidia
Department of Experimental Pharmacology, Pharmacoeconomic and
Pharmacoutilization Research Centre, Faculty of Pharmacy, University
of Naples Federico II, Naples, Italy
245. GENDER
DIFFERENCE IN ADVERSE DRUG REACTIONS: ANALYSIS OF SPONTANEOUS REPORTS
OF AN ITALIAN INTERREGIONAL DATABASE (GIF)
Francesco Salvo (1), Paola Maria Cutroneo (1), Ilaria Meneghelli
(2), Domenico Motola (3), Mario Del Tacca (4), Barbara Ros (5),
Annalisa Capuano (6), Olivia Leoni, and Giovanni Polimeri (1)
(1) Dep. Clin Experim Med and Pharmacol, University of Messina,
Italy - (2) Clinical Pharmacology Unit, University of Verona, Italy
- (3) Interuniversity Research Centre for Pharmacoepidemiology,
University of Bologna, Italy - (4) Division of Pharmacology and
Chemotherapy, University of Pisa, Italy; (5) Pharmaceutical Service
of Friuli Venezia Giulia Health Department, Trieste, Italy - (6)
Department of Experimental Medicine, Second University of Naples,
Italy - (7) Lombardy Centre of Pharmacovigilance, Milan, Italy
246. GENDER
AND AGE-RELATED DRUG PRESCRIPTION PATTERNS IN THE VARESE LOCAL HEALTH
AUTHORITY
Leoni Olivia1, Banfi Fabio2, Soma Renato1, Manfredi Luca1, Oria
Cristina1, Roi Cinzia1
1PAC Department, Varese Local Health Authority, Italy; 2Health
Managed, Varese Local Health Authority, Italy
247. THE
PHARMACOLOGICAL CONSULTATION SERVICE AS A VALID TOOL FOR DEVELOPING
A CORRECT DRUG APPROACH: "THE POPPERS' CASE"
Stochino M. Erminia, Asuni Carlo, Carta Paolo, Del Zompo Maria
Drug Information Centre, Section of Clinical Pharmacology, Department
of Neurosciences “B.B. Brodie”, University of Cagliari
248. ADVERSE
REACTIONS TO CONTRAST MEDIA: AN ANALYSIS FROM SPONTANEOUS REPORTING
DATA
Paola Cutroneo1, Giovanni Polimeni1,2, Roberto Curcuruto1, Alessandra
Russo1, Gioacchino Calapai1, Achille P. Caputi1
1Department of Clinical and Experimental Medicine and Pharmacology,
School of Medicine, University of Messina, Italy; 2Istituto di Ricovero
e Cura a Carattere Scientifico (IRCCS) Centro Neurolesi "Bonino-Pulejo,"
Messina, Italy
249. REGIONAL
SURVEILLANCE OF EMERGENCY DEPARTMENT VISITS FOR OUTPATIENT ADVERSE
DRUG EVENTS
M. Gallo, L. Ferrante, M.L. Illiano, F. Russo, R. Annibale, A. Filippelli,
F. Rossi, A. Captano
Department of Experimental Medicine, Section of Pharmacology
“Leonardo Donatelli”. Center of Pharmacosurveillance
and Pharmacoepidemiology, Faculty of Medicine and Surgery, Second
University of Naples, Italy
250. PHARMACOVIGILANCE
TEACHING IN THE EUROPEAN FACULTIES OF PHARMACY
Rossi Antonietta1, Pergola Carlo1 and Sautebin Lidia1,2
1Department of Experimental Pharmacology, 2Pharmacoeconomic
and Pharmacoutilization Research Centre, Faculty of Pharmacy, University
of Naples Federico II, Naples, Italy.
251. PROMOTING
CONTINUING EDUCATION IN PHARMACOVIGILANCE: THE EXPERIENCE OF "PHARMASEARCH",
A NETWORK OF GENERAL PRACTITIONERS REPORTING ADVERSE DRUG REACTIONS
Catania Maria A1., Salvo Francesco1, Oteri Alessandro1, Polimeni
Giovanni1,5, Russo Alessandra1, Giustini Saffi E.2, Sessa Aurelio2,
Tuccori Marco3, Martelli Antonietta4, Del Tacca Mario3, Caputi Achille
P.1,5
1University of Messina; 2Area Pharmasearch, SIMG; 3University
of Pisa; 4University of Genova; 5IRCCS Neurolesi “Bonino-Pulejo”,
Messina
252. THE
BLINK PROJECT: A NEW BIOMEDICAL RESEARCHERS' DATABASE (WWW.DOYOUBLINK.NET)
Busconi Pietro1, Ferranti Stefano2, Ceserani Ida3, Pistotti Vanna4,
Casale Federico3, Caglioti Luciano5, Biggio Giovanni3, Garattini
Silvio4
1Promotore, Fondazione Schering, Italy – 2Sviluppo tecnico
database, New! S.a.s., Milano, Italy; 3Società Italiana di
Farmacologia, Milano, Italy - 4Istituto di Ricerche Farmacologiche
“Mario Negri”, Italy - 5Università "La Sapienza",
Roma, Italy
253. ON
PARENTERAL FORMULATIONS AND GOLDEN STANDARDS FOR QUALITY AND SAFETY
Naccari C. a, Giovinazzo C. a, Saija A. a, Tomaino A. a
a Dept. Farmaco-Biologico, Faculty of Pharmacy, University of
Messina, Contrada Annunziata, 98168 Messina, Italy; b Faculty of
Pharmacy, University of Messina, Contrada Annunziata, 98168 Italy |
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FARMACOGNOSIA E FITOTERAPIA: ASPETTI SPERIMENTALI
E CLINICI |
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254. CENTRAL
EFFECTS OF A NEW SECOISOPIMARANE DITERPENOID FROM AERIAL PARTS OF
SALVIA CINNABARINA
Francesco Maione1,2, Mariantonella Colucci2, Angela Bisio3, Romussi
Giovanni3, Stefano Pieretti2, Amalia Di Giannuario2, Maria C. Bonito1,2,
Nicola Mascolo1
1Department of Experimental Pharmacology, University of Naples
“Federico II, Naples; 2Department of Drug Research and Evaluation,
Italian National Institute of Health, Rome; 3Department of Chemistry
and Pharmaceutical Technology and Alimentary, University of Genoa,
Genoa
255. IN
VITRO ANTIOXIDANT ACTIVITY OF AGED EXTRACTS OF SOME ITALIAN SPONTANEOUS
ALLIUM SPECIES
Nencini Cristina, Micheli Lucia, Giorgi Giorgio, Franchi Gian Gabriele
Department of Pharmacology “Giorgio Segre”, University
of Siena
256. EFFECT
OF ALLIUM NEAPOLITANUM ON LIVER INJURY INDUCED BY ETHANOL IN RATS
Nencini Cristina, Franchi Gian Gabriele, Giorgi Giorgio, Micheli
Lucia.
Department of Pharmacology “Giorgio Segre”, University
of Siena
257. ANTIOXIDANT
PROPERTIES OF INFUSIONS FROM LEAVES AND INFLORESCENCES OF ACHILLEA
MILLEFOLIUM SSP. COLLINA B. BY USE OF CHEMICAL AND BIOLOGICAL ASSAYS
Raffaella Bombelli1, A. Luini1, A. Giorgi2, G. Licheri2, E. Carcano1,
F. Marino1, M.Cosentino1, M. Cocucci2, S. Lecchini1
1Dipartimento di Medicina Clinica, Sezione di Farmacologia Sperimentale
e Clinica, Università degli Studi dell’Insubria, Varese
and 2Dipartimento di Produzione Vegetale, Università degli
Studi di Milano, Milano
258. IN
VITRO ANTIOXIDANT, ANTIMUTAGEN AND ANTI-INFLAMMATORY ACTIVITY OF
EXTRACTS AND STILBENES FROM GLYCYRRHIZA GLABRA LEAVES
1CRISTANI M., 1SAIJA A., 1D’ARRIGO M., 1NACCARI C., 2RUBERTO
G., 2BIONDI D.M., 1TROMBETTA D.
1Dept. Farmaco-Biologico, School of Pharmacy, University of
Messina, Italy - 2CNR Institute of Biomolecular Chemistry - Catania,
Valverde, Catania, Italy
259. PROTECTIVE
EFFECT OF HYPERICUM PERFORATUM IN ZYMOSAN-INDUCED MULTIPLE ORGAN
DYSFUNCTION SYNDROME
1Angelina De Sarro, 1,2Emanuela Mazzon, 1,2Rosanna Di Paola, 1Carmelo
Muià, 1,2Tiziana Genovese, 2Placido Bramanti, 3Emanuela Esposito,
4Marta Menegazzi, 3Rosaria Meli, 4Hisanori Suzuki, and 1,2Salvatore
Cuzzocrea
1Department of Clinical and Experimental Medicine and Pharmacology,
School of Medicine, University of Messina, Italy; 2IRCCS Centro
Neurolesi "Bonino-Pulejo", Messina, Italy; 3Dipartimento
di Farmacologia Sperimentale, Università di Napoli “Federico
II”, Napoli, Italy; 4Department of Neuroscience and Vision,
University of Verona, Verona, Italy
260. INHIBITION
OF HUMAN CAMP PHOSPHODIESTERASES AS A MECHANISM OF THE SPASMOLYTIC
EFFECT OF MATRICARIA RECUTITA L. WATER EXTRACT
Dell’Agli Mario, Dal Cero Esther, Maschi Omar, Bosisio Enrica
Department of Pharmacological Sciences, Faculty of Pharmacy,
University of Milan, Italy
261. PHENYLPROPANOID
RICH ESSENTIAL OILS AS POTENTIAL ANTITHROMBOTICS ENDOWED WITH GASTROPROTECTIVE
EFFECTS
Tognolini Massimiliano 1, Barocelli Elisabetta 1, Bertoni Simona
1, Impicciatore Mariannina 1, Bruni Renato 2, Ballabeni Vigilio
1
1Dept of pharmacological, biological and applied chemical sciences.
University of Parma. Viale Usberti 27/a, 43100 Parma, Italy; 2Dept
of evolutionary and functional biology. University of Parma. Viale
Usberti 11/a, 43100 Parma, Italy
262. BIOLOGICAL
ACTIVITY OF BERGAMOT PEEL EXTRACTS (CITRUS BERGAMIA RISSO)
Trombetta D., D’Arrigo M., Ginestra G., Arcoraci T., Mandalari
G., Saija A., Cristani M.
Dept. Farmaco-Biologico, School of Pharmacy, University of Messina
- Vill. SS. Annunziata 98168 Messina, Italy
263. EVIDENCE
TO IMPLICATE PHOSPHO-AKT (P-AKT) IN THE MECHANISMS UNDERLYING NEUROPROTECTION
AFFORDED BY THE ESSENTIAL OIL OF BERGAMOT AGAINST EXCITOTOXICITY
IN VITRO
Maida Simona1, Fratto Vincenza, Navarra Michele1, Bagetta Giacinto2
and Corasaniti M.Tiziana1
1Department of Pharmacobiological Sciences, University “Magna
Graecia” of Catanzaro, Catanzaro, Italy; 2Department of Pharmacobiology
and University Centre of Adaptive Disorders and Headache (UCADH),
section of Neuropharmacology of Normal and Pathological Neuronal
Plasticity, University of Calabria, Rende (CS), Italy
264. THE
PROTECTIVE EFFECT OF BERGAMOT OIL NON VOLATILE FRACTION ON LOX-1
EXPRESSION IN BALLOON INJURY-RELATED NEOINTIMA FORMATION
Iolanda Sacco1, E Palma1, F Sculco1, C. Colica1, V Visalli1, S Muscoli3,
S Ragusa1, L Mondello4, D. Rotiroti1, F Romeo3, V Mollace1,2
1Faculty of Pharmacy, University “Magna Graecia”
of Catanzaro, Italy; 2San Raffaele Pisana IRCCS, Rome, Italy; 3Chair
of Cardiology, University of Rome “Tor Vergata”, Rome,
Italy; 4Faculty of Pharmacy, University of Messina, Italy
265. VASCULAR
ACTIVITY OF ISOLATES FROM THE HYACINTHACEAE OF SOUTH AFRICA
Ferrara Antonella, F Fusi, C Koorbanally, NR Crouch, DA Mulholland
& G Sgaragli
Dipartimento di Scienze Biomediche, Università
degli Studi di Siena, via A. Moro 2, 53100 Siena, email: ferrara14@unisi.it
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FARMACOGENETICA, FARMACOGENOMICA E TERAPIA
GENICA |
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266. OLYMORPHISMS
OF THE ABCB1 GENE PREDICT DRUG RESISTANCE IN EPILEPTIC PATIENTS
Lastella Marianna*, Danesi Romano*, Cascio Elisa*, Jensen Stella§
, Iudice Alfonso§,
Murri Luigi§ , Del Tacca Mario*, Di Paolo Antonello*
*Division of Pharmacology and Chemotherapy, Department of Internal
Medicine;
§Division of Neurology, Department of Neurosciences - University
of Pisa
267. HERPES
SIMPLEX VECTORS EXPRESSING FGF-2 AND BDNF PROMPT NEURONOGENESIS
AND EXERT DISEASE-MODIFYING EFFECTS IN A MODEL OF TEMPORAL LOBE
EPILEPSY
Mazzuferi Manuela,1 Paradiso Beatrice,1 Marconi Peggy,1 Zucchini
Silvia,1 Elena Berto,1 Binaschi Anna,1 Bozac Aleksandra,1 Buzzi
Andrea,1 Magri Eros,1 Navarro Mora Graciela,2 Rodi Donata,1 Volpi
Ilaria,1 Fabene Paolo F.,2 Marzola Andrea,1 Manservigi Roberto,1
Simonato Michele 1
1University of Ferrara,2University of Verona, Italy
268. ALZHEIMER'S
DISEASE: ASSOCIATION STUDY BETWEEN RESPONSE TO CHOLINESTERASE INHIBITORS
AND CANDIDATE GENES IN A SARDINIAN SAMPLE
Squassina Alessio1, Congiu Donatella1, Manconi Francesca1, Putzu
Paolo F2, Chillotti Caterina1, Del Zompo Maria1, Piccardi Mariapaola1
1Unit of Clinical Pharmacology, Department of Neurosciences
‘‘B. B. Brodie’’, University of Cagliari,
2Division of Geriatrics, Local Health Agency 8, Cagliari, Italy
269. IMPACT
OF CYP3A4 AND CYP3A5 POLYMORPHISMS ON CLINICAL OUTCOME OF DONEPEZIL
IN ALZHEIMER'S DISEASE PATIENTS
T. Paoletti1, M.G. Scordo2, G. Miglio1, M.L. Villa3, M.L. Dahl2,
G. Lombardi1
1 DISCAFF Department, University of “Piemonte Orientale
Amedeo Avogadro”, Novara, Italy; 2 Department of Medical Sciences,
Clinical Pharmacology, Uppsala University Hospital, Uppsala, Sweden;
3 Geriatric Clinical Unit, “ Ospedale Maggiore della Carità”,
Novara, Italy
270. ROLE
OF POLYMORPHISMS OF THE UGT1A9 GENE IN COMT INHIBITOR-INDUCED HEPATOTOXICITY
IN PARKINSON'S DISEASE: A CLINICAL STUDY
1Marco Ferrari, 1Marco Cosentino, 1Franca Marino, 1Giorgio Bono,
2Emilia Martignoni, 3,4Giuseppe Nappi, 1Sergio Lecchini
1Dept. Clin. Med., University of Insubria, Varese, 2Dept. Med.
Sci., University of Piemonte Orientale “Amedeo Avogadro”,
Novara and Dept. Neurorehabil. Mov. Disord., “Salvatore Maugeri”
Foundation, Scientific Institute of Veruno, NO, 3Dept. of Neurol.
Otorhinolaryngol., University “La Sapienza”, Rome, and
4I.R.C.C.S. C. Mondino, Pavia, Italy
271. GENETIC
POLYMORHISMS OF SEROTONIN TRANSPORTER AND MONOAMINE OXIDASE; AND
RESPONSE TO SSRI ANTIDEPRESSANT DRUGS IN TERMINAL CANCER PATIENTS
Schillani Giulia, Capozzo Marianna, Conte Anna Maria, De Vanna Maurizio,
Giraldi Tullio
Department of Biomedical Sciences, University of Triest
272. LITHIUM
RESPONSE: ASSOCIATION STUDY WITH CANDIDATE GENES
Manchia Mirko, Squassina Alessio, Lampus Simona, Ardau Raffaella,
Chillotti Caterina, Del Zompo Maria, Severino Giovanni
Section of Clinical Pharmacology, Department of Neurosciences
“B.B. Brodie”, University of Cagliari
273. PHARMACOGENOMICS
AND TRIPTANS: A PILOT STUDY OF ASSOCIATION BETWEEN CLINICAL RESPONSE
TO RIZATRIPTAN AND SOME CANDIDATE GENES
Asuni Carlo, Stochino M. Erminia, Congiu Donatella, Cherchi Alessandra,
Piccardi M. Paola, Del Zompo Maria
Headache Centre, Section of Clinical Pharmacology, Department
of Neurosciences “B.B. Brodie”, University of Cagliari
274. SYNERGISTIC
CYTOTOXICITY OF OXALIPLATIN AND PEMETREXED IN COLON CANCER CELLS:
CELLULAR AND MOLECULAR MECHANISMS
Sara Nannizzi, Elisa Giovannetti, Valentina Mey, Simona Ricciardi,
Mario Del Tacca, Romano Danesi
Division of Pharmacology and Chemotherapy, Department of Internal
Medicine, University of Pisa
275. MOLECULAR
MECHANISMS UNDERLYING THE SYNERGISTIC INTERACTION OF THE EGFR TYROSINE
KINASE INHIBITOR ERLOTINIB WITH THE MULTITARGETED ANTIFOLATE PEMETREXED
IN NON-SMALL CELL LUNG CANCER CELLS
Giovannetti Elisa,1,2 Smid Kees,1 Mey Valentina,2 Tekle Christina,1
Nannizzi Sara,2 Rodriguez José A,1 Ricciardi Simona,2 Del
Tacca Mario ,2 Giaccone Giuseppe,1Danesi Romano,2 Peters Godefridus
J1
1Dept. Medical Oncology, VU University Medical Center, Amsterdam,
The Netherlands; 2Dept. Internal Medicine, Div. Pharmacology and
Chemotherapy, University of Pisa, Italy
276. PHARMACOGENETIC
EVALUATION OF AURORA A KINASE IN COLORECTAL CANCERS
Amatori Federica Maria*, Boldrini L§, Di Paolo A*, Lastella
M*, Fontanini G§, Del Tacca M*, Danesi R*.
* Division of Pharmacology and Chemotherapy, Department of Internal
Medicine; §Division of Pathology, Department of General Surgery,
University of Pisa
277. EPIGENETIC
MECHANISMS OF SENSITIVITY TO IRINOTECAN IN COLORECTAL CANCER CELL
LINES
Crea Francesco, Giovannetti Elisa, Mey Valentina, Nannizzi Sara,
Ricciardi Simona, Danesi Romano, Del Tacca Mario
Division of Pharmacology and Chemotherapy, Department of Internal
Medicine, University of Pisa, Pisa, Italy
278. GENETIC POLYMORPHISMS IN DNA REPAIR
GENES AND THEIR IMPACT ON SUSCEPTIBILITY TO MULTIPLE MYELOMA
Sabrina ANGELINI1, Cantelli-Forti Giorgio1, Carolina Terragna2,
Matteo Renzulli2, Michele Cavo2, Patrizia Hrelia1
1. Department of Pharmacology, University of Bologna; 2. Institute
of Haematology and Medical Oncology “Seragnoli”, University
of Bologna
(Abstract non disponibile su richiesta dell'autore)
279. GENETIC
POLYMORPHISM OF BLEOMYCIN HYDROLASE: A NEW BIOMARKER FOR HUMAN MUTAGEN
SENSITIVITY
Maffei Francesca1, Carbone Fabio1, Angelini Sabrina1, Cantelli Forti
Giorgio1, Norppa Hannu2, Hrelia Patrizia1
1 Department of Pharmacology, University of Bologna, Via Irnerio
48 40126 Bologna, Italy; 2 Finnish Institute of Occupational Health,
Topeliuksenkatu 41 aA, FI-00250 Helsinki, Finland
280. DNA
VACCINE STRATEGY AGAINST CHRONIC B-CELL LYMPHOMA: ANTI-IDIOTYPIC
CDR3 VACCINATION
Schirru Cristina1, Maullu Carlo1, Deidda Federico1, Rinaldi Monica3,
Signori Emanuela2,3, Massi Emanuela2, Chiarella Pieranna1,2, Marelli
Ornella4, Tonon Giancarlo1 and Fazio Vito Michele2,3
1 Bioker S.r.l. Polaris Loc.piscinamanna Pula (CA); 2 CIR, Section
of Molecular Medicine and Biotechnology, University "Campus
Bio-Medico", Rome, Italy; 3 Institute of Neurobiology and Molecular
Medicine, CNR Rome, Italy; 4 Dipartimento Di Farmacologia, Chemioterapia
E Tossicologia Medica, Università di Milano |
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